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PRJNA207719: Tissue specific transcriptome profiling

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Results for eomesa

Z-value: 1.44

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Transcription factors associated with eomesa

Gene Symbol Gene ID Gene Info
eomesa
ENSDARG00000006640 eomesodermin homolog a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
eomesadr11_v1_chr19_-_868187_8681870.118.6e-01Click!

Activity profile of eomesa motif

Sorted Z-values of eomesa motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_21877726 1.11 ENSDART00000127819
ENSDART00000145646
ENSDART00000100897
ENSDART00000144739
zgc:162608
zgc:162608
chr2_-_32637592 1.09 ENSDART00000136353
si:dkeyp-73d8.8
si:dkeyp-73d8.8
chr10_+_19596214 0.83 ENSDART00000183110
CABZ01059626.1

chr7_+_27691647 0.77 ENSDART00000079091
cyp2r1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr16_+_23947196 0.73 ENSDART00000103190
ENSDART00000132961
ENSDART00000147690
ENSDART00000142168
apoa4b.2
apolipoprotein A-IV b, tandem duplicate 2
chr22_+_25352530 0.72 ENSDART00000176742
ENSDART00000113186
si:dkey-240e12.6
si:dkey-240e12.6
chr22_+_25693295 0.72 ENSDART00000123888
ENSDART00000150783
si:dkeyp-98a7.4
si:dkeyp-98a7.3
si:dkeyp-98a7.4
si:dkeyp-98a7.3
chr22_+_25715925 0.70 ENSDART00000150650
si:dkeyp-98a7.7
si:dkeyp-98a7.7
chr20_-_40755614 0.70 ENSDART00000061247
cx32.3
connexin 32.3
chr22_+_25687525 0.69 ENSDART00000135717
si:dkeyp-98a7.3
si:dkeyp-98a7.3
chr22_+_25681911 0.69 ENSDART00000113381
si:dkeyp-98a7.3
si:dkeyp-98a7.3
chr22_+_25704430 0.67 ENSDART00000143776
si:dkeyp-98a7.3
si:dkeyp-98a7.3
chr21_-_1742159 0.66 ENSDART00000151049
onecut2
one cut homeobox 2
chr23_-_31647793 0.66 ENSDART00000145621
sgk1
serum/glucocorticoid regulated kinase 1
chr23_-_31648026 0.64 ENSDART00000133569
sgk1
serum/glucocorticoid regulated kinase 1
chr1_+_29741843 0.64 ENSDART00000136066
raph1b
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b
chr11_-_40504170 0.64 ENSDART00000165394
si:dkeyp-61b2.1
si:dkeyp-61b2.1
chr10_+_19595009 0.57 ENSDART00000112276
zgc:173837
zgc:173837
chr19_-_27564458 0.51 ENSDART00000123155
si:dkeyp-46h3.6
si:dkeyp-46h3.6
chr10_-_25217347 0.51 ENSDART00000036906
kpna7
karyopherin alpha 7 (importin alpha 8)
chr22_+_25753972 0.50 ENSDART00000188417
AL929192.2

chr16_+_44314097 0.48 ENSDART00000148684
dpys
dihydropyrimidinase
chr13_-_9318891 0.48 ENSDART00000137364
si:dkey-33c12.3
si:dkey-33c12.3
chr17_+_36588281 0.43 ENSDART00000076115
htr1b
5-hydroxytryptamine (serotonin) receptor 1B
chr3_+_59051503 0.42 ENSDART00000160767
rasd4
rasd family member 4
chr1_+_45323142 0.42 ENSDART00000132210
emp1
epithelial membrane protein 1
chr25_-_13703826 0.41 ENSDART00000163398
pla2g15
phospholipase A2, group XV
chr13_-_51952020 0.34 ENSDART00000181079
LT631676.1

chr11_-_1550709 0.32 ENSDART00000110097
si:ch73-303b9.1
si:ch73-303b9.1
chr25_+_24250247 0.32 ENSDART00000064646
tmem86a
transmembrane protein 86A
chr14_-_2361692 0.31 ENSDART00000167696
PCDHGC3 (1 of many)
si:ch73-233f7.4
chr7_+_73332486 0.31 ENSDART00000174119
ENSDART00000092051
ENSDART00000192388
CABZ01081780.1

chr22_+_25274712 0.28 ENSDART00000137341
BX950205.1

chr5_+_31036911 0.28 ENSDART00000141463
ENSDART00000162121
zzef1
zinc finger, ZZ-type with EF hand domain 1
chr10_-_5847904 0.27 ENSDART00000161096
ankrd55
ankyrin repeat domain 55
chr5_+_62319217 0.26 ENSDART00000050879
pho
phoenix
chr22_-_36690742 0.26 ENSDART00000017188
ENSDART00000124698
ncl
nucleolin
chr9_-_12885201 0.26 ENSDART00000124957
ankzf1
ankyrin repeat and zinc finger domain containing 1
chr3_+_16449490 0.25 ENSDART00000141467
kcnj12b
potassium inwardly-rectifying channel, subfamily J, member 12b
chr1_-_45042210 0.25 ENSDART00000073694
smu1b
SMU1, DNA replication regulator and spliceosomal factor b
chr10_-_28193642 0.25 ENSDART00000019050
rps6kb1a
ribosomal protein S6 kinase b, polypeptide 1a
chr10_+_35953068 0.25 ENSDART00000015279
rtn4rl1a
reticulon 4 receptor-like 1a
chr2_-_57469115 0.24 ENSDART00000192201
pias4b
protein inhibitor of activated STAT, 4b
chr10_-_5847655 0.24 ENSDART00000192773
ankrd55
ankyrin repeat domain 55
chr1_+_45323400 0.24 ENSDART00000148906
ENSDART00000132366
emp1
epithelial membrane protein 1
chr7_+_23907692 0.23 ENSDART00000045479
syt4
synaptotagmin IV
chr22_-_5252005 0.23 ENSDART00000132942
ENSDART00000081801
ncln
nicalin
chr16_+_14812585 0.23 ENSDART00000134087
col14a1a
collagen, type XIV, alpha 1a
chr18_+_6641542 0.23 ENSDART00000160379
c2cd5
C2 calcium-dependent domain containing 5
chr19_-_867071 0.23 ENSDART00000122257
eomesa
eomesodermin homolog a
chr2_-_13216269 0.22 ENSDART00000149947
bcl2b
BCL2, apoptosis regulator b
chr20_-_46773258 0.21 ENSDART00000060653
si:ch211-57i17.5
si:ch211-57i17.5
chr5_+_32007627 0.21 ENSDART00000183061
scai
suppressor of cancer cell invasion
chr22_+_19111444 0.21 ENSDART00000109655
fgf22
fibroblast growth factor 22
chr22_-_6066867 0.21 ENSDART00000142383
si:dkey-19a16.1
si:dkey-19a16.1
chr13_-_280827 0.21 ENSDART00000144819
slc30a6
solute carrier family 30 (zinc transporter), member 6
chr5_-_45877387 0.20 ENSDART00000183714
ENSDART00000041503
slc4a4a
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr2_-_34555945 0.19 ENSDART00000056671
brinp2
bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr12_-_48960308 0.17 ENSDART00000176247
CABZ01112647.1

chr23_+_4362463 0.16 ENSDART00000039829
zgc:112175
zgc:112175
chr1_+_5576151 0.16 ENSDART00000109756
cpo
carboxypeptidase O
chr6_+_54538948 0.16 ENSDART00000149270
tulp1b
tubby like protein 1b
chr11_+_14622379 0.15 ENSDART00000112589
efna2b
ephrin-A2b
chr14_-_2602445 0.14 ENSDART00000166910
etf1a
eukaryotic translation termination factor 1a
chr15_-_35112937 0.13 ENSDART00000154565
ENSDART00000099642
zgc:77118
zgc:77118
chr25_-_17367578 0.12 ENSDART00000064591
ENSDART00000110692
cyp2x6
cytochrome P450, family 2, subfamily X, polypeptide 6
chr11_-_40728380 0.12 ENSDART00000023745
ccdc114
coiled-coil domain containing 114
chr3_-_60827402 0.12 ENSDART00000053494
anks4b
ankyrin repeat and sterile alpha motif domain containing 4B
chr20_-_32007209 0.12 ENSDART00000021575
adgb
androglobin
chr1_+_57142509 0.11 ENSDART00000146799
si:ch73-94k4.3
si:ch73-94k4.3
chr22_+_26263290 0.11 ENSDART00000184840
BX649315.1

chr1_-_55750208 0.10 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr21_-_27010796 0.10 ENSDART00000065398
ENSDART00000144342
ENSDART00000126542
ppp1r14ba
protein phosphatase 1, regulatory (inhibitor) subunit 14Ba
chr24_-_24060460 0.10 ENSDART00000142813
abcc13
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr18_+_33779440 0.09 ENSDART00000133349
si:dkey-145c18.3
si:dkey-145c18.3
chr10_+_26612321 0.09 ENSDART00000134322
fhl1b
four and a half LIM domains 1b
chr8_+_45003659 0.09 ENSDART00000132663
si:ch211-163b2.4
si:ch211-163b2.4
chr7_+_9981757 0.09 ENSDART00000113429
ENSDART00000173233
adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr7_+_21275152 0.09 ENSDART00000173612
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr5_-_67762434 0.09 ENSDART00000167301
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr2_+_42177113 0.09 ENSDART00000056441
tmeff1a
transmembrane protein with EGF-like and two follistatin-like domains 1a
chr10_-_8956973 0.09 ENSDART00000189564
mocs2
molybdenum cofactor synthesis 2
chr1_-_57129179 0.09 ENSDART00000157226
ENSDART00000152469
si:ch73-94k4.2
si:ch73-94k4.2
chr19_+_2275019 0.09 ENSDART00000136138
itgb8
integrin, beta 8
chr7_-_69983462 0.09 ENSDART00000123380
KCNIP4
potassium voltage-gated channel interacting protein 4
chr17_-_29312506 0.07 ENSDART00000133668
tecpr2
tectonin beta-propeller repeat containing 2
chr15_+_28940352 0.07 ENSDART00000154085
gipr
gastric inhibitory polypeptide receptor
chr11_-_13341051 0.07 ENSDART00000121872
mast3b
microtubule associated serine/threonine kinase 3b
chr4_-_77624155 0.07 ENSDART00000099761
si:ch211-250m6.7
si:ch211-250m6.7
chr2_+_35240485 0.07 ENSDART00000179804
tnr
tenascin R (restrictin, janusin)
chr15_-_45538773 0.06 ENSDART00000113494
MB21D2
Mab-21 domain containing 2
chr4_-_51460013 0.06 ENSDART00000193382
CR628395.1

chr18_-_20444296 0.06 ENSDART00000132993
kif23
kinesin family member 23
chr10_-_9115383 0.06 ENSDART00000139324
si:dkeyp-41f9.3
si:dkeyp-41f9.3
chr20_-_35052464 0.06 ENSDART00000037195
kif26bb
kinesin family member 26Bb
chr22_-_14475927 0.06 ENSDART00000135768
lrp1ba
low density lipoprotein receptor-related protein 1Ba
chr12_+_5129245 0.05 ENSDART00000169073
pde6c
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr2_-_10896745 0.05 ENSDART00000114609
cdcp2
CUB domain containing protein 2
chr22_+_25774750 0.05 ENSDART00000174421
AL929192.1

chr5_-_41645058 0.05 ENSDART00000051092
riok2
RIO kinase 2 (yeast)
chr4_-_72555545 0.05 ENSDART00000172315
si:ch211-161m3.4
si:ch211-161m3.4
chr12_-_10421955 0.04 ENSDART00000052004
zgc:153595
zgc:153595
chr22_-_9896180 0.04 ENSDART00000138343
znf990
zinc finger protein 990
chr7_+_30493684 0.04 ENSDART00000027466
mindy2
MINDY lysine 48 deubiquitinase 2
chr22_+_10010292 0.04 ENSDART00000180096
BX324216.4

chr10_+_16092671 0.04 ENSDART00000182761
ENSDART00000154835
megf10
multiple EGF-like-domains 10
chr7_-_1101694 0.04 ENSDART00000183017
ENSDART00000182681
dctn1a
dynactin 1a
chr8_+_25267903 0.04 ENSDART00000093090
ampd2b
adenosine monophosphate deaminase 2b
chr24_-_36196077 0.03 ENSDART00000154395
esco1
establishment of sister chromatid cohesion N-acetyltransferase 1
chr5_-_16475374 0.03 ENSDART00000134274
ENSDART00000136004
piwil2
piwi-like RNA-mediated gene silencing 2
chr22_-_18544701 0.03 ENSDART00000132156
cirbpb
cold inducible RNA binding protein b
chr25_+_32071558 0.03 ENSDART00000155992
tjp1b
tight junction protein 1b
chr9_-_23824290 0.02 ENSDART00000059209
wdfy2
WD repeat and FYVE domain containing 2
chr7_-_61845282 0.02 ENSDART00000182586
HTRA3
HtrA serine peptidase 3
chr5_+_45000597 0.02 ENSDART00000051146
dmrt3a
doublesex and mab-3 related transcription factor 3a
chr21_-_14815952 0.01 ENSDART00000134278
ENSDART00000067004
phpt1
phosphohistidine phosphatase 1
chr25_-_23583101 0.01 ENSDART00000149107
ENSDART00000103704
ENSDART00000184903
nap1l4a
nucleosome assembly protein 1-like 4a
chr15_-_35126632 0.01 ENSDART00000187324
ENSDART00000037389
zgc:77118
zgc:55413
zgc:77118
zgc:55413
chr3_+_37083765 0.00 ENSDART00000125611
retreg3
reticulophagy regulator family member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of eomesa

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.1 0.8 GO:0071305 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.1 0.2 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.0 0.2 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 0.2 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 0.1 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.5 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.4 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.3 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.2 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.5 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.3 GO:1990399 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 0.1 GO:1990798 pancreas regeneration(GO:1990798)
0.0 0.0 GO:0034421 post-translational protein acetylation(GO:0034421)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0042627 chylomicron(GO:0042627)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.1 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.5 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.3 GO:0016803 ether hydrolase activity(GO:0016803)
0.0 1.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.5 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.4 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 4.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.0 0.9 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.4 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 0.5 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation