ISMARA results: foxa_foxa1

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PRJNA207719: Tissue specific transcriptome profiling

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Results for foxa_foxa1_foxa2

Z-value: 2.38

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Transcription factors associated with foxa_foxa1_foxa2

Gene Symbol	Gene ID	Gene Info
foxa NCBI UniProt	ENSDARG00000087094	forkhead box A sequence
foxa NCBI UniProt	ENSDARG00000110743	forkhead box A sequence
foxa NCBI UniProt	ENSDARG00000115019	forkhead box A sequence
foxa1 NCBI UniProt	ENSDARG00000102138	forkhead box A1
foxa2 NCBI UniProt	ENSDARG00000003411	forkhead box A2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
foxa2	dr11_v1_chr17_-_42568498_42568498	0.82	9.0e-02	Click!
foxa	dr11_v1_chr14_-_33981544_33981544	0.34	5.7e-01	Click!
foxa1	dr11_v1_chr17_+_10318071_10318071	0.31	6.1e-01	Click!

Activity profile of foxa_foxa1_foxa2 motif

Sorted Z-values of foxa_foxa1_foxa2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr22_-_24967348 Show fit	3.12	ENSDART00000153490 ENSDART00000084871	fam20cl NCBI UniProt Show fit	family with sequence similarity 20, member C like
chr12_+_31616412 Show fit	3.11	ENSDART00000124439	cpn1 NCBI UniProt Show fit	carboxypeptidase N, polypeptide 1
chr20_+_6142433 Show fit	2.97	ENSDART00000054084 ENSDART00000136986	ttr NCBI UniProt Show fit	transthyretin (prealbumin, amyloidosis type I)
chr6_-_55864687 Show fit	2.51	ENSDART00000160991	cyp24a1 NCBI UniProt Show fit	cytochrome P450, family 24, subfamily A, polypeptide 1
chr16_-_21785261 Show fit	2.50	ENSDART00000078858	si:ch73-86n18.1 NCBI UniProt Show fit	si:ch73-86n18.1
chr16_-_54455573 Show fit	2.38	ENSDART00000075275	pklr NCBI UniProt Show fit	pyruvate kinase L/R
chr22_-_36856405 Show fit	2.33	ENSDART00000029588	kng1 NCBI UniProt Show fit	kininogen 1
chr23_+_28770225 Show fit	2.28	ENSDART00000132179 ENSDART00000142273	masp2 NCBI UniProt Show fit	mannan-binding lectin serine peptidase 2
chr2_+_10134345 Show fit	2.23	ENSDART00000100725	ahsg2 NCBI UniProt Show fit	alpha-2-HS-glycoprotein 2
chr5_+_28857969 Show fit	2.13	ENSDART00000149850	si:ch211-186e20.2 NCBI UniProt Show fit	si:ch211-186e20.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of foxa_foxa1_foxa2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	14.8	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
0.2	3.5	GO:0009749	response to carbohydrate(GO:0009743) response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.8	3.1	GO:0070166	enamel mineralization(GO:0070166)
0.1	3.1	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.3	3.0	GO:0072337	modified amino acid transport(GO:0072337)
0.8	2.5	GO:0010430	fatty acid omega-oxidation(GO:0010430)
0.2	2.5	GO:0019731	antibacterial humoral response(GO:0019731)
0.0	2.5	GO:0007596	blood coagulation(GO:0007596)
0.3	2.4	GO:0030195	negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0	2.4	GO:0006096	glycolytic process(GO:0006096)

Showing 1 to 10 of 101 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	23.7	GO:0005615	extracellular space(GO:0005615)
0.1	3.2	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	2.4	GO:0055037	recycling endosome(GO:0055037)
0.1	1.5	GO:0005579	membrane attack complex(GO:0005579)
0.0	1.5	GO:0031227	intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0	1.3	GO:0032040	small-subunit processome(GO:0032040)
0.1	1.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.2	0.9	GO:0035339	SPOTS complex(GO:0035339)
0.0	0.9	GO:0043596	nuclear replication fork(GO:0043596)
0.1	0.8	GO:0001891	phagocytic cup(GO:0001891)

Showing 1 to 10 of 30 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	5.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	3.4	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.8	3.3	GO:0004373	glycogen (starch) synthase activity(GO:0004373)
0.1	3.1	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.7	3.0	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	2.7	GO:0030246	carbohydrate binding(GO:0030246)
0.6	2.5	GO:0070643	vitamin D 25-hydroxylase activity(GO:0070643)
0.4	2.4	GO:0004743	pyruvate kinase activity(GO:0004743)
0.2	1.2	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)

Showing 1 to 10 of 77 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	5.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	2.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	1.2	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	0.9	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.8	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.0	0.7	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.6	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.5	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.4	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.1	3.0	REACTOME AMYLOIDS	Genes involved in Amyloids
0.1	3.0	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.1	2.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	2.5	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.2	2.3	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.1	1.9	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	1.8	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	1.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	1.2	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

Showing 1 to 10 of 29 entries

Results for foxa_foxa1_foxa2

Z-value: 2.38

Motif logo

Transcription factors associated with foxa_foxa1_foxa2

Activity-expression correlation:

Activity profile of foxa_foxa1_foxa2 motif

Sorted Z-values of foxa_foxa1_foxa2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of foxa_foxa1_foxa2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: