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PRJNA207719: Tissue specific transcriptome profiling

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Results for foxo3a

Z-value: 0.57

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Transcription factors associated with foxo3a

Gene Symbol Gene ID Gene Info
foxo3a
ENSDARG00000023058 forkhead box O3A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxo3adr11_v1_chr17_+_6793001_67930010.385.3e-01Click!

Activity profile of foxo3a motif

Sorted Z-values of foxo3a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_36378494 0.62 ENSDART00000058503
gpm6aa
glycoprotein M6Aa
chr19_+_2275019 0.50 ENSDART00000136138
itgb8
integrin, beta 8
chr12_-_13886952 0.39 ENSDART00000110503
adam11
ADAM metallopeptidase domain 11
chr15_+_8043751 0.39 ENSDART00000193701
cadm2b
cell adhesion molecule 2b
chr5_+_36611128 0.38 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr11_-_44409856 0.33 ENSDART00000162886
il1rapl1b
interleukin 1 receptor accessory protein-like 1b
chr19_-_28367413 0.32 ENSDART00000079092
si:dkey-261i16.5
si:dkey-261i16.5
chr3_-_28258462 0.32 ENSDART00000191573
rbfox1
RNA binding fox-1 homolog 1
chr13_+_1100197 0.32 ENSDART00000139560
ppp3r1a
protein phosphatase 3, regulatory subunit B, alpha a
chr8_-_25011157 0.32 ENSDART00000078795
ahcyl1
adenosylhomocysteinase-like 1
chr15_+_16897554 0.31 ENSDART00000154679
ypel2b
yippee-like 2b
chr6_+_48618512 0.31 ENSDART00000111190
FAM19A3
si:dkey-238f9.1
chr3_+_54168007 0.30 ENSDART00000109894
olfm2a
olfactomedin 2a
chr20_+_30445971 0.30 ENSDART00000153150
myt1la
myelin transcription factor 1-like, a
chr16_-_22251414 0.30 ENSDART00000158500
ENSDART00000179998
atp8b2
ATPase phospholipid transporting 8B2
chr3_-_51912019 0.30 ENSDART00000149914
aatka
apoptosis-associated tyrosine kinase a
chr4_-_4256300 0.30 ENSDART00000103319
ENSDART00000150279
cd9b
CD9 molecule b
chr19_+_10396042 0.29 ENSDART00000028048
ENSDART00000151735
necap1
NECAP endocytosis associated 1
chr13_+_24834199 0.29 ENSDART00000101274
zgc:153981
zgc:153981
chr1_-_8917902 0.29 ENSDART00000137900
grin2ab
glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
chr1_-_9277986 0.28 ENSDART00000146065
ENSDART00000114876
ENSDART00000132812
ubn1
ubinuclein 1
chr18_+_1703984 0.28 ENSDART00000114010
slitrk3a
SLIT and NTRK-like family, member 3a
chr11_+_18873619 0.27 ENSDART00000176141
magi1b
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr6_-_52156427 0.27 ENSDART00000082821
rims4
regulating synaptic membrane exocytosis 4
chr25_-_11088839 0.26 ENSDART00000154748
sv2bb
synaptic vesicle glycoprotein 2Bb
chr20_-_39273987 0.25 ENSDART00000127173
clu
clusterin
chr5_-_28679135 0.24 ENSDART00000193585
tnc
tenascin C
chr14_-_34044369 0.24 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cyfip2
cytoplasmic FMR1 interacting protein 2
chr8_+_10823069 0.23 ENSDART00000081341
mapk13
mitogen-activated protein kinase 13
chr15_+_23657051 0.23 ENSDART00000078336
klc3
kinesin light chain 3
chr18_-_26675699 0.23 ENSDART00000113280
FRMD5
si:ch211-69m14.1
chr21_+_32338897 0.22 ENSDART00000110137
si:ch211-247j9.1
si:ch211-247j9.1
chr22_-_7129631 0.21 ENSDART00000171359
asic1b
acid-sensing (proton-gated) ion channel 1b
chr6_-_12172424 0.20 ENSDART00000109344
tanc1a
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1a
chr18_+_15271993 0.20 ENSDART00000099777
si:dkey-103i16.6
si:dkey-103i16.6
chr9_+_17971935 0.19 ENSDART00000149736
akap11
A kinase (PRKA) anchor protein 11
chr7_+_47287307 0.19 ENSDART00000114669
dpy19l3
dpy-19 like C-mannosyltransferase 3
chr12_+_12112384 0.19 ENSDART00000152431
grid1b
glutamate receptor, ionotropic, delta 1b
chr8_+_26432677 0.19 ENSDART00000078369
ENSDART00000131925
zgc:136971
zgc:136971
chr6_-_12270226 0.18 ENSDART00000180473
pkp4
plakophilin 4
chr15_-_31498123 0.18 ENSDART00000153665
si:dkey-1m11.6
si:dkey-1m11.6
chr4_-_14926637 0.17 ENSDART00000110199
prdm4
PR domain containing 4
chr8_+_40081403 0.17 ENSDART00000138036
lrrc75ba
leucine rich repeat containing 75Ba
chr13_+_28854438 0.17 ENSDART00000193407
ENSDART00000189554
CU639469.1

chr14_-_25599002 0.16 ENSDART00000040955
slc25a48
solute carrier family 25, member 48
chr23_-_12158685 0.16 ENSDART00000135035
fam217b
family with sequence similarity 217, member B
chr1_-_6494384 0.16 ENSDART00000109356
klf7a
Kruppel-like factor 7a
chr4_+_5741733 0.16 ENSDART00000110243
pou3f2a
POU class 3 homeobox 2a
chr9_+_29603649 0.16 ENSDART00000140477
mcf2lb
mcf.2 cell line derived transforming sequence-like b
chr7_+_38278860 0.15 ENSDART00000016265
lrp3
low density lipoprotein receptor-related protein 3
chr9_-_3400727 0.15 ENSDART00000183979
ENSDART00000111386
dlx2a
distal-less homeobox 2a
chr6_-_18698456 0.15 ENSDART00000166587
rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr3_+_19207176 0.15 ENSDART00000087803
rln3a
relaxin 3a
chr10_-_20669635 0.15 ENSDART00000131361
kcnip3b
Kv channel interacting protein 3b, calsenilin
chr1_+_16127825 0.14 ENSDART00000122503
tusc3
tumor suppressor candidate 3
chr20_-_39273505 0.14 ENSDART00000153114
clu
clusterin
chr11_+_6819050 0.14 ENSDART00000104289
rab3ab
RAB3A, member RAS oncogene family, b
chr22_+_30335936 0.14 ENSDART00000059923
mxi1
max interactor 1, dimerization protein
chr15_-_25527580 0.13 ENSDART00000167005
ENSDART00000157498
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr5_-_38384289 0.13 ENSDART00000135260
mink1
misshapen-like kinase 1
chr6_+_9398074 0.13 ENSDART00000151772
kalrnb
kalirin RhoGEF kinase b
chr24_+_17007407 0.13 ENSDART00000110652
zfx
zinc finger protein, X-linked
chr1_+_45839927 0.13 ENSDART00000148086
ENSDART00000180413
ENSDART00000048191
ENSDART00000179047
map2k7
mitogen-activated protein kinase kinase 7
chr21_-_42202792 0.12 ENSDART00000124708
gabra6b
gamma-aminobutyric acid (GABA) A receptor, alpha 6b
chr2_+_9061885 0.12 ENSDART00000028906
pigk
phosphatidylinositol glycan anchor biosynthesis, class K
chr20_+_40457599 0.12 ENSDART00000017553
serinc1
serine incorporator 1
chr21_+_32339158 0.12 ENSDART00000161723
si:ch211-247j9.1
si:ch211-247j9.1
chr24_-_6678640 0.12 ENSDART00000042478
enkur
enkurin, TRPC channel interacting protein
chr1_+_45969240 0.11 ENSDART00000042086
arhgef7b
Rho guanine nucleotide exchange factor (GEF) 7b
chr21_-_32301109 0.11 ENSDART00000139890
clk4b
CDC-like kinase 4b
chr12_-_22509069 0.10 ENSDART00000179755
ENSDART00000109707
neurl4
neuralized E3 ubiquitin protein ligase 4
chr14_-_48939560 0.10 ENSDART00000021736
scocb
short coiled-coil protein b
chr13_+_12761707 0.10 ENSDART00000015127
zgc:100846
zgc:100846
chr14_-_30960470 0.10 ENSDART00000129989
si:ch211-191o15.6
si:ch211-191o15.6
chr25_+_13662606 0.09 ENSDART00000008989
ccdc113
coiled-coil domain containing 113
chr25_+_3035384 0.09 ENSDART00000184219
ENSDART00000149360
mpi
mannose phosphate isomerase
chr9_-_10532591 0.09 ENSDART00000175269
thsd7ba
thrombospondin, type I, domain containing 7Ba
chr9_-_16876474 0.09 ENSDART00000185450
fbxl3a
F-box and leucine-rich repeat protein 3a
chr23_-_33680265 0.09 ENSDART00000138416
tfcp2
transcription factor CP2
chr8_+_7778770 0.09 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr16_+_25011994 0.08 ENSDART00000157312
znf1035
zinc finger protein 1035
chr16_-_32671782 0.08 ENSDART00000123980
pnisr
PNN-interacting serine/arginine-rich protein
chr1_-_28749604 0.08 ENSDART00000148522
GK3P
zgc:172295
chr3_-_7656059 0.08 ENSDART00000170917
junbb
JunB proto-oncogene, AP-1 transcription factor subunit b
chr3_+_24458899 0.08 ENSDART00000156655
cbx6b
chromobox homolog 6b
chr2_+_44615153 0.08 ENSDART00000156523
yeats2
YEATS domain containing 2
chr10_+_2529037 0.07 ENSDART00000123467
zmp:0000001301
zmp:0000001301
chr16_-_36748374 0.07 ENSDART00000133310
pik3r4
phosphoinositide-3-kinase, regulatory subunit 4
chr20_+_19562383 0.07 ENSDART00000103798
nme6
NME/NM23 nucleoside diphosphate kinase 6
chr9_-_16877456 0.07 ENSDART00000161105
ENSDART00000160869
fbxl3a
F-box and leucine-rich repeat protein 3a
chr1_+_8984068 0.07 ENSDART00000122568
tlr2
toll-like receptor 2
chr2_-_25553607 0.07 ENSDART00000150075
ENSDART00000078695
ghsra
growth hormone secretagogue receptor a
chr3_+_53116172 0.07 ENSDART00000115117
brd4
bromodomain containing 4
chr11_-_18323059 0.07 ENSDART00000182590
SFMBT1
Scm like with four mbt domains 1
chr4_-_6809323 0.06 ENSDART00000099467
ifrd1
interferon-related developmental regulator 1
chr10_-_8197049 0.06 ENSDART00000129467
dhx29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
chr5_+_53009083 0.06 ENSDART00000157836
hint2
histidine triad nucleotide binding protein 2
chr7_+_24023653 0.06 ENSDART00000141165
tinf2
TERF1 (TRF1)-interacting nuclear factor 2
chr24_-_18659147 0.05 ENSDART00000166039
zgc:66014
zgc:66014
chr16_-_12496632 0.05 ENSDART00000019941
slc2a3b
solute carrier family 2 (facilitated glucose transporter), member 3b
chr1_+_41886830 0.05 ENSDART00000185887
ENSDART00000084735
si:dkey-37g12.1
si:dkey-37g12.1
chr10_+_42589707 0.05 ENSDART00000075269
fgfr1b
fibroblast growth factor receptor 1b
chr23_+_22785375 0.04 ENSDART00000142085
rerea
arginine-glutamic acid dipeptide (RE) repeats a
chr12_+_27213733 0.04 ENSDART00000133048
nbr1a
neighbor of brca1 gene 1a
chr21_-_11820379 0.04 ENSDART00000126640
RHOBTB3
si:dkey-6b12.5
chr16_-_32671998 0.04 ENSDART00000161395
pnisr
PNN-interacting serine/arginine-rich protein
chr6_-_40922971 0.04 ENSDART00000155363
sfi1
SFI1 centrin binding protein
chr16_-_49646625 0.04 ENSDART00000101629
efhb
EF-hand domain family, member B
chr3_-_26191960 0.04 ENSDART00000113843
ypel3
yippee-like 3
chr3_+_55031685 0.04 ENSDART00000132587
mpg
N-methylpurine DNA glycosylase
chr6_-_54111928 0.03 ENSDART00000083880
hyal2a
hyaluronoglucosaminidase 2a
chr4_-_14926106 0.03 ENSDART00000147629
prdm4
PR domain containing 4
chr10_-_15879569 0.03 ENSDART00000136789
tjp2a
tight junction protein 2a (zona occludens 2)
chr11_+_2710530 0.03 ENSDART00000132768
ENSDART00000030921
ENSDART00000040147
mapk14b
mitogen-activated protein kinase 14b
chr17_+_44756247 0.03 ENSDART00000153773
cipca
CLOCK-interacting pacemaker a
chr3_+_27786601 0.03 ENSDART00000086994
nat15
N-acetyltransferase 15 (GCN5-related, putative)
chr23_-_24226533 0.03 ENSDART00000109134
plekhm2
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr5_-_18046053 0.03 ENSDART00000144898
rnf215
ring finger protein 215
chr18_-_40913294 0.03 ENSDART00000059196
ENSDART00000098878
polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr16_+_49647402 0.03 ENSDART00000015694
ENSDART00000132547
rab5ab
RAB5A, member RAS oncogene family, b
chr2_+_23790748 0.02 ENSDART00000041877
csrnp1a
cysteine-serine-rich nuclear protein 1a
chr8_+_53204027 0.02 ENSDART00000135353
CFAP74
cilia and flagella associated protein 74
chr9_+_13229585 0.02 ENSDART00000154879
ENSDART00000141705
carf
calcium responsive transcription factor
chr3_-_45308394 0.02 ENSDART00000155324
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr9_+_13230214 0.02 ENSDART00000017932
ENSDART00000179850
carf
calcium responsive transcription factor
chr13_+_45980163 0.02 ENSDART00000074547
ENSDART00000005195
bsdc1
BSD domain containing 1
chr15_+_20543770 0.02 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr14_-_33177935 0.02 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr18_-_12052132 0.02 ENSDART00000074361
zgc:110789
zgc:110789
chr13_+_29926094 0.02 ENSDART00000057528
cuedc2
CUE domain containing 2
chr19_-_10324182 0.02 ENSDART00000151352
ENSDART00000151162
ENSDART00000023571
u2af2b
U2 small nuclear RNA auxiliary factor 2b
chr2_-_47957673 0.02 ENSDART00000056305
fzd8b
frizzled class receptor 8b
chr17_-_50220228 0.02 ENSDART00000058707
jdp2a
Jun dimerization protein 2a
chr5_+_24063046 0.01 ENSDART00000051548
ENSDART00000133355
ENSDART00000142268
gps2
G protein pathway suppressor 2
chr25_+_17920361 0.01 ENSDART00000185644
borcs5
BLOC-1 related complex subunit 5
chr3_-_20063671 0.01 ENSDART00000056614
ENSDART00000126915
ubtf
upstream binding transcription factor, RNA polymerase I
chr13_+_5978809 0.01 ENSDART00000102563
ENSDART00000121598
phf10
PHD finger protein 10
chr19_+_1878500 0.01 ENSDART00000113392
ggcta
gamma-glutamylcyclotransferase a
chr25_-_18249751 0.01 ENSDART00000153950
si:dkey-106n21.1
si:dkey-106n21.1
chr15_+_23784842 0.01 ENSDART00000192889
ENSDART00000138375
ift20
intraflagellar transport 20 homolog (Chlamydomonas)
chr10_+_42589391 0.01 ENSDART00000067689
ENSDART00000075259
fgfr1b
fibroblast growth factor receptor 1b
chr5_-_69212184 0.01 ENSDART00000053963
mat2ab
methionine adenosyltransferase II, alpha b
chr9_+_50600355 0.01 ENSDART00000187567
fign
fidgetin
chr9_-_13355071 0.01 ENSDART00000084055
fzd7a
frizzled class receptor 7a
chr16_-_44900306 0.01 ENSDART00000058380
rbm42
RNA binding motif protein 42
chr15_+_19990068 0.01 ENSDART00000154033
ENSDART00000054428
zgc:112083
zgc:112083
chr7_+_72279584 0.01 ENSDART00000172021
tollip
toll interacting protein
chr22_+_37631234 0.01 ENSDART00000007346
psmd1
proteasome 26S subunit, non-ATPase 1
chr20_-_35470891 0.01 ENSDART00000152993
ENSDART00000016090
pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr17_-_14966384 0.00 ENSDART00000105064
txndc16
thioredoxin domain containing 16
chr7_+_33372680 0.00 ENSDART00000193436
ENSDART00000099988
glceb
glucuronic acid epimerase b
chr6_-_54126463 0.00 ENSDART00000161059
tusc2a
tumor suppressor candidate 2a
chr17_+_24718272 0.00 ENSDART00000007271
mtfr1l
mitochondrial fission regulator 1-like
chr4_-_14207471 0.00 ENSDART00000015134
twf1b
twinfilin actin-binding protein 1b
chr24_-_2312868 0.00 ENSDART00000140125
ENSDART00000138432
cul2
cullin 2
chr25_+_19149241 0.00 ENSDART00000184982
ENSDART00000067324
mfge8b
milk fat globule-EGF factor 8 protein b

Network of associatons between targets according to the STRING database.

First level regulatory network of foxo3a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.1 0.3 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.2 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.1 0.3 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.1 0.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.1 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.0 0.2 GO:0006844 acyl carnitine transport(GO:0006844)
0.0 0.1 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.1 GO:0042546 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.2 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.2 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.0 0.1 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.2 GO:0001964 startle response(GO:0001964)
0.0 0.5 GO:0033627 cell adhesion mediated by integrin(GO:0033627)
0.0 0.3 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.0 GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion(GO:0061400)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0036268 swimming(GO:0036268)
0.0 0.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.4 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.5 GO:0008305 integrin complex(GO:0008305)
0.0 0.1 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.1 0.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.2 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.4 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.2 GO:0070403 NAD+ binding(GO:0070403)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.2 REACTOME KINESINS Genes involved in Kinesins