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PRJNA207719: Tissue specific transcriptome profiling

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Results for foxo4

Z-value: 1.13

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Transcription factors associated with foxo4

Gene Symbol Gene ID Gene Info
foxo4
ENSDARG00000055792 forkhead box O4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
foxo4dr11_v1_chr14_+_30910114_309101140.108.7e-01Click!

Activity profile of foxo4 motif

Sorted Z-values of foxo4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_25583125 0.50 ENSDART00000031665
ENSDART00000145353
anxa1a
annexin A1a
chr20_-_39273987 0.46 ENSDART00000127173
clu
clusterin
chr10_+_39084354 0.44 ENSDART00000158245
si:ch73-1a9.3
si:ch73-1a9.3
chr22_-_29689981 0.42 ENSDART00000009223
pdcd4b
programmed cell death 4b
chr14_-_34044369 0.41 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cyfip2
cytoplasmic FMR1 interacting protein 2
chr7_-_24828296 0.40 ENSDART00000138193
otub1b
OTU deubiquitinase, ubiquitin aldehyde binding 1b
chr24_+_17007407 0.40 ENSDART00000110652
zfx
zinc finger protein, X-linked
chr20_-_39273505 0.38 ENSDART00000153114
clu
clusterin
chr16_-_38001040 0.38 ENSDART00000133861
ENSDART00000138711
ENSDART00000143846
ENSDART00000146564
si:ch211-198c19.3
si:ch211-198c19.3
chr12_+_25640480 0.38 ENSDART00000105608
prkcea
protein kinase C, epsilon a
chr1_+_45969240 0.38 ENSDART00000042086
arhgef7b
Rho guanine nucleotide exchange factor (GEF) 7b
chr22_-_29689485 0.36 ENSDART00000182173
pdcd4b
programmed cell death 4b
chr23_-_17450746 0.34 ENSDART00000145399
ENSDART00000136457
ENSDART00000133125
ENSDART00000145719
ENSDART00000147524
ENSDART00000005366
ENSDART00000104680
tpd52l2b
tumor protein D52-like 2b
chr19_-_32600823 0.33 ENSDART00000134149
ENSDART00000187858
zgc:91944
zgc:91944
chr11_+_25257022 0.33 ENSDART00000156052
tp53inp2
tumor protein p53 inducible nuclear protein 2
chr11_-_183328 0.33 ENSDART00000168562
avil
advillin
chr5_-_20446082 0.32 ENSDART00000051607
ISCU (1 of many)
si:ch211-191d15.2
chr5_-_46329880 0.32 ENSDART00000156577
si:ch211-130m23.5
si:ch211-130m23.5
chr13_+_1100197 0.32 ENSDART00000139560
ppp3r1a
protein phosphatase 3, regulatory subunit B, alpha a
chr14_-_33177935 0.31 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr18_+_17428506 0.31 ENSDART00000100223
zgc:91860
zgc:91860
chr3_-_29962345 0.30 ENSDART00000136819
bcat2
branched chain amino-acid transaminase 2, mitochondrial
chr21_+_33459524 0.30 ENSDART00000053205
cd74b
CD74 molecule, major histocompatibility complex, class II invariant chain b
chr19_-_5103313 0.29 ENSDART00000037007
tpi1a
triosephosphate isomerase 1a
chr13_+_22675802 0.29 ENSDART00000145538
ENSDART00000143312
zgc:193505
zgc:193505
chr19_+_5315987 0.28 ENSDART00000145749
si:dkeyp-113d7.1
si:dkeyp-113d7.1
chr15_+_37589698 0.28 ENSDART00000076066
ENSDART00000153894
ENSDART00000156298
lin37
lin-37 DREAM MuvB core complex component
chr10_+_20070178 0.28 ENSDART00000027612
ENSDART00000145264
ENSDART00000172713
xpo7
exportin 7
chr19_-_5103141 0.27 ENSDART00000150952
tpi1a
triosephosphate isomerase 1a
chr17_+_24718272 0.27 ENSDART00000007271
mtfr1l
mitochondrial fission regulator 1-like
chr18_+_20226843 0.27 ENSDART00000100632
tle3a
transducin-like enhancer of split 3a
chr6_+_51932563 0.26 ENSDART00000181778
angpt4
angiopoietin 4
chr20_-_20610812 0.26 ENSDART00000181870
ppm1ab
protein phosphatase, Mg2+/Mn2+ dependent, 1Ab
chr15_+_19990068 0.26 ENSDART00000154033
ENSDART00000054428
zgc:112083
zgc:112083
chr22_+_4707663 0.26 ENSDART00000042194
cers4a
ceramide synthase 4a
chr11_-_16152400 0.26 ENSDART00000123665
arpc4l
actin related protein 2/3 complex, subunit 4, like
chr12_-_11457625 0.25 ENSDART00000012318
htra1b
HtrA serine peptidase 1b
chr4_+_9612574 0.25 ENSDART00000150336
ENSDART00000041289
ENSDART00000150828
tmem243b
transmembrane protein 243, mitochondrial b
chr12_-_28848015 0.25 ENSDART00000153200
si:ch211-194k22.8
si:ch211-194k22.8
chr11_-_12051805 0.24 ENSDART00000110117
ENSDART00000182744
socs7
suppressor of cytokine signaling 7
chr23_+_3731375 0.24 ENSDART00000141782
smim29
small integral membrane protein 29
chr21_-_32081552 0.24 ENSDART00000135659
mat2b
methionine adenosyltransferase II, beta
chr17_+_24111392 0.24 ENSDART00000180123
ENSDART00000182787
ENSDART00000189752
ENSDART00000184940
ENSDART00000185363
ENSDART00000064067
ehbp1
EH domain binding protein 1
chr1_+_16127825 0.24 ENSDART00000122503
tusc3
tumor suppressor candidate 3
chr9_+_32358514 0.24 ENSDART00000144608
plcl1
phospholipase C like 1
chr14_-_36378494 0.23 ENSDART00000058503
gpm6aa
glycoprotein M6Aa
chr19_-_32600638 0.23 ENSDART00000143497
zgc:91944
zgc:91944
chr13_+_22280983 0.23 ENSDART00000173258
ENSDART00000173379
usp54a
ubiquitin specific peptidase 54a
chr3_-_28258462 0.23 ENSDART00000191573
rbfox1
RNA binding fox-1 homolog 1
chr25_+_28823952 0.23 ENSDART00000067072
nfybb
nuclear transcription factor Y, beta b
chr6_+_51932267 0.23 ENSDART00000156256
angpt4
angiopoietin 4
chr23_-_36449111 0.22 ENSDART00000110478
zgc:174906
zgc:174906
chr4_+_5156117 0.22 ENSDART00000067392
tigarb
tp53-induced glycolysis and apoptosis regulator b
chr17_+_38295847 0.22 ENSDART00000008532
mbip
MAP3K12 binding inhibitory protein 1
chr6_+_48618512 0.22 ENSDART00000111190
FAM19A3
si:dkey-238f9.1
chr18_-_25177230 0.21 ENSDART00000013363
slco3a1
solute carrier organic anion transporter family, member 3A1
chr15_+_21252532 0.21 ENSDART00000162619
ENSDART00000019636
ENSDART00000144901
ENSDART00000138676
ENSDART00000133821
ENSDART00000146967
ENSDART00000143990
ENSDART00000142070
ENSDART00000132373
usf1
upstream transcription factor 1
chr7_+_72279584 0.21 ENSDART00000172021
tollip
toll interacting protein
chr3_+_19685873 0.21 ENSDART00000006490
tlk2
tousled-like kinase 2
chr21_+_19547806 0.21 ENSDART00000159707
ENSDART00000184869
ENSDART00000181321
ENSDART00000058487
ENSDART00000058485
rai14
retinoic acid induced 14
chr19_+_46222428 0.21 ENSDART00000183984
vps28
vacuolar protein sorting 28 (yeast)
chr1_-_9940494 0.20 ENSDART00000138726
tmem8a
transmembrane protein 8A
chr23_-_3758637 0.20 ENSDART00000131536
ENSDART00000139408
ENSDART00000137826
hmga1a
high mobility group AT-hook 1a
chr12_+_25223843 0.20 ENSDART00000077180
ENSDART00000127454
ENSDART00000122665
mta3
metastasis associated 1 family, member 3
chr16_+_28578352 0.20 ENSDART00000149306
nmt2
N-myristoyltransferase 2
chr14_+_33427837 0.20 ENSDART00000105687
zbtb33
zinc finger and BTB domain containing 33
chr1_+_25801648 0.20 ENSDART00000129471
gucy1b1
guanylate cyclase 1 soluble subunit beta 1
chr7_+_60359347 0.19 ENSDART00000145201
ENSDART00000039827
ppp1r14bb
protein phosphatase 1, regulatory (inhibitor) subunit 14Bb
chr23_-_12158685 0.19 ENSDART00000135035
fam217b
family with sequence similarity 217, member B
chr15_+_30157602 0.19 ENSDART00000047248
ENSDART00000123937
nlk2
nemo-like kinase, type 2
chr20_-_16156419 0.19 ENSDART00000037420
ralgps2
Ral GEF with PH domain and SH3 binding motif 2
chr9_-_2572790 0.19 ENSDART00000135076
ENSDART00000016710
scrn3
secernin 3
chr3_+_10152092 0.19 ENSDART00000066053
cbx2
chromobox homolog 2 (Drosophila Pc class)
chr11_+_16153207 0.19 ENSDART00000192356
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr13_+_30951155 0.19 ENSDART00000057469
ENSDART00000162254
vstm4a
V-set and transmembrane domain containing 4a
chr14_+_29769336 0.19 ENSDART00000105898
si:dkey-34l15.1
si:dkey-34l15.1
chr11_-_36001495 0.18 ENSDART00000190330
itpr1b
inositol 1,4,5-trisphosphate receptor, type 1b
chr2_+_1988036 0.18 ENSDART00000155956
ssx2ipa
synovial sarcoma, X breakpoint 2 interacting protein a
chr13_-_34781984 0.18 ENSDART00000172138
ism1
isthmin 1
chr10_+_26834985 0.18 ENSDART00000147518
fam89b
family with sequence similarity 89, member B
chr19_+_2275019 0.18 ENSDART00000136138
itgb8
integrin, beta 8
chr5_+_55934129 0.18 ENSDART00000050969
tmem150ab
transmembrane protein 150Ab
chr4_-_4256300 0.18 ENSDART00000103319
ENSDART00000150279
cd9b
CD9 molecule b
chr9_-_2573121 0.18 ENSDART00000181340
scrn3
secernin 3
chr21_+_45757317 0.18 ENSDART00000163152
h2afy
H2A histone family, member Y
chr10_-_8197049 0.18 ENSDART00000129467
dhx29
DEAH (Asp-Glu-Ala-His) box polypeptide 29
chr3_+_32403758 0.17 ENSDART00000156982
si:ch211-195b15.8
si:ch211-195b15.8
chr2_+_16696052 0.17 ENSDART00000022356
ENSDART00000164329
ppp1r7
protein phosphatase 1, regulatory (inhibitor) subunit 7
chr3_+_31621774 0.17 ENSDART00000076636
fzd2
frizzled class receptor 2
chr8_+_16990120 0.17 ENSDART00000018934
pde4d
phosphodiesterase 4D, cAMP-specific
chr15_+_46313082 0.17 ENSDART00000153830
si:ch1073-190k2.1
si:ch1073-190k2.1
chr3_-_15496295 0.17 ENSDART00000144369
sgf29
SAGA complex associated factor 29
chr14_-_7885707 0.17 ENSDART00000029981
ppp3cb
protein phosphatase 3, catalytic subunit, beta isozyme
chr12_+_22404108 0.17 ENSDART00000153055
hdlbpb
high density lipoprotein binding protein b
chr17_-_20236228 0.17 ENSDART00000136490
ENSDART00000029380
bnip4
BCL2 interacting protein 4
chr7_+_24528866 0.17 ENSDART00000180552
si:dkeyp-75h12.2
si:dkeyp-75h12.2
chr19_+_46222918 0.17 ENSDART00000158703
vps28
vacuolar protein sorting 28 (yeast)
chr25_+_17920361 0.17 ENSDART00000185644
borcs5
BLOC-1 related complex subunit 5
chr5_+_12528693 0.16 ENSDART00000051670
rfc5
replication factor C (activator 1) 5
chr2_-_26720854 0.16 ENSDART00000148110
si:dkey-181m9.8
si:dkey-181m9.8
chr3_-_26191960 0.16 ENSDART00000113843
ypel3
yippee-like 3
chr16_+_6944564 0.16 ENSDART00000104252
eaf1
ELL associated factor 1
chr7_-_41013575 0.16 ENSDART00000150139
insig1
insulin induced gene 1
chr5_-_40190949 0.16 ENSDART00000175588
wdfy3
WD repeat and FYVE domain containing 3
chr21_-_42202792 0.16 ENSDART00000124708
gabra6b
gamma-aminobutyric acid (GABA) A receptor, alpha 6b
chr22_+_26798853 0.16 ENSDART00000087576
ENSDART00000179780
slx4
SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
chr20_-_45062514 0.16 ENSDART00000183529
ENSDART00000182955
klhl29
kelch-like family member 29
chr20_-_19365875 0.16 ENSDART00000063703
ENSDART00000187707
ENSDART00000161065
si:dkey-71h2.2
si:dkey-71h2.2
chr3_-_60142530 0.16 ENSDART00000153247
si:ch211-120g10.1
si:ch211-120g10.1
chr13_-_22903246 0.16 ENSDART00000089133
rufy2
RUN and FYVE domain containing 2
chr25_-_25142387 0.16 ENSDART00000031814
tsg101a
tumor susceptibility 101a
chr18_+_6857071 0.16 ENSDART00000018735
ENSDART00000181969
dnaja2l
DnaJ (Hsp40) homolog, subfamily A, member 2, like
chr9_-_24209083 0.16 ENSDART00000134599
zgc:153521
zgc:153521
chr5_+_28271412 0.16 ENSDART00000031727
vamp8
vesicle-associated membrane protein 8 (endobrevin)
chr6_-_12270226 0.16 ENSDART00000180473
pkp4
plakophilin 4
chr11_+_16152316 0.15 ENSDART00000081054
tada3l
transcriptional adaptor 3 (NGG1 homolog, yeast)-like
chr13_-_25842074 0.15 ENSDART00000015154
papolg
poly(A) polymerase gamma
chr21_-_11820379 0.15 ENSDART00000126640
RHOBTB3
si:dkey-6b12.5
chr14_+_41406321 0.15 ENSDART00000111480
bcorl1
BCL6 corepressor-like 1
chr19_-_34063567 0.15 ENSDART00000157815
ENSDART00000183907
elmo1
engulfment and cell motility 1 (ced-12 homolog, C. elegans)
chr6_-_32045951 0.15 ENSDART00000016629
ENSDART00000139055
efcab7
EF-hand calcium binding domain 7
chr16_+_6944311 0.15 ENSDART00000144763
eaf1
ELL associated factor 1
chr23_-_5683147 0.15 ENSDART00000102766
ENSDART00000067351
tnnt2a
troponin T type 2a (cardiac)
chr3_+_32532645 0.15 ENSDART00000055312
ENSDART00000150981
nosip
nitric oxide synthase interacting protein
chr15_-_22147860 0.15 ENSDART00000149784
scn3b
sodium channel, voltage-gated, type III, beta
chr8_-_1267247 0.15 ENSDART00000150064
cdc14b
cell division cycle 14B
chr3_-_15496551 0.15 ENSDART00000124063
ENSDART00000007726
sgf29
SAGA complex associated factor 29
chr5_-_51998708 0.15 ENSDART00000097194
serinc5
serine incorporator 5
chr11_+_25112269 0.15 ENSDART00000147546
ndrg3a
ndrg family member 3a
chr16_+_10413551 0.15 ENSDART00000032877
ENSDART00000172827
ino80e
INO80 complex subunit E
chr10_-_9089545 0.15 ENSDART00000080781
arl15b
ADP-ribosylation factor-like 15b
chr16_+_5612547 0.15 ENSDART00000140226
ENSDART00000189352
CYTH2
si:dkey-283b15.4
chr17_-_14966384 0.15 ENSDART00000105064
txndc16
thioredoxin domain containing 16
chr20_+_34596205 0.15 ENSDART00000138338
si:ch211-242b18.1
si:ch211-242b18.1
chr17_-_43399896 0.15 ENSDART00000156033
ENSDART00000156418
itpk1b
inositol-tetrakisphosphate 1-kinase b
chr19_+_20177887 0.14 ENSDART00000008595
tra2a
transformer 2 alpha homolog
chr11_+_18873619 0.14 ENSDART00000176141
magi1b
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr6_-_40657653 0.14 ENSDART00000154359
ppil1
peptidylprolyl isomerase (cyclophilin)-like 1
chr3_+_27798094 0.14 ENSDART00000075100
ENSDART00000151437
carhsp1
calcium regulated heat stable protein 1
chr3_+_52999962 0.14 ENSDART00000104683
pbx4
pre-B-cell leukemia transcription factor 4
chr18_+_26899316 0.14 ENSDART00000050230
tspan3a
tetraspanin 3a
chr10_+_33744098 0.14 ENSDART00000147775
rxfp2a
relaxin/insulin-like family peptide receptor 2a
chr12_-_19346678 0.14 ENSDART00000044860
maff
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr19_-_22843480 0.14 ENSDART00000052503
nudcd1
NudC domain containing 1
chr10_-_41156348 0.14 ENSDART00000058622
aak1b
AP2 associated kinase 1b
chr14_-_48939560 0.14 ENSDART00000021736
scocb
short coiled-coil protein b
chr19_-_10656667 0.14 ENSDART00000081379
ENSDART00000151456
ENSDART00000143271
ENSDART00000182126
olah
oleoyl-ACP hydrolase
chr13_+_27316934 0.14 ENSDART00000164533
eef1a1a
eukaryotic translation elongation factor 1 alpha 1a
chr21_-_27272657 0.14 ENSDART00000040754
ENSDART00000175009
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr17_+_31221761 0.14 ENSDART00000155580
ccdc32
coiled-coil domain containing 32
chr5_-_56924747 0.14 ENSDART00000014028
ppm1db
protein phosphatase, Mg2+/Mn2+ dependent, 1Db
chr3_+_15817644 0.14 ENSDART00000055787
natd1
zgc:110779
chr2_-_11662851 0.14 ENSDART00000145108
zgc:110130
zgc:110130
chr15_+_20543770 0.14 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr5_-_20678300 0.14 ENSDART00000088639
wscd2
WSC domain containing 2
chr9_-_52386733 0.13 ENSDART00000171721
dap1b
death associated protein 1b
chr22_-_4769140 0.13 ENSDART00000165235
calr3a
calreticulin 3a
chr23_-_16682186 0.13 ENSDART00000020810
sdcbp2
syndecan binding protein (syntenin) 2
chr13_-_13030851 0.13 ENSDART00000009499
nsd2
nuclear receptor binding SET domain protein 2
chr14_-_36799280 0.13 ENSDART00000168615
rnf130
ring finger protein 130
chr3_-_33113879 0.13 ENSDART00000044677
rarab
retinoic acid receptor, alpha b
chr4_-_16876281 0.13 ENSDART00000016690
ENSDART00000044005
ENSDART00000042874
ENSDART00000125762
ENSDART00000185974
tmpoa
thymopoietin a
chr20_-_31497300 0.13 ENSDART00000046841
sash1a
SAM and SH3 domain containing 1a
chr3_-_16039619 0.13 ENSDART00000143324
spsb3a
splA/ryanodine receptor domain and SOCS box containing 3a
chr7_+_60551133 0.13 ENSDART00000148038
lrfn4b
leucine rich repeat and fibronectin type III domain containing 4b
chr25_+_17920668 0.13 ENSDART00000093358
borcs5
BLOC-1 related complex subunit 5
chr2_-_30200206 0.13 ENSDART00000130142
ube2w
ubiquitin-conjugating enzyme E2W (putative)
chr15_+_8043751 0.13 ENSDART00000193701
cadm2b
cell adhesion molecule 2b
chr17_+_25519089 0.13 ENSDART00000041721
aim1a
crystallin beta-gamma domain containing 1a
chr5_+_22579975 0.13 ENSDART00000080877
tnfsf10l4
tumor necrosis factor (ligand) superfamily, member 10 like 4
chr12_+_19188542 0.13 ENSDART00000134726
ENSDART00000148011
ENSDART00000109541
cby1
chibby homolog 1 (Drosophila)
chr17_+_14965570 0.13 ENSDART00000066604
gpr137c
G protein-coupled receptor 137c
chr6_-_30839763 0.13 ENSDART00000154228
sgip1a
SH3-domain GRB2-like (endophilin) interacting protein 1a
chr12_-_33314894 0.13 ENSDART00000152908
c1qtnf1
C1q and TNF related 1
chr18_+_16749091 0.13 ENSDART00000061265
rnf141
ring finger protein 141
chr15_+_39977461 0.13 ENSDART00000063786
cab39
calcium binding protein 39
chr23_+_19759128 0.13 ENSDART00000135820
flna
filamin A, alpha (actin binding protein 280)
chr8_+_7778770 0.12 ENSDART00000171325
tfe3a
transcription factor binding to IGHM enhancer 3a
chr1_-_9277986 0.12 ENSDART00000146065
ENSDART00000114876
ENSDART00000132812
ubn1
ubinuclein 1
chr7_-_18547420 0.12 ENSDART00000173969
rgs12a
regulator of G protein signaling 12a
chr19_+_10396042 0.12 ENSDART00000028048
ENSDART00000151735
necap1
NECAP endocytosis associated 1
chr16_-_15988320 0.12 ENSDART00000160883
CABZ01060453.1

chr25_-_16589461 0.12 ENSDART00000064204
cpa4
carboxypeptidase A4
chr11_-_34577034 0.12 ENSDART00000133302
ENSDART00000184367
pfkfb4a
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
chr2_+_26179096 0.12 ENSDART00000024662
plppr3a
phospholipid phosphatase related 3a
chr18_+_17660402 0.12 ENSDART00000143475
cpne2
copine II
chr9_+_3388099 0.12 ENSDART00000019910
dlx1a
distal-less homeobox 1a
chr3_-_25369557 0.12 ENSDART00000055491
smurf2
SMAD specific E3 ubiquitin protein ligase 2
chr25_-_3393705 0.12 ENSDART00000163096
gpr22b
G protein-coupled receptor 22b
chr4_+_14926948 0.12 ENSDART00000019647
psmc2
proteasome 26S subunit, ATPase 2
chr12_+_18916285 0.12 ENSDART00000127536
cbx7b
chromobox homolog 7b
chr10_+_33754967 0.12 ENSDART00000153442
rxfp2a
relaxin/insulin-like family peptide receptor 2a
chr18_+_1703984 0.12 ENSDART00000114010
slitrk3a
SLIT and NTRK-like family, member 3a
chr5_+_37504309 0.12 ENSDART00000165465
si:ch1073-224n8.1
si:ch1073-224n8.1
chr16_-_44900306 0.12 ENSDART00000058380
rbm42
RNA binding motif protein 42
chr14_+_16937997 0.12 ENSDART00000163013
ENSDART00000167856
limch1b
LIM and calponin homology domains 1b
chr21_+_25071805 0.12 ENSDART00000078651
dixdc1b
DIX domain containing 1b
chr11_-_21586157 0.12 ENSDART00000190095
srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr20_-_35470891 0.12 ENSDART00000152993
ENSDART00000016090
pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr23_+_31596441 0.12 ENSDART00000053534
tbpl1
TBP-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of foxo4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.4 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 0.3 GO:0010935 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.1 0.5 GO:0002828 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) regulation of type 2 immune response(GO:0002828) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.1 0.3 GO:0009098 leucine biosynthetic process(GO:0009098)
0.1 0.2 GO:0043455 regulation of secondary metabolic process(GO:0043455)
0.1 0.4 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.1 0.2 GO:0018377 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.1 0.2 GO:0036314 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.4 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.2 GO:0099548 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.0 0.1 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.1 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
0.0 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.2 GO:0061010 gall bladder development(GO:0061010)
0.0 0.1 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.0 0.1 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.0 0.1 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.0 0.1 GO:0086005 ventricular cardiac muscle cell action potential(GO:0086005)
0.0 0.1 GO:0016116 tetraterpenoid metabolic process(GO:0016108) tetraterpenoid biosynthetic process(GO:0016109) carotenoid metabolic process(GO:0016116) carotenoid biosynthetic process(GO:0016117) xanthophyll metabolic process(GO:0016122) xanthophyll biosynthetic process(GO:0016123) zeaxanthin metabolic process(GO:1901825) zeaxanthin biosynthetic process(GO:1901827)
0.0 0.1 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.0 0.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.0 0.4 GO:0001964 startle response(GO:0001964)
0.0 0.1 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037)
0.0 0.1 GO:0051196 regulation of glycolytic process(GO:0006110) regulation of nucleotide catabolic process(GO:0030811) regulation of cofactor metabolic process(GO:0051193) regulation of coenzyme metabolic process(GO:0051196)
0.0 0.1 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.1 GO:0042940 D-amino acid transport(GO:0042940) D-alanine transport(GO:0042941) D-serine transport(GO:0042942)
0.0 0.3 GO:0061056 sclerotome development(GO:0061056)
0.0 0.2 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 0.2 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.2 GO:0070254 mucus secretion(GO:0070254)
0.0 0.8 GO:0003171 atrioventricular valve development(GO:0003171)
0.0 0.3 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.1 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 0.1 GO:0003232 bulbus arteriosus development(GO:0003232)
0.0 0.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.1 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.0 0.1 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.0 0.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.0 0.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.1 GO:0010692 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.0 0.1 GO:1903723 negative regulation of centriole elongation(GO:1903723)
0.0 0.2 GO:0071715 icosanoid transport(GO:0071715) fatty acid derivative transport(GO:1901571)
0.0 0.1 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0 0.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.1 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.3 GO:0014812 muscle cell migration(GO:0014812)
0.0 0.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:1900120 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.0 0.1 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0 0.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.1 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.1 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 0.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.1 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.0 0.1 GO:0071881 adenylate cyclase-inhibiting adrenergic receptor signaling pathway(GO:0071881)
0.0 0.1 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.0 GO:0042416 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.0 0.3 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.1 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 0.1 GO:0051881 regulation of mitochondrial membrane potential(GO:0051881)
0.0 0.8 GO:1901214 regulation of neuron death(GO:1901214)
0.0 0.1 GO:1904184 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.0 0.1 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031) pancreas morphogenesis(GO:0061113)
0.0 0.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.3 GO:0051014 actin filament severing(GO:0051014)
0.0 0.5 GO:0021854 hypothalamus development(GO:0021854)
0.0 0.2 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.1 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.1 GO:0003139 secondary heart field specification(GO:0003139)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 0.2 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.1 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.1 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.1 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.1 GO:0099612 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.0 0.2 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.0 GO:0010591 regulation of lamellipodium assembly(GO:0010591)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.3 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.1 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.2 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.3 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0044279 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0031213 RSF complex(GO:0031213)
0.0 0.1 GO:0016460 myosin II complex(GO:0016460)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0042611 MHC protein complex(GO:0042611) MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0017177 glucosidase II complex(GO:0017177)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.0 0.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.2 GO:0030667 secretory granule membrane(GO:0030667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0004807 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1 0.5 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 0.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.1 0.3 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.4 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.1 0.2 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
0.1 0.2 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.1 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.6 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.1 GO:0047325 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0052885 retinol isomerase activity(GO:0050251) all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity(GO:0052885)
0.0 0.1 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0032038 myosin head/neck binding(GO:0032028) myosin II head/neck binding(GO:0032034) myosin II heavy chain binding(GO:0032038)
0.0 0.1 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.0 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.7 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.1 GO:0031701 angiotensin receptor binding(GO:0031701)
0.0 0.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.0 0.1 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.1 GO:0052855 ATP-dependent NAD(P)H-hydrate dehydratase activity(GO:0047453) ADP-dependent NAD(P)H-hydrate dehydratase activity(GO:0052855)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.4 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.1 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0 0.0 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.3 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0 0.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.0 0.1 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.2 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.1 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.1 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin