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PRJNA207719: Tissue specific transcriptome profiling

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Results for her6+her9

Z-value: 0.36

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Transcription factors associated with her6+her9

Gene Symbol Gene ID Gene Info
her6
ENSDARG00000006514 hairy-related 6
her9
ENSDARG00000056438 hairy-related 9
her6
ENSDARG00000111099 hairy-related 6
her9
ENSDARG00000115775 hairy-related 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
her6dr11_v1_chr6_-_36552844_36552844-0.385.3e-01Click!
her9dr11_v1_chr23_-_23401305_23401305-0.237.1e-01Click!

Activity profile of her6+her9 motif

Sorted Z-values of her6+her9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_68789 0.15 ENSDART00000058569
cldn1
claudin 1
chr5_-_12560569 0.14 ENSDART00000133587
wsb2
WD repeat and SOCS box containing 2
chr1_+_31942961 0.12 ENSDART00000007522
anos1a
anosmin 1a
chr5_-_29122834 0.11 ENSDART00000087197
whrnb
whirlin b
chr5_-_29122615 0.10 ENSDART00000144802
whrnb
whirlin b
chr18_+_3169579 0.09 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr4_-_77551860 0.08 ENSDART00000188176
AL935186.6

chr17_-_3986236 0.08 ENSDART00000188794
ENSDART00000160830
PLCB1
si:ch1073-140o9.2
chr13_+_7241170 0.07 ENSDART00000109434
aifm2
apoptosis-inducing factor, mitochondrion-associated, 2
chr19_-_35450661 0.07 ENSDART00000113574
ENSDART00000136895
anln
anillin, actin binding protein
chr8_+_36509885 0.07 ENSDART00000109530
slc7a4
solute carrier family 7, member 4
chr7_+_24528430 0.07 ENSDART00000133022
si:dkeyp-75h12.2
si:dkeyp-75h12.2
chr15_-_12319065 0.07 ENSDART00000162973
ENSDART00000170543
fxyd6
FXYD domain containing ion transport regulator 6
chr25_+_19954576 0.07 ENSDART00000149335
kcna1a
potassium voltage-gated channel, shaker-related subfamily, member 1a
chr7_+_529522 0.07 ENSDART00000190811
nrxn2b
neurexin 2b
chr21_-_44731865 0.07 ENSDART00000013814
ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 homolog (human)
chr8_-_39977026 0.06 ENSDART00000141707
asphd2
aspartate beta-hydroxylase domain containing 2
chr19_-_15397946 0.06 ENSDART00000143480
hivep3a
human immunodeficiency virus type I enhancer binding protein 3a
chr24_-_33291784 0.06 ENSDART00000124938
si:ch1073-406l10.2
si:ch1073-406l10.2
chr4_-_77563411 0.06 ENSDART00000186841
AL935186.8

chr4_+_9669717 0.06 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr13_+_35925490 0.06 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr15_-_1765098 0.06 ENSDART00000149980
ENSDART00000093074
bud23
BUD23, rRNA methyltransferase and ribosome maturation factor
chr9_+_500052 0.06 ENSDART00000166707
CU984600.1

chr19_-_6385594 0.06 ENSDART00000104950
atp1a3a
ATPase Na+/K+ transporting subunit alpha 3a
chr10_-_2942900 0.05 ENSDART00000002622
oclna
occludin a
chr14_-_2189889 0.05 ENSDART00000181557
ENSDART00000106707
pcdh2ab9
pcdh2ab11
protocadherin 2 alpha b 9
protocadherin 2 alpha b 11
chr2_+_58841181 0.05 ENSDART00000164102
cirbpa
cold inducible RNA binding protein a
chr20_-_8304271 0.05 ENSDART00000179057
dab1a
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr3_-_29977495 0.05 ENSDART00000077111
hsd17b14
hydroxysteroid (17-beta) dehydrogenase 14
chr14_-_30387894 0.05 ENSDART00000176136
slc7a2
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
chr20_-_16498991 0.04 ENSDART00000104137
ches1
checkpoint suppressor 1
chr18_+_41772474 0.04 ENSDART00000097547
trpc6b
transient receptor potential cation channel, subfamily C, member 6b
chr5_-_32890807 0.04 ENSDART00000007512
pole3
polymerase (DNA directed), epsilon 3 (p17 subunit)
chr5_-_54395488 0.04 ENSDART00000160781
zmynd19
zinc finger, MYND-type containing 19
chr9_-_6624663 0.04 ENSDART00000092537
GPR45
si:dkeyp-118h3.5
chr3_+_431208 0.04 ENSDART00000154296
ENSDART00000048733
si:ch73-308m11.1
si:dkey-167k11.5
si:ch73-308m11.1
si:dkey-167k11.5
chr14_-_32520295 0.04 ENSDART00000165463
atp11c
ATPase phospholipid transporting 11C
chr11_-_12800945 0.04 ENSDART00000191178
txlng
taxilin gamma
chr3_-_11828206 0.03 ENSDART00000018159
si:ch211-262e15.1
si:ch211-262e15.1
chr11_-_12801157 0.03 ENSDART00000103449
txlng
taxilin gamma
chr23_+_44732863 0.03 ENSDART00000160044
ENSDART00000172268
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr3_-_58823762 0.03 ENSDART00000101253
luc7l3
LUC7-like 3 pre-mRNA splicing factor
chr25_+_388258 0.03 ENSDART00000166834
rfx7b
regulatory factor X7b
chr2_-_58257624 0.03 ENSDART00000098940
foxl2b
forkhead box L2b
chr7_+_17938128 0.03 ENSDART00000141044
mta2
metastasis associated 1 family, member 2
chr1_-_22756898 0.03 ENSDART00000158915
prom1b
prominin 1 b
chr1_+_49955869 0.03 ENSDART00000150517
gstcd
glutathione S-transferase, C-terminal domain containing
chr5_-_36916790 0.03 ENSDART00000143827
kptn
kaptin (actin binding protein)
chr20_-_6196989 0.02 ENSDART00000013343
b4galt6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr4_+_68562464 0.02 ENSDART00000192954
BX548011.4

chr3_+_14641962 0.02 ENSDART00000091070
zgc:158403
zgc:158403
chr13_-_45022301 0.02 ENSDART00000183589
ENSDART00000125633
ENSDART00000074787
khdrbs1a
KH domain containing, RNA binding, signal transduction associated 1a
chr1_+_37195919 0.02 ENSDART00000159684
ENSDART00000172742
ENSDART00000158395
dclk2a
doublecortin-like kinase 2a
chr25_-_21280584 0.02 ENSDART00000143644
tmem60
transmembrane protein 60
chr17_-_20666616 0.02 ENSDART00000020167
slc16a9a
solute carrier family 16, member 9a
chr21_+_1647990 0.02 ENSDART00000148540
fech
ferrochelatase
chr13_-_45022527 0.02 ENSDART00000159021
khdrbs1a
KH domain containing, RNA binding, signal transduction associated 1a
chr1_-_52461322 0.02 ENSDART00000083836
si:ch211-217k17.7
si:ch211-217k17.7
chr1_+_37196106 0.02 ENSDART00000008756
ENSDART00000157503
ENSDART00000162971
ENSDART00000191004
ENSDART00000078206
ENSDART00000045111
dclk2a
doublecortin-like kinase 2a
chr24_+_39537565 0.02 ENSDART00000140868
ENSDART00000145358
si:dkey-161j23.5
si:dkey-161j23.5
chr14_+_12109535 0.01 ENSDART00000054620
ENSDART00000121913
kctd12b
potassium channel tetramerisation domain containing 12b
chr3_-_8765165 0.01 ENSDART00000191131
CABZ01058333.1

chr6_-_40195510 0.01 ENSDART00000156156
col7a1
collagen, type VII, alpha 1
chr20_-_5328637 0.01 ENSDART00000075974
ism2b
isthmin 2b
chr23_-_6765653 0.01 ENSDART00000192310
FP102169.1

chr16_+_11029762 0.01 ENSDART00000091183
erfl3
Ets2 repressor factor like 3
chr4_+_62576422 0.01 ENSDART00000180679
si:ch211-79g12.2
si:ch211-79g12.2
chr9_-_43538328 0.01 ENSDART00000140526
znf385b
zinc finger protein 385B
chr7_-_6438544 0.00 ENSDART00000173180
zgc:165555
zgc:165555
chr14_-_41075262 0.00 ENSDART00000180518
drp2
dystrophin related protein 2
chr14_+_15064870 0.00 ENSDART00000167075
nkx1.2lb
NK1 transcription factor related 2-like,b
chr20_-_40766387 0.00 ENSDART00000061173
hsdl1
hydroxysteroid dehydrogenase like 1
chr14_+_12110020 0.00 ENSDART00000192462
kctd12b
potassium channel tetramerisation domain containing 12b

Network of associatons between targets according to the STRING database.

First level regulatory network of her6+her9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.1 GO:0003232 bulbus arteriosus development(GO:0003232)
0.0 0.1 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.0 0.1 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.0 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.0 GO:0006272 leading strand elongation(GO:0006272)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0002141 stereocilia coupling link(GO:0002139) stereocilia ankle link(GO:0002141) stereocilia ankle link complex(GO:0002142) stereocilium tip(GO:0032426)
0.0 0.0 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway