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PRJNA207719: Tissue specific transcriptome profiling

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Results for hic1

Z-value: 0.85

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Transcription factors associated with hic1

Gene Symbol Gene ID Gene Info
hic1
ENSDARG00000055493 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hic1dr11_v1_chr15_+_25683069_25683069-0.913.1e-02Click!

Activity profile of hic1 motif

Sorted Z-values of hic1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_77557279 1.35 ENSDART00000180113
AL935186.10

chr4_-_55728559 1.28 ENSDART00000186201
CT583728.14

chr4_-_77561679 1.28 ENSDART00000180809
AL935186.9

chr4_+_55778679 1.20 ENSDART00000183009
CT583728.19

chr4_+_55794876 1.20 ENSDART00000189043
CT583728.17

chr4_+_55810436 1.20 ENSDART00000182875
CT583728.16

chr4_-_68568233 1.20 ENSDART00000184284
BX548011.1

chr1_+_135903 0.85 ENSDART00000124837
f10
coagulation factor X
chr14_-_21064199 0.72 ENSDART00000172099
si:dkey-74k8.3
si:dkey-74k8.3
chr14_-_21063977 0.68 ENSDART00000164373
si:dkey-74k8.3
si:dkey-74k8.3
chr17_-_49412313 0.31 ENSDART00000152100
mthfd1b
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr3_+_46762703 0.27 ENSDART00000133283
prkcsh
protein kinase C substrate 80K-H
chr10_+_23088 0.25 ENSDART00000022840
riox2
ribosomal oxygenase 2
chr23_+_45845423 0.24 ENSDART00000183404
lmnl3
lamin L3
chr5_+_62723233 0.22 ENSDART00000183718
nanos2
nanos homolog 2
chr6_+_28203 0.22 ENSDART00000191561
CZQB01141835.1

chr16_+_25285998 0.18 ENSDART00000154112
si:dkey-29h14.10
si:dkey-29h14.10
chr9_+_7358749 0.17 ENSDART00000081660
ihha
Indian hedgehog homolog a
chr1_-_59571758 0.17 ENSDART00000193546
ENSDART00000167087
wfikkn1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr11_-_6420917 0.17 ENSDART00000193717
FO681393.2

chr23_+_45845159 0.16 ENSDART00000023944
lmnl3
lamin L3
chr23_-_31060350 0.16 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
si:ch211-197l9.5
chr1_+_18863060 0.15 ENSDART00000139241
rnf38
ring finger protein 38
chr2_-_49370042 0.15 ENSDART00000180515
CT583662.1

chr10_-_21484065 0.14 ENSDART00000064545
fgf18b
fibroblast growth factor 18b
chr16_+_2565433 0.13 ENSDART00000188014
ENSDART00000171378
preb
prolactin regulatory element binding
chr3_+_23721808 0.11 ENSDART00000012470
hoxb4a
homeobox B4a
chr7_-_24995631 0.11 ENSDART00000173955
ENSDART00000173791
rcor2
REST corepressor 2
chr10_-_9192450 0.10 ENSDART00000139783
si:dkeyp-41f9.4
si:dkeyp-41f9.4
chr19_-_12967986 0.08 ENSDART00000151064
slc25a32a
solute carrier family 25 (mitochondrial folate carrier), member 32a
chr2_+_21063660 0.08 ENSDART00000022765
riok1
RIO kinase 1 (yeast)
chr19_+_17642356 0.08 ENSDART00000176431
CR382334.1

chr19_-_22488952 0.05 ENSDART00000179856
ENSDART00000141503
pleca
plectin a
chr13_-_37519774 0.05 ENSDART00000141420
ENSDART00000185478
sgpp1
sphingosine-1-phosphate phosphatase 1
chr4_-_68831753 0.04 ENSDART00000189170
si:dkey-264f17.1
si:dkey-264f17.1
chr21_+_13389499 0.04 ENSDART00000151268
zgc:113162
zgc:113162
chr8_-_13678415 0.04 ENSDART00000134153
ENSDART00000143331
si:dkey-258f14.3
si:dkey-258f14.3
chr23_+_14590767 0.03 ENSDART00000143675
si:rp71-79p20.2
si:rp71-79p20.2
chr3_-_61592417 0.03 ENSDART00000155082
nptx2a
neuronal pentraxin 2a
chr17_+_132555 0.01 ENSDART00000158159
zgc:77287
zgc:77287
chr19_-_3574060 0.01 ENSDART00000105120
tmem170b
transmembrane protein 170B

Network of associatons between targets according to the STRING database.

First level regulatory network of hic1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.1 0.3 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.1 GO:0090113 regulation of COPII vesicle coating(GO:0003400) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.2 GO:0048795 swim bladder morphogenesis(GO:0048795)
0.0 0.3 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.8 GO:0007596 blood coagulation(GO:0007596)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0017177 glucosidase II complex(GO:0017177)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.0 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.3 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling