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PRJNA207719: Tissue specific transcriptome profiling

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Results for hmga1a

Z-value: 0.79

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Transcription factors associated with hmga1a

Gene Symbol Gene ID Gene Info
hmga1a
ENSDARG00000028335 high mobility group AT-hook 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hmga1adr11_v1_chr23_-_3758637_37588240.731.6e-01Click!

Activity profile of hmga1a motif

Sorted Z-values of hmga1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_-_45439903 1.57 ENSDART00000170729
NPNT (1 of many)
nephronectin
chr12_+_46483618 0.60 ENSDART00000186970
BX005305.5

chr12_+_46443477 0.58 ENSDART00000191873
BX005305.1

chr12_+_46425800 0.58 ENSDART00000191965
BX005305.1

chr12_+_46404307 0.58 ENSDART00000185011
BX005305.4

chr12_+_46386983 0.58 ENSDART00000183982
BX005305.3
Danio rerio legumain (LOC100005356), mRNA.
chr12_+_46512881 0.56 ENSDART00000105454
CU855711.1

chr12_+_46462090 0.56 ENSDART00000130748
BX005305.2

chr3_+_62161184 0.49 ENSDART00000090370
ENSDART00000192665
noxo1a
NADPH oxidase organizer 1a
chr3_+_57820913 0.33 ENSDART00000168101
CU571328.1

chr10_-_22106331 0.29 ENSDART00000187654
BX005027.2

chr22_-_10580194 0.25 ENSDART00000105848
SHISA4 (1 of many)
si:dkey-42i9.7
chr7_+_19615056 0.25 ENSDART00000124752
ENSDART00000190297
si:ch211-212k18.15
si:ch211-212k18.15
chr13_+_1089942 0.23 ENSDART00000054322
cnrip1b
cannabinoid receptor interacting protein 1b
chr8_+_49975160 0.21 ENSDART00000156403
ENSDART00000080135
gfpt1
glutamine--fructose-6-phosphate transaminase 1
chr9_-_2892250 0.21 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr19_+_29808699 0.20 ENSDART00000051799
ENSDART00000164205
hdac1
histone deacetylase 1
chr7_-_64971839 0.20 ENSDART00000164682
sinhcafl
SIN3-HDAC complex associated factor, like
chr24_-_31306724 0.20 ENSDART00000165399
acp5b
acid phosphatase 5b, tartrate resistant
chr6_-_35472923 0.19 ENSDART00000185907
rgs8
regulator of G protein signaling 8
chr19_+_29808471 0.18 ENSDART00000186428
hdac1
histone deacetylase 1
chr4_-_992063 0.17 ENSDART00000181630
ENSDART00000183898
ENSDART00000160902
naga
N-acetylgalactosaminidase, alpha
chr4_+_72668095 0.16 ENSDART00000182282
ENSDART00000162637
CABZ01054391.1

chr11_-_12051502 0.15 ENSDART00000183462
socs7
suppressor of cytokine signaling 7
chr15_-_33807758 0.15 ENSDART00000158445
pds5b
PDS5 cohesin associated factor B
chr21_+_21743599 0.15 ENSDART00000101700
pold3
polymerase (DNA-directed), delta 3, accessory subunit
chr18_+_31410652 0.14 ENSDART00000098504
def8
differentially expressed in FDCP 8 homolog (mouse)
chr20_+_34400715 0.14 ENSDART00000061632
fam129aa
family with sequence similarity 129, member Aa
chr2_+_25839193 0.14 ENSDART00000078634
eif5a2
eukaryotic translation initiation factor 5A2
chr11_-_12051283 0.14 ENSDART00000170516
socs7
suppressor of cytokine signaling 7
chr6_-_7123210 0.12 ENSDART00000041304
atg3
autophagy related 3
chr21_+_7545062 0.12 ENSDART00000023997
tbca
tubulin cofactor a
chr18_-_35407695 0.12 ENSDART00000191845
ENSDART00000141703
snrpa
small nuclear ribonucleoprotein polypeptide A
chr12_+_46841918 0.12 ENSDART00000157464
adkb
adenosine kinase b
chr18_-_35407289 0.11 ENSDART00000012018
snrpa
small nuclear ribonucleoprotein polypeptide A
chr14_-_38827442 0.11 ENSDART00000160000
spdl1
spindle apparatus coiled-coil protein 1
chr23_-_27633730 0.11 ENSDART00000103639
arf3a
ADP-ribosylation factor 3a
chr12_-_656540 0.11 ENSDART00000172651
sult2st2
sulfotransferase family 2, cytosolic sulfotransferase 2
chr22_+_23359369 0.10 ENSDART00000170886
dennd1b
DENN/MADD domain containing 1B
chr21_-_588858 0.10 ENSDART00000168983
TMEM38B
transmembrane protein 38B
chr20_+_35255403 0.10 ENSDART00000002773
ENSDART00000137915
fam49a
family with sequence similarity 49, member A
chr25_-_13549577 0.10 ENSDART00000166772
ano10b
anoctamin 10b
chr22_-_784110 0.10 ENSDART00000061775
rbbp5
retinoblastoma binding protein 5
chr10_-_26202766 0.10 ENSDART00000136393
fhdc3
FH2 domain containing 3
chr11_-_34151487 0.10 ENSDART00000173039
atp13a3
ATPase 13A3
chr9_-_41507712 0.09 ENSDART00000135821
mfsd6b
major facilitator superfamily domain containing 6b
chr1_-_54971968 0.09 ENSDART00000140016
khsrp
KH-type splicing regulatory protein
chr24_-_18477672 0.09 ENSDART00000126928
ENSDART00000158393
si:dkey-73n8.3
si:dkey-73n8.3
chr6_-_39518489 0.08 ENSDART00000185446
atf1
activating transcription factor 1
chr5_+_20421539 0.08 ENSDART00000164499
selplg
selectin P ligand
chr16_-_26232411 0.08 ENSDART00000139355
arhgef1b
Rho guanine nucleotide exchange factor (GEF) 1b
chr17_+_31739418 0.08 ENSDART00000155073
ENSDART00000156180
arhgap5
Rho GTPase activating protein 5
chr1_+_49814461 0.08 ENSDART00000132405
lef1
lymphoid enhancer-binding factor 1
chr11_+_36683859 0.08 ENSDART00000170102
si:ch211-11c3.12
si:ch211-11c3.12
chr2_+_32846602 0.08 ENSDART00000056649
tmem53
transmembrane protein 53
chr18_-_35407530 0.07 ENSDART00000137663
snrpa
small nuclear ribonucleoprotein polypeptide A
chr25_+_32390794 0.07 ENSDART00000012600
galk2
galactokinase 2
chr19_-_3741602 0.07 ENSDART00000170301
btr22
bloodthirsty-related gene family, member 22
chr14_-_33521071 0.07 ENSDART00000052789
c1galt1c1
C1GALT1-specific chaperone 1
chr8_+_1843135 0.06 ENSDART00000141452
snap29
synaptosomal-associated protein 29
chr8_-_50981175 0.06 ENSDART00000004065
zgc:91909
zgc:91909
chr9_-_12885201 0.06 ENSDART00000124957
ankzf1
ankyrin repeat and zinc finger domain containing 1
chr9_-_27738110 0.06 ENSDART00000060347
crygs2
crystallin, gamma S2
chr8_-_42579446 0.06 ENSDART00000189792
dok2
docking protein 2
chr1_-_54972170 0.06 ENSDART00000150548
ENSDART00000038330
khsrp
KH-type splicing regulatory protein
chr18_+_328689 0.06 ENSDART00000167841
ss18l2
synovial sarcoma translocation gene on chromosome 18-like 2
chr1_+_19849168 0.06 ENSDART00000111454
si:dkey-82j4.2
si:dkey-82j4.2
chr8_+_42917515 0.06 ENSDART00000021715
slc23a2
solute carrier family 23 (ascorbic acid transporter), member 2
chr24_+_39137001 0.06 ENSDART00000181086
ENSDART00000183724
ENSDART00000193466
tbc1d24
TBC1 domain family, member 24
chr4_+_65537216 0.06 ENSDART00000181458
si:dkey-205i10.1
si:dkey-205i10.1
chr10_+_20364009 0.06 ENSDART00000186139
ENSDART00000080395
golga7
golgin A7
chr25_+_19739665 0.05 ENSDART00000067353
zgc:101783
zgc:101783
chr24_-_35534273 0.05 ENSDART00000026578
ube2v2
ubiquitin-conjugating enzyme E2 variant 2
chr17_-_1703259 0.05 ENSDART00000156489
xgb
x globin
chr17_-_23221504 0.05 ENSDART00000156411
fam98a
family with sequence similarity 98, member A
chr1_+_47335038 0.05 ENSDART00000188153
bcl9
B cell CLL/lymphoma 9
chr5_+_32831561 0.05 ENSDART00000169358
ENSDART00000192078
si:ch211-208h16.4
si:ch211-208h16.4
chr14_-_2348917 0.05 ENSDART00000159004
si:ch73-233f7.8
si:ch73-233f7.8
chr16_+_1383914 0.05 ENSDART00000185089
cers2b
ceramide synthase 2b
chr11_-_16975190 0.04 ENSDART00000122222
suclg2
succinate-CoA ligase, GDP-forming, beta subunit
chr5_-_20814576 0.04 ENSDART00000098682
ENSDART00000147639
si:ch211-225b11.1
si:ch211-225b11.1
chr7_-_33130552 0.04 ENSDART00000127006
mns1
meiosis-specific nuclear structural 1
chr5_+_41476443 0.04 ENSDART00000145228
ENSDART00000137981
ENSDART00000142538
pias2
protein inhibitor of activated STAT, 2
chr6_-_2222707 0.04 ENSDART00000022179
prkag1
protein kinase, AMP-activated, gamma 1 non-catalytic subunit
chr11_+_5817202 0.04 ENSDART00000126084
ctdspl3
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 3
chr7_-_22956716 0.03 ENSDART00000122113
tnfsf10l
TNF superfamily member 10, like
chr14_+_46020571 0.03 ENSDART00000157617
ENSDART00000083928
c1qtnf2
C1q and TNF related 2
chr12_+_4686145 0.03 ENSDART00000128145
kansl1a
KAT8 regulatory NSL complex subunit 1a
chr22_-_16416882 0.03 ENSDART00000062749
cts12
cathepsin 12
chr25_-_17910714 0.03 ENSDART00000191586
arntl1a
aryl hydrocarbon receptor nuclear translocator-like 1a
chr7_+_15871156 0.03 ENSDART00000145946
pax6b
paired box 6b
chr12_+_33919502 0.03 ENSDART00000085888
trim8b
tripartite motif containing 8b
chr7_-_22956889 0.03 ENSDART00000101447
tnfsf10l
TNF superfamily member 10, like
chr9_+_36314867 0.03 ENSDART00000176763
lrp1bb
low density lipoprotein receptor-related protein 1Bb
chr23_+_45512825 0.03 ENSDART00000064846
prelid1b
PRELI domain containing 1b
chr14_+_11909966 0.02 ENSDART00000171829
frmpd3
FERM and PDZ domain containing 3
chr3_-_33437796 0.02 ENSDART00000075499
si:dkey-283b1.7
si:dkey-283b1.7
chr2_+_45548890 0.02 ENSDART00000113994
fndc7a
fibronectin type III domain containing 7a
chr6_-_58764672 0.02 ENSDART00000154322
soat2
sterol O-acyltransferase 2
chr7_-_69521481 0.02 ENSDART00000148465
slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr2_-_10062575 0.02 ENSDART00000091726
fam78ba
family with sequence similarity 78, member B a
chr17_-_21200406 0.02 ENSDART00000104708
abhd12
abhydrolase domain containing 12
chr18_-_19350792 0.02 ENSDART00000147902
megf11
multiple EGF-like-domains 11
chr6_-_58757131 0.02 ENSDART00000083582
soat2
sterol O-acyltransferase 2
chr14_+_34951202 0.01 ENSDART00000047524
ENSDART00000115105
il12ba
interleukin 12Ba
chr1_-_14258409 0.01 ENSDART00000079359
pde5aa
phosphodiesterase 5A, cGMP-specific, a
chr14_-_38828057 0.01 ENSDART00000186088
spdl1
spindle apparatus coiled-coil protein 1
chr20_-_874807 0.01 ENSDART00000020506
snx14
sorting nexin 14
chr10_+_3049636 0.00 ENSDART00000081794
ENSDART00000183167
ENSDART00000191634
ENSDART00000183514
rasgrf2a
Ras protein-specific guanine nucleotide-releasing factor 2a
chr25_-_13789955 0.00 ENSDART00000167742
ENSDART00000165116
ENSDART00000171461
ckap5
cytoskeleton associated protein 5
chr4_-_45028479 0.00 ENSDART00000143150
ENSDART00000076870
si:dkey-51d8.1
si:dkey-51d8.1
chr12_-_36740781 0.00 ENSDART00000105484
si:ch211-216b21.2
si:ch211-216b21.2
chr4_+_19127973 0.00 ENSDART00000136611
si:dkey-21o22.2
si:dkey-21o22.2

Network of associatons between targets according to the STRING database.

First level regulatory network of hmga1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0033687 osteoblast proliferation(GO:0033687)
0.0 0.1 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.2 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 0.2 GO:0016139 glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139)
0.0 0.1 GO:0042590 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.0 0.1 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0045901 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.0 0.1 GO:0019852 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0044209 AMP salvage(GO:0044209)
0.0 0.2 GO:0045453 bone resorption(GO:0045453)
0.0 0.5 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.1 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.0 0.1 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.0 0.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0006012 galactose metabolic process(GO:0006012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.0 GO:0042709 succinate-CoA ligase complex(GO:0042709)
0.0 0.3 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.2 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004557 alpha-galactosidase activity(GO:0004557)
0.1 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.1 GO:0019777 Atg12 transferase activity(GO:0019777)
0.0 0.3 GO:0030619 U1 snRNA binding(GO:0030619)
0.0 0.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.4 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0004001 adenosine kinase activity(GO:0004001)
0.0 0.1 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.2 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.0 GO:0004775 succinate-CoA ligase activity(GO:0004774) succinate-CoA ligase (ADP-forming) activity(GO:0004775) succinate-CoA ligase (GDP-forming) activity(GO:0004776)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.0 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.1 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand