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PRJNA207719: Tissue specific transcriptome profiling
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Results for hnf1a
Z-value: 4.92
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Transcription factors associated with hnf1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hnf1a | dr11_v1_chr8_+_39802506_39802506 | 0.85 | 6.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_24757785 Show fit | 7.09 |
ENSDART00000078225
|
vitellogenin 5 |
|
| chr22_-_24791505 Show fit | 7.06 |
ENSDART00000136837
|
vitellogenin 4 |
|
| chr22_-_23625351 Show fit | 6.87 |
ENSDART00000192588
ENSDART00000163423 |
complement factor H like 4 |
|
| chr22_-_24858042 Show fit | 6.74 |
ENSDART00000137998
ENSDART00000078216 ENSDART00000138378 |
vitellogenin 7 |
|
| chr1_+_10051763 Show fit | 6.69 |
ENSDART00000011701
|
fibrinogen beta chain |
|
| chr22_-_24738188 Show fit | 6.04 |
ENSDART00000050238
|
vitellogenin 1 |
|
| chr13_+_23988442 Show fit | 6.03 |
ENSDART00000010918
|
angiotensinogen |
|
| chr5_+_32345187 Show fit | 5.52 |
ENSDART00000147132
|
complement component 9 |
|
| chr5_+_45677781 Show fit | 5.42 |
ENSDART00000163120
ENSDART00000126537 |
group-specific component (vitamin D binding protein) |
|
| chr23_+_25856541 Show fit | 5.34 |
ENSDART00000145426
ENSDART00000028236 |
hepatocyte nuclear factor 4, alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of hnf1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 35.0 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.8 | 32.2 | GO:0032355 | response to estradiol(GO:0032355) |
| 0.6 | 8.8 | GO:0016556 | mRNA modification(GO:0016556) |
| 0.3 | 8.5 | GO:0051180 | vitamin transport(GO:0051180) |
| 0.1 | 8.4 | GO:0007492 | endoderm development(GO:0007492) |
| 0.2 | 8.0 | GO:0007596 | blood coagulation(GO:0007596) |
| 0.4 | 6.7 | GO:0070527 | platelet aggregation(GO:0070527) blood coagulation, fibrin clot formation(GO:0072378) |
| 1.8 | 5.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 5.5 | GO:0009410 | response to xenobiotic stimulus(GO:0009410) |
| 0.5 | 5.3 | GO:0070365 | hepatocyte differentiation(GO:0070365) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 52.8 | GO:0005615 | extracellular space(GO:0005615) |
| 2.2 | 6.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 1.8 | 5.5 | GO:0044217 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.0 | 4.7 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 4.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 3.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 2.8 | GO:0005770 | late endosome(GO:0005770) |
| 0.9 | 2.7 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.3 | 2.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.2 | 2.7 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 35.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 4.6 | 31.9 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
| 0.2 | 12.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 9.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 8.8 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.3 | 5.5 | GO:0010181 | FMN binding(GO:0010181) |
| 1.8 | 5.4 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.0 | 5.4 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) |
| 0.1 | 5.2 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.5 | 4.9 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 6.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 6.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 5.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.2 | 3.8 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 3.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 3.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 2.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.0 | 7.3 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 0.6 | 6.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.3 | 6.4 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 6.0 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.1 | 6.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.2 | 4.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 4.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 4.8 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.4 | 4.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |