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PRJNA207719: Tissue specific transcriptome profiling
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Results for hnf1ba+hnf1bb
Z-value: 4.85
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Transcription factors associated with hnf1ba+hnf1bb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hnf1ba | dr11_v1_chr15_-_16012963_16012963 | 0.92 | 2.8e-02 | Click! |
| hnf1bb | dr11_v1_chr21_+_38817785_38817843 | 0.87 | 5.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_23440632 Show fit | 7.11 |
ENSDART00000180685
ENSDART00000042820 |
si:dkey-90m5.4 |
|
| chr20_-_40750953 Show fit | 7.03 |
ENSDART00000061256
|
connexin 28.9 |
|
| chr22_-_24791505 Show fit | 7.01 |
ENSDART00000136837
|
vitellogenin 4 |
|
| chr1_+_10051763 Show fit | 6.51 |
ENSDART00000011701
|
fibrinogen beta chain |
|
| chr22_-_24880824 Show fit | 6.11 |
ENSDART00000061165
|
vitellogenin 2 |
|
| chr5_+_32345187 Show fit | 6.10 |
ENSDART00000147132
|
complement component 9 |
|
| chr22_-_24738188 Show fit | 6.03 |
ENSDART00000050238
|
vitellogenin 1 |
|
| chr6_+_60055168 Show fit | 5.81 |
ENSDART00000008752
|
phosphoenolpyruvate carboxykinase 1 (soluble) |
|
| chr2_+_1486822 Show fit | 5.72 |
ENSDART00000132500
|
complement component 8, alpha polypeptide |
|
| chr2_+_1487118 Show fit | 5.64 |
ENSDART00000147283
|
complement component 8, alpha polypeptide |
Network of associatons between targets according to the STRING database.
First level regulatory network of hnf1ba+hnf1bb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 30.2 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.6 | 22.9 | GO:0032355 | response to estradiol(GO:0032355) |
| 0.4 | 11.4 | GO:0019835 | cytolysis(GO:0019835) |
| 0.2 | 11.1 | GO:0007596 | blood coagulation(GO:0007596) |
| 0.3 | 7.5 | GO:0051180 | vitamin transport(GO:0051180) |
| 0.4 | 6.5 | GO:0072378 | platelet aggregation(GO:0070527) blood coagulation, fibrin clot formation(GO:0072378) |
| 2.0 | 6.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 1.0 | 6.1 | GO:0050764 | regulation of phagocytosis(GO:0050764) |
| 0.1 | 5.9 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 1.5 | 5.8 | GO:0071548 | glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 49.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 14.4 | GO:0005576 | extracellular region(GO:0005576) |
| 0.8 | 11.4 | GO:0005579 | membrane attack complex(GO:0005579) |
| 2.2 | 6.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 2.0 | 6.1 | GO:0044216 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.0 | 5.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 3.4 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 3.3 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 3.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 3.1 | GO:0005770 | late endosome(GO:0005770) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 30.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 4.1 | 28.9 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
| 0.1 | 14.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 5.9 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.2 | 5.8 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.0 | 5.4 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) |
| 0.1 | 5.1 | GO:0017046 | peptide hormone binding(GO:0017046) |
| 0.2 | 4.9 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 1.2 | 4.6 | GO:1904121 | phosphatidylethanolamine transporter activity(GO:1904121) |
| 1.5 | 4.4 | GO:0005499 | vitamin D binding(GO:0005499) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 11.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 6.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.3 | 5.1 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 4.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 3.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 3.2 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 1.9 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 1.2 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 24.7 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.6 | 6.5 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 1.9 | 5.8 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.3 | 5.6 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.3 | 5.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 1.3 | 5.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 5.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.5 | 4.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 4.4 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.5 | 3.7 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |