Project
PRJNA207719: Tissue specific transcriptome profiling
Navigation
Downloads
Results for hnf4a+hnf4b
Z-value: 3.97
Motif logo
Transcription factors associated with hnf4a+hnf4b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hnf4a | dr11_v1_chr23_+_25832689_25832689 | 0.89 | 4.5e-02 | Click! |
| CABZ01057488.1 | dr11_v1_chr7_+_69019851_69019851 | 0.81 | 9.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_1412193 Show fit | 5.37 |
ENSDART00000064419
|
liver-enriched gene 1, tandem duplicate 1 |
|
| chr20_+_1398564 Show fit | 5.19 |
ENSDART00000002242
|
liver-enriched gene 1, tandem duplicate 2 |
|
| chr16_+_23913943 Show fit | 4.83 |
ENSDART00000175404
ENSDART00000129525 |
apolipoprotein A-IV b, tandem duplicate 1 |
|
| chr15_-_26552393 Show fit | 4.49 |
ENSDART00000150152
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b |
|
| chr15_-_26552652 Show fit | 4.03 |
ENSDART00000152336
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b |
|
| chr22_-_24818066 Show fit | 3.94 |
ENSDART00000143443
|
vitellogenin 6 |
|
| chr1_+_17900306 Show fit | 3.79 |
ENSDART00000089480
|
cytochrome P450, family 4, subfamily V, polypeptide 8 |
|
| chr16_+_23923746 Show fit | 3.76 |
ENSDART00000137962
|
si:dkey-7f3.14 |
|
| chr7_+_25036188 Show fit | 3.71 |
ENSDART00000163957
ENSDART00000169749 |
sb:cb1058 |
|
| chr17_-_2584423 Show fit | 3.61 |
ENSDART00000013506
|
zona pellucida glycoprotein 3, tandem duplicate 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of hnf4a+hnf4b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.8 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.6 | 10.2 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.1 | 7.7 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.5 | 5.4 | GO:1990402 | embryonic liver development(GO:1990402) |
| 0.0 | 5.0 | GO:0055123 | digestive system development(GO:0055123) |
| 0.1 | 3.9 | GO:0032355 | response to estradiol(GO:0032355) |
| 1.3 | 3.8 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
| 0.1 | 3.8 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
| 1.1 | 3.2 | GO:0005991 | trehalose metabolic process(GO:0005991) |
| 0.2 | 3.2 | GO:1901571 | icosanoid transport(GO:0071715) fatty acid derivative transport(GO:1901571) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 46.7 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 15.1 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 2.7 | GO:0016459 | myosin complex(GO:0016459) |
| 0.2 | 2.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.5 | 2.0 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.2 | 1.3 | GO:0031332 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.1 | 0.9 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 0.8 | GO:0030428 | cell septum(GO:0030428) |
| 0.0 | 0.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.6 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.9 | 10.2 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 0.0 | 7.3 | GO:0008289 | lipid binding(GO:0008289) |
| 0.1 | 6.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 5.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 5.6 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.6 | 3.9 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
| 0.0 | 3.8 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.0 | 3.5 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 1.1 | 3.2 | GO:0015927 | alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 3.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 3.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.2 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.9 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 0.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.6 | 3.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 3.2 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.4 | 3.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 2.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 2.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 2.0 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.2 | 2.0 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 1.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.2 | 1.4 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |