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PRJNA207719: Tissue specific transcriptome profiling

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Results for hnf4a+hnf4b

Z-value: 3.97

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Transcription factors associated with hnf4a+hnf4b

Gene Symbol Gene ID Gene Info
hnf4a
ENSDARG00000021494 hepatocyte nuclear factor 4, alpha
hnf4b
ENSDARG00000104742 hepatic nuclear factor 4, beta
hnf4a
ENSDARG00000112985 hepatocyte nuclear factor 4, alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hnf4adr11_v1_chr23_+_25832689_258326890.894.5e-02Click!
CABZ01057488.1dr11_v1_chr7_+_69019851_690198510.819.7e-02Click!

Activity profile of hnf4a+hnf4b motif

Sorted Z-values of hnf4a+hnf4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_1412193 5.37 ENSDART00000064419
leg1.1
liver-enriched gene 1, tandem duplicate 1
chr20_+_1398564 5.19 ENSDART00000002242
leg1.2
liver-enriched gene 1, tandem duplicate 2
chr16_+_23913943 4.83 ENSDART00000175404
ENSDART00000129525
apoa4b.1
apolipoprotein A-IV b, tandem duplicate 1
chr15_-_26552393 4.49 ENSDART00000150152
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr15_-_26552652 4.03 ENSDART00000152336
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr22_-_24818066 3.94 ENSDART00000143443
vtg6
vitellogenin 6
chr1_+_17900306 3.79 ENSDART00000089480
cyp4v8
cytochrome P450, family 4, subfamily V, polypeptide 8
chr16_+_23923746 3.76 ENSDART00000137962
si:dkey-7f3.14
si:dkey-7f3.14
chr7_+_25036188 3.71 ENSDART00000163957
ENSDART00000169749
sb:cb1058
sb:cb1058
chr17_-_2584423 3.61 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr20_+_54304800 3.57 ENSDART00000121661
zp2.6
zona pellucida glycoprotein 2, tandem duplicate 6
chr2_-_37960688 3.47 ENSDART00000055565
cbln14
cerebellin 14
chr10_-_322769 3.44 ENSDART00000165244
akt2l
v-akt murine thymoma viral oncogene homolog 2, like
chr8_-_30791266 3.34 ENSDART00000062220
gstt1a
glutathione S-transferase theta 1a
chr10_+_17026870 3.32 ENSDART00000184529
ENSDART00000157480
CR855996.2

chr8_+_1766206 3.28 ENSDART00000021820
serpind1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr22_-_20126230 3.26 ENSDART00000138688
creb3l3a
cAMP responsive element binding protein 3-like 3a
chr1_+_53374454 3.15 ENSDART00000038807
ucp1
uncoupling protein 1
chr3_-_45848257 3.11 ENSDART00000147198
igfals
insulin-like growth factor binding protein, acid labile subunit
chr3_+_16762483 3.06 ENSDART00000132732
tmem86b
transmembrane protein 86B
chr16_+_23924040 3.03 ENSDART00000161124
si:dkey-7f3.14
si:dkey-7f3.14
chr10_+_26747755 3.00 ENSDART00000100329
f9b
coagulation factor IXb
chr22_+_37888249 2.99 ENSDART00000076082
fetub
fetuin B
chr21_-_27443995 2.95 ENSDART00000003508
bfb
complement component bfb
chr14_+_21107032 2.84 ENSDART00000138319
ENSDART00000139103
ENSDART00000184735
aldob
aldolase b, fructose-bisphosphate
chr16_+_23947196 2.84 ENSDART00000103190
ENSDART00000132961
ENSDART00000147690
ENSDART00000142168
apoa4b.2
apolipoprotein A-IV b, tandem duplicate 2
chr2_+_22659787 2.82 ENSDART00000043956
zgc:161973
zgc:161973
chr8_+_39802506 2.74 ENSDART00000018862
hnf1a
HNF1 homeobox a
chr23_-_44786844 2.62 ENSDART00000148669
si:ch73-269m23.5
si:ch73-269m23.5
chr17_+_20174044 2.60 ENSDART00000156028
si:ch211-248a14.8
si:ch211-248a14.8
chr20_-_40754794 2.55 ENSDART00000187251
cx32.3
connexin 32.3
chr16_+_23921777 2.55 ENSDART00000163213
apoa4b.3
apolipoprotein A-IV b, tandem duplicate 3
chr2_-_37956768 2.54 ENSDART00000034595
cbln10
cerebellin 10
chr16_+_23921610 2.53 ENSDART00000143855
apoa4b.3
apolipoprotein A-IV b, tandem duplicate 3
chr19_+_9277327 2.51 ENSDART00000104623
ENSDART00000151164
si:rp71-15k1.1
si:rp71-15k1.1
chr12_-_6172154 2.48 ENSDART00000185434
a1cf
apobec1 complementation factor
chr17_-_30702411 2.45 ENSDART00000114358
zgc:194392
zgc:194392
chr9_-_9982696 2.39 ENSDART00000192548
ENSDART00000125852
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr17_-_2573021 2.26 ENSDART00000074181
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr18_+_17611627 2.25 ENSDART00000046891
cetp
cholesteryl ester transfer protein, plasma
chr20_-_43741159 2.22 ENSDART00000192621
si:dkeyp-50f7.2
si:dkeyp-50f7.2
chr17_-_2578026 2.20 ENSDART00000065821
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr17_-_2595736 2.12 ENSDART00000128797
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr3_-_3496738 2.02 ENSDART00000186849
CABZ01040998.1

chr17_+_20173882 2.00 ENSDART00000155379
si:ch211-248a14.8
si:ch211-248a14.8
chr8_+_30699429 1.97 ENSDART00000005345
upb1
ureidopropionase, beta
chr6_+_27624023 1.96 ENSDART00000147789
slco2a1
solute carrier organic anion transporter family, member 2A1
chr17_-_2590222 1.93 ENSDART00000185711
CR759892.1

chr20_+_2281933 1.89 ENSDART00000137579
si:ch73-18b11.2
si:ch73-18b11.2
chr3_+_12744083 1.81 ENSDART00000158554
ENSDART00000169545
cyp2k21
cytochrome P450, family 2, subfamily k, polypeptide 21
chr19_-_27564458 1.80 ENSDART00000123155
si:dkeyp-46h3.6
si:dkeyp-46h3.6
chr1_+_24387659 1.80 ENSDART00000130356
qdprb2
quinoid dihydropteridine reductase b2
chr18_-_43866001 1.73 ENSDART00000150218
treh
trehalase (brush-border membrane glycoprotein)
chr2_-_37967368 1.72 ENSDART00000050345
cbln9
cerebellin 9
chr2_+_3533458 1.69 ENSDART00000133007
gpt2l
glutamic pyruvate transaminase (alanine aminotransferase) 2, like
chr18_+_40462445 1.69 ENSDART00000087645
ugt5c2
UDP glucuronosyltransferase 5 family, polypeptide C2
chr19_+_31532043 1.68 ENSDART00000136289
tmem64
transmembrane protein 64
chr16_-_17197546 1.63 ENSDART00000139939
ENSDART00000135146
ENSDART00000063800
ENSDART00000163606
gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr16_-_17200120 1.61 ENSDART00000147739
gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr13_-_40726865 1.60 ENSDART00000099847
st3gal7
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr23_-_27702561 1.60 ENSDART00000053876
dnajc22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr5_-_3839285 1.54 ENSDART00000122292
mlxipl
MLX interacting protein like
chr7_-_24520866 1.52 ENSDART00000077039
faah2b
fatty acid amide hydrolase 2b
chr9_+_8380728 1.52 ENSDART00000133501
si:ch1073-75o15.4
si:ch1073-75o15.4
chr5_-_62317496 1.51 ENSDART00000180089
zgc:85789
zgc:85789
chr16_-_25607266 1.46 ENSDART00000192602
zgc:110410
zgc:110410
chr18_-_43866526 1.46 ENSDART00000111309
treh
trehalase (brush-border membrane glycoprotein)
chr2_+_3533117 1.36 ENSDART00000132572
gpt2l
glutamic pyruvate transaminase (alanine aminotransferase) 2, like
chr7_+_52135791 1.36 ENSDART00000098705
cyp2x12
cytochrome P450, family 2, subfamily X, polypeptide 12
chr4_-_19693978 1.34 ENSDART00000100974
ENSDART00000040405
snd1
staphylococcal nuclease and tudor domain containing 1
chr17_+_450956 1.32 ENSDART00000183022
ENSDART00000171386
zgc:194887
zgc:194887
chr15_+_26603395 1.31 ENSDART00000188667
slc47a3
solute carrier family 47 (multidrug and toxin extrusion), member 3
chr17_-_14613711 1.31 ENSDART00000157345
sdsl
serine dehydratase-like
chr2_-_24407933 1.29 ENSDART00000088584
si:dkey-208k22.6
si:dkey-208k22.6
chr15_-_1885247 1.28 ENSDART00000149703
porb
P450 (cytochrome) oxidoreductase b
chr5_-_69940868 1.25 ENSDART00000185924
ENSDART00000097357
ugt2a4
UDP glucuronosyltransferase 2 family, polypeptide A4
chr5_-_44843738 1.23 ENSDART00000003926
fbp1a
fructose-1,6-bisphosphatase 1a
chr25_+_418932 1.22 ENSDART00000059193
prtgb
protogenin homolog b (Gallus gallus)
chr8_+_6576940 1.19 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr14_+_6429399 1.12 ENSDART00000149783
ENSDART00000148461
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr19_-_27564980 1.12 ENSDART00000171967
si:dkeyp-46h3.8
si:dkeyp-46h3.8
chr11_-_24347644 1.12 ENSDART00000089777
si:ch211-15p9.2
si:ch211-15p9.2
chr8_-_33154677 1.09 ENSDART00000133300
zbtb34
zinc finger and BTB domain containing 34
chr5_-_3885727 1.08 ENSDART00000143250
mlxipl
MLX interacting protein like
chr24_-_26369185 1.07 ENSDART00000080039
lrrc31
leucine rich repeat containing 31
chr25_-_12803723 1.06 ENSDART00000158787
ca5a
carbonic anhydrase Va
chr4_-_16451375 1.02 ENSDART00000192700
ENSDART00000128835
wu:fc23c09
wu:fc23c09
chr19_-_18130567 0.99 ENSDART00000190659
ENSDART00000022803
snx10a
sorting nexin 10a
chr22_-_7050 0.97 ENSDART00000127829
atad3
ATPase family, AAA domain containing 3
chr17_-_49407091 0.96 ENSDART00000021950
mthfd1b
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr8_-_8698607 0.95 ENSDART00000046712
zgc:86609
zgc:86609
chr12_-_34580988 0.94 ENSDART00000152926
bahcc1b
BAH domain and coiled-coil containing 1b
chr23_+_2740741 0.94 ENSDART00000134938
zgc:114123
zgc:114123
chr25_-_26758253 0.91 ENSDART00000123004
si:dkeyp-73b11.8
si:dkeyp-73b11.8
chr12_-_44199316 0.90 ENSDART00000170378
si:ch73-329n5.1
si:ch73-329n5.1
chr18_-_46183462 0.89 ENSDART00000021192
kcnk6
potassium channel, subfamily K, member 6
chr15_+_19797918 0.89 ENSDART00000113314
si:ch211-229d2.5
si:ch211-229d2.5
chr2_-_22927581 0.85 ENSDART00000109515
myo7bb
myosin VIIBb
chr16_+_16969060 0.84 ENSDART00000182819
ENSDART00000191876
si:ch211-120k19.1
rpl18
si:ch211-120k19.1
ribosomal protein L18
chr25_-_20049449 0.83 ENSDART00000104315
zgc:136858
zgc:136858
chr2_+_24536762 0.83 ENSDART00000144149
angptl4
angiopoietin-like 4
chr17_+_1360192 0.82 ENSDART00000184561
siva1
SIVA1, apoptosis-inducing factor
chr1_-_37383741 0.82 ENSDART00000193155
ENSDART00000191887
ENSDART00000189077
scpp1
secretory calcium-binding phosphoprotein 1
chr21_-_37194669 0.81 ENSDART00000192748
fgfr4
fibroblast growth factor receptor 4
chr16_+_16968682 0.81 ENSDART00000111074
si:ch211-120k19.1
si:ch211-120k19.1
chr1_-_9641845 0.79 ENSDART00000121490
ENSDART00000159411
ugt5b2
ugt5b3
UDP glucuronosyltransferase 5 family, polypeptide B2
UDP glucuronosyltransferase 5 family, polypeptide B3
chr16_+_32029090 0.79 ENSDART00000041054
tmc4
transmembrane channel-like 4
chr11_+_14281100 0.79 ENSDART00000193664
ENSDART00000161597
si:ch211-262i1.3
si:ch211-262i1.3
chr22_+_24645325 0.77 ENSDART00000159531
lpar3
lysophosphatidic acid receptor 3
chr12_-_31457301 0.77 ENSDART00000043887
ENSDART00000148603
acsl5
acyl-CoA synthetase long chain family member 5
chr8_-_65189 0.76 ENSDART00000168412
hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
chr24_-_36727922 0.76 ENSDART00000135142
si:ch73-334d15.1
si:ch73-334d15.1
chr13_-_22843562 0.75 ENSDART00000142738
pbld
phenazine biosynthesis like protein domain containing
chr25_-_8625601 0.75 ENSDART00000155280
GDPGP1
zgc:153343
chr10_-_39055620 0.75 ENSDART00000187437
igsf5a
immunoglobulin superfamily, member 5a
chr15_-_24178893 0.75 ENSDART00000077980
pipox
pipecolic acid oxidase
chr13_-_303137 0.75 ENSDART00000099131
chs1
chitin synthase 1
chr16_-_25606889 0.74 ENSDART00000077447
ENSDART00000131528
zgc:110410
zgc:110410
chr2_-_24407732 0.74 ENSDART00000180612
ENSDART00000153688
ENSDART00000179913
si:dkey-208k22.6
si:dkey-208k22.6
chr2_-_22927958 0.73 ENSDART00000141621
myo7bb
myosin VIIBb
chr12_-_5120175 0.72 ENSDART00000160729
rbp4
retinol binding protein 4, plasma
chr16_+_54875530 0.71 ENSDART00000149795
nr0b2a
nuclear receptor subfamily 0, group B, member 2a
chr12_-_5120339 0.70 ENSDART00000168759
rbp4
retinol binding protein 4, plasma
chr2_-_5728843 0.70 ENSDART00000014020
sst2
somatostatin 2
chr10_-_11385155 0.68 ENSDART00000064214
plac8.1
placenta-specific 8, tandem duplicate 1
chr3_-_50139860 0.68 ENSDART00000101563
btr02
bloodthirsty-related gene family, member 2
chr14_+_6182346 0.67 ENSDART00000075525
si:ch73-22a13.3
si:ch73-22a13.3
chr13_+_50375800 0.67 ENSDART00000099537
cox5b2
cytochrome c oxidase subunit Vb 2
chr23_-_43595956 0.67 ENSDART00000162186
itchb
itchy E3 ubiquitin protein ligase b
chr6_-_2627488 0.66 ENSDART00000044089
ENSDART00000158333
ENSDART00000155109
hyi
hydroxypyruvate isomerase
chr22_+_21549419 0.65 ENSDART00000139411
plpp2b
phospholipid phosphatase 2b
chr8_+_47099033 0.65 ENSDART00000142979
arhgef16
Rho guanine nucleotide exchange factor (GEF) 16
chr17_+_15216022 0.64 ENSDART00000138831
gnpnat1
glucosamine-phosphate N-acetyltransferase 1
chr6_-_46474483 0.62 ENSDART00000155761
rdh20
retinol dehydrogenase 20
chr13_+_8696825 0.62 ENSDART00000109059
ttc7a
tetratricopeptide repeat domain 7A
chr5_+_31959954 0.62 ENSDART00000142826
myo1hb
myosin IHb
chr21_-_37194365 0.62 ENSDART00000100286
fgfr4
fibroblast growth factor receptor 4
chr15_+_6459847 0.61 ENSDART00000157250
ENSDART00000065824
bace2
beta-site APP-cleaving enzyme 2
chr13_+_18520738 0.59 ENSDART00000113952
tlr4al
toll-like receptor 4a, like
chr15_+_34069746 0.59 ENSDART00000163513
arl4aa
ADP-ribosylation factor-like 4aa
chr12_-_44307963 0.58 ENSDART00000161009
si:ch73-329n5.1
si:ch73-329n5.1
chr9_-_38036984 0.58 ENSDART00000134574
hacd2
3-hydroxyacyl-CoA dehydratase 2
chr23_+_9522942 0.58 ENSDART00000137751
osbpl2b
oxysterol binding protein-like 2b
chr8_-_37263524 0.57 ENSDART00000061327
rh50
Rh50-like protein
chr15_+_21882419 0.57 ENSDART00000157216
si:dkey-103g5.4
si:dkey-103g5.4
chr21_+_25236297 0.57 ENSDART00000112783
tmem45b
transmembrane protein 45B
chr14_+_9009600 0.56 ENSDART00000133904
si:ch211-274f20.2
si:ch211-274f20.2
chr6_+_30091811 0.55 ENSDART00000088403
meltf
melanotransferrin
chr22_-_11648094 0.54 ENSDART00000191791
dpp4
dipeptidyl-peptidase 4
chr23_-_24488696 0.53 ENSDART00000155593
tmem82
transmembrane protein 82
chr20_-_26936887 0.53 ENSDART00000160827
ftr79
finTRIM family, member 79
chr24_-_33703504 0.52 ENSDART00000079292
cavin4b
caveolae associated protein 4b
chr22_+_15323930 0.51 ENSDART00000142416
si:dkey-236e20.3
si:dkey-236e20.3
chr5_-_24112175 0.50 ENSDART00000131595
si:ch211-114c12.5
si:ch211-114c12.5
chr12_-_44070043 0.50 ENSDART00000180059
si:ch73-329n5.3
si:ch73-329n5.3
chr1_-_12064715 0.50 ENSDART00000143628
ENSDART00000103406
pla2g12a
phospholipase A2, group XIIA
chr4_+_35590588 0.49 ENSDART00000183582
si:dkeyp-4c4.2
si:dkeyp-4c4.2
chr3_-_50443607 0.49 ENSDART00000074036
rcvrna
recoverin a
chr22_-_24992532 0.49 ENSDART00000102751
si:dkey-179j5.5
si:dkey-179j5.5
chr6_+_28051978 0.49 ENSDART00000143218
si:ch73-194h10.2
si:ch73-194h10.2
chr22_+_15331214 0.49 ENSDART00000136566
sult3st4
sulfotransferase family 3, cytosolic sulfotransferase 4
chr12_-_20362041 0.48 ENSDART00000184145
ENSDART00000105952
aqp8a.2
aquaporin 8a, tandem duplicate 2
chr19_-_25005609 0.48 ENSDART00000151129
xkr8.2
XK, Kell blood group complex subunit-related family, member 8, tandem duplicate 2
chr4_-_64605318 0.47 ENSDART00000170391
znf1099
zinc finger protein 1099
chr12_-_44122412 0.47 ENSDART00000169094
si:ch73-329n5.3
si:ch73-329n5.3
chr5_-_55981288 0.47 ENSDART00000146616
si:dkey-189h5.6
si:dkey-189h5.6
chr13_-_37254777 0.47 ENSDART00000139734
syne2b
spectrin repeat containing, nuclear envelope 2b
chr23_-_21758253 0.46 ENSDART00000046613
vps13d
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr3_+_31662126 0.46 ENSDART00000113441
mylk5
myosin, light chain kinase 5
chr6_-_49873020 0.45 ENSDART00000148511
gnas
GNAS complex locus
chr18_+_26829086 0.45 ENSDART00000098356
slc28a1
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr2_-_38261272 0.45 ENSDART00000143743
si:ch211-14a17.10
si:ch211-14a17.10
chr3_-_10312232 0.44 ENSDART00000081766
nog1
noggin 1
chr15_-_30989360 0.43 ENSDART00000155265
lgals9l6
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 6
chr20_-_26937453 0.43 ENSDART00000139756
ftr97
finTRIM family, member 97
chr11_+_30296332 0.43 ENSDART00000192843
ugt1b7
UDP glucuronosyltransferase 1 family, polypeptide B7
chr14_+_33329761 0.43 ENSDART00000161138
sowahd
sosondowah ankyrin repeat domain family d
chr14_+_30413312 0.42 ENSDART00000186864
cnot7
CCR4-NOT transcription complex, subunit 7
chr24_-_32150276 0.42 ENSDART00000166212
cubn
cubilin (intrinsic factor-cobalamin receptor)
chr4_+_1283068 0.41 ENSDART00000167233
chrm2a
cholinergic receptor, muscarinic 2a
chr14_+_33329420 0.41 ENSDART00000171090
ENSDART00000164062
sowahd
sosondowah ankyrin repeat domain family d
chr5_-_30984010 0.40 ENSDART00000182367
spns3
spinster homolog 3 (Drosophila)
chr1_-_37383539 0.40 ENSDART00000127579
scpp1
secretory calcium-binding phosphoprotein 1
chr2_-_42958113 0.40 ENSDART00000139945
oc90
otoconin 90
chr6_+_55819038 0.39 ENSDART00000108786
si:ch211-81n22.1
si:ch211-81n22.1
chr18_-_27858123 0.39 ENSDART00000142068
iqcg
IQ motif containing G
chr15_-_30857350 0.39 ENSDART00000138988
akap1b
A kinase (PRKA) anchor protein 1b
chr18_+_26829362 0.38 ENSDART00000132728
slc28a1
solute carrier family 28 (concentrative nucleoside transporter), member 1
chr10_+_8197827 0.38 ENSDART00000026244
mtrex
Mtr4 exosome RNA helicase
chr22_-_16400484 0.38 ENSDART00000135987
lama3
laminin, alpha 3
chr4_+_38981587 0.38 ENSDART00000142713
si:dkey-66k12.3
si:dkey-66k12.3
chr2_-_42958619 0.38 ENSDART00000144317
oc90
otoconin 90
chr6_+_18298444 0.37 ENSDART00000166018
card14
caspase recruitment domain family, member 14
chr1_-_52292235 0.37 ENSDART00000132638
si:dkey-121b10.7
si:dkey-121b10.7
chr9_-_1986014 0.37 ENSDART00000142842
hoxd12a
homeobox D12a
chr3_-_58116314 0.37 ENSDART00000154901
si:ch211-256e16.6
si:ch211-256e16.6
chr20_+_5106568 0.36 ENSDART00000028039
cyp46a1.1
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 1
chr20_-_46128590 0.36 ENSDART00000123744
taar1b
trace amine associated receptor 1b
chr5_-_20205075 0.35 ENSDART00000051611
dao.3
D-amino-acid oxidase, tandem duplicate 3
chr18_-_7400075 0.35 ENSDART00000101250
si:dkey-30c15.13
si:dkey-30c15.13

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf4a+hnf4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0010430 fatty acid omega-oxidation(GO:0010430)
1.1 3.2 GO:0005991 trehalose metabolic process(GO:0005991)
0.8 2.3 GO:0034375 high-density lipoprotein particle remodeling(GO:0034375)
0.6 10.2 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.5 5.4 GO:1990402 embryonic liver development(GO:1990402)
0.5 1.4 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.4 1.2 GO:0005984 disaccharide metabolic process(GO:0005984)
0.4 2.0 GO:0019483 beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483)
0.4 3.1 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 1.3 GO:0009097 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.3 1.1 GO:1904182 regulation of pyruvate dehydrogenase activity(GO:1904182) positive regulation of pyruvate dehydrogenase activity(GO:1904184)
0.3 0.8 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.3 0.8 GO:0010747 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.2 0.4 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 1.4 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.2 3.2 GO:1901571 icosanoid transport(GO:0071715) fatty acid derivative transport(GO:1901571)
0.2 1.0 GO:0070986 left/right axis specification(GO:0070986)
0.2 0.8 GO:0046440 lysine catabolic process(GO:0006554) L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.2 1.8 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.2 2.5 GO:0016556 mRNA modification(GO:0016556)
0.2 14.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.2 0.8 GO:0006031 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.1 2.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 3.9 GO:0032355 response to estradiol(GO:0032355)
0.1 0.8 GO:0070328 acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.1 0.9 GO:0033206 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.1 1.1 GO:0033700 phospholipid efflux(GO:0033700)
0.1 2.7 GO:0030073 insulin secretion(GO:0030073)
0.1 3.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.7 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.1 3.2 GO:0050821 protein stabilization(GO:0050821)
0.1 0.5 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 0.4 GO:0046144 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.1 3.8 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.1 0.4 GO:0035739 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.1 0.2 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.6 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.2 GO:1903173 fatty alcohol metabolic process(GO:1903173)
0.1 0.5 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 0.5 GO:0033292 T-tubule organization(GO:0033292)
0.1 0.2 GO:0015882 L-ascorbic acid transport(GO:0015882)
0.1 0.2 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.1 1.0 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.4 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 0.8 GO:0015858 nucleoside transport(GO:0015858) nucleoside transmembrane transport(GO:1901642)
0.1 0.3 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 0.6 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.1 0.4 GO:0006707 steroid catabolic process(GO:0006706) cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.7 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 7.7 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 0.5 GO:0036368 cone photoresponse recovery(GO:0036368)
0.0 0.5 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 3.0 GO:0007596 blood coagulation(GO:0007596)
0.0 0.2 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.4 GO:0042664 negative regulation of endodermal cell fate specification(GO:0042664)
0.0 0.3 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.7 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 3.0 GO:0072376 complement activation(GO:0006956) protein activation cascade(GO:0072376)
0.0 0.7 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 5.0 GO:0055123 digestive system development(GO:0055123)
0.0 0.2 GO:0032475 otolith formation(GO:0032475)
0.0 0.6 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 1.4 GO:0042737 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.5 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 1.1 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.6 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.1 GO:0070376 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.0 1.6 GO:0031047 gene silencing by RNA(GO:0031047)
0.0 0.5 GO:0006826 iron ion transport(GO:0006826)
0.0 0.2 GO:0090279 regulation of calcium ion import(GO:0090279)
0.0 0.3 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.8 GO:0097191 extrinsic apoptotic signaling pathway(GO:0097191)
0.0 1.1 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.4 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 2.3 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0061689 tricellular tight junction(GO:0061689)
0.2 1.3 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.2 2.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 0.3 GO:0034457 Mpp10 complex(GO:0034457)
0.1 0.8 GO:0030428 cell septum(GO:0030428)
0.1 0.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.9 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.2 GO:0005913 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.0 46.7 GO:0005615 extracellular space(GO:0005615)
0.0 0.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 15.1 GO:0005576 extracellular region(GO:0005576)
0.0 2.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.4 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.5 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.6 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.9 10.2 GO:0035804 structural constituent of egg coat(GO:0035804)
0.8 3.2 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.8 3.1 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.6 3.9 GO:0045735 nutrient reservoir activity(GO:0045735)
0.5 1.6 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.4 1.8 GO:0070404 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.4 1.2 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.4 3.1 GO:0016803 ether hydrolase activity(GO:0016803)
0.4 2.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 1.3 GO:0016841 ammonia-lyase activity(GO:0016841)
0.3 1.3 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.3 1.1 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.2 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.2 1.4 GO:0034632 retinol transporter activity(GO:0034632)
0.2 3.0 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.6 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.6 GO:0102344 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 1.0 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.8 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.1 0.8 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 6.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 12.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 2.3 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.1 0.8 GO:0004100 chitin synthase activity(GO:0004100)
0.1 0.5 GO:0050780 mu-type opioid receptor binding(GO:0031852) dopamine receptor binding(GO:0050780) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.4 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.1 0.3 GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity(GO:0043878)
0.1 2.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 3.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 0.2 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.8 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.7 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.1 0.4 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.1 0.4 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.1 0.2 GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity(GO:0047453) ADP-dependent NAD(P)H-hydrate dehydratase activity(GO:0052855)
0.1 0.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 1.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 0.8 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.0 3.2 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 3.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.2 GO:0008887 glycerate kinase activity(GO:0008887)
0.0 0.3 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.3 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048) cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 3.8 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.6 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.8 GO:0015248 sterol transporter activity(GO:0015248)
0.0 2.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.7 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 5.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.8 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 1.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 5.6 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.1 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.0 0.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.8 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0030515 snoRNA binding(GO:0030515)
0.0 1.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 7.3 GO:0008289 lipid binding(GO:0008289)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.2 PID FGF PATHWAY FGF signaling pathway
0.0 0.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 3.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 1.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.1 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.4 3.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 6.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 2.0 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.2 2.0 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.2 2.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 1.4 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 2.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 0.9 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 0.5 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.1 0.8 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 0.8 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 3.2 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 1.5 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA