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PRJNA207719: Tissue specific transcriptome profiling

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Results for hoxa1a+hoxb1b-1+hoxc1a

Z-value: 1.88

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Transcription factors associated with hoxa1a+hoxb1b-1+hoxc1a

Gene Symbol Gene ID Gene Info
hoxb1b-1
ENSDARG00000054033 homeobox B1b
hoxc1a
ENSDARG00000070337 homeobox C1a
hoxa1a
ENSDARG00000104307 homeobox A1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxc1adr11_v1_chr23_+_36178104_361781040.771.3e-01Click!
hoxa1adr11_v1_chr19_+_19786117_197862130.721.7e-01Click!
hoxb1bdr11_v1_chr12_+_27141140_271411400.335.9e-01Click!

Activity profile of hoxa1a+hoxb1b-1+hoxc1a motif

Sorted Z-values of hoxa1a+hoxb1b-1+hoxc1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_51370293 2.41 ENSDART00000084806
slc4a10b
solute carrier family 4, sodium bicarbonate transporter, member 10b
chr25_+_7461624 1.92 ENSDART00000170569
syt12
synaptotagmin XII
chr12_-_25916530 1.89 ENSDART00000186386
sncgb
synuclein, gamma b (breast cancer-specific protein 1)
chr10_+_466926 1.74 ENSDART00000145220
arvcfa
ARVCF, delta catenin family member a
chr22_-_600016 1.51 ENSDART00000086434
tmcc2
transmembrane and coiled-coil domain family 2
chr11_-_1131569 1.51 ENSDART00000173228
slc6a11b
solute carrier family 6 (neurotransmitter transporter), member 11b
chr20_-_9462433 1.46 ENSDART00000152674
ENSDART00000040557
zgc:101840
zgc:101840
chr7_-_72067475 1.44 ENSDART00000017763
LO018380.1

chr14_-_7888748 1.41 ENSDART00000166293
ppp3cb
protein phosphatase 3, catalytic subunit, beta isozyme
chr23_-_12015139 1.21 ENSDART00000110627
ENSDART00000193988
ENSDART00000184528
si:dkey-178k16.1
si:dkey-178k16.1
chr4_+_4816695 1.20 ENSDART00000136962
slc13a4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr23_-_11870962 1.19 ENSDART00000143481
si:dkey-178k16.1
si:dkey-178k16.1
chr4_+_21129752 1.17 ENSDART00000169764
syt1a
synaptotagmin Ia
chr22_+_635813 1.13 ENSDART00000179067
CU856139.1

chr6_-_29105727 1.11 ENSDART00000184355
fam69ab
family with sequence similarity 69, member Ab
chr23_-_12014931 1.10 ENSDART00000134652
si:dkey-178k16.1
si:dkey-178k16.1
chr15_-_16704417 1.08 ENSDART00000155163
caln1
calneuron 1
chr18_+_24919614 1.06 ENSDART00000008638
rgma
repulsive guidance molecule family member a
chr5_-_55600689 1.06 ENSDART00000013229
gnaq
guanine nucleotide binding protein (G protein), q polypeptide
chr17_+_8183393 1.03 ENSDART00000155957
tulp4b
tubby like protein 4b
chr23_+_21067684 1.01 ENSDART00000132066
kcnab2b
potassium voltage-gated channel, shaker-related subfamily, beta member 2 b
chr10_-_26766780 0.98 ENSDART00000146666
mcf2b
MCF.2 cell line derived transforming sequence b
chr21_-_43079161 0.98 ENSDART00000144151
jakmip2
janus kinase and microtubule interacting protein 2
chr16_-_13730152 0.97 ENSDART00000138772
ttyh1
tweety family member 1
chr8_-_22698651 0.96 ENSDART00000181411
iqsec2a
IQ motif and Sec7 domain 2a
chr13_+_35745572 0.94 ENSDART00000159690
gpr75
G protein-coupled receptor 75
chr19_-_45985989 0.92 ENSDART00000165897
si:ch211-153f2.3
si:ch211-153f2.3
chr14_+_19258702 0.90 ENSDART00000187087
ENSDART00000005738
slitrk2
SLIT and NTRK-like family, member 2
chr3_+_29714775 0.88 ENSDART00000041388
cacng2a
calcium channel, voltage-dependent, gamma subunit 2a
chr6_-_55585423 0.88 ENSDART00000157129
slc12a5a
solute carrier family 12 (potassium/chloride transporter), member 5a
chr16_-_31188715 0.86 ENSDART00000058829
scrt1b
scratch family zinc finger 1b
chr18_-_23875370 0.84 ENSDART00000130163
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr19_-_43226124 0.83 ENSDART00000168965
gnrhr1
gonadotropin releasing hormone receptor 1
chr9_+_11202552 0.83 ENSDART00000151931
asic4a
acid-sensing (proton-gated) ion channel family member 4a
chr9_+_34425736 0.81 ENSDART00000135147
si:ch211-218d20.15
si:ch211-218d20.15
chr3_+_46628885 0.79 ENSDART00000006602
pde4a
phosphodiesterase 4A, cAMP-specific
chr2_+_45354747 0.79 ENSDART00000083957
ENSDART00000135582
ENSDART00000160867
camsap2b
calmodulin regulated spectrin-associated protein family, member 2b
chr18_-_23874929 0.79 ENSDART00000134910
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr11_+_30817943 0.78 ENSDART00000150130
ENSDART00000159997
cacna1ab
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
chr5_+_65492183 0.77 ENSDART00000162804
si:dkey-21e5.1
si:dkey-21e5.1
chr6_+_23752593 0.76 ENSDART00000164366
zgc:158654
zgc:158654
chr20_+_26349002 0.75 ENSDART00000152842
syne1a
spectrin repeat containing, nuclear envelope 1a
chr13_-_39736938 0.75 ENSDART00000141645
zgc:171482
zgc:171482
chr16_+_46111849 0.75 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr11_-_1509773 0.74 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr23_-_333457 0.74 ENSDART00000114486
uhrf1bp1
UHRF1 binding protein 1
chr12_+_41510492 0.74 ENSDART00000170976
ENSDART00000176164
kif5bb
kinesin family member 5B, b
chr10_-_2527342 0.73 ENSDART00000184168
CU856539.1

chr18_-_23875219 0.72 ENSDART00000059976
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr17_-_6399920 0.72 ENSDART00000022010
hivep2b
human immunodeficiency virus type I enhancer binding protein 2b
chr1_+_10221568 0.68 ENSDART00000152424
npy2rl
neuropeptide Y receptor Y2, like
chr5_-_52277643 0.67 ENSDART00000010757
rgmb
repulsive guidance molecule family member b
chr16_-_13004166 0.67 ENSDART00000133735
cacng7b
calcium channel, voltage-dependent, gamma subunit 7b
chr14_+_2478994 0.67 ENSDART00000170538
CU929317.1

chr1_+_20069535 0.66 ENSDART00000088653
prss12
protease, serine, 12 (neurotrypsin, motopsin)
chr17_-_7436766 0.66 ENSDART00000162002
grm1b
glutamate receptor, metabotropic 1b
chr6_-_13401133 0.65 ENSDART00000151206
fmnl2b
formin-like 2b
chr15_+_42933236 0.65 ENSDART00000167763
slc8a2b
solute carrier family 8 (sodium/calcium exchanger), member 2b
chr6_-_31576397 0.63 ENSDART00000111837
raver2
ribonucleoprotein, PTB-binding 2
chr25_-_24074500 0.63 ENSDART00000040410
th
tyrosine hydroxylase
chr17_-_26604549 0.63 ENSDART00000174773
fam149b1
family with sequence similarity 149, member B1
chr9_-_23217196 0.63 ENSDART00000083567
kif5c
kinesin family member 5C
chr20_-_35841570 0.62 ENSDART00000037855
tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr17_-_26604946 0.61 ENSDART00000087062
fam149b1
family with sequence similarity 149, member B1
chr25_-_29987839 0.61 ENSDART00000154088
fam19a5b
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5b
chr12_+_38770654 0.59 ENSDART00000155367
kif19
kinesin family member 19
chr6_-_16561536 0.59 ENSDART00000167295
unc80
unc-80 homolog (C. elegans)
chr24_+_26039464 0.58 ENSDART00000131017
tnk2a
tyrosine kinase, non-receptor, 2a
chr4_+_11384891 0.58 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr20_-_47550577 0.57 ENSDART00000187361
CABZ01053323.1

chr2_+_42872661 0.56 ENSDART00000036979
efr3a
EFR3 homolog A (S. cerevisiae)
chr13_-_36184476 0.56 ENSDART00000057185
map3k9
mitogen-activated protein kinase kinase kinase 9
chr4_+_74226447 0.55 ENSDART00000174336
ENSDART00000191455
ENSDART00000180062
ptprr
protein tyrosine phosphatase, receptor type, r
chr22_-_34937455 0.55 ENSDART00000169217
ENSDART00000188330
ENSDART00000165142
slit1b
slit homolog 1b (Drosophila)
chr9_+_32073606 0.55 ENSDART00000184170
ENSDART00000180355
ENSDART00000110204
ENSDART00000123278
pikfyve
phosphoinositide kinase, FYVE finger containing
chr12_+_39685485 0.54 ENSDART00000163403
LO017650.1

chr17_-_20394566 0.53 ENSDART00000154667
sorcs3b
sortilin related VPS10 domain containing receptor 3b
chr5_-_22544151 0.53 ENSDART00000006474
glra4b
glycine receptor, alpha 4b
chr5_-_31689796 0.53 ENSDART00000184319
ENSDART00000190229
ENSDART00000186294
ENSDART00000170313
ENSDART00000147065
ENSDART00000134427
ENSDART00000098172
sh3glb2b
SH3-domain GRB2-like endophilin B2b
chr17_+_40684 0.53 ENSDART00000164231
CABZ01111555.1

chr8_-_51930826 0.52 ENSDART00000109785
cabin1
calcineurin binding protein 1
chr17_-_45009782 0.52 ENSDART00000123971
fam161b
family with sequence similarity 161, member B
chr5_+_61301525 0.52 ENSDART00000128773
doc2b
double C2-like domains, beta
chr19_+_4463389 0.51 ENSDART00000168805
kcnk9
potassium channel, subfamily K, member 9
chr12_-_33582382 0.51 ENSDART00000009794
ENSDART00000136617
tdrkh
tudor and KH domain containing
chr21_+_43561650 0.50 ENSDART00000085071
gpr185a
G protein-coupled receptor 185 a
chr20_-_32446406 0.47 ENSDART00000026635
nr2e1
nuclear receptor subfamily 2, group E, member 1
chr3_+_15805917 0.47 ENSDART00000055834
phospho1
phosphatase, orphan 1
chr25_+_2668892 0.45 ENSDART00000122929
bbs4
Bardet-Biedl syndrome 4
chr18_+_24922125 0.45 ENSDART00000180385
rgma
repulsive guidance molecule family member a
chr11_-_21528056 0.45 ENSDART00000181626
srgap2
SLIT-ROBO Rho GTPase activating protein 2
chr10_+_39692241 0.44 ENSDART00000113414
kirrel3a
kirre like nephrin family adhesion molecule 3a
chr16_+_14707960 0.44 ENSDART00000137912
col14a1a
collagen, type XIV, alpha 1a
chr10_-_31175744 0.43 ENSDART00000191728
pknox2
pbx/knotted 1 homeobox 2
chr17_+_51764310 0.42 ENSDART00000157171
si:ch211-168d23.3
si:ch211-168d23.3
chr17_+_19626479 0.42 ENSDART00000044993
ENSDART00000131863
rgs7a
regulator of G protein signaling 7a
chr16_+_19033554 0.42 ENSDART00000182430
rapgef5b
Rap guanine nucleotide exchange factor (GEF) 5b
chr25_+_336503 0.41 ENSDART00000160395
CU929262.1

chr7_+_13464878 0.41 ENSDART00000172969
dagla
diacylglycerol lipase, alpha
chr11_+_33628104 0.41 ENSDART00000165318
thsd7bb
thrombospondin, type I, domain containing 7Bb
chr3_-_55650771 0.40 ENSDART00000162413
axin2
axin 2 (conductin, axil)
chr4_-_9191220 0.40 ENSDART00000156919
hcfc2
host cell factor C2
chr7_+_31074636 0.40 ENSDART00000173805
tjp1a
tight junction protein 1a
chr3_+_37824268 0.39 ENSDART00000137038
asic2
acid-sensing (proton-gated) ion channel 2
chr8_-_44015210 0.36 ENSDART00000186879
ENSDART00000188965
ENSDART00000001313
ENSDART00000188902
ENSDART00000185935
ENSDART00000147869
rimbp2
rimbp2
RIMS binding protein 2
RIMS binding protein 2
chr8_-_40464935 0.36 ENSDART00000040013
myl7
myosin, light chain 7, regulatory
chr14_+_34547554 0.35 ENSDART00000074819
gabrp
gamma-aminobutyric acid (GABA) A receptor, pi
chr24_+_27548474 0.35 ENSDART00000105774
ENSDART00000123368
ek1
eph-like kinase 1
chr8_+_6410933 0.34 ENSDART00000168789
lrrtm4l2
leucine rich repeat transmembrane neuronal 4 like 2
chr6_+_2174082 0.34 ENSDART00000073936
acvr1bb
activin A receptor type 1Bb
chr9_-_48296469 0.34 ENSDART00000058255
bbs5
Bardet-Biedl syndrome 5
chr21_+_30194904 0.34 ENSDART00000137023
ENSDART00000078403
BRD8
si:ch211-59d17.3
chr5_+_31959954 0.34 ENSDART00000142826
myo1hb
myosin IHb
chr14_+_24215046 0.34 ENSDART00000079215
stc2a
stanniocalcin 2a
chr7_+_7151832 0.32 ENSDART00000109485
gal3st3
galactose-3-O-sulfotransferase 3
chr3_-_55650417 0.32 ENSDART00000171441
axin2
axin 2 (conductin, axil)
chr2_-_45630823 0.32 ENSDART00000183553
CR450720.1

chr3_-_214709 0.31 ENSDART00000098311
CABZ01079818.1

chr10_-_27741793 0.31 ENSDART00000129369
ENSDART00000192440
ENSDART00000189808
ENSDART00000138149
auts2a
si:dkey-33o22.1
autism susceptibility candidate 2a
si:dkey-33o22.1
chr5_-_16791223 0.30 ENSDART00000192744
atad1a
ATPase family, AAA domain containing 1a
chr20_+_29587995 0.30 ENSDART00000153339
adam17b
ADAM metallopeptidase domain 17b
chr24_+_30521619 0.29 ENSDART00000162903
dpyda.3
dihydropyrimidine dehydrogenase a, tandem duplicate 3
chr7_+_16835218 0.28 ENSDART00000173580
nav2a
neuron navigator 2a
chr17_-_53282539 0.28 ENSDART00000164953
FO704905.1

chr15_-_25099679 0.28 ENSDART00000154628
rflnb
refilin B
chr3_-_6417328 0.28 ENSDART00000160979
jpt1b
Jupiter microtubule associated homolog 1b
chr2_-_31754292 0.28 ENSDART00000192498
ralyl
RALY RNA binding protein like
chr17_+_31914877 0.28 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr25_-_36827491 0.27 ENSDART00000170941
CU929365.1

chr17_+_45009868 0.27 ENSDART00000085009
coq6
coenzyme Q6 monooxygenase
chr24_+_119680 0.27 ENSDART00000061973
tgfbr1b
transforming growth factor, beta receptor 1 b
chr1_-_14258409 0.25 ENSDART00000079359
pde5aa
phosphodiesterase 5A, cGMP-specific, a
chr23_+_27782071 0.25 ENSDART00000131379
kmt2d
lysine (K)-specific methyltransferase 2D
chr15_-_33304133 0.25 ENSDART00000186092
nbeab
neurobeachin b
chr18_-_18875308 0.25 ENSDART00000127182
arl2bp
ADP-ribosylation factor-like 2 binding protein
chr4_-_14926637 0.24 ENSDART00000110199
prdm4
PR domain containing 4
chr6_+_19383267 0.23 ENSDART00000166549
mchr1a
melanin-concentrating hormone receptor 1a
chr6_-_14038804 0.23 ENSDART00000184606
ENSDART00000184609
etv5b
ets variant 5b
chr18_-_16392448 0.21 ENSDART00000180253
mgat4c
mgat4 family, member C
chr14_-_24101897 0.21 ENSDART00000143695
cpeb4a
cytoplasmic polyadenylation element binding protein 4a
chr3_+_40409100 0.21 ENSDART00000103486
tnrc18
trinucleotide repeat containing 18
chr2_-_16217344 0.20 ENSDART00000152031
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr3_-_21118969 0.20 ENSDART00000129016
maza
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr17_-_28097760 0.19 ENSDART00000149861
kdm1a
lysine (K)-specific demethylase 1a
chr4_-_71983381 0.19 ENSDART00000169130
ftr64
finTRIM family, member 64
chr3_+_18846488 0.18 ENSDART00000148133
tmem104
transmembrane protein 104
chr3_-_1283247 0.18 ENSDART00000149814
tcf20
transcription factor 20
chr1_-_10577945 0.18 ENSDART00000179237
ENSDART00000040502
ENSDART00000186876
trpc5a
transient receptor potential cation channel, subfamily C, member 5a
chr22_+_35089031 0.16 ENSDART00000076040
srfa
serum response factor a
chr22_-_15602760 0.16 ENSDART00000009054
tpm4a
tropomyosin 4a
chr16_+_46869010 0.16 ENSDART00000153619
thsd7ab
thrombospondin, type I, domain containing 7Ab
chr23_+_40951443 0.16 ENSDART00000115161
reps2
RALBP1 associated Eps domain containing 2
chr4_-_17642168 0.14 ENSDART00000007030
klhl42
kelch-like family, member 42
chr17_+_8754020 0.14 ENSDART00000105322
edrf1
erythroid differentiation regulatory factor 1
chr17_-_7060477 0.13 ENSDART00000081797
sash1b
SAM and SH3 domain containing 1b
chr19_+_13994563 0.12 ENSDART00000164696
tmem222b
transmembrane protein 222b
chr21_-_26495700 0.12 ENSDART00000109379
cd248b
CD248 molecule, endosialin b
chr18_-_18874921 0.12 ENSDART00000193332
arl2bp
ADP-ribosylation factor-like 2 binding protein
chr3_-_49925313 0.11 ENSDART00000164361
gcgra
glucagon receptor a
chr22_+_3232925 0.10 ENSDART00000166754
CU929402.1

chr22_-_15602593 0.10 ENSDART00000036075
tpm4a
tropomyosin 4a
chr22_+_10676981 0.10 ENSDART00000138016
hyal2b
hyaluronoglucosaminidase 2b
chr10_+_42589391 0.08 ENSDART00000067689
ENSDART00000075259
fgfr1b
fibroblast growth factor receptor 1b
chr25_+_20215964 0.08 ENSDART00000139235
tnnt2d
troponin T2d, cardiac
chr4_-_13255700 0.05 ENSDART00000162277
ENSDART00000026593
grip1
glutamate receptor interacting protein 1
chr12_+_48581588 0.04 ENSDART00000114996
CABZ01078415.1

chr6_+_4255319 0.04 ENSDART00000170351
nbeal1
neurobeachin-like 1
chr13_-_11679486 0.02 ENSDART00000108694
si:ch211-195e19.1
si:ch211-195e19.1
chr9_-_12652984 0.02 ENSDART00000052256
sumo3b
small ubiquitin-like modifier 3b
chr22_+_21398508 0.02 ENSDART00000089408
ENSDART00000186091
shdb
Src homology 2 domain containing transforming protein D, b
chr17_-_19626357 0.02 ENSDART00000011432
reep3a
receptor accessory protein 3a
chr8_+_18830759 0.00 ENSDART00000089079
mpnd
MPN domain containing
chr20_-_53624645 0.00 ENSDART00000083427
ENSDART00000152920
slc25a29
solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
chr17_+_8754426 0.00 ENSDART00000185519
edrf1
erythroid differentiation regulatory factor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxa1a+hoxb1b-1+hoxc1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
0.3 1.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.2 0.6 GO:0042416 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.2 0.6 GO:0031645 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
0.2 1.0 GO:0051969 regulation of transmission of nerve impulse(GO:0051969)
0.1 2.4 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.5 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 0.4 GO:0098920 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 0.3 GO:0061037 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.1 1.4 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.1 1.6 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 0.6 GO:0098971 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 0.4 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.1 0.3 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.1 1.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 1.9 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.1 1.9 GO:0060291 long-term synaptic potentiation(GO:0060291)
0.1 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.1 4.2 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 0.4 GO:0055014 ventricular cardiac myofibril assembly(GO:0055005) atrial cardiac muscle cell development(GO:0055014)
0.1 1.0 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.1 0.6 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 0.3 GO:0019860 uracil catabolic process(GO:0006212) beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483) uracil metabolic process(GO:0019860) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.7 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 0.9 GO:0055075 potassium ion homeostasis(GO:0055075)
0.1 1.1 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 1.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.5 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.8 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.4 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.5 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.7 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.3 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 0.2 GO:0002931 response to ischemia(GO:0002931)
0.0 0.6 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.3 GO:0051893 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.0 0.4 GO:0072595 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) maintenance of protein localization in organelle(GO:0072595)
0.0 0.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 1.1 GO:0001508 action potential(GO:0001508)
0.0 0.7 GO:0060349 bone morphogenesis(GO:0060349)
0.0 0.7 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 1.0 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.3 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 3.5 GO:0006814 sodium ion transport(GO:0006814)
0.0 0.5 GO:0021602 cranial nerve morphogenesis(GO:0021602)
0.0 0.4 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.3 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.3 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.6 GO:0032924 activin receptor signaling pathway(GO:0032924)
0.0 0.3 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.7 GO:0031638 zymogen activation(GO:0031638)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0005955 calcineurin complex(GO:0005955)
0.2 1.2 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 1.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.7 GO:0043083 synaptic cleft(GO:0043083)
0.1 2.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.8 GO:0036449 microtubule minus-end(GO:0036449)
0.1 1.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.6 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 1.9 GO:0043679 axon terminus(GO:0043679)
0.1 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.6 GO:0048179 activin receptor complex(GO:0048179)
0.0 2.2 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 2.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.4 GO:0044327 dendritic spine head(GO:0044327) phagocytic vesicle(GO:0045335)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.6 GO:0043204 perikaryon(GO:0043204)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 2.7 GO:0070382 exocytic vesicle(GO:0070382)
0.0 0.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:1903136 cuprous ion binding(GO:1903136)
0.3 2.3 GO:0001972 retinoic acid binding(GO:0001972)
0.2 1.4 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 0.8 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.2 2.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 1.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 1.5 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 2.2 GO:0015026 coreceptor activity(GO:0015026)
0.1 1.0 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.6 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 1.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 0.7 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 0.2 GO:0030273 melanin-concentrating hormone receptor activity(GO:0030273)
0.1 0.3 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 0.3 GO:0031005 filamin binding(GO:0031005)
0.1 0.6 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 3.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.2 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.6 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.8 GO:0030507 spectrin binding(GO:0030507)
0.1 0.5 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.0 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.1 0.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.7 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.4 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 1.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.6 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.2 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 2.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.9 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.1 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.0 0.1 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.0 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.5 GO:0022842 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.5 GO:0015377 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.4 GO:0031267 small GTPase binding(GO:0031267)
0.0 1.7 GO:0045296 cadherin binding(GO:0045296)
0.0 0.5 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 0.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.5 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.7 GO:0005044 scavenger receptor activity(GO:0005044)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 1.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 2.2 PID BMP PATHWAY BMP receptor signaling
0.0 0.6 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.6 ST JNK MAPK PATHWAY JNK MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 0.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.2 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 2.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.2 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway