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PRJNA207719: Tissue specific transcriptome profiling

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Results for hoxb4a

Z-value: 0.87

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Transcription factors associated with hoxb4a

Gene Symbol Gene ID Gene Info
hoxb4a
ENSDARG00000013533 homeobox B4a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb4adr11_v1_chr3_+_23710839_23710839-0.941.8e-02Click!

Activity profile of hoxb4a motif

Sorted Z-values of hoxb4a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_20901505 0.92 ENSDART00000132741
c7b
complement component 7b
chr17_+_23937262 0.56 ENSDART00000113276
si:ch211-189k9.2
si:ch211-189k9.2
chr20_-_29420713 0.49 ENSDART00000147464
ryr3
ryanodine receptor 3
chr25_-_4482449 0.46 ENSDART00000056278
ENSDART00000149425
slc25a22a
solute carrier family 25 member 22a
chr21_-_24632778 0.43 ENSDART00000132533
ENSDART00000058370
arhgap32b
Rho GTPase activating protein 32b
chr24_+_32472155 0.41 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr25_-_13842618 0.40 ENSDART00000160258
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr10_-_20445549 0.40 ENSDART00000064613
loxl2a
lysyl oxidase-like 2a
chr18_-_14836600 0.40 ENSDART00000045232
mtss1la
metastasis suppressor 1-like a
chr12_+_9703172 0.39 ENSDART00000091489
ppp1r9bb
protein phosphatase 1, regulatory subunit 9Bb
chr7_-_41964877 0.38 ENSDART00000092351
ENSDART00000193395
ENSDART00000187947
neto2b
neuropilin (NRP) and tolloid (TLL)-like 2b
chr18_-_12957451 0.38 ENSDART00000140403
srgap1a
SLIT-ROBO Rho GTPase activating protein 1a
chr18_-_42172101 0.36 ENSDART00000124211
cntn5
contactin 5
chr18_-_14836862 0.35 ENSDART00000124843
mtss1la
metastasis suppressor 1-like a
chr17_+_27434626 0.35 ENSDART00000052446
vgll2b
vestigial-like family member 2b
chr2_-_54039293 0.34 ENSDART00000166013
abhd8a
abhydrolase domain containing 8a
chr2_+_27010439 0.34 ENSDART00000030547
cdh7a
cadherin 7a
chr6_+_18367388 0.33 ENSDART00000163394
dgke
diacylglycerol kinase, epsilon
chr16_-_32672883 0.32 ENSDART00000124515
ENSDART00000190920
ENSDART00000188776
pnisr
PNN-interacting serine/arginine-rich protein
chr7_-_19369002 0.32 ENSDART00000165680
ntn4
netrin 4
chr11_-_13341483 0.25 ENSDART00000164978
mast3b
microtubule associated serine/threonine kinase 3b
chr19_+_14059349 0.25 ENSDART00000166230
tpbga
trophoblast glycoprotein a
chr23_-_33038423 0.25 ENSDART00000180539
plxna2
plexin A2
chr11_-_13341051 0.24 ENSDART00000121872
mast3b
microtubule associated serine/threonine kinase 3b
chr2_+_37480669 0.24 ENSDART00000029801
sppl2
signal peptide peptidase-like 2
chr7_-_52842007 0.24 ENSDART00000182710
map1aa
microtubule-associated protein 1Aa
chr17_+_19626479 0.23 ENSDART00000044993
ENSDART00000131863
rgs7a
regulator of G protein signaling 7a
chr1_-_681116 0.23 ENSDART00000165894
adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr9_-_3653259 0.23 ENSDART00000140425
ENSDART00000025332
gad1a
glutamate decarboxylase 1a
chr5_-_18446483 0.22 ENSDART00000180027
si:dkey-215k6.1
si:dkey-215k6.1
chr10_-_26744131 0.22 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fgf13b
fibroblast growth factor 13b
chr17_-_8727699 0.21 ENSDART00000049236
ENSDART00000149505
ENSDART00000148619
ENSDART00000149668
ENSDART00000148827
ctbp2a
C-terminal binding protein 2a
chr12_+_28854410 0.21 ENSDART00000152991
nfe2l1b
nuclear factor, erythroid 2-like 1b
chr19_-_10425140 0.21 ENSDART00000145319
si:ch211-171h4.3
si:ch211-171h4.3
chr3_-_52644737 0.18 ENSDART00000126180
si:dkey-210j14.3
si:dkey-210j14.3
chr9_-_15789526 0.18 ENSDART00000141318
si:dkey-103d23.3
si:dkey-103d23.3
chr15_-_26552652 0.17 ENSDART00000152336
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr1_-_46981134 0.17 ENSDART00000130607
pknox1.2
pbx/knotted 1 homeobox 1.2
chr13_-_33207367 0.16 ENSDART00000146138
ENSDART00000109667
ENSDART00000182741
trip11
thyroid hormone receptor interactor 11
chr6_-_29105727 0.16 ENSDART00000184355
fam69ab
family with sequence similarity 69, member Ab
chr21_-_20328375 0.16 ENSDART00000079593
slc26a1
solute carrier family 26 (anion exchanger), member 1
chr11_+_13223625 0.16 ENSDART00000161275
abcb11b
ATP-binding cassette, sub-family B (MDR/TAP), member 11b
chr18_+_6126506 0.16 ENSDART00000125725
si:ch1073-390k14.1
si:ch1073-390k14.1
chr5_-_7834582 0.15 ENSDART00000162626
ENSDART00000157661
pdlim5a
PDZ and LIM domain 5a
chr23_-_3721444 0.13 ENSDART00000141682
nudt3a
nudix (nucleoside diphosphate linked moiety X)-type motif 3a
chr20_+_51479263 0.13 ENSDART00000148798
tlr5a
toll-like receptor 5a
chr2_-_36818132 0.12 ENSDART00000110447
slitrk3b
SLIT and NTRK-like family, member 3b
chr23_+_13814978 0.12 ENSDART00000090864
lmod3
leiomodin 3 (fetal)
chr6_-_57635577 0.11 ENSDART00000168708
cbfa2t2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr20_+_51478939 0.11 ENSDART00000149758
tlr5a
toll-like receptor 5a
chr20_-_32188897 0.11 ENSDART00000133887
si:ch211-51a19.5
si:ch211-51a19.5
chr1_+_1712140 0.11 ENSDART00000081047
atp1a1a.1
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 1
chr12_+_28854963 0.11 ENSDART00000153227
nfe2l1b
nuclear factor, erythroid 2-like 1b
chr24_-_26460853 0.10 ENSDART00000078628
slc7a14b
solute carrier family 7, member 14b
chr4_-_17257435 0.10 ENSDART00000131973
lrmp
lymphoid-restricted membrane protein
chr2_+_44972720 0.10 ENSDART00000075146
alg3
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr14_-_30876708 0.10 ENSDART00000147597
ubl3b
ubiquitin-like 3b
chr3_-_51109286 0.09 ENSDART00000172010
si:ch211-148f13.1
si:ch211-148f13.1
chr9_+_16449398 0.09 ENSDART00000006787
epha3
eph receptor A3
chr23_+_27756984 0.08 ENSDART00000137103
kmt2d
lysine (K)-specific methyltransferase 2D
chr16_-_18960613 0.08 ENSDART00000183197
fhod3b
formin homology 2 domain containing 3b
chr21_+_22423286 0.07 ENSDART00000133190
capslb
calcyphosine-like b
chr15_+_25489406 0.07 ENSDART00000162482
zgc:152863
zgc:152863
chr14_+_46274611 0.06 ENSDART00000134363
cabp2b
calcium binding protein 2b
chr3_+_33300522 0.06 ENSDART00000114023
hspb9
heat shock protein, alpha-crystallin-related, 9
chr24_+_26402110 0.06 ENSDART00000133684
si:ch211-230g15.5
si:ch211-230g15.5
chr14_-_30876299 0.05 ENSDART00000180305
ubl3b
ubiquitin-like 3b
chr11_+_40530748 0.05 ENSDART00000173239
mmel1
membrane metallo-endopeptidase-like 1
chr4_-_13255700 0.05 ENSDART00000162277
ENSDART00000026593
grip1
glutamate receptor interacting protein 1
chr13_+_36622100 0.05 ENSDART00000133198
si:ch211-67f24.7
si:ch211-67f24.7
chr1_+_11881559 0.05 ENSDART00000166981
snx8b
sorting nexin 8b
chr6_-_28345002 0.03 ENSDART00000158955
si:busm1-105l16.2
si:busm1-105l16.2
chr13_+_30912117 0.03 ENSDART00000133138
drgx
dorsal root ganglia homeobox
chr2_-_57473980 0.02 ENSDART00000149353
ENSDART00000150034
pias4b
protein inhibitor of activated STAT, 4b
chr5_-_64103863 0.01 ENSDART00000135014
ENSDART00000083684
pappab
pregnancy-associated plasma protein A, pappalysin 1b
chr13_+_30912385 0.01 ENSDART00000182642
drgx
dorsal root ganglia homeobox
chr1_-_11372456 0.01 ENSDART00000144164
ENSDART00000141238
sdk1b
sidekick cell adhesion molecule 1b
chr18_-_25401002 0.00 ENSDART00000055567
gnrhr4
gonadotropin releasing hormone receptor 4

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb4a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 0.2 GO:0003403 optic vesicle formation(GO:0003403)
0.1 0.2 GO:0060829 negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060829)
0.1 0.2 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.1 0.4 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.5 GO:0015810 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.2 GO:0019532 oxalate transport(GO:0019532)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 0.8 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.1 GO:0035046 pronuclear migration(GO:0035046)
0.0 0.9 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 0.2 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.0 0.1 GO:1901909 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.5 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.1 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.3 GO:0060034 notochord cell differentiation(GO:0060034)
0.0 0.1 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.3 GO:0070831 basement membrane assembly(GO:0070831)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.4 GO:0001650 fibrillar center(GO:0001650)
0.1 0.2 GO:0071556 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.9 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.3 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.0 0.2 GO:0015432 canalicular bile acid transmembrane transporter activity(GO:0015126) bile acid-exporting ATPase activity(GO:0015432)
0.0 0.5 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.2 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis