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PRJNA207719: Tissue specific transcriptome profiling

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Results for hoxb5a+hoxb5b

Z-value: 0.32

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Transcription factors associated with hoxb5a+hoxb5b

Gene Symbol Gene ID Gene Info
hoxb5a
ENSDARG00000013057 homeobox B5a
hoxb5b
ENSDARG00000054030 homeobox B5b
hoxb5b
ENSDARG00000113174 homeobox B5b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb5adr11_v1_chr3_+_23707691_237076910.692.0e-01Click!
hoxb5bdr11_v1_chr12_+_27129659_271296590.484.2e-01Click!

Activity profile of hoxb5a+hoxb5b motif

Sorted Z-values of hoxb5a+hoxb5b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_22656477 0.26 ENSDART00000009337
ENSDART00000133322
eno1a
enolase 1a, (alpha)
chr20_-_29418620 0.19 ENSDART00000172634
ryr3
ryanodine receptor 3
chr5_-_26284276 0.18 ENSDART00000148608
arvcfb
ARVCF, delta catenin family member b
chr14_-_25078569 0.17 ENSDART00000172802
ENSDART00000173345
ENSDART00000135004
matr3l1.1
matrin 3-like 1.1
chr9_+_30475563 0.17 ENSDART00000133118
gja5a
gap junction protein, alpha 5a
chr7_+_30867008 0.16 ENSDART00000193106
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr15_-_12500938 0.16 ENSDART00000159627
scn4ba
sodium channel, voltage-gated, type IV, beta a
chr22_+_11857356 0.15 ENSDART00000179540
mras
muscle RAS oncogene homolog
chr19_+_46259619 0.14 ENSDART00000158032
grinaa
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr1_-_46981134 0.14 ENSDART00000130607
pknox1.2
pbx/knotted 1 homeobox 1.2
chr14_-_31893996 0.13 ENSDART00000173222
gpr101
G protein-coupled receptor 101
chr1_+_12766351 0.13 ENSDART00000165785
pcdh10a
protocadherin 10a
chr4_+_3482312 0.13 ENSDART00000109044
grm8a
glutamate receptor, metabotropic 8a
chr16_-_9980402 0.13 ENSDART00000066372
id4
inhibitor of DNA binding 4
chr24_-_29822913 0.13 ENSDART00000160929
aglb
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase b
chr3_+_28831450 0.12 ENSDART00000055422
flr
fleer
chr22_+_696931 0.12 ENSDART00000149712
ENSDART00000009756
gpr37l1a
G protein-coupled receptor 37 like 1a
chr19_-_8600383 0.12 ENSDART00000081546
trim46b
tripartite motif containing 46b
chr15_-_25099679 0.11 ENSDART00000154628
rflnb
refilin B
chr11_-_44030962 0.11 ENSDART00000171910
FP016005.1

chr6_-_52156427 0.10 ENSDART00000082821
rims4
regulating synaptic membrane exocytosis 4
chr16_-_27640995 0.10 ENSDART00000019658
nacad
NAC alpha domain containing
chr5_-_41142467 0.10 ENSDART00000129415
zfr
zinc finger RNA binding protein
chr2_+_24317465 0.10 ENSDART00000139339
ENSDART00000136284
mrpl34
mitochondrial ribosomal protein L34
chr8_+_44783424 0.10 ENSDART00000025875
si:ch1073-459j12.1
si:ch1073-459j12.1
chr9_-_12034444 0.09 ENSDART00000038651
znf804a
zinc finger protein 804A
chr10_+_35439952 0.09 ENSDART00000006284
hhla2a.2
HERV-H LTR-associating 2a, tandem duplicate 2
chr22_-_15385442 0.09 ENSDART00000090975
tmem264
transmembrane protein 264
chr12_+_7865470 0.09 ENSDART00000161683
BX548028.1

chr7_+_56889879 0.09 ENSDART00000039810
myo9aa
myosin IXAa
chr3_-_5413018 0.08 ENSDART00000063138
vmo1a
vitelline membrane outer layer 1 homolog a
chr1_-_49498116 0.08 ENSDART00000137357
zgc:175214
zgc:175214
chr17_+_15041647 0.08 ENSDART00000108999
samd4a
sterile alpha motif domain containing 4A
chr5_-_71838520 0.08 ENSDART00000174396
CU927890.1

chr8_-_15398760 0.08 ENSDART00000162011
agbl4
ATP/GTP binding protein-like 4
chr10_+_2684958 0.08 ENSDART00000112019
setd9
SET domain containing 9
chr9_+_6082793 0.07 ENSDART00000192045
st6gal2a
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr21_-_43117327 0.07 ENSDART00000122352
p4ha2
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
chr6_-_15603675 0.07 ENSDART00000143502
lrrfip1b
leucine rich repeat (in FLII) interacting protein 1b
chr7_+_33314925 0.07 ENSDART00000148590
coro2ba
coronin, actin binding protein, 2Ba
chr23_-_637347 0.07 ENSDART00000132175
l1camb
L1 cell adhesion molecule, paralog b
chr23_+_39331216 0.07 ENSDART00000160957
kcng1
potassium voltage-gated channel, subfamily G, member 1
chr2_-_42065069 0.07 ENSDART00000140188
cspp1b
centrosome and spindle pole associated protein 1b
chr15_-_12319065 0.07 ENSDART00000162973
ENSDART00000170543
fxyd6
FXYD domain containing ion transport regulator 6
chr14_+_33723309 0.06 ENSDART00000132488
apln
apelin
chr12_+_17436904 0.06 ENSDART00000079130
atad1b
ATPase family, AAA domain containing 1b
chr7_-_5039562 0.06 ENSDART00000154438
ltb4r
leukotriene B4 receptor
chr5_+_59392183 0.06 ENSDART00000082983
ENSDART00000180882
clip2
CAP-GLY domain containing linker protein 2
chr15_-_2803313 0.06 ENSDART00000060839
tgfb1a
transforming growth factor, beta 1a
chr2_+_44426609 0.06 ENSDART00000112711
ENSDART00000154188
kcnab1b
potassium voltage-gated channel, shaker-related subfamily, beta member 1 b
chr1_-_8192418 0.06 ENSDART00000136654
grapb
GRB2-related adaptor protein b
chr8_+_25962833 0.05 ENSDART00000086583
si:dkey-72l14.4
si:dkey-72l14.4
chr22_-_7461603 0.05 ENSDART00000170630
BX511034.6

chr11_-_2297832 0.05 ENSDART00000158266
znf740a
zinc finger protein 740a
chr18_+_33580391 0.04 ENSDART00000189300
si:dkey-47k20.4
si:dkey-47k20.4
chr21_-_308852 0.04 ENSDART00000151613
lhfpl2a
LHFPL tetraspan subfamily member 2a
chr19_-_30904590 0.04 ENSDART00000137633
si:ch211-194e15.5
si:ch211-194e15.5
chr12_-_7710563 0.04 ENSDART00000187382
CABZ01050062.1

chr14_+_8476769 0.04 ENSDART00000131773
dnajc4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr22_+_17536989 0.04 ENSDART00000149531
hnrnpm
heterogeneous nuclear ribonucleoprotein M
chr11_+_24957858 0.04 ENSDART00000145647
sulf2a
sulfatase 2a
chr15_-_35031523 0.03 ENSDART00000154848
si:ch211-272b8.6
si:ch211-272b8.6
chr17_-_39772999 0.03 ENSDART00000155727
pimr60
Pim proto-oncogene, serine/threonine kinase, related 60
chr13_-_44819254 0.03 ENSDART00000131673
si:dkeyp-2e4.8
si:dkeyp-2e4.8
chr15_+_32643873 0.03 ENSDART00000189433
trpc4b
transient receptor potential cation channel, subfamily C, member 4b
chr5_-_33769211 0.03 ENSDART00000133504
dab2ipb
DAB2 interacting protein b
chr23_+_3513201 0.03 ENSDART00000092258
spata2
spermatogenesis associated 2
chr25_+_36316280 0.03 ENSDART00000152735
si:ch211-113a14.11
si:ch211-113a14.11
chr2_-_24317240 0.03 ENSDART00000078975
trnau1apb
tRNA selenocysteine 1 associated protein 1b
chr1_+_42224769 0.02 ENSDART00000177496
ENSDART00000184778
ENSDART00000110860
ctnna2
catenin (cadherin-associated protein), alpha 2
chr5_-_16791223 0.02 ENSDART00000192744
atad1a
ATPase family, AAA domain containing 1a
chr3_+_39579393 0.02 ENSDART00000055170
cln3
ceroid-lipofuscinosis, neuronal 3
chr16_+_16826504 0.02 ENSDART00000108691
kcnj14
potassium inwardly-rectifying channel, subfamily J, member 14
chr10_+_26944418 0.02 ENSDART00000135493
frmd8
FERM domain containing 8
chr17_+_49081828 0.02 ENSDART00000156492
tiam2a
T cell lymphoma invasion and metastasis 2a
chr20_+_53181017 0.02 ENSDART00000189692
ENSDART00000177109
FIG4
FIG4 phosphoinositide 5-phosphatase
chr13_-_36134317 0.02 ENSDART00000015664
ENSDART00000188301
ENSDART00000191073
ENSDART00000184192
ENSDART00000139593
pcnx
pecanex homolog (Drosophila)
chr8_+_247163 0.01 ENSDART00000122378
cep120
centrosomal protein 120
chr19_-_40175800 0.01 ENSDART00000102904
illr4
immune-related, lectin-like receptor 4
chr20_+_51730658 0.01 ENSDART00000010271
aida
axin interactor, dorsalization associated
chr25_+_35212919 0.01 ENSDART00000180127
ano5a
anoctamin 5a
chr6_-_19340889 0.01 ENSDART00000181407
mif4gda
MIF4G domain containing a
chr2_-_3038904 0.00 ENSDART00000186795
guk1a
guanylate kinase 1a
chr7_-_72426484 0.00 ENSDART00000190063
rph3ab
rabphilin 3A homolog (mouse), b
chr8_-_43847138 0.00 ENSDART00000148358
adgrd1
adhesion G protein-coupled receptor D1
chr4_+_42295479 0.00 ENSDART00000162279
znf1118
zinc finger protein 1118

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb5a+hoxb5b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0061037 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.0 0.3 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.0 0.1 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.1 GO:0098529 neuromuscular junction development, skeletal muscle fiber(GO:0098529)
0.0 0.1 GO:0036372 opsin transport(GO:0036372)
0.0 0.1 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.0 0.1 GO:0003307 regulation of Wnt signaling pathway involved in heart development(GO:0003307)
0.0 0.1 GO:0090133 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070735 protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.0 0.2 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0004133 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.0 0.1 GO:0031005 filamin binding(GO:0031005)
0.0 0.1 GO:0031704 apelin receptor binding(GO:0031704)
0.0 0.1 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)