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PRJNA207719: Tissue specific transcriptome profiling
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Results for hoxb6a+hoxb6b
Z-value: 7.50
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Transcription factors associated with hoxb6a+hoxb6b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| hoxb6a | dr11_v1_chr3_+_23703704_23703704 | 0.34 | 5.7e-01 | Click! |
| hoxb6b | dr11_v1_chr12_+_27127139_27127139 | 0.06 | 9.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_49431939 Show fit | 5.45 |
ENSDART00000011453
ENSDART00000088240 ENSDART00000114173 |
synaptophysin b |
|
| chr21_+_7582036 Show fit | 5.44 |
ENSDART00000135485
ENSDART00000027268 |
orthopedia homeobox a |
|
| chr2_-_54387550 Show fit | 4.72 |
ENSDART00000097388
|
N-ethylmaleimide-sensitive factor attachment protein, gamma b |
|
| chr21_-_42007213 Show fit | 4.65 |
ENSDART00000188804
ENSDART00000092821 ENSDART00000165743 |
gamma-aminobutyric acid (GABA) A receptor, gamma 2 |
|
| chr20_+_34915945 Show fit | 4.61 |
ENSDART00000153064
|
synaptosomal-associated protein, 25a |
|
| chr5_+_58372164 Show fit | 4.53 |
ENSDART00000057910
|
neurogranin (protein kinase C substrate, RC3) a |
|
| chr21_-_22115136 Show fit | 4.43 |
ENSDART00000134715
ENSDART00000089246 ENSDART00000139789 |
ELMO/CED-12 domain containing 1 |
|
| chr12_-_25916530 Show fit | 4.38 |
ENSDART00000186386
|
synuclein, gamma b (breast cancer-specific protein 1) |
|
| chr3_-_46817499 Show fit | 4.03 |
ENSDART00000013717
|
ELAV like neuron-specific RNA binding protein 3 |
|
| chr16_+_37582872 Show fit | 3.95 |
ENSDART00000169331
|
adhesion G protein-coupled receptor B1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of hoxb6a+hoxb6b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 30.6 | GO:0031175 | neuron projection development(GO:0031175) |
| 0.2 | 21.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 19.4 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.1 | 16.6 | GO:0099536 | synaptic signaling(GO:0099536) |
| 0.1 | 13.4 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 1.5 | 13.3 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 2.4 | 12.0 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.2 | 10.8 | GO:0035249 | synaptic transmission, glutamatergic(GO:0035249) |
| 0.4 | 10.2 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 58.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 45.1 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 40.0 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.2 | 26.1 | GO:0030424 | axon(GO:0030424) |
| 0.6 | 21.9 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.3 | 21.8 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.2 | 20.5 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.2 | 20.0 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.5 | 19.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 14.3 | GO:0045202 | synapse(GO:0045202) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 36.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.7 | 27.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 21.8 | GO:0003712 | transcription factor activity, transcription factor binding(GO:0000989) transcription cofactor activity(GO:0003712) |
| 1.3 | 19.5 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 19.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.3 | 18.6 | GO:0022851 | benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851) |
| 0.1 | 16.9 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.4 | 16.8 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.2 | 14.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 13.8 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 4.9 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 4.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 4.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 4.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 3.8 | ST ADRENERGIC | Adrenergic Pathway |
| 0.2 | 3.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 3.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 3.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 3.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 19.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 8.1 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.1 | 7.4 | REACTOME NEURONAL SYSTEM | Genes involved in Neuronal System |
| 0.1 | 5.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 1.1 | 5.7 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.4 | 5.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 5.1 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.4 | 4.9 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.3 | 4.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.6 | 4.0 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |