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PRJNA207719: Tissue specific transcriptome profiling

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Results for insm1a+insm1b

Z-value: 0.62

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Transcription factors associated with insm1a+insm1b

Gene Symbol Gene ID Gene Info
ENSDARG00000053301 insulinoma-associated 1b
ENSDARG00000091756 insulinoma-associated 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
insm1bdr11_v1_chr17_+_41463942_414639420.583.0e-01Click!
insm1adr11_v1_chr20_-_48485354_484853540.237.1e-01Click!

Activity profile of insm1a+insm1b motif

Sorted Z-values of insm1a+insm1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_49566364 0.72 ENSDART00000161507
zgc:153426
chr2_+_58221163 0.67 ENSDART00000157939

chr5_-_51830997 0.64 ENSDART00000163616
homer scaffolding protein 1b
chr7_+_73397283 0.61 ENSDART00000174390

chr9_+_4429593 0.60 ENSDART00000184855

chr17_-_4318393 0.59 ENSDART00000167995
ENSDART00000153824
N-ethylmaleimide-sensitive factor attachment protein, beta a
chr8_-_37391372 0.47 ENSDART00000190407
ENSDART00000009569
solute carrier family 12 (potassium/chloride transporter), member 5b
chr7_+_23515966 0.44 ENSDART00000186893
ENSDART00000186189
zgc:109889
chr4_+_13733838 0.44 ENSDART00000067166
ENSDART00000133157
contactin 1b
chr8_+_1082100 0.44 ENSDART00000149276
leucine zipper, putative tumor suppressor family member 3b
chr18_+_18612388 0.43 ENSDART00000186455
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr18_+_5137241 0.43 ENSDART00000159601
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr18_+_642889 0.41 ENSDART00000189007

chr15_-_33925851 0.41 ENSDART00000187807
ENSDART00000187780
myelin associated glycoprotein
chr10_+_21801030 0.40 ENSDART00000160881
ENSDART00000187969
protocadherin 1 gamma 30
chr13_+_23176330 0.39 ENSDART00000168351
sorbin and SH3 domain containing 1
chr17_-_52579709 0.36 ENSDART00000156806
ribosomal protein S6 kinase-like 1
chr7_+_73649686 0.35 ENSDART00000185589
si:dkey-46i9.1
chr1_+_12767318 0.35 ENSDART00000162652
protocadherin 10a
chr15_-_19128705 0.34 ENSDART00000152428
Rho GTPase activating protein 32a
chr18_+_50278858 0.34 ENSDART00000014582
si:dkey-105e17.1
chr12_-_48992527 0.34 ENSDART00000169696
cadherin related family member 1
chr9_+_53719230 0.32 ENSDART00000165827
si:ch211-199f5.1
chr12_+_11352630 0.31 ENSDART00000129495
si:rp71-19m20.1
chr23_+_19594608 0.29 ENSDART00000134865
sarcolemma associated protein b
chr7_-_41489997 0.29 ENSDART00000174300
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr21_+_32332616 0.29 ENSDART00000154105
si:ch211-247j9.1
chr3_-_6768905 0.29 ENSDART00000193638
ENSDART00000123809
ENSDART00000189440
ENSDART00000188335
microtubule associated serine/threonine kinase 1b
chr6_+_3166941 0.27 ENSDART00000168912
protein tyrosine phosphatase, receptor type, f, a
chr13_+_40034176 0.27 ENSDART00000189797
golgin A7 family, member Bb
chr16_-_29458806 0.27 ENSDART00000047931
leucine rich repeat and Ig domain containing 4b
chr24_-_28306484 0.26 ENSDART00000148618
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr20_+_1996202 0.25 ENSDART00000184143

chr17_+_45454943 0.25 ENSDART00000074838
potassium channel, subfamily K, member 3b
chr23_-_21797517 0.25 ENSDART00000110041
leucine rich repeat containing 38a
chr14_+_8504410 0.24 ENSDART00000123364
vascular endothelial growth factor Ba
chr5_+_57641554 0.24 ENSDART00000171309
ENSDART00000157992
ENSDART00000164742
crystallin, alpha B, b
chr11_+_24620742 0.24 ENSDART00000182471
ENSDART00000048365
synaptotagmin VIb
chr17_+_6793001 0.23 ENSDART00000030773
forkhead box O3A
chr10_-_41157135 0.23 ENSDART00000134851
AP2 associated kinase 1b
chr21_+_30673183 0.22 ENSDART00000144652
chloride channel, voltage-sensitive 5a
chr19_+_2726819 0.22 ENSDART00000187122
ENSDART00000112414
Rap guanine nucleotide exchange factor (GEF) 5a
chr9_+_29040425 0.22 ENSDART00000150201
si:ch73-116o1.2
chr4_-_25908871 0.22 ENSDART00000066949
FYVE, RhoGEF and PH domain containing 6
chr22_-_881080 0.20 ENSDART00000185489
choline/ethanolamine phosphotransferase 1b
chr3_+_17346502 0.20 ENSDART00000187786
ENSDART00000131584
si:ch211-210g13.5
chr14_+_42172677 0.20 ENSDART00000148544
protocadherin 18b
chr18_+_45573416 0.20 ENSDART00000132184
ENSDART00000145288
kinesin family member C3
chr4_+_90048 0.20 ENSDART00000166440
low density lipoprotein receptor-related protein 6
chr1_-_40341306 0.19 ENSDART00000190649
mastermind-like transcriptional coactivator 3
chr18_+_48608366 0.19 ENSDART00000151229
potassium inwardly-rectifying channel, subfamily J, member 5
chr23_+_16430559 0.19 ENSDART00000112436
neurotensin receptor 1 (high affinity)
chr25_-_21085661 0.19 ENSDART00000099355
proline rich 5a (renal)
chr1_-_21599219 0.18 ENSDART00000148327
ADAMTS-like 7
chr18_+_45573251 0.18 ENSDART00000191309
kinesin family member C3
chr6_-_10828880 0.18 ENSDART00000131458
ENSDART00000020261
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr4_-_5597802 0.18 ENSDART00000136229
vascular endothelial growth factor Ab
chr9_-_4598883 0.17 ENSDART00000171927
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13
chr7_-_72261721 0.17 ENSDART00000172229
RAS guanyl releasing protein 2
chr4_+_7888047 0.16 ENSDART00000104676
calcium/calmodulin-dependent protein kinase 1Da
chr12_+_30368145 0.16 ENSDART00000153454
si:ch211-225b10.4
chr10_+_41549819 0.15 ENSDART00000114210

chr3_+_22079219 0.15 ENSDART00000122782
KAT8 regulatory NSL complex subunit 1b
chr7_-_72423666 0.15 ENSDART00000191214
rabphilin 3A homolog (mouse), b
chr11_-_30352333 0.15 ENSDART00000030794
transmembrane protein 169a
chr19_-_19556778 0.15 ENSDART00000164060
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr8_-_49705058 0.15 ENSDART00000083760
FERM domain containing 3
chr21_+_25068215 0.14 ENSDART00000167523
ENSDART00000189259
DIX domain containing 1b
chr14_-_6402769 0.14 ENSDART00000121552
solute carrier family 44 (choline transporter), member 1b
chr8_+_41453691 0.14 ENSDART00000061144
actin related protein 2/3 complex, subunit 5-like, a
chr14_-_30876299 0.13 ENSDART00000180305
ubiquitin-like 3b
chr25_-_28443607 0.13 ENSDART00000157243
protein tyrosine phosphatase, receptor-type, Z polypeptide 1a
chr1_+_2112726 0.13 ENSDART00000131714
ENSDART00000138396
muscleblind-like splicing regulator 2
chr2_-_16216568 0.13 ENSDART00000173758
Rho guanine nucleotide exchange factor (GEF) 4
chr25_-_24046870 0.13 ENSDART00000047569
insulin-like growth factor 2b
chr19_+_1097393 0.13 ENSDART00000168218

chr18_-_41211980 0.13 ENSDART00000171431
zinc finger and BTB domain containing 38
chr8_+_23521974 0.13 ENSDART00000188130
ENSDART00000129378
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr13_-_49666615 0.13 ENSDART00000148083
translocase of outer mitochondrial membrane 20
chr17_+_9310259 0.13 ENSDART00000186158
ENSDART00000190329
neuronal PAS domain protein 3
chr10_+_6383270 0.12 ENSDART00000170548
zgc:114200
chr3_-_40051425 0.12 ENSDART00000146700
lethal giant larvae homolog 1 (Drosophila)
chr25_-_13659249 0.12 ENSDART00000045488
casein kinase 2, alpha prime polypeptide b
chr10_+_22527715 0.12 ENSDART00000134864
GRB10 interacting GYF protein 1b
chr9_-_1434484 0.12 ENSDART00000093412
oxysterol binding protein-like 6
chr15_-_3078600 0.12 ENSDART00000172842
fibronectin type III domain containing 3A
chr14_-_4076480 0.12 ENSDART00000059231
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr21_+_11105007 0.12 ENSDART00000128859
ENSDART00000193105
prolactin receptor a
chr19_+_46158078 0.11 ENSDART00000183933
ENSDART00000164055
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr5_+_50371951 0.11 ENSDART00000184488
ENSDART00000171295
SMC5-SMC6 complex localization factor 1
chr9_+_38427572 0.11 ENSDART00000108860
zgc:136333
chr6_-_55354004 0.11 ENSDART00000165911
PDX1 C-terminal inhibiting factor 1
chr13_-_24874950 0.11 ENSDART00000077775
K(lysine) acetyltransferase 6B
chr24_-_33873451 0.10 ENSDART00000159840
acid-sensing (proton-gated) ion channel 1c
chr2_+_1202347 0.10 ENSDART00000075837

chr3_+_18437397 0.10 ENSDART00000136243
ENSDART00000184882
ENSDART00000135470
TBC1 domain family, member 16
chr19_-_33996277 0.10 ENSDART00000159384
engulfment and cell motility 1 (ced-12 homolog, C. elegans)
chr21_+_21791799 0.10 ENSDART00000151759
sialidase 3 (membrane sialidase), tandem duplicate 1
chr7_-_30605089 0.09 ENSDART00000173775
ENSDART00000173789
ENSDART00000166046
ENSDART00000111626
ring finger protein 111
chr10_+_44940693 0.09 ENSDART00000157515
cyclin and CBS domain divalent metal cation transport mediator 4a
chr2_+_7132292 0.09 ENSDART00000153404
ENSDART00000012119
zgc:110366
chr24_-_2917540 0.09 ENSDART00000164776
family with sequence similarity 69, member C
chr3_-_43650189 0.08 ENSDART00000161127
axin 1
chr12_+_47907277 0.08 ENSDART00000097714
thymus, brain and testes associated
chr3_-_43646733 0.08 ENSDART00000180959
axin 1
chr8_-_1264893 0.08 ENSDART00000190371
cell division cycle 14B
chr12_+_47280839 0.08 ENSDART00000187574
ryanodine receptor 2
chr15_+_1796313 0.07 ENSDART00000126253
family with sequence similarity 124B
chr21_-_35534401 0.07 ENSDART00000112308
si:dkeyp-23e4.3
chr25_+_16601839 0.07 ENSDART00000008986
ATPase H+ transporting V1 subunit E1a
chr3_+_20001608 0.07 ENSDART00000137944
ankyrin repeat and SOCS box containing 16
chr21_-_30415524 0.07 ENSDART00000101036
GrpE-like 2, mitochondrial
chr24_-_10394277 0.07 ENSDART00000127568
ANKH inorganic pyrophosphate transport regulator a
chr13_+_30951155 0.06 ENSDART00000057469
ENSDART00000162254
V-set and transmembrane domain containing 4a
chr11_+_19060278 0.06 ENSDART00000164294
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr11_-_23697217 0.06 ENSDART00000124810
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr2_+_15100742 0.06 ENSDART00000027171
coagulation factor IIIb
chr21_+_5800306 0.06 ENSDART00000020603
cyclin G2
chr3_-_15668433 0.05 ENSDART00000115022
zgc:66474
chr9_+_41690153 0.05 ENSDART00000100226
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr7_+_31871830 0.05 ENSDART00000139899
myosin binding protein C, cardiac
chr19_+_9032073 0.05 ENSDART00000127755
ash1 (absent, small, or homeotic)-like (Drosophila)
chr25_-_25575241 0.05 ENSDART00000150636
hypermethylated in cancer 1 like
chr18_+_17493859 0.05 ENSDART00000090754
si:dkey-102f14.5
chr10_-_105100 0.05 ENSDART00000145716
tetratricopeptide repeat domain 3
chr18_-_127873 0.05 ENSDART00000148490
transient receptor potential cation channel, subfamily M, member 7
chr4_+_70791887 0.04 ENSDART00000164234
si:ch211-127b6.2
chr15_-_47822597 0.04 ENSDART00000193236
ENSDART00000161391

chr17_+_25197180 0.04 ENSDART00000148775
Rho guanine nucleotide exchange factor (GEF) 10
chr11_-_26040594 0.04 ENSDART00000144115
kazrin, periplakin interacting protein b
chr14_-_30983011 0.04 ENSDART00000014095
RAP2C, member of RAS oncogene family
chr12_-_4683325 0.04 ENSDART00000152771
si:ch211-255p10.3
chr2_+_21486529 0.04 ENSDART00000047468
inhibin, beta Ab
chr22_+_17536989 0.03 ENSDART00000149531
heterogeneous nuclear ribonucleoprotein M
chr21_-_43117327 0.03 ENSDART00000122352
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
chr3_-_61592417 0.03 ENSDART00000155082
neuronal pentraxin 2a
chr1_-_18803919 0.03 ENSDART00000020970
phosphoglucomutase 2
chr13_-_2981472 0.03 ENSDART00000184820

chr3_-_7129057 0.03 ENSDART00000125947

chr5_-_10236599 0.03 ENSDART00000099834
si:ch73-42k18.1
chr13_+_36680564 0.03 ENSDART00000136030
ENSDART00000006923
ATP synthase, H+ transporting, mitochondrial F0 complex subunit s
chr9_-_42989297 0.03 ENSDART00000126871
titin, tandem duplicate 2
chr14_-_49992709 0.02 ENSDART00000159988
family with sequence similarity 193, member B
chr20_+_1834262 0.02 ENSDART00000185316

chr14_+_8174828 0.02 ENSDART00000167228
pleckstrin and Sec7 domain containing 2
chr6_+_9421279 0.02 ENSDART00000161036
kalirin RhoGEF kinase b
chr8_-_14484599 0.01 ENSDART00000057644
LIM homeobox 4
chr18_+_18000695 0.01 ENSDART00000146898
si:ch211-212o1.2
chr13_-_36680531 0.01 ENSDART00000085298
L-2-hydroxyglutarate dehydrogenase
chr6_-_39051319 0.01 ENSDART00000155093
tensin 2b
chr8_+_15251448 0.01 ENSDART00000063717
zgc:171480
chr4_+_69577362 0.00 ENSDART00000160913
zinc finger protein 1030
chr25_+_32496723 0.00 ENSDART00000087978
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr4_+_40329524 0.00 ENSDART00000165722
zinc finger protein 993
chr25_-_25575717 0.00 ENSDART00000067138
hypermethylated in cancer 1 like
chr17_+_43013171 0.00 ENSDART00000055541
gsk3b interacting protein

Network of associatons between targets according to the STRING database.

First level regulatory network of insm1a+insm1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.1 0.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.3 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.0 0.2 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.4 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 0.3 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.3 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.0 0.4 GO:0051127 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.1 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.2 GO:0086009 membrane repolarization(GO:0086009)
0.0 0.3 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.1 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.5 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.2 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747) regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.1 GO:0003210 cardiac atrium formation(GO:0003210)
0.0 0.1 GO:0010960 magnesium ion homeostasis(GO:0010960)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.3 GO:0001650 fibrillar center(GO:0001650)
0.0 0.4 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.3 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0044545 NSL complex(GO:0044545)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 0.6 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 0.2 GO:0005252 open rectifier potassium channel activity(GO:0005252)
0.1 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.2 GO:0042166 neurotransmitter binding(GO:0042165) acetylcholine binding(GO:0042166)
0.0 0.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.2 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.4 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.5 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 0.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.1 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.0 0.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade