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PRJNA207719: Tissue specific transcriptome profiling
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Results for irf10+irf8+irf9
Z-value: 3.93
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Transcription factors associated with irf10+irf8+irf9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| irf10 | dr11_v1_chr23_+_642395_642395 | 0.86 | 6.1e-02 | Click! |
| irf8 | dr11_v1_chr18_+_30567945_30567945 | 0.58 | 3.0e-01 | Click! |
| irf9 | dr11_v1_chr12_+_13282797_13282807 | 0.50 | 3.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_13373593 Show fit | 4.83 |
ENSDART00000051668
ENSDART00000183883 |
chemokine (C-C motif) ligand 19a, tandem duplicate 2 |
|
| chr11_-_20096018 Show fit | 4.71 |
ENSDART00000030420
|
opioid growth factor receptor-like 2 |
|
| chr21_-_22648007 Show fit | 4.65 |
ENSDART00000121788
|
grass carp reovirus (GCRV)-induced gene 2l |
|
| chr19_-_7115229 Show fit | 4.65 |
ENSDART00000001930
|
proteasome subunit beta 13a |
|
| chr1_-_52443379 Show fit | 3.56 |
ENSDART00000144676
|
si:ch211-217k17.11 |
|
| chr13_-_37608441 Show fit | 3.36 |
ENSDART00000140230
|
zgc:123068 |
|
| chr19_+_7115223 Show fit | 3.34 |
ENSDART00000001359
|
proteasome subunit beta 12 |
|
| chr21_-_22673758 Show fit | 3.25 |
ENSDART00000164910
|
grass carp reovirus (GCRV)-induced gene 2i |
|
| chr21_-_22647695 Show fit | 3.22 |
ENSDART00000187553
|
grass carp reovirus (GCRV)-induced gene 2l |
|
| chr22_-_10580194 Show fit | 3.21 |
ENSDART00000105848
|
si:dkey-42i9.7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of irf10+irf8+irf9
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.9 | GO:0051603 | proteolysis involved in cellular protein catabolic process(GO:0051603) |
| 0.4 | 13.2 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.1 | 8.0 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.2 | 5.9 | GO:0071346 | cellular response to interferon-gamma(GO:0071346) |
| 0.0 | 4.2 | GO:0017148 | negative regulation of translation(GO:0017148) |
| 0.2 | 3.4 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) antigen processing and presentation of peptide antigen(GO:0048002) |
| 0.0 | 3.4 | GO:0061136 | regulation of proteasomal protein catabolic process(GO:0061136) |
| 0.5 | 3.1 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.7 | 2.9 | GO:0046168 | NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168) |
| 0.9 | 2.8 | GO:1901533 | negative regulation of hematopoietic progenitor cell differentiation(GO:1901533) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.1 | GO:0005829 | cytosol(GO:0005829) |
| 0.5 | 13.2 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 9.9 | GO:0005764 | lysosome(GO:0005764) |
| 0.0 | 3.3 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 3.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.5 | 2.9 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.1 | 2.2 | GO:0043186 | P granule(GO:0043186) |
| 0.0 | 2.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 2.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.8 | GO:0000779 | condensed chromosome, centromeric region(GO:0000779) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.1 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 12.1 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.5 | 10.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 7.7 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 5.9 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.7 | 4.6 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.0 | 4.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 3.1 | GO:0004175 | endopeptidase activity(GO:0004175) |
| 0.1 | 3.0 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.7 | 2.9 | GO:0004367 | glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 4.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 3.4 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 2.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 1.6 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 1.5 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 1.3 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 1.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.9 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.2 | 6.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 3.0 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 2.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.2 | 2.1 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 1.8 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.1 | 1.6 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.3 | 1.5 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 1.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 1.3 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |