ISMARA results: irf1b+irf2+irf2a

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PRJNA207719: Tissue specific transcriptome profiling

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Results for irf1b+irf2+irf2a

Z-value: 4.82

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Transcription factors associated with irf1b+irf2+irf2a

Gene Symbol	Gene ID	Gene Info
irf2a NCBI UniProt	ENSDARG00000007387	interferon regulatory factor 2a
irf2 NCBI UniProt	ENSDARG00000040465	interferon regulatory factor 2
irf1b NCBI UniProt	ENSDARG00000043249	interferon regulatory factor 1b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
irf2	dr11_v1_chr14_-_4121052_4121052	0.93	2.1e-02	Click!
irf1b	dr11_v1_chr21_+_45627775_45627775	0.81	9.7e-02	Click!
irf2a	dr11_v1_chr1_+_39865748_39865753	-0.61	2.8e-01	Click!

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr21_-_22648007 Show fit	7.79	ENSDART00000121788	gig2l NCBI UniProt Show fit	grass carp reovirus (GCRV)-induced gene 2l
chr19_-_7115229 Show fit	6.78	ENSDART00000001930	psmb13a NCBI UniProt Show fit	proteasome subunit beta 13a
chr19_+_7115223 Show fit	4.96	ENSDART00000001359	psmb12 NCBI UniProt Show fit	proteasome subunit beta 12
chr16_+_23487051 Show fit	4.87	ENSDART00000145496	icn2 NCBI UniProt Show fit	ictacalcin 2
chr11_-_20096018 Show fit	4.63	ENSDART00000030420	ogfrl2 NCBI UniProt Show fit	opioid growth factor receptor-like 2
chr3_-_60316118 Show fit	4.58	ENSDART00000171458	si:ch211-214b16.2 NCBI UniProt Show fit	si:ch211-214b16.2
chr13_+_13681681 Show fit	4.52	ENSDART00000057825	cfd NCBI UniProt Show fit	complement factor D (adipsin)
chr9_-_45601103 Show fit	4.23	ENSDART00000180465	agr1 NCBI UniProt Show fit	anterior gradient 1
chr12_-_4388704 Show fit	4.18	ENSDART00000152168	si:ch211-173d10.1 NCBI UniProt Show fit	si:ch211-173d10.1
chr5_+_13373593 Show fit	4.17	ENSDART00000051668 ENSDART00000183883	ccl19a.2 NCBI UniProt Show fit	chemokine (C-C motif) ligand 19a, tandem duplicate 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	18.8	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2	9.9	GO:0051607	defense response to virus(GO:0051607)
0.9	8.7	GO:1900407	regulation of cellular response to oxidative stress(GO:1900407)
0.0	8.1	GO:0016567	protein ubiquitination(GO:0016567)
0.1	6.7	GO:0017148	negative regulation of translation(GO:0017148)
0.2	6.2	GO:0071346	response to interferon-gamma(GO:0034341) cellular response to interferon-gamma(GO:0071346)
0.1	6.0	GO:0010950	positive regulation of endopeptidase activity(GO:0010950) positive regulation of peptidase activity(GO:0010952)
0.1	4.6	GO:0009612	response to mechanical stimulus(GO:0009612)
1.5	4.5	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	4.4	GO:0031101	fin regeneration(GO:0031101)

Showing 1 to 10 of 136 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	19.1	GO:0005615	extracellular space(GO:0005615)
0.7	18.8	GO:0005839	proteasome core complex(GO:0005839)
0.0	17.9	GO:0005829	cytosol(GO:0005829)
0.0	12.6	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	9.0	GO:0000151	ubiquitin ligase complex(GO:0000151)
0.0	6.5	GO:0000785	chromatin(GO:0000785)
0.5	4.3	GO:0042613	MHC class II protein complex(GO:0042613)
1.0	3.9	GO:0008537	proteasome activator complex(GO:0008537)
0.1	2.9	GO:0000145	exocyst(GO:0000145)
0.5	2.8	GO:0042611	MHC protein complex(GO:0042611) MHC class I protein complex(GO:0042612)

Showing 1 to 10 of 51 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	26.3	GO:0008270	zinc ion binding(GO:0008270)
0.4	20.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.7	14.2	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	12.0	GO:0005525	GTP binding(GO:0005525)
0.3	10.3	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	8.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	7.8	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	6.2	GO:0048020	CCR chemokine receptor binding(GO:0048020)
0.3	4.8	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	4.5	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)

Showing 1 to 10 of 98 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.6	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	3.6	PID E2F PATHWAY	E2F transcription factor network
0.4	3.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	2.7	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	2.4	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.0	2.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	1.9	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.2	1.6	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	1.6	PID AURORA B PATHWAY	Aurora B signaling
0.2	1.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	10.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	6.0	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.5	5.9	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.1	5.3	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1	3.5	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.4	3.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.3	2.9	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.2	2.9	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.4	1.9	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	1.9	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination

Showing 1 to 10 of 37 entries

Results for irf1b+irf2+irf2a

Z-value: 4.82

Motif logo

Transcription factors associated with irf1b+irf2+irf2a

Activity-expression correlation:

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: