ISMARA results: irf5

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PRJNA207719: Tissue specific transcriptome profiling

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Results for irf5

Z-value: 3.57

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Transcription factors associated with irf5

Gene Symbol	Gene ID	Gene Info
irf5 NCBI UniProt	ENSDARG00000045681	interferon regulatory factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
irf5	dr11_v1_chr4_-_13614797_13614936	0.85	6.6e-02	Click!

Activity profile of irf5 motif

Sorted Z-values of irf5 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_2039511 Show fit	6.15	ENSDART00000160223	spint1a NCBI UniProt Show fit	serine peptidase inhibitor, Kunitz type 1 a
chr15_-_2640966 Show fit	3.84	ENSDART00000063320	cldne NCBI UniProt Show fit	claudin e
chr7_+_69187585 Show fit	3.04	ENSDART00000160499 ENSDART00000166258	marveld3 NCBI UniProt Show fit	MARVEL domain containing 3
chr9_-_30264415 Show fit	2.75	ENSDART00000060150	mid1ip1a NCBI UniProt Show fit	MID1 interacting protein 1a
chr10_-_22150419 Show fit	2.74	ENSDART00000006173	cldn7b NCBI UniProt Show fit	claudin 7b
chr17_-_22552678 Show fit	2.70	ENSDART00000079401	si:ch211-125o16.4 NCBI UniProt Show fit	si:ch211-125o16.4
chr1_-_7582859 Show fit	2.60	ENSDART00000110696	mxb NCBI UniProt Show fit	myxovirus (influenza) resistance B
chr7_-_19614916 Show fit	2.45	ENSDART00000169029	zgc:194655 NCBI UniProt Show fit	zgc:194655
chr1_-_7570181 Show fit	2.42	ENSDART00000103588	mxa NCBI UniProt Show fit	myxovirus (influenza) resistance A
chr22_-_17688868 Show fit	2.42	ENSDART00000012336 ENSDART00000147070	tjp3 NCBI UniProt Show fit	tight junction protein 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of irf5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.6	GO:0051604	protein maturation(GO:0051604)
0.2	6.2	GO:0030199	collagen fibril organization(GO:0030199)
0.3	6.0	GO:0098884	postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1	3.8	GO:0070830	apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.1	3.4	GO:0051607	defense response to virus(GO:0051607)
1.0	3.0	GO:0010633	negative regulation of epithelial cell migration(GO:0010633)
0.0	2.8	GO:0019722	calcium-mediated signaling(GO:0019722)
0.5	2.7	GO:0060876	semicircular canal formation(GO:0060876)
0.0	2.5	GO:0046890	regulation of lipid biosynthetic process(GO:0046890)
0.2	2.4	GO:0030104	water homeostasis(GO:0030104)

Showing 1 to 10 of 84 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	13.7	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.3	6.0	GO:0098844	postsynaptic endocytic zone membrane(GO:0098844)
0.0	3.6	GO:0031902	late endosome membrane(GO:0031902)
0.5	2.7	GO:0043034	costamere(GO:0043034)
0.1	2.7	GO:0043186	P granule(GO:0043186)
0.0	2.7	GO:0005764	lysosome(GO:0005764)
0.1	2.5	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.6	2.3	GO:0061702	inflammasome complex(GO:0061702)
0.1	2.3	GO:0042555	MCM complex(GO:0042555)
0.0	2.1	GO:0005770	late endosome(GO:0005770)

Showing 1 to 10 of 33 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	14.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	6.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	6.3	GO:0005525	GTP binding(GO:0005525)
0.0	3.9	GO:0050839	cell adhesion molecule binding(GO:0050839)
0.9	2.7	GO:0032574	5'-3' RNA helicase activity(GO:0032574)
0.0	2.7	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.2	2.5	GO:0031386	protein tag(GO:0031386)
0.5	2.3	GO:1990756	protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.2	2.3	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1	2.2	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)

Showing 1 to 10 of 58 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.7	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	2.0	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.1	1.8	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	1.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	1.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	1.6	PID ARF6 PATHWAY	Arf6 signaling events
0.0	1.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	1.1	PID AURORA B PATHWAY	Aurora B signaling
0.0	1.1	PID CXCR4 PATHWAY	CXCR4-mediated signaling events

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.1	3.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.5	2.3	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	2.0	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	1.6	REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS	Genes involved in Regulation of Water Balance by Renal Aquaporins
0.3	1.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	1.4	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	1.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.1	1.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	1.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling

Showing 1 to 10 of 34 entries

Results for irf5

Z-value: 3.57

Motif logo

Transcription factors associated with irf5

Activity-expression correlation:

Activity profile of irf5 motif

Sorted Z-values of irf5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of irf5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: