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PRJNA207719: Tissue specific transcriptome profiling

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Results for irf6

Z-value: 0.51

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Transcription factors associated with irf6

Gene Symbol Gene ID Gene Info
irf6
ENSDARG00000101986 interferon regulatory factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf6dr11_v1_chr22_+_1170294_11702950.533.6e-01Click!

Activity profile of irf6 motif

Sorted Z-values of irf6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_22552678 0.46 ENSDART00000079401
si:ch211-125o16.4
si:ch211-125o16.4
chr6_+_52064304 0.37 ENSDART00000153468
abraa
actin binding Rho activating protein a
chr7_+_69187585 0.31 ENSDART00000160499
ENSDART00000166258
marveld3
MARVEL domain containing 3
chr16_+_19637384 0.29 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
macc1
metastasis associated in colon cancer 1
chr18_+_44532883 0.27 ENSDART00000121994
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr4_-_17669881 0.25 ENSDART00000066997
dram1
DNA-damage regulated autophagy modulator 1
chr18_+_44532370 0.23 ENSDART00000086952
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr18_+_44532199 0.22 ENSDART00000135386
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr8_-_27687095 0.21 ENSDART00000086946
mov10b.1
Moloney leukemia virus 10b, tandem duplicate 1
chr7_+_19482877 0.20 ENSDART00000077868
si:ch211-212k18.7
si:ch211-212k18.7
chr9_+_23765587 0.20 ENSDART00000145120
si:ch211-219a4.3
si:ch211-219a4.3
chr19_-_15420678 0.20 ENSDART00000151454
ENSDART00000027697
serinc2
serine incorporator 2
chr2_-_37140423 0.18 ENSDART00000144220
tspan37
tetraspanin 37
chr9_-_23765480 0.18 ENSDART00000027212
si:ch211-219a4.6
si:ch211-219a4.6
chr18_+_44532668 0.15 ENSDART00000140672
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr7_+_19483277 0.13 ENSDART00000173750
si:ch211-212k18.7
si:ch211-212k18.7
chr15_-_21702317 0.12 ENSDART00000155824
IL4I1
si:dkey-40g16.6
chr10_+_28160265 0.12 ENSDART00000022484
rnft1
ring finger protein, transmembrane 1
chr17_-_30666037 0.10 ENSDART00000156509
alkal2b
ALK and LTK ligand 2b
chr23_-_30045661 0.10 ENSDART00000122239
ENSDART00000103480
ccdc187
coiled-coil domain containing 187
chr12_+_16452912 0.10 ENSDART00000192467
kif20bb
kinesin family member 20Bb
chr14_+_33329420 0.09 ENSDART00000171090
ENSDART00000164062
sowahd
sosondowah ankyrin repeat domain family d
chr21_+_21010786 0.08 ENSDART00000079692
ndr1
nodal-related 1
chr3_-_4501026 0.07 ENSDART00000163052
zgc:162198
zgc:162198
chr18_+_17624295 0.07 ENSDART00000151865
ENSDART00000190408
ENSDART00000189204
ENSDART00000188894
ENSDART00000033762
ENSDART00000193471
nlrc5
NLR family, CARD domain containing 5
chr12_+_16452575 0.06 ENSDART00000058665
kif20bb
kinesin family member 20Bb
chr21_-_22543611 0.05 ENSDART00000177084
myo5b
myosin VB
chr2_-_26620803 0.04 ENSDART00000003946
ENSDART00000126826
tmem59
transmembrane protein 59
chr16_+_27383717 0.03 ENSDART00000132329
ENSDART00000136256
stx17
syntaxin 17
chr20_-_3911546 0.03 ENSDART00000169787
cnksr3
cnksr family member 3
chr16_+_26601364 0.03 ENSDART00000087537
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr9_+_34089156 0.02 ENSDART00000000005
ccdc80
coiled-coil domain containing 80
chr14_+_33329761 0.02 ENSDART00000161138
sowahd
sosondowah ankyrin repeat domain family d

Network of associatons between targets according to the STRING database.

First level regulatory network of irf6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.2 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.1 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.0 0.1 GO:0070375 ERK5 cascade(GO:0070375) regulation of ERK5 cascade(GO:0070376) positive regulation of ERK5 cascade(GO:0070378)
0.0 0.1 GO:0003242 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0 0.1 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.0 0.1 GO:0030298 receptor signaling protein tyrosine kinase activator activity(GO:0030298)
0.0 0.1 GO:0070698 type I activin receptor binding(GO:0070698)