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PRJNA207719: Tissue specific transcriptome profiling

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Results for irx1b+irx4a+irx4b

Z-value: 0.65

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Transcription factors associated with irx1b+irx4a+irx4b

Gene Symbol Gene ID Gene Info
irx4a
ENSDARG00000035648 iroquois homeobox 4a
irx4b
ENSDARG00000036051 iroquois homeobox 4b
irx1b
ENSDARG00000056594 iroquois homeobox 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irx4bdr11_v1_chr19_+_28116410_28116410-0.781.2e-01Click!
irx1bdr11_v1_chr19_-_28130658_28130658-0.662.3e-01Click!
irx4adr11_v1_chr16_-_383664_383664-0.335.9e-01Click!

Activity profile of irx1b+irx4a+irx4b motif

Sorted Z-values of irx1b+irx4a+irx4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_23440632 0.87 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
si:dkey-90m5.4
chr8_-_50147948 0.82 ENSDART00000149010
hp
haptoglobin
chr7_+_56577522 0.74 ENSDART00000149130
ENSDART00000149624
hp
haptoglobin
chr7_+_56577906 0.64 ENSDART00000184023
hp
haptoglobin
chr17_-_5352924 0.60 ENSDART00000167275
supt3h
SPT3 homolog, SAGA and STAGA complex component
chr5_+_66170479 0.53 ENSDART00000172117
gldc
glycine dehydrogenase (decarboxylating)
chr13_+_2908764 0.47 ENSDART00000162362
wu:fj16a03
wu:fj16a03
chr20_-_23440955 0.44 ENSDART00000153386
slc10a4
solute carrier family 10, member 4
chr25_-_29072162 0.43 ENSDART00000169269
arid3b
AT rich interactive domain 3B (BRIGHT-like)
chr3_-_34100700 0.35 ENSDART00000151628
ighv6-1
immunoglobulin heavy variable 6-1
chr24_-_25098719 0.35 ENSDART00000193651
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr5_-_35159379 0.33 ENSDART00000144105
fcho2
FCH domain only 2
chr21_-_45871866 0.26 ENSDART00000161716
larp1
La ribonucleoprotein domain family, member 1
chr5_-_58996324 0.22 ENSDART00000033923
mis12
MIS12 kinetochore complex component
chr18_+_22109379 0.18 ENSDART00000147230
zgc:158868
zgc:158868
chr23_+_45845423 0.17 ENSDART00000183404
lmnl3
lamin L3
chr11_+_14284866 0.17 ENSDART00000163729
si:ch211-262i1.3
si:ch211-262i1.3
chr15_+_11381532 0.16 ENSDART00000124172
si:ch73-321d9.2
si:ch73-321d9.2
chr1_-_7951002 0.16 ENSDART00000138187
si:dkey-79f11.8
si:dkey-79f11.8
chr1_+_53919110 0.15 ENSDART00000020680
nup133
nucleoporin 133
chr2_-_13333932 0.14 ENSDART00000150238
ENSDART00000168258
si:dkey-185p13.1
vps4b
si:dkey-185p13.1
vacuolar protein sorting 4b homolog B (S. cerevisiae)
chr15_+_33991928 0.13 ENSDART00000170177
vwde
von Willebrand factor D and EGF domains
chr8_+_26410197 0.11 ENSDART00000145836
ENSDART00000053447
ifrd2
interferon-related developmental regulator 2
chr3_-_402714 0.11 ENSDART00000134062
ENSDART00000105659
mhc1zja
major histocompatibility complex class I ZJA
chr8_-_23783633 0.10 ENSDART00000132657
si:ch211-163l21.7
si:ch211-163l21.7
chr23_+_19701587 0.10 ENSDART00000104425
dnase1l1
deoxyribonuclease I-like 1
chr23_+_45845159 0.10 ENSDART00000023944
lmnl3
lamin L3
chr6_-_43262400 0.10 ENSDART00000156267
frmd4ba
FERM domain containing 4Ba
chr15_+_37331585 0.09 ENSDART00000170715
zgc:171592
zgc:171592
chr16_-_44709832 0.09 ENSDART00000156784
si:ch211-151m7.6
si:ch211-151m7.6
chr2_-_707152 0.09 ENSDART00000082304
ftr93
finTRIM family, member 93
chr22_-_7778265 0.09 ENSDART00000097276
si:ch73-44m9.3
si:ch73-44m9.3
chr9_-_2945008 0.07 ENSDART00000183452
zak
sterile alpha motif and leucine zipper containing kinase AZK
chr8_+_23784471 0.07 ENSDART00000189457
si:ch211-163l21.8
si:ch211-163l21.8
chr1_+_961607 0.06 ENSDART00000184660
n6amt1
N-6 adenine-specific DNA methyltransferase 1
chr7_-_31830936 0.05 ENSDART00000052514
ENSDART00000129720
cars
cysteinyl-tRNA synthetase
chr20_-_27190393 0.04 ENSDART00000149024
btbd7
BTB (POZ) domain containing 7
chr23_+_40275400 0.04 ENSDART00000184259
fam46ab
family with sequence similarity 46, member Ab
chr21_+_12036238 0.04 ENSDART00000102463
ENSDART00000155426
zgc:162344
zgc:162344
chr13_-_43149063 0.03 ENSDART00000099601
vsir
V-set immunoregulatory receptor
chr23_+_40275601 0.03 ENSDART00000076876
fam46ab
family with sequence similarity 46, member Ab
chr15_-_23522653 0.01 ENSDART00000144685
hmbsb
hydroxymethylbilane synthase, b
chr10_+_45345574 0.01 ENSDART00000166085
ppiab
peptidylprolyl isomerase Ab (cyclophilin A)
chr2_-_7185460 0.01 ENSDART00000092078
rc3h1b
ring finger and CCCH-type domains 1b
chr4_-_5691257 0.01 ENSDART00000110497
tmem63a
transmembrane protein 63A
chr4_+_33012407 0.00 ENSDART00000151873
si:dkey-26h11.2
si:dkey-26h11.2
chr10_-_22912255 0.00 ENSDART00000131992
si:ch1073-143l10.2
si:ch1073-143l10.2

Network of associatons between targets according to the STRING database.

First level regulatory network of irx1b+irx4a+irx4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.2 GO:0071459 protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.0 0.1 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.0 0.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.3 GO:0048268 clathrin coat assembly(GO:0048268)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.6 GO:0030914 STAGA complex(GO:0030914)
0.1 0.2 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.5 GO:0016594 glycine binding(GO:0016594)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID MYC PATHWAY C-MYC pathway