ISMARA results: irx1b+irx4a+irx4b

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PRJNA207719: Tissue specific transcriptome profiling

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Results for irx1b+irx4a+irx4b

Z-value: 0.65

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Transcription factors associated with irx1b+irx4a+irx4b

Gene Symbol	Gene ID	Gene Info
irx4a NCBI UniProt	ENSDARG00000035648	iroquois homeobox 4a
irx4b NCBI UniProt	ENSDARG00000036051	iroquois homeobox 4b
irx1b NCBI UniProt	ENSDARG00000056594	iroquois homeobox 1b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
irx4b	dr11_v1_chr19_+_28116410_28116410	-0.78	1.2e-01	Click!
irx1b	dr11_v1_chr19_-_28130658_28130658	-0.66	2.3e-01	Click!
irx4a	dr11_v1_chr16_-_383664_383664	-0.33	5.9e-01	Click!

Activity profile of irx1b+irx4a+irx4b motif

Sorted Z-values of irx1b+irx4a+irx4b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_23440632 Show fit	0.87	ENSDART00000180685 ENSDART00000042820	si:dkey-90m5.4 NCBI UniProt Show fit	si:dkey-90m5.4
chr8_-_50147948 Show fit	0.82	ENSDART00000149010	hp NCBI UniProt Show fit	haptoglobin
chr7_+_56577522 Show fit	0.74	ENSDART00000149130 ENSDART00000149624	hp NCBI UniProt Show fit	haptoglobin
chr7_+_56577906 Show fit	0.64	ENSDART00000184023	hp NCBI UniProt Show fit	haptoglobin
chr17_-_5352924 Show fit	0.60	ENSDART00000167275	supt3h NCBI UniProt Show fit	SPT3 homolog, SAGA and STAGA complex component
chr5_+_66170479 Show fit	0.53	ENSDART00000172117	gldc NCBI UniProt Show fit	glycine dehydrogenase (decarboxylating)
chr13_+_2908764 Show fit	0.47	ENSDART00000162362	wu:fj16a03 NCBI UniProt Show fit	wu:fj16a03
chr20_-_23440955 Show fit	0.44	ENSDART00000153386	slc10a4 NCBI UniProt Show fit	solute carrier family 10, member 4
chr25_-_29072162 Show fit	0.43	ENSDART00000169269	arid3b NCBI UniProt Show fit	AT rich interactive domain 3B (BRIGHT-like)
chr3_-_34100700 Show fit	0.35	ENSDART00000151628	ighv6-1 NCBI UniProt Show fit	immunoglobulin heavy variable 6-1

Showing 1 to 10 of 47 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of irx1b+irx4a+irx4b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0043966	histone H3 acetylation(GO:0043966)
0.1	0.5	GO:0019464	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.4	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.0	0.3	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.2	GO:0071459	protein localization to kinetochore(GO:0034501) protein localization to chromosome, centromeric region(GO:0071459)
0.0	0.1	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)

Showing 1 to 6 of 6 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0030914	STAGA complex(GO:0030914)
0.2	0.5	GO:0005960	glycine cleavage complex(GO:0005960)
0.0	0.3	GO:0045180	basal cortex(GO:0045180)
0.1	0.2	GO:0000818	nuclear MIS12/MIND complex(GO:0000818)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)

Showing 1 to 5 of 5 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	GO:0016594	glycine binding(GO:0016594)
0.1	0.4	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0004530	deoxyribonuclease I activity(GO:0004530)

Showing 1 to 4 of 4 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	PID MYC PATHWAY	C-MYC pathway

Showing 1 to 1 of 1 entries

Results for irx1b+irx4a+irx4b

Z-value: 0.65

Motif logo

Transcription factors associated with irx1b+irx4a+irx4b

Activity-expression correlation:

Activity profile of irx1b+irx4a+irx4b motif

Sorted Z-values of irx1b+irx4a+irx4b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of irx1b+irx4a+irx4b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category: