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PRJNA207719: Tissue specific transcriptome profiling

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Results for klf15+si:ch211-117k10.3

Z-value: 1.19

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Transcription factors associated with klf15+si:ch211-117k10.3

Gene Symbol Gene ID Gene Info
ENSDARG00000090914 si_ch211-117k10.3
ENSDARG00000091127 Kruppel-like factor 15

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
si:ch211-117k10.3dr11_v1_chr11_-_38510469_38510469-0.791.1e-01Click!
klf15dr11_v1_chr23_-_35195908_351959080.326.1e-01Click!

Activity profile of klf15+si:ch211-117k10.3 motif

Sorted Z-values of klf15+si:ch211-117k10.3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_55758103 3.40 ENSDART00000185964

chr19_+_48117995 1.49 ENSDART00000170865
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1
chr2_+_7192966 1.30 ENSDART00000142735
si:ch211-13f8.1
chr4_-_68569527 1.13 ENSDART00000192091

chr7_+_1449999 1.07 ENSDART00000173864
si:cabz01101003.1
chr24_-_38110779 1.05 ENSDART00000147783
c-reactive protein, pentraxin-related
chr1_-_44638058 0.87 ENSDART00000081835
solute carrier family 43 (amino acid system L transporter), member 1b
chr11_-_40504170 0.83 ENSDART00000165394
si:dkeyp-61b2.1
chr18_-_26715655 0.82 ENSDART00000181497
MALT paracaspase 3
chr9_-_8314028 0.80 ENSDART00000102739
si:ch211-145c1.1
chr18_-_26715156 0.74 ENSDART00000142043
MALT paracaspase 3
chr3_-_16289826 0.63 ENSDART00000131972
branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr12_-_16990896 0.58 ENSDART00000152402
interferon-induced protein with tetratricopeptide repeats 12
chr6_+_36821621 0.58 ENSDART00000104157
transmembrane protein 45a
chr10_+_44719697 0.58 ENSDART00000158087
scavenger receptor class B, member 1
chr5_+_22067570 0.57 ENSDART00000045574
shisa family member 2a
chr11_+_11719575 0.56 ENSDART00000003891
junction plakoglobin a
chr22_-_5918670 0.56 ENSDART00000141373
si:rp71-36a1.1
chr17_-_4395373 0.56 ENSDART00000015923
kelch-like family member 10a
chr10_-_24961310 0.55 ENSDART00000037303
si:ch211-214k5.3
chr13_-_45523026 0.53 ENSDART00000020663
Rh blood group, D antigen
chr25_+_150570 0.53 ENSDART00000170892
ADAM metallopeptidase domain 10b
chr25_-_34284144 0.53 ENSDART00000188109
glucosaminyl (N-acetyl) transferase 3, mucin type
chr20_-_7080427 0.51 ENSDART00000140166
ENSDART00000023677
si:ch211-121a2.2
chr11_+_6010177 0.51 ENSDART00000170047
ENSDART00000022526
ENSDART00000161001
ENSDART00000188999
GTP binding protein 3, mitochondrial
chr5_+_27525477 0.50 ENSDART00000051491
secreted frizzled-related protein 1a
chr2_-_23479714 0.50 ENSDART00000167291
si:ch211-14p21.3
chr6_-_442163 0.49 ENSDART00000163564
ENSDART00000189134
ENSDART00000169789
GRB2-related adaptor protein 2b
chr18_+_46151505 0.48 ENSDART00000015034
ENSDART00000141287
biliverdin reductase B
chr5_-_69621227 0.47 ENSDART00000178543
aldehyde dehydrogenase 2 family (mitochondrial), tandem duplicate 2
chr5_-_16351306 0.47 ENSDART00000168643

chr8_-_53488832 0.46 ENSDART00000191801
choline dehydrogenase
chr24_-_4450238 0.45 ENSDART00000066835
frizzled class receptor 8a
chr16_-_31976269 0.45 ENSDART00000139664
serine/threonine/tyrosine kinase 1
chr22_-_24285432 0.44 ENSDART00000164083
si:ch211-117l17.4
chr25_+_25464630 0.42 ENSDART00000150537
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr23_+_7518294 0.41 ENSDART00000081536
HCK proto-oncogene, Src family tyrosine kinase
chr24_-_32582378 0.41 ENSDART00000066590
retinol dehydrogenase 12, like
chr18_+_33725576 0.40 ENSDART00000146816
si:dkey-145c18.5
chr6_-_43677125 0.40 ENSDART00000150128
forkhead box P1b
chr12_+_10443785 0.38 ENSDART00000029133
SNU13 homolog, small nuclear ribonucleoprotein b (U4/U6.U5)
chr15_-_28618502 0.38 ENSDART00000086902
solute carrier family 6 (neurotransmitter transporter), member 4a
chr7_-_55454406 0.37 ENSDART00000108646
piezo-type mechanosensitive ion channel component 1
chr21_+_11244068 0.36 ENSDART00000163432
AT-rich interaction domain 6
chr17_+_53418445 0.35 ENSDART00000097631
solute carrier family 9 member A1b
chr23_+_36308717 0.35 ENSDART00000131711
heterogeneous nuclear ribonucleoprotein A1b
chr22_+_7738966 0.33 ENSDART00000147073
si:ch73-44m9.5
chr8_-_34762163 0.32 ENSDART00000114080
SET domain containing 1B, b
chr6_+_52918537 0.30 ENSDART00000174229
odorant receptor, family H, subfamily 137, member 1
chr21_+_1143141 0.30 ENSDART00000178294

chr5_-_8636168 0.30 ENSDART00000134877
FYN binding protein a
chr6_+_23712911 0.30 ENSDART00000167795
zgc:158654
chr5_+_9382301 0.29 ENSDART00000124017
UDP glucuronosyltransferase 2 family, polypeptide A7
chr22_-_13042992 0.29 ENSDART00000028787
aryl hydrocarbon receptor 1b
chr20_-_16972351 0.29 ENSDART00000148312
ENSDART00000186702
si:ch73-74h11.1
chr5_-_35264517 0.29 ENSDART00000114981
pentatricopeptide repeat domain 2
chr2_-_51700709 0.29 ENSDART00000188601
transglutaminase 1 like 1
chr9_-_39968820 0.28 ENSDART00000100311
si:zfos-1425h8.1
chr3_-_36690348 0.28 ENSDART00000192513
myosin, heavy chain 11b, smooth muscle
chr4_-_11064073 0.27 ENSDART00000150760
si:dkey-21h14.8
chr6_-_29377092 0.27 ENSDART00000078665
transmembrane protein 131
chr4_-_73572030 0.27 ENSDART00000121652
zinc finger protein 1015
chr19_-_2707048 0.26 ENSDART00000166112
interleukin 6 (interferon, beta 2)
chr4_+_9057427 0.26 ENSDART00000113867
solute carrier family 41 (magnesium transporter), member 2b
chr8_-_52938439 0.25 ENSDART00000168185
nuclear receptor subfamily 6, group A, member 1a
chr21_+_15601100 0.24 ENSDART00000180558
ENSDART00000145454
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr10_-_9115383 0.23 ENSDART00000139324
si:dkeyp-41f9.3
chr22_-_1168291 0.23 ENSDART00000167724
si:ch1073-181h11.4
chr22_-_4872418 0.23 ENSDART00000132360
si:ch73-256j6.6
chr7_-_5711197 0.22 ENSDART00000134367
si:dkey-10h3.2
chr4_-_75505048 0.22 ENSDART00000163665
si:dkey-71l4.5
chr22_-_17474583 0.22 ENSDART00000148027
si:ch211-197g15.8
chr16_+_9713850 0.21 ENSDART00000164103
extracellular matrix protein 1b
chr20_-_48516765 0.21 ENSDART00000150200
si:zfos-223e1.2
chr12_-_4540564 0.21 ENSDART00000106566

chr5_-_71838520 0.20 ENSDART00000174396

chr2_+_44977889 0.20 ENSDART00000144024
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr6_-_42003780 0.19 ENSDART00000032527
caveolin 3
chr24_-_11467004 0.18 ENSDART00000144316
PX domain containing 1b
chr5_-_30074332 0.17 ENSDART00000147963
beta-carotene oxygenase 2a
chr14_+_48960078 0.16 ENSDART00000165514
macrophage migration inhibitory factor
chr10_+_33382858 0.15 ENSDART00000063662
malate dehydrogenase 2, NAD (mitochondrial)
chr14_-_15154695 0.15 ENSDART00000160677
UV-stimulated scaffold protein A
chr22_-_24284961 0.15 ENSDART00000141230
si:ch211-117l17.4
chr7_-_71331690 0.15 ENSDART00000149682
DEAH (Asp-Glu-Ala-His) box helicase 15
chr21_+_25660613 0.15 ENSDART00000134017
si:dkey-17e16.15
chr21_-_45086170 0.14 ENSDART00000188963
Rap guanine nucleotide exchange factor (GEF) 6
chr12_+_5530247 0.14 ENSDART00000114637
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
chr17_+_33313566 0.13 ENSDART00000045040
si:ch211-132f19.7
chr2_-_48512450 0.13 ENSDART00000160132

chr8_+_35356944 0.13 ENSDART00000143243
si:dkeyp-14d3.1
chr9_-_50000144 0.11 ENSDART00000123416
sodium channel, voltage-gated, type I, alpha
chr8_-_13722682 0.10 ENSDART00000142052
si:dkey-258f14.2
chr22_-_6219674 0.10 ENSDART00000182582
si:ch211-274k16.2
chr19_+_13994563 0.09 ENSDART00000164696
transmembrane protein 222b
chr19_-_46037835 0.08 ENSDART00000163815
nucleoporin 153
chr8_+_8947623 0.08 ENSDART00000131215
solute carrier family 35 (UDP-galactose transporter), member 2
chr1_+_7414318 0.08 ENSDART00000127426
si:ch73-383l1.1
chr7_+_13918349 0.08 ENSDART00000172772
ENSDART00000173384
si:cabz01059983.1
chr22_+_12477996 0.07 ENSDART00000177704

chr10_+_5645887 0.07 ENSDART00000171426
PDZ and pleckstrin homology domains 1
chr24_+_42131564 0.07 ENSDART00000153854
WW domain containing E3 ubiquitin protein ligase 1
chr3_+_52467879 0.07 ENSDART00000156039
adhesion G protein-coupled receptor E5a
chr21_-_43117327 0.06 ENSDART00000122352
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
chr22_+_26853254 0.06 ENSDART00000182487
transmembrane protein 186
chr22_-_6777976 0.06 ENSDART00000187946

chr20_+_35279968 0.05 ENSDART00000168216
ENSDART00000153332
family with sequence similarity 49, member A
chr4_+_65306260 0.04 ENSDART00000167558
si:dkey-14o6.8
chr14_-_32089117 0.04 ENSDART00000158014
si:ch211-69b22.5
chr24_+_28525507 0.04 ENSDART00000191121
Rho GTPase activating protein 29a
chr3_+_23703704 0.04 ENSDART00000024256
homeobox B6a
chr7_-_71331499 0.03 ENSDART00000081245
DEAH (Asp-Glu-Ala-His) box helicase 15
chr11_-_19501439 0.03 ENSDART00000158328
ENSDART00000103983
solute carrier family 2 (facilitated glucose transporter), member 9-like 1
chr21_+_13389499 0.02 ENSDART00000151268
zgc:113162
chr10_-_43113731 0.02 ENSDART00000138099
transmembrane protein 167A
chr7_+_44445595 0.02 ENSDART00000108766
cadherin 5
chr8_-_23776399 0.01 ENSDART00000114800
si:ch211-163l21.4
chr5_-_36916790 0.01 ENSDART00000143827
kaptin (actin binding protein)
chr16_+_11029762 0.01 ENSDART00000091183
Ets2 repressor factor like 3
chr16_+_10918252 0.00 ENSDART00000172949
POU class 2 homeobox 2a
chr15_-_23376541 0.00 ENSDART00000078570
C1q and TNF related 5

Network of associatons between targets according to the STRING database.

First level regulatory network of klf15+si:ch211-117k10.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.2 0.5 GO:0019695 choline metabolic process(GO:0019695)
0.2 0.5 GO:0060898 spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.1 0.6 GO:0002159 desmosome assembly(GO:0002159)
0.1 0.4 GO:0006837 serotonin transport(GO:0006837) serotonin uptake(GO:0051610)
0.1 1.5 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.1 0.4 GO:0010482 ventriculo bulbo valve development(GO:0003173) epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.1 0.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.3 GO:0006953 acute-phase response(GO:0006953)
0.0 0.4 GO:0097369 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.9 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.3 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.2 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.5 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 1.3 GO:0007098 centrosome cycle(GO:0007098)
0.0 0.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0016121 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.3 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.4 GO:0000470 maturation of LSU-rRNA(GO:0000470)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.9 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0035060 brahma complex(GO:0035060)
0.0 0.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.3 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.8 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 1.3 GO:0016324 apical plasma membrane(GO:0016324)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.1 0.4 GO:0015222 serotonin:sodium symporter activity(GO:0005335) serotonin transmembrane transporter activity(GO:0015222)
0.1 0.6 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 1.3 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.5 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.6 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.4 GO:0015385 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 1.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.9 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.1 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.4 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 1.6 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins