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PRJNA207719: Tissue specific transcriptome profiling

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Results for klf3+klf8

Z-value: 0.79

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Transcription factors associated with klf3+klf8

Gene Symbol Gene ID Gene Info
klf3
ENSDARG00000015495 Kruppel-like factor 3 (basic)
klf8
ENSDARG00000060661 Kruppel-like factor 8
klf3
ENSDARG00000114143 Kruppel-like factor 3 (basic)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf8dr11_v1_chr21_+_38089036_38089036-0.731.6e-01Click!
klf3dr11_v1_chr1_-_18615063_186150630.069.2e-01Click!

Activity profile of klf3+klf8 motif

Sorted Z-values of klf3+klf8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_22797959 0.88 ENSDART00000183269
pcolcea
procollagen C-endopeptidase enhancer a
chr18_+_5549672 0.75 ENSDART00000184970
nnt2
nicotinamide nucleotide transhydrogenase 2
chr1_-_44940830 0.63 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
tmem176
transmembrane protein 176
chr2_-_35566938 0.62 ENSDART00000029006
ENSDART00000077178
ENSDART00000125298
tnn
tenascin N
chr12_+_34273240 0.56 ENSDART00000037904
socs3b
suppressor of cytokine signaling 3b
chr3_+_55093581 0.54 ENSDART00000101709
hbaa2
hemoglobin, alpha adult 2
chr24_-_40668208 0.48 ENSDART00000171543
smyhc1
slow myosin heavy chain 1
chr24_-_40667800 0.46 ENSDART00000169315
smyhc1
slow myosin heavy chain 1
chr15_+_28410664 0.43 ENSDART00000132028
ENSDART00000057697
ENSDART00000057257
pitpnaa
phosphatidylinositol transfer protein, alpha a
chr20_-_54377933 0.42 ENSDART00000182664
entpd5b
ectonucleoside triphosphate diphosphohydrolase 5b
chr11_+_37278457 0.38 ENSDART00000188946
creld1a
cysteine-rich with EGF-like domains 1a
chr21_+_27448856 0.37 ENSDART00000100784
cfbl
complement factor b-like
chr19_-_677713 0.33 ENSDART00000025146
slc6a19a.1
solute carrier family 6 (neutral amino acid transporter), member 19a, tandem duplicate 1
chr21_+_11244068 0.33 ENSDART00000163432
arid6
AT-rich interaction domain 6
chr7_+_35229645 0.32 ENSDART00000144327
tppp3
tubulin polymerization-promoting protein family member 3
chr10_+_15106808 0.31 ENSDART00000141588
scpp8
secretory calcium-binding phosphoprotein 8
chr24_-_14212521 0.31 ENSDART00000130825
xkr9
XK, Kell blood group complex subunit-related family, member 9
chr24_+_37461457 0.31 ENSDART00000165775
nlrc3
NLR family, CARD domain containing 3
chr18_-_45617146 0.31 ENSDART00000146543
wt1b
wilms tumor 1b
chr6_-_13022166 0.31 ENSDART00000157139
tmbim1a
transmembrane BAX inhibitor motif containing 1a
chr8_-_30204650 0.28 ENSDART00000133209
zgc:162939
zgc:162939
chr7_+_35229805 0.28 ENSDART00000173911
tppp3
tubulin polymerization-promoting protein family member 3
chr1_+_57235896 0.26 ENSDART00000152621
si:dkey-27j5.7
si:dkey-27j5.7
chr7_-_6356875 0.26 ENSDART00000173426
zgc:112234
zgc:112234
chr25_-_28587896 0.25 ENSDART00000111908
si:dkeyp-67e1.6
si:dkeyp-67e1.6
chr4_+_54618332 0.23 ENSDART00000171824
si:ch211-227e10.2
si:ch211-227e10.2
chr1_+_44941031 0.23 ENSDART00000141145
si:dkey-9i23.16
si:dkey-9i23.16
chr5_-_24174956 0.22 ENSDART00000137631
si:ch211-137i24.10
si:ch211-137i24.10
chr4_+_50401133 0.21 ENSDART00000150644
si:dkey-156k2.7
si:dkey-156k2.7
chr1_-_49434798 0.21 ENSDART00000150842
ENSDART00000150789
ATP5MD
si:dkeyp-80c12.10
chr13_-_50567658 0.21 ENSDART00000132281
blnk
B cell linker
chr18_+_7309150 0.19 ENSDART00000052792
cers3b
ceramide synthase 3b
chr22_-_5051689 0.19 ENSDART00000113521
matk
megakaryocyte-associated tyrosine kinase
chr16_-_50918908 0.19 ENSDART00000108744
CU855821.1

chr20_-_52928541 0.19 ENSDART00000162812
fdft1
farnesyl-diphosphate farnesyltransferase 1
chr21_-_29197700 0.18 ENSDART00000172614
si:ch211-57b15.2
si:ch211-57b15.2
chr25_-_36370292 0.18 ENSDART00000152766
CR354435.1
Histone H2B 1/2
chr7_-_6351021 0.18 ENSDART00000159542
zgc:112234
zgc:112234
chr19_+_19786117 0.17 ENSDART00000167757
ENSDART00000163546
hoxa1a
homeobox A1a
chr21_-_280769 0.17 ENSDART00000157753
plgrkt
plasminogen receptor, C-terminal lysine transmembrane protein
chr16_+_44768361 0.17 ENSDART00000036302
upk1a
uroplakin 1a
chr25_+_37348730 0.17 ENSDART00000156639
pamr1
peptidase domain containing associated with muscle regeneration 1
chr4_-_74109792 0.17 ENSDART00000174320
RAB21
zgc:154045
chr6_+_120181 0.16 ENSDART00000151209
ENSDART00000185930
cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr12_+_19030391 0.16 ENSDART00000153927
si:ch73-139e5.2
si:ch73-139e5.2
chr7_+_5968225 0.16 ENSDART00000083397
zgc:165555
zgc:165555
chr20_-_52902693 0.15 ENSDART00000166115
ENSDART00000161050
ctsbb
cathepsin Bb
chr20_+_48129759 0.15 ENSDART00000148494
tram2
translocation associated membrane protein 2
chr15_-_5580093 0.15 ENSDART00000143726
wdr62
WD repeat domain 62
chr17_-_24353462 0.14 ENSDART00000191021
wdpcp
WD repeat containing planar cell polarity effector
chr16_+_23978978 0.14 ENSDART00000058964
ENSDART00000135084
apoa2
apolipoprotein A-II
chr23_+_9057999 0.14 ENSDART00000091899
ccm2l
cerebral cavernous malformation 2-like
chr3_-_1190132 0.14 ENSDART00000149709
smdt1a
single-pass membrane protein with aspartate-rich tail 1a
chr25_-_207214 0.13 ENSDART00000193448
FP236318.3

chr19_+_7847920 0.13 ENSDART00000132454
si:dkeyp-85e10.1
si:dkeyp-85e10.1
chr10_+_15025006 0.13 ENSDART00000145192
ENSDART00000140084
si:dkey-88l16.5
si:dkey-88l16.5
chr7_-_2039060 0.13 ENSDART00000173879
si:cabz01007794.1
si:cabz01007794.1
chr3_+_60034194 0.13 ENSDART00000189858
ENSDART00000153642
CR352258.1

chr12_+_34763795 0.12 ENSDART00000153097
slc38a10
solute carrier family 38, member 10
chr1_-_59571758 0.12 ENSDART00000193546
ENSDART00000167087
wfikkn1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr21_+_21811867 0.11 ENSDART00000185752
neu3.4
sialidase 3 (membrane sialidase), tandem duplicate 4
chr21_-_35832548 0.11 ENSDART00000180840
sgcd
sarcoglycan, delta (dystrophin-associated glycoprotein)
chr8_-_34762163 0.11 ENSDART00000114080
setd1bb
SET domain containing 1B, b
chr11_-_8269227 0.11 ENSDART00000127202
ENSDART00000158079
ENSDART00000158748
si:cabz01021067.1
pimr202
si:cabz01021067.1
Pim proto-oncogene, serine/threonine kinase, related 202
chr8_-_3413139 0.11 ENSDART00000182673
ENSDART00000166741
ENSDART00000169430
ENSDART00000170478
FUT9 (1 of many)
FUT9 (1 of many)
fut9b
zgc:103510
zgc:165519
fucosyltransferase 9b
chr23_-_4930229 0.10 ENSDART00000189456
ngfa
nerve growth factor a (beta polypeptide)
chr19_-_24218942 0.10 ENSDART00000189198
BX547993.2

chr2_+_10007113 0.10 ENSDART00000155213
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr25_+_37435720 0.10 ENSDART00000164390
chmp1a
charged multivesicular body protein 1A
chr4_+_53976731 0.10 ENSDART00000165813
si:ch211-249c2.1
si:ch211-249c2.1
chr6_+_46258866 0.09 ENSDART00000134584
zgc:162324
zgc:162324
chr6_+_41181869 0.09 ENSDART00000002046
opn1mw1
opsin 1 (cone pigments), medium-wave-sensitive, 1
chr7_+_4624926 0.09 ENSDART00000137387
si:dkey-83f18.6
si:dkey-83f18.6
chr9_+_18576047 0.09 ENSDART00000145174
lacc1
laccase (multicopper oxidoreductase) domain containing 1
chr3_+_9332984 0.08 ENSDART00000185184
ENSDART00000183535
LO018550.2

chr22_-_30948457 0.08 ENSDART00000139887
ssuh2.1
ssu-2 homolog, tandem duplicate 1
chr8_-_1973220 0.08 ENSDART00000184435
si:dkey-178e17.1
si:dkey-178e17.1
chr24_+_81527 0.08 ENSDART00000192139
reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr7_-_67317119 0.08 ENSDART00000183915
psmd7
proteasome 26S subunit, non-ATPase 7
chr14_-_22108718 0.07 ENSDART00000054410
med19a
mediator complex subunit 19a
chr12_-_14143344 0.07 ENSDART00000152742
buc2l
bucky ball 2-like
chr22_+_1006573 0.07 ENSDART00000123458
pparda
peroxisome proliferator-activated receptor delta a
chr9_-_11551608 0.07 ENSDART00000128629
fev
FEV (ETS oncogene family)
chr4_+_64562090 0.07 ENSDART00000188810
si:ch211-223a21.3
si:ch211-223a21.3
chr18_+_814328 0.07 ENSDART00000157801
ENSDART00000188492
ENSDART00000184489
fam219b
family with sequence similarity 219, member B
chr17_+_20569806 0.06 ENSDART00000113936
SAMD8
zgc:162183
chr9_-_56420087 0.06 ENSDART00000112016
actr3
ARP3 actin related protein 3 homolog
chr20_+_54356272 0.06 ENSDART00000145735
znf410
zinc finger protein 410
chr9_-_56459660 0.06 ENSDART00000162771
ubxn4
UBX domain protein 4
chr18_+_5618368 0.06 ENSDART00000159945
ulk3
unc-51 like kinase 3
chr2_-_54639964 0.05 ENSDART00000100103
acss2l
acyl-CoA synthetase short chain family member 2 like
chr15_-_47822597 0.05 ENSDART00000193236
ENSDART00000161391
CZQB01095947.1

chr14_+_13453130 0.05 ENSDART00000054849
pls3
plastin 3 (T isoform)
chr6_+_41186320 0.05 ENSDART00000025241
opn1mw2
opsin 1 (cone pigments), medium-wave-sensitive, 2
chr2_-_30135446 0.05 ENSDART00000141906
trpa1a
transient receptor potential cation channel, subfamily A, member 1a
chr18_+_54354 0.04 ENSDART00000097163
zgc:158482
zgc:158482
chr23_-_1017605 0.04 ENSDART00000138290
cdh26.1
cadherin 26, tandem duplicate 1
chr3_+_1179601 0.04 ENSDART00000173378
triobpb
TRIO and F-actin binding protein b
chr11_+_45461419 0.03 ENSDART00000173424
sos1
son of sevenless homolog 1 (Drosophila)
chr23_-_1017428 0.03 ENSDART00000110588
ENSDART00000183158
cdh26.1
cadherin 26, tandem duplicate 1
chr2_-_58900077 0.02 ENSDART00000183362
ENSDART00000190274
mau2
MAU2 sister chromatid cohesion factor
chr5_-_29587351 0.02 ENSDART00000136446
ENSDART00000051434
entpd2a.1
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 1
chr19_-_35450857 0.02 ENSDART00000179357
anln
anillin, actin binding protein
chr7_-_67316903 0.02 ENSDART00000159408
psmd7
proteasome 26S subunit, non-ATPase 7
chr3_-_32927516 0.01 ENSDART00000140117
aoc2
amine oxidase, copper containing 2
chr6_-_52757276 0.01 ENSDART00000159154
AL954861.2

chr6_-_19665114 0.01 ENSDART00000168985
usp43a
ubiquitin specific peptidase 43a
chr6_-_39344259 0.01 ENSDART00000104074
zgc:158846
zgc:158846
chr20_+_50052627 0.00 ENSDART00000188799
cpsf2
cleavage and polyadenylation specific factor 2

Network of associatons between targets according to the STRING database.

First level regulatory network of klf3+klf8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.9 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.2 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.0 0.3 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.5 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.1 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.0 0.2 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
0.0 0.1 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.0 0.6 GO:0046785 microtubule polymerization(GO:0046785)
0.0 0.1 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.0 GO:0050955 thermoception(GO:0050955) detection of temperature stimulus involved in thermoception(GO:0050960) detection of temperature stimulus involved in sensory perception(GO:0050961)
0.0 0.3 GO:0048246 organ regeneration(GO:0031100) macrophage chemotaxis(GO:0048246)
0.0 0.6 GO:0097696 JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0097541 axonemal basal plate(GO:0097541)
0.0 0.1 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.2 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.1 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.5 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.4 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.6 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.1 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL