ISMARA results: klf5l+klf6a+klf6b

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PRJNA207719: Tissue specific transcriptome profiling

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Results for klf5l+klf6a+klf6b

Z-value: 0.60

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Transcription factors associated with klf5l+klf6a+klf6b

Gene Symbol	Gene ID	Gene Info
klf5l NCBI UniProt	ENSDARG00000018757	Kruppel-like factor 5 like
klf6a NCBI UniProt	ENSDARG00000029072	Kruppel-like factor 6a
klf6b NCBI UniProt	ENSDARG00000038561	Kruppel-like factor 6b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
klf6a	dr11_v1_chr24_-_4148914_4148915	-0.65	2.4e-01	Click!
klf5l	dr11_v1_chr21_-_38153824_38153824	0.38	5.3e-01	Click!
klf6b	dr11_v1_chr2_+_48073972_48073972	0.33	5.9e-01	Click!

Activity profile of klf5l+klf6a+klf6b motif

Sorted Z-values of klf5l+klf6a+klf6b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_9952103 Show fit	0.48	ENSDART00000065475	zp2l2 NCBI UniProt Show fit	zona pellucida glycoprotein 2, like 2
chr17_-_2584423 Show fit	0.48	ENSDART00000013506	zp3.2 NCBI UniProt Show fit	zona pellucida glycoprotein 3, tandem duplicate 2
chr22_+_1006573 Show fit	0.42	ENSDART00000123458	pparda NCBI UniProt Show fit	peroxisome proliferator-activated receptor delta a
chr21_-_30293224 Show fit	0.41	ENSDART00000101051	slbp2 NCBI UniProt Show fit	stem-loop binding protein 2
chr13_-_12021566 Show fit	0.38	ENSDART00000125430	pprc1 NCBI UniProt Show fit	peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr22_+_344763 Show fit	0.30	ENSDART00000181934	CU914780.1 NCBI UniProt Show fit
chr19_+_7636941 Show fit	0.26	ENSDART00000081611 ENSDART00000163805 ENSDART00000112404	cgnb NCBI UniProt Show fit	cingulin b
chr17_-_12712776 Show fit	0.25	ENSDART00000064511	il17a/f1 NCBI UniProt Show fit	interleukin 17a/f1
chr6_-_60104628 Show fit	0.25	ENSDART00000057463 ENSDART00000169188	pmepa1 NCBI UniProt Show fit	prostate transmembrane protein, androgen induced 1
chr21_-_5056812 Show fit	0.22	ENSDART00000139713 ENSDART00000140859	zgc:77838 NCBI UniProt Show fit	zgc:77838

Showing 1 to 10 of 78 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of klf5l+klf6a+klf6b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0010887	negative regulation of cholesterol storage(GO:0010887)
0.0	0.5	GO:0007339	binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1	0.4	GO:0040016	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) embryonic cleavage(GO:0040016)
0.0	0.3	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.2	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.2	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0	0.2	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0010586	miRNA metabolic process(GO:0010586)
0.0	0.1	GO:0060017	parathyroid gland development(GO:0060017)

Showing 1 to 10 of 11 entries

Gene overrepresentation in cellular component category:

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Total log-likelihood	Term	Description
0.2	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.2	GO:0098835	presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.1	GO:1990077	primosome complex(GO:1990077)

Showing 1 to 3 of 3 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	GO:0035804	structural constituent of egg coat(GO:0035804)
0.0	0.5	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0	0.4	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.4	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1	0.3	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.1	GO:0001223	transcription coactivator binding(GO:0001223)
0.0	0.1	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)

Showing 1 to 10 of 11 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling

Showing 1 to 1 of 1 entries

Results for klf5l+klf6a+klf6b

Z-value: 0.60

Motif logo

Transcription factors associated with klf5l+klf6a+klf6b

Activity-expression correlation:

Activity profile of klf5l+klf6a+klf6b motif

Sorted Z-values of klf5l+klf6a+klf6b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of klf5l+klf6a+klf6b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: