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PRJNA207719: Tissue specific transcriptome profiling

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Results for lhx1a+lhx1b

Z-value: 0.57

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Transcription factors associated with lhx1a+lhx1b

Gene Symbol Gene ID Gene Info
lhx1b
ENSDARG00000007944 LIM homeobox 1b
lhx1a
ENSDARG00000014018 LIM homeobox 1a
lhx1b
ENSDARG00000111635 LIM homeobox 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx1bdr11_v1_chr5_+_56268436_562684360.217.4e-01Click!
lhx1adr11_v1_chr15_-_27710513_277105750.207.4e-01Click!

Activity profile of lhx1a+lhx1b motif

Sorted Z-values of lhx1a+lhx1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_43297546 0.37 ENSDART00000168002
laptm5
lysosomal protein transmembrane 5
chr15_-_43284021 0.28 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr9_-_9415000 0.26 ENSDART00000146210
si:ch211-214p13.9
si:ch211-214p13.9
chr20_+_11731039 0.25 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr3_-_19368435 0.24 ENSDART00000132987
s1pr5a
sphingosine-1-phosphate receptor 5a
chr1_+_51039558 0.23 ENSDART00000024743
dpy30
dpy-30 histone methyltransferase complex regulatory subunit
chr22_-_19552796 0.22 ENSDART00000148088
ENSDART00000105485
si:dkey-78l4.14
si:dkey-78l4.14
chr7_-_38658411 0.22 ENSDART00000109463
ENSDART00000017155
npsn
nephrosin
chr8_+_50953776 0.21 ENSDART00000013870
zgc:56596
zgc:56596
chr24_+_2495197 0.20 ENSDART00000146887
f13a1a.1
coagulation factor XIII, A1 polypeptide a, tandem duplicate 1
chr10_-_11261565 0.20 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr23_+_4689626 0.19 ENSDART00000131532
gp9
glycoprotein IX (platelet)
chr19_+_2631565 0.19 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr1_+_10318089 0.18 ENSDART00000029774
pip4p1b
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b
chr19_+_46158078 0.18 ENSDART00000183933
ENSDART00000164055
cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr23_-_16485190 0.18 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr4_+_12966640 0.17 ENSDART00000113357
vhll
von Hippel-Lindau tumor suppressor like
chr4_+_16885854 0.16 ENSDART00000017726
etnk1
ethanolamine kinase 1
chr2_-_16217344 0.15 ENSDART00000152031
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr4_+_9669717 0.15 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr3_-_15999501 0.15 ENSDART00000160668
nme3
NME/NM23 nucleoside diphosphate kinase 3
chr21_-_20939488 0.15 ENSDART00000039043
rgs7bpb
regulator of G protein signaling 7 binding protein b
chr3_-_32818607 0.14 ENSDART00000075465
mylpfa
myosin light chain, phosphorylatable, fast skeletal muscle a
chr5_+_4054704 0.14 ENSDART00000140537
dhrs11a
dehydrogenase/reductase (SDR family) member 11a
chr3_+_26342768 0.13 ENSDART00000163832
si:ch211-156b7.4
si:ch211-156b7.4
chr8_-_49728590 0.13 ENSDART00000135714
ENSDART00000138810
ENSDART00000098319
gkap1
G kinase anchoring protein 1
chr12_+_45200744 0.13 ENSDART00000098932
wbp2
WW domain binding protein 2
chr9_-_27398369 0.13 ENSDART00000186499
tex30
testis expressed 30
chr16_+_54209504 0.13 ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr19_-_5769728 0.12 ENSDART00000133106
si:ch211-264f5.6
si:ch211-264f5.6
chr6_-_35052145 0.12 ENSDART00000073970
ENSDART00000185790
uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr19_-_5769553 0.11 ENSDART00000175003
si:ch211-264f5.6
si:ch211-264f5.6
chr1_-_51038885 0.11 ENSDART00000035150
spast
spastin
chr10_+_11261576 0.11 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr23_-_31969786 0.11 ENSDART00000134550
ormdl2
ORMDL sphingolipid biosynthesis regulator 2
chr5_-_31901468 0.11 ENSDART00000147814
ENSDART00000141446
coro1cb
coronin, actin binding protein, 1Cb
chr25_-_13490744 0.11 ENSDART00000056721
ldhd
lactate dehydrogenase D
chr3_-_29941357 0.10 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr21_-_2415808 0.10 ENSDART00000171179
si:ch211-241b2.5
si:ch211-241b2.5
chr13_+_11440389 0.10 ENSDART00000186463
zbtb18
zinc finger and BTB domain containing 18
chr6_-_50730749 0.10 ENSDART00000157153
ENSDART00000110441
pigu
phosphatidylinositol glycan anchor biosynthesis, class U
chr24_+_26328787 0.10 ENSDART00000003884
mynn
myoneurin
chr15_-_20939579 0.10 ENSDART00000152371
usp2a
ubiquitin specific peptidase 2a
chr22_-_28226948 0.10 ENSDART00000147686
si:dkey-222p3.1
si:dkey-222p3.1
chr1_+_6172786 0.10 ENSDART00000126468
prkag3a
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr22_-_22242884 0.10 ENSDART00000020937
hdgfl2
HDGF like 2
chr5_+_61301525 0.10 ENSDART00000128773
doc2b
double C2-like domains, beta
chr2_+_38373272 0.10 ENSDART00000113111
psmb5
proteasome subunit beta 5
chr4_+_77943184 0.10 ENSDART00000159094
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr23_-_4409668 0.10 ENSDART00000081823
si:ch73-142c19.1
si:ch73-142c19.1
chr17_-_16422654 0.10 ENSDART00000150149
tdp1
tyrosyl-DNA phosphodiesterase 1
chr6_+_11989537 0.09 ENSDART00000190817
baz2ba
bromodomain adjacent to zinc finger domain, 2Ba
chr8_+_19504011 0.09 ENSDART00000158859
ENSDART00000159044
sec22bb
SEC22 homolog B, vesicle trafficking protein b
chr23_-_17509656 0.09 ENSDART00000148423
dnajc5ab
DnaJ (Hsp40) homolog, subfamily C, member 5ab
chr25_-_21031007 0.09 ENSDART00000138985
gnaia
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr22_-_12160283 0.09 ENSDART00000146785
ENSDART00000128176
tmem163b
transmembrane protein 163b
chr2_+_105748 0.09 ENSDART00000169601
CABZ01098670.1

chr6_-_40029423 0.09 ENSDART00000103230
pfkfb4b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b
chr20_-_28642061 0.08 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr11_-_40204621 0.08 ENSDART00000086287
znf362a
zinc finger protein 362a
chr24_-_26328721 0.08 ENSDART00000125468
apodb
apolipoprotein Db
chr5_+_41477954 0.08 ENSDART00000185871
pias2
protein inhibitor of activated STAT, 2
chr13_+_33268657 0.08 ENSDART00000002095
tmem39b
transmembrane protein 39B
chr4_+_5255041 0.08 ENSDART00000137966
ccdc167
coiled-coil domain containing 167
chr6_+_35052721 0.08 ENSDART00000191090
ENSDART00000082940
uhmk1
U2AF homology motif (UHM) kinase 1
chr1_-_669717 0.08 ENSDART00000160564
cyyr1
cysteine/tyrosine-rich 1
chr22_-_10156581 0.08 ENSDART00000168304
rbck1
RanBP-type and C3HC4-type zinc finger containing 1
chr23_+_20640484 0.07 ENSDART00000054691
uba1
ubiquitin-like modifier activating enzyme 1
chr9_-_14504834 0.07 ENSDART00000056103
nrp2b
neuropilin 2b
chr1_-_45616470 0.07 ENSDART00000150165
atf7ip
activating transcription factor 7 interacting protein
chr6_-_30839763 0.07 ENSDART00000154228
sgip1a
SH3-domain GRB2-like (endophilin) interacting protein 1a
chr23_-_16484383 0.07 ENSDART00000187839
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr20_-_45812144 0.07 ENSDART00000147897
ENSDART00000147637
fermt1
fermitin family member 1
chr5_+_60590796 0.06 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr23_-_35649000 0.06 ENSDART00000053310
tmem18
transmembrane protein 18
chr10_-_11261386 0.06 ENSDART00000189946
ptbp3
polypyrimidine tract binding protein 3
chr3_-_26806032 0.06 ENSDART00000143710
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr6_-_55399214 0.06 ENSDART00000168367
ctsa
cathepsin A
chr10_+_17235370 0.06 ENSDART00000038780
sppl3
signal peptide peptidase 3
chr17_+_45405821 0.06 ENSDART00000189482
ENSDART00000177422
tagapa
T cell activation RhoGTPase activating protein a
chr16_+_13965923 0.05 ENSDART00000103857
zgc:162509
zgc:162509
chr3_-_26787430 0.05 ENSDART00000087047
rab40c
RAB40c, member RAS oncogene family
chr5_+_41477526 0.05 ENSDART00000153567
pias2
protein inhibitor of activated STAT, 2
chr1_+_54124209 0.05 ENSDART00000187730
LO017722.1

chr23_-_18567088 0.05 ENSDART00000192371
sephs2
selenophosphate synthetase 2
chr3_+_36424055 0.05 ENSDART00000170318
si:ch1073-443f11.2
si:ch1073-443f11.2
chr2_-_30668580 0.05 ENSDART00000087270
ctnnd2b
catenin (cadherin-associated protein), delta 2b
chr16_+_2820340 0.05 ENSDART00000092299
ENSDART00000192931
ENSDART00000148512
si:dkey-288i20.2
si:dkey-288i20.2
chr8_+_7801060 0.05 ENSDART00000161618
tfe3a
transcription factor binding to IGHM enhancer 3a
chr6_+_7444899 0.04 ENSDART00000053775
arf3b
ADP-ribosylation factor 3b
chr8_-_53926228 0.04 ENSDART00000015554
ubiad1
UbiA prenyltransferase domain containing 1
chr6_-_12912606 0.04 ENSDART00000164640
ical1
islet cell autoantigen 1-like
chr24_+_28953089 0.04 ENSDART00000153761
rnpc3
RNA-binding region (RNP1, RRM) containing 3
chr1_+_21731382 0.04 ENSDART00000054395
pax5
paired box 5
chr16_-_28856112 0.04 ENSDART00000078543
syt11b
synaptotagmin XIb
chr25_-_25058508 0.04 ENSDART00000087570
ENSDART00000178891
FQ311928.1

chr12_+_48480632 0.04 ENSDART00000158157
arhgap44
Rho GTPase activating protein 44
chr10_+_45089820 0.04 ENSDART00000175481
camk2b2
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr4_+_72723304 0.04 ENSDART00000186791
ENSDART00000158902
ENSDART00000191925
rab3ip
RAB3A interacting protein (rabin3)
chr21_+_25802190 0.03 ENSDART00000128987
nf2b
neurofibromin 2b (merlin)
chr23_+_4709607 0.03 ENSDART00000166503
ENSDART00000158752
ENSDART00000163860
ENSDART00000172739
raf1a
raf1a
Raf-1 proto-oncogene, serine/threonine kinase a
Raf-1 proto-oncogene, serine/threonine kinase a
chr16_-_12173399 0.03 ENSDART00000142574
clstn3
calsyntenin 3
chr7_+_22809905 0.03 ENSDART00000166900
ENSDART00000143455
ENSDART00000126037
sf1
splicing factor 1
chr19_+_7424347 0.03 ENSDART00000004622
sf3b4
splicing factor 3b, subunit 4
chr24_-_35767501 0.03 ENSDART00000105680
ENSDART00000042290
ENSDART00000166264
dtna
dystrobrevin, alpha
chr17_-_200316 0.03 ENSDART00000190561
CABZ01083778.1

chr25_+_4751879 0.03 ENSDART00000169465
si:zfos-2372e4.1
si:zfos-2372e4.1
chr6_-_11768198 0.03 ENSDART00000183463
march7
membrane-associated ring finger (C3HC4) 7
chr11_-_25733910 0.03 ENSDART00000171935
brpf3a
bromodomain and PHD finger containing, 3a
chr25_+_4855549 0.03 ENSDART00000163839
ap4e1
adaptor-related protein complex 4, epsilon 1 subunit
chr16_-_42965192 0.03 ENSDART00000113714
mtx1a
metaxin 1a
chr25_+_18711804 0.03 ENSDART00000011149
fam185a
family with sequence similarity 185, member A
chr24_+_26329018 0.02 ENSDART00000145752
mynn
myoneurin
chr9_-_47472998 0.02 ENSDART00000134480
tns1b
tensin 1b
chr6_-_35052388 0.02 ENSDART00000181000
ENSDART00000170116
uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr6_-_34838397 0.02 ENSDART00000060169
ENSDART00000169605
mier1a
mesoderm induction early response 1a, transcriptional regulator
chr8_-_12867128 0.02 ENSDART00000142201
slc2a6
solute carrier family 2 (facilitated glucose transporter), member 6
chr23_+_17509794 0.02 ENSDART00000148457
gid8b
GID complex subunit 8 homolog b (S. cerevisiae)
chr9_+_34641237 0.02 ENSDART00000133996
shox
short stature homeobox
chr24_-_40860603 0.02 ENSDART00000188032
CU633479.7

chr7_+_4474880 0.02 ENSDART00000143528
si:dkey-83f18.14
si:dkey-83f18.14
chr4_-_1801519 0.02 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr21_-_13972745 0.02 ENSDART00000143874
akna
AT-hook transcription factor
chr21_-_35419486 0.02 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr19_+_5480327 0.02 ENSDART00000148794
jupb
junction plakoglobin b
chr3_+_39853788 0.01 ENSDART00000154869
cacna1ha
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr10_+_42423318 0.01 ENSDART00000134282
npy8ar
neuropeptide Y receptor Y8a
chr6_+_39905021 0.01 ENSDART00000064904
endou
endonuclease, polyU-specific
chr6_-_44402358 0.01 ENSDART00000193007
ENSDART00000193603
pdzrn3b
PDZ domain containing RING finger 3b
chr9_+_24159725 0.01 ENSDART00000137756
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr9_+_24159280 0.01 ENSDART00000184624
ENSDART00000178422
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr12_+_7497882 0.01 ENSDART00000134608
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr10_+_16584382 0.01 ENSDART00000112039
CR790388.1

chr5_-_30620625 0.01 ENSDART00000098273
tcnl
transcobalamin like
chr9_+_54039006 0.01 ENSDART00000112441
tlr7
toll-like receptor 7
chr15_-_35112937 0.01 ENSDART00000154565
ENSDART00000099642
zgc:77118
zgc:77118
chr16_+_23303859 0.00 ENSDART00000006093
slc50a1
solute carrier family 50 (sugar efflux transporter), member 1
chr21_-_17482465 0.00 ENSDART00000004548
barhl1b
BarH-like homeobox 1b
chr17_+_28533102 0.00 ENSDART00000156218
mdga2a
MAM domain containing glycosylphosphatidylinositol anchor 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx1a+lhx1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0000012 single strand break repair(GO:0000012)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214) mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.1 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.0 0.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.1 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.0 GO:0071498 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.0 0.2 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.1 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.1 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.3 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.2 GO:0030891 VCB complex(GO:0030891)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.1 GO:0032838 cell projection cytoplasm(GO:0032838)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.1 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.0 0.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.2 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.1 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.0 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen