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PRJNA207719: Tissue specific transcriptome profiling

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Results for lhx3+lhx4

Z-value: 1.36

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Transcription factors associated with lhx3+lhx4

Gene Symbol Gene ID Gene Info
lhx3
ENSDARG00000003803 LIM homeobox 3
lhx4
ENSDARG00000039458 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx4dr11_v1_chr8_-_14484599_144845990.951.3e-02Click!
LHX3dr11_v1_chr5_+_71802014_718020140.847.3e-02Click!

Activity profile of lhx3+lhx4 motif

Sorted Z-values of lhx3+lhx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_9669717 2.51 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr21_-_20939488 2.00 ENSDART00000039043
rgs7bpb
regulator of G protein signaling 7 binding protein b
chr9_+_34641237 1.75 ENSDART00000133996
shox
short stature homeobox
chr20_+_34933183 1.51 ENSDART00000062738
snap25a
synaptosomal-associated protein, 25a
chr15_-_44601331 1.34 ENSDART00000161514
zgc:165508
zgc:165508
chr9_-_42418470 1.30 ENSDART00000144353
calcrla
calcitonin receptor-like a
chr10_-_27049170 1.27 ENSDART00000143451
cnih2
cornichon family AMPA receptor auxiliary protein 2
chr9_+_54039006 1.19 ENSDART00000112441
tlr7
toll-like receptor 7
chr21_+_3093419 1.18 ENSDART00000162520
SHC3
SHC adaptor protein 3
chr4_-_5019113 1.13 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2
chr8_-_34052019 1.12 ENSDART00000040126
ENSDART00000159208
ENSDART00000048994
ENSDART00000098822
pbx3b
pre-B-cell leukemia homeobox 3b
chr18_+_21408794 1.10 ENSDART00000140161
necab2
N-terminal EF-hand calcium binding protein 2
chr12_+_1139690 1.09 ENSDART00000160442
CABZ01072885.1

chr3_+_29714775 1.08 ENSDART00000041388
cacng2a
calcium channel, voltage-dependent, gamma subunit 2a
chr17_-_29119362 1.05 ENSDART00000104204
foxg1a
forkhead box G1a
chr10_+_45089820 1.03 ENSDART00000175481
camk2b2
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr25_-_13839743 1.01 ENSDART00000158780
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr16_+_46111849 1.01 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr1_+_33969015 1.00 ENSDART00000042984
ENSDART00000146530
epha6
eph receptor A6
chr18_+_1703984 1.00 ENSDART00000114010
slitrk3a
SLIT and NTRK-like family, member 3a
chr7_-_28148310 0.99 ENSDART00000044208
lmo1
LIM domain only 1
chr17_+_15433518 0.97 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr9_-_31278048 0.95 ENSDART00000022204
zic5
zic family member 5 (odd-paired homolog, Drosophila)
chr17_+_15433671 0.95 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr9_+_24159280 0.95 ENSDART00000184624
ENSDART00000178422
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr10_+_22381802 0.95 ENSDART00000112484
nlgn2b
neuroligin 2b
chr6_-_51386656 0.93 ENSDART00000154732
ENSDART00000177990
ENSDART00000184928
ENSDART00000180197
ptprt
protein tyrosine phosphatase, receptor type, t
chr13_-_29421331 0.91 ENSDART00000150228
chata
choline O-acetyltransferase a
chr6_-_11768198 0.91 ENSDART00000183463
march7
membrane-associated ring finger (C3HC4) 7
chr11_-_1509773 0.90 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr25_+_7671640 0.90 ENSDART00000145367
kcnj11l
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr20_+_40457599 0.88 ENSDART00000017553
serinc1
serine incorporator 1
chr2_-_9059955 0.88 ENSDART00000022768
ak5
adenylate kinase 5
chr8_-_39952727 0.86 ENSDART00000181310
cabp1a
calcium binding protein 1a
chr16_-_28856112 0.84 ENSDART00000078543
syt11b
synaptotagmin XIb
chr12_-_26383242 0.83 ENSDART00000152941
usp54b
ubiquitin specific peptidase 54b
chr2_+_20430366 0.82 ENSDART00000155108
si:ch211-153l6.6
si:ch211-153l6.6
chr20_+_52389858 0.81 ENSDART00000185863
ENSDART00000166651
arhgap39
Rho GTPase activating protein 39
chr24_+_24461341 0.81 ENSDART00000147658
bhlhe22
basic helix-loop-helix family, member e22
chr2_-_30668580 0.80 ENSDART00000087270
ctnnd2b
catenin (cadherin-associated protein), delta 2b
chr10_-_2524297 0.80 ENSDART00000192475
CU856539.1

chr6_+_7444899 0.79 ENSDART00000053775
arf3b
ADP-ribosylation factor 3b
chr3_-_30061985 0.79 ENSDART00000189583
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr23_+_16638639 0.79 ENSDART00000143545
snphb
syntaphilin b
chr1_+_12766351 0.79 ENSDART00000165785
pcdh10a
protocadherin 10a
chr5_-_21422390 0.78 ENSDART00000144198
tenm1
teneurin transmembrane protein 1
chr17_+_13664442 0.78 ENSDART00000171689
lrfn5a
leucine rich repeat and fibronectin type III domain containing 5a
chr8_+_31821396 0.77 ENSDART00000077053
plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr1_+_6172786 0.76 ENSDART00000126468
prkag3a
protein kinase, AMP-activated, gamma 3a non-catalytic subunit
chr15_+_22435460 0.76 ENSDART00000031976
tmem136a
transmembrane protein 136a
chr18_-_38088099 0.74 ENSDART00000146120
luzp2
leucine zipper protein 2
chr14_-_4556896 0.73 ENSDART00000044678
ENSDART00000192863
GABRA2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr19_-_30524952 0.73 ENSDART00000103506
hpcal4
hippocalcin like 4
chr9_-_51436377 0.72 ENSDART00000006612
tbr1b
T-box, brain, 1b
chr11_+_30663300 0.72 ENSDART00000161662
ttbk1a
tau tubulin kinase 1a
chr15_-_15449929 0.72 ENSDART00000101918
proca1
protein interacting with cyclin A1
chr5_-_67911111 0.72 ENSDART00000051833
gsx1
GS homeobox 1
chr20_+_32552912 0.71 ENSDART00000009691
scml4
Scm polycomb group protein like 4
chr3_-_48716422 0.70 ENSDART00000164979
si:ch211-114m9.1
si:ch211-114m9.1
chr8_+_10561922 0.70 ENSDART00000133348
fam19a5l
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5-like
chr19_+_5480327 0.69 ENSDART00000148794
jupb
junction plakoglobin b
chr24_-_7697274 0.69 ENSDART00000186077
syt5b
synaptotagmin Vb
chr2_+_29491314 0.68 ENSDART00000181774
dlgap1a
discs, large (Drosophila) homolog-associated protein 1a
chr10_-_34870667 0.67 ENSDART00000161272
dclk1a
doublecortin-like kinase 1a
chr16_-_44945224 0.66 ENSDART00000156921
ncam3
neural cell adhesion molecule 3
chr8_-_34051548 0.66 ENSDART00000105204
pbx3b
pre-B-cell leukemia homeobox 3b
chr7_+_19552381 0.66 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr9_+_29643036 0.65 ENSDART00000023210
ENSDART00000175160
trim13
tripartite motif containing 13
chr9_+_24159725 0.64 ENSDART00000137756
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr10_-_34871737 0.64 ENSDART00000138755
dclk1a
doublecortin-like kinase 1a
chr24_+_24461558 0.64 ENSDART00000182424
bhlhe22
basic helix-loop-helix family, member e22
chr6_+_49551614 0.63 ENSDART00000022581
rab22a
RAB22A, member RAS oncogene family
chr20_+_19512727 0.61 ENSDART00000063696
atraid
all-trans retinoic acid-induced differentiation factor
chr8_+_26141680 0.61 ENSDART00000078334
celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
chr10_-_2524917 0.60 ENSDART00000188642
CU856539.1

chr19_-_5865766 0.59 ENSDART00000191007
LO018585.1

chr14_+_3411771 0.59 ENSDART00000164778
trpc3
transient receptor potential cation channel, subfamily C, member 3
chr16_-_41004731 0.58 ENSDART00000102591
KCNV1
si:dkey-201i6.2
chr23_-_6660985 0.58 ENSDART00000162405
CR450824.2

chr22_-_13466246 0.58 ENSDART00000134035
cntnap5b
contactin associated protein-like 5b
chr20_+_32523576 0.58 ENSDART00000147319
scml4
Scm polycomb group protein like 4
chr1_-_19215336 0.58 ENSDART00000162949
ENSDART00000170680
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr24_+_15020402 0.57 ENSDART00000148102
dok6
docking protein 6
chr2_+_2223837 0.57 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr16_+_33593116 0.57 ENSDART00000013148
pou3f1
POU class 3 homeobox 1
chr2_+_38554260 0.57 ENSDART00000171527
cdh24b
cadherin 24, type 2b
chr3_-_56456527 0.56 ENSDART00000156553
cyth1a
cytohesin 1a
chr12_+_31735159 0.55 ENSDART00000185442
RNF157
si:dkey-49c17.3
chr4_-_2219705 0.54 ENSDART00000131046
si:ch73-278m9.1
si:ch73-278m9.1
chr19_-_41371978 0.54 ENSDART00000166063
ENSDART00000170343
slc25a13
solute carrier family 25 (aspartate/glutamate carrier), member 13
chr23_+_30730121 0.53 ENSDART00000134141
asxl1
additional sex combs like transcriptional regulator 1
chr11_+_41242644 0.52 ENSDART00000172008
pax7a
paired box 7a
chr22_-_22416337 0.52 ENSDART00000142947
ENSDART00000089569
camsap2a
calmodulin regulated spectrin-associated protein family, member 2a
chr7_-_71829649 0.52 ENSDART00000160449
cacnb2a
calcium channel, voltage-dependent, beta 2a
chr17_-_42213285 0.51 ENSDART00000140549
nkx2.2a
NK2 homeobox 2a
chr14_-_17306261 0.51 ENSDART00000191747
jakmip1
janus kinase and microtubule interacting protein 1
chr3_+_34919810 0.51 ENSDART00000055264
ca10b
carbonic anhydrase Xb
chr9_-_37749973 0.50 ENSDART00000087663
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr1_+_6862917 0.50 ENSDART00000182953
erbb4a
erb-b2 receptor tyrosine kinase 4a
chr7_+_13382852 0.50 ENSDART00000166318
dagla
diacylglycerol lipase, alpha
chr10_-_43404027 0.50 ENSDART00000086227
edil3b
EGF-like repeats and discoidin I-like domains 3b
chr13_-_29420885 0.50 ENSDART00000024225
chata
choline O-acetyltransferase a
chr5_+_21144269 0.49 ENSDART00000028087
cds2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr5_-_34185115 0.49 ENSDART00000192771
fibcd1
fibrinogen C domain containing 1
chr19_-_20482261 0.49 ENSDART00000056205
satb1a
SATB homeobox 1a
chr16_-_29480335 0.49 ENSDART00000148930
lingo4b
leucine rich repeat and Ig domain containing 4b
chr4_-_75157223 0.49 ENSDART00000174127
CABZ01066312.1

chr13_+_11440389 0.49 ENSDART00000186463
zbtb18
zinc finger and BTB domain containing 18
chr19_+_24872159 0.48 ENSDART00000158490
si:ch211-195b13.1
si:ch211-195b13.1
chr11_+_28476298 0.48 ENSDART00000122319
lrrc38b
leucine rich repeat containing 38b
chr7_+_26629084 0.47 ENSDART00000101044
ENSDART00000173765
hsbp1a
heat shock factor binding protein 1a
chr3_+_39853788 0.47 ENSDART00000154869
cacna1ha
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr11_+_30057762 0.47 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr5_+_19712011 0.46 ENSDART00000131924
fam222a
family with sequence similarity 222, member A
chr22_-_26865361 0.46 ENSDART00000182504
hmox2a
heme oxygenase 2a
chr23_+_4253957 0.46 ENSDART00000008761
arl6ip5b
ADP-ribosylation factor-like 6 interacting protein 5b
chr15_-_18162647 0.45 ENSDART00000012064
pih1d2
PIH1 domain containing 2
chr1_-_21297748 0.45 ENSDART00000142109
npy1r
neuropeptide Y receptor Y1
chr6_+_51773873 0.45 ENSDART00000156516
tmem74b
transmembrane protein 74B
chr13_+_18371208 0.45 ENSDART00000138172
ccar1
cell division cycle and apoptosis regulator 1
chr25_-_25058508 0.44 ENSDART00000087570
ENSDART00000178891
FQ311928.1

chr21_-_17482465 0.44 ENSDART00000004548
barhl1b
BarH-like homeobox 1b
chr6_+_40591149 0.44 ENSDART00000189060
ENSDART00000188298
frs3
fibroblast growth factor receptor substrate 3
chr5_+_44064764 0.43 ENSDART00000143843
si:dkey-84j12.1
si:dkey-84j12.1
chr24_+_20969358 0.43 ENSDART00000129675
drd3
dopamine receptor D3
chr15_+_22867174 0.43 ENSDART00000035812
grik4
glutamate receptor, ionotropic, kainate 4
chr20_+_4060839 0.43 ENSDART00000178565
TRIM67
tripartite motif containing 67
chr17_-_2386569 0.43 ENSDART00000121614
PLCB2
phospholipase C beta 2
chr8_+_25959940 0.42 ENSDART00000143011
ENSDART00000140626
si:dkey-72l14.4
si:dkey-72l14.4
chr10_-_5844915 0.42 ENSDART00000185929
ankrd55
ankyrin repeat domain 55
chr21_-_18648861 0.41 ENSDART00000112113
si:dkey-112m2.1
si:dkey-112m2.1
chr9_+_33009284 0.41 ENSDART00000036926
vangl1
VANGL planar cell polarity protein 1
chr4_+_12111154 0.41 ENSDART00000036779
tmem178b
transmembrane protein 178B
chr17_+_11675362 0.41 ENSDART00000157911
kif26ba
kinesin family member 26Ba
chr19_-_11106315 0.41 ENSDART00000059102
arhgef1a
Rho guanine nucleotide exchange factor (GEF) 1a
chr6_-_8377055 0.40 ENSDART00000131513
ilf3a
interleukin enhancer binding factor 3a
chr23_-_18707418 0.40 ENSDART00000144668
ENSDART00000141205
ENSDART00000016765
zgc:103759
zgc:103759
chr4_-_75158035 0.40 ENSDART00000174353
CABZ01066312.1

chr13_+_40034176 0.40 ENSDART00000189797
golga7bb
golgin A7 family, member Bb
chr16_+_54209504 0.40 ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr5_+_42400777 0.40 ENSDART00000183114
BX548073.8

chr13_+_15656042 0.39 ENSDART00000134240
mark3a
MAP/microtubule affinity-regulating kinase 3a
chr20_-_20930926 0.39 ENSDART00000123909
btbd6b
BTB (POZ) domain containing 6b
chr18_+_924949 0.39 ENSDART00000170888
ENSDART00000193163
pkma
pyruvate kinase M1/2a
chr7_+_10701770 0.39 ENSDART00000167323
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr21_+_13387965 0.39 ENSDART00000134347
zgc:113162
zgc:113162
chr20_-_20931197 0.39 ENSDART00000152726
btbd6b
BTB (POZ) domain containing 6b
chr3_-_47876427 0.38 ENSDART00000180844
ENSDART00000124480
adgrl1a
adhesion G protein-coupled receptor L1a
chr11_+_7432533 0.38 ENSDART00000180977
adgrl2a
adhesion G protein-coupled receptor L2a
chr13_+_33282095 0.38 ENSDART00000135200
ccdc28b
coiled-coil domain containing 28B
chr15_+_23550890 0.38 ENSDART00000009796
ENSDART00000152720
MARK4
si:dkey-31m14.7
chr9_+_2574122 0.38 ENSDART00000166326
ENSDART00000191822
CIR1
si:ch73-167c12.2
chr9_+_36314867 0.37 ENSDART00000176763
lrp1bb
low density lipoprotein receptor-related protein 1Bb
chr15_+_32297441 0.37 ENSDART00000153657
trim3a
tripartite motif containing 3a
chr25_-_6432463 0.37 ENSDART00000110389
ptpn9a
protein tyrosine phosphatase, non-receptor type 9, a
chr1_-_15797663 0.37 ENSDART00000177122
SGCZ
sarcoglycan zeta
chr11_-_25733910 0.37 ENSDART00000171935
brpf3a
bromodomain and PHD finger containing, 3a
chr5_+_42379517 0.35 ENSDART00000103325
pimr59
Pim proto-oncogene, serine/threonine kinase, related 59
chr1_+_38858399 0.35 ENSDART00000165454
CU915762.1

chr22_-_26865181 0.35 ENSDART00000138311
hmox2a
heme oxygenase 2a
chr5_+_42386705 0.35 ENSDART00000143034
pimr58
Pim proto-oncogene, serine/threonine kinase, related 58
chr5_+_42407962 0.35 ENSDART00000188489
BX548073.11

chr15_-_46718759 0.35 ENSDART00000085926
ENSDART00000154577
zgc:162872
zgc:162872
chr5_+_42393896 0.34 ENSDART00000189550
BX548073.13

chr7_+_71547747 0.34 ENSDART00000180869
adcyap1a
adenylate cyclase activating polypeptide 1a
chr14_-_2933185 0.34 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
si:dkey-201i24.6
chr17_+_16564921 0.34 ENSDART00000151904
foxn3
forkhead box N3
chr17_-_39772999 0.34 ENSDART00000155727
pimr60
Pim proto-oncogene, serine/threonine kinase, related 60
chr7_+_10701938 0.33 ENSDART00000158162
arnt2
aryl-hydrocarbon receptor nuclear translocator 2
chr20_-_28642061 0.33 ENSDART00000135513
rgs6
regulator of G protein signaling 6
chr23_-_10048533 0.32 ENSDART00000166663
plxnb1a
plexin b1a
chr5_+_32009542 0.32 ENSDART00000182025
ENSDART00000179879
scai
suppressor of cancer cell invasion
chr21_+_27513859 0.32 ENSDART00000065420
pacs1a
phosphofurin acidic cluster sorting protein 1a
chr17_-_40956035 0.32 ENSDART00000124715
si:dkey-16j16.4
si:dkey-16j16.4
chr4_-_20081621 0.32 ENSDART00000024647
dennd6b
DENN/MADD domain containing 6B
chr13_+_31205439 0.31 ENSDART00000132326
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr11_+_40812590 0.31 ENSDART00000186690
errfi1a
ERBB receptor feedback inhibitor 1a
chr12_-_41684729 0.30 ENSDART00000184461
jakmip3
Janus kinase and microtubule interacting protein 3
chr16_+_28932038 0.30 ENSDART00000149480
npr1b
natriuretic peptide receptor 1b
chr21_-_275377 0.30 ENSDART00000157509
rln1
relaxin 1
chr5_-_26566435 0.30 ENSDART00000146070
arvcfb
ARVCF, delta catenin family member b
chr24_-_33873451 0.30 ENSDART00000159840
asic1c
acid-sensing (proton-gated) ion channel 1c
chr2_+_33368414 0.29 ENSDART00000077462
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr13_+_31211050 0.29 ENSDART00000111705
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr5_-_66397688 0.29 ENSDART00000161483
hip1rb
huntingtin interacting protein 1 related b
chr12_-_48006835 0.29 ENSDART00000108989
adamts14
ADAM metallopeptidase with thrombospondin type 1 motif, 14
chr10_+_40214877 0.29 ENSDART00000109689
gramd1ba
GRAM domain containing 1Ba
chr17_+_43623598 0.28 ENSDART00000154138
znf365
zinc finger protein 365
chr7_-_25895189 0.28 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr6_-_20952187 0.28 ENSDART00000074327
igfbp2a
insulin-like growth factor binding protein 2a
chr9_+_10014514 0.28 ENSDART00000185590
nxph2a
neurexophilin 2a
chr9_-_38021889 0.28 ENSDART00000183482
ENSDART00000124333
adcy5
adenylate cyclase 5
chr22_-_31517300 0.28 ENSDART00000164799
slc6a6b
solute carrier family 6 (neurotransmitter transporter), member 6b
chr23_-_30954738 0.28 ENSDART00000188996
osbpl2a
oxysterol binding protein-like 2a
chr9_+_10014817 0.27 ENSDART00000132065
nxph2a
neurexophilin 2a
chr14_+_6615564 0.27 ENSDART00000139292
si:dkeyp-44a8.2
si:dkeyp-44a8.2
chr17_+_28533102 0.27 ENSDART00000156218
mdga2a
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr21_+_34976600 0.27 ENSDART00000191672
ENSDART00000139635
rbm11
RNA binding motif protein 11
chr13_-_12006007 0.27 ENSDART00000111438
mgea5
meningioma expressed antigen 5 (hyaluronidase)
chr19_+_41464870 0.27 ENSDART00000102778
dlx6a
distal-less homeobox 6a

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx3+lhx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1900620 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.4 1.2 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.3 0.8 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.2 1.6 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.2 0.7 GO:0099563 modification of synaptic structure(GO:0099563)
0.2 0.5 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.2 0.8 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.2 1.1 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.2 0.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 0.7 GO:0002159 desmosome assembly(GO:0002159)
0.1 1.0 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.1 0.8 GO:0006788 heme oxidation(GO:0006788)
0.1 1.1 GO:0043584 nose development(GO:0043584)
0.1 0.5 GO:0098921 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 0.5 GO:0000012 single strand break repair(GO:0000012)
0.1 0.5 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.1 0.3 GO:0021611 facial nerve formation(GO:0021611)
0.1 1.0 GO:0097090 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.4 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 1.1 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.1 0.3 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.1 2.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 0.5 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.5 GO:0034394 protein localization to cell surface(GO:0034394)
0.1 0.7 GO:0048798 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 0.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.5 GO:0015810 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 1.3 GO:0048844 artery morphogenesis(GO:0048844)
0.1 0.7 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 0.5 GO:0050975 sensory perception of touch(GO:0050975)
0.0 1.5 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 1.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.1 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.0 0.3 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.0 0.3 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 2.0 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.5 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 0.3 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.7 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.8 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.2 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.2 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0 0.6 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.1 GO:2000677 histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.0 0.7 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 3.1 GO:0033339 pectoral fin development(GO:0033339)
0.0 0.6 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 0.4 GO:0016074 snoRNA metabolic process(GO:0016074)
0.0 0.2 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.3 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.0 0.1 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.0 0.2 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 0.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.0 0.3 GO:0040014 regulation of multicellular organism growth(GO:0040014)
0.0 0.5 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.2 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.2 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.4 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.5 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 0.6 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.6 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.3 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.2 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.3 GO:0032418 lysosome localization(GO:0032418)
0.0 0.1 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.0 1.0 GO:0046328 regulation of JNK cascade(GO:0046328)
0.0 0.3 GO:0045471 response to ethanol(GO:0045471)
0.0 0.1 GO:0021588 cerebellum formation(GO:0021588)
0.0 0.3 GO:0030073 insulin secretion(GO:0030073)
0.0 0.3 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 0.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 1.3 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.0 1.9 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 0.2 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.1 GO:1900045 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 1.3 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
0.0 0.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.2 GO:0044247 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.3 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.0 GO:0015871 choline transport(GO:0015871)
0.0 0.7 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 0.5 GO:0036269 swimming behavior(GO:0036269)
0.0 0.8 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.1 GO:0070309 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0060077 inhibitory synapse(GO:0060077)
0.3 1.5 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.5 GO:0097255 R2TP complex(GO:0097255)
0.1 0.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 0.5 GO:0035517 PR-DUB complex(GO:0035517)
0.1 0.8 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.7 GO:0031045 dense core granule(GO:0031045)
0.1 0.5 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.7 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.4 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 2.6 GO:0014069 postsynaptic density(GO:0014069)
0.0 1.7 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.2 GO:0031932 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)
0.0 0.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.8 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.8 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0001635 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.2 0.5 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 0.8 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 0.4 GO:1990174 phosphodiesterase decapping endonuclease activity(GO:1990174)
0.1 0.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.9 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.5 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.1 1.4 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.4 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 0.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.3 GO:0030882 lipid antigen binding(GO:0030882)
0.1 0.3 GO:0019777 Atg12 transferase activity(GO:0019777)
0.1 0.3 GO:0016521 pituitary adenylate cyclase activating polypeptide activity(GO:0016521)
0.1 0.5 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.4 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.2 GO:0004377 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity(GO:0004377)
0.1 0.3 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 1.0 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 2.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.2 GO:0004133 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.0 0.6 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.1 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.0 0.5 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.5 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.5 GO:0030507 spectrin binding(GO:0030507)
0.0 1.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 1.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0031151 histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.4 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.2 GO:0016211 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 1.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.4 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.5 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.2 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.0 1.0 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.6 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 1.7 GO:0045296 cadherin binding(GO:0045296)
0.0 0.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0043560 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.0 0.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.8 GO:0044325 ion channel binding(GO:0044325)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.3 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.2 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.4 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.5 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade