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PRJNA207719: Tissue specific transcriptome profiling
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Results for mafb+mafba+nrl
Z-value: 3.51
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Transcription factors associated with mafb+mafba+nrl
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000017121 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba | |
| ENSDARG00000076520 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog b (paralog b) | |
| ENSDARG00000100466 | neural retina leucine zipper |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nrl | dr11_v1_chr20_+_661037_661037 | 0.81 | 9.9e-02 | Click! |
| mafba | dr11_v1_chr23_-_3409140_3409140 | 0.68 | 2.1e-01 | Click! |
| mafb | dr11_v1_chr25_+_36674715_36674715 | 0.33 | 5.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_1291012 Show fit | 4.07 |
ENSDART00000158390
|
ATPase plasma membrane Ca2+ transporting 2 |
|
| chr6_-_60147517 Show fit | 3.66 |
ENSDART00000083453
|
solute carrier family 32 (GABA vesicular transporter), member 1 |
|
| chr8_-_14052349 Show fit | 3.60 |
ENSDART00000135811
|
ATPase plasma membrane Ca2+ transporting 3a |
|
| chr10_-_7858553 Show fit | 3.18 |
ENSDART00000182010
|
inositol polyphosphate-5-phosphatase Ja |
|
| chr19_+_233143 Show fit | 3.09 |
ENSDART00000175273
|
synaptic Ras GTPase activating protein 1a |
|
| chr25_-_3503164 Show fit | 2.84 |
ENSDART00000191477
ENSDART00000186345 ENSDART00000180199 |
si:ch211-272n13.7 |
|
| chr15_+_16897554 Show fit | 2.62 |
ENSDART00000154679
|
yippee-like 2b |
|
| chr25_-_4482449 Show fit | 2.56 |
ENSDART00000056278
ENSDART00000149425 |
solute carrier family 25 member 22a |
|
| chr7_-_26087807 Show fit | 2.47 |
ENSDART00000052989
|
acetylcholinesterase |
|
| chr2_-_44720551 Show fit | 2.31 |
ENSDART00000146380
|
MAP6 domain containing 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of mafb+mafba+nrl
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.6 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.0 | 6.1 | GO:0006814 | sodium ion transport(GO:0006814) |
| 0.0 | 4.4 | GO:0043087 | regulation of GTPase activity(GO:0043087) |
| 0.6 | 4.3 | GO:0098937 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971) |
| 0.0 | 4.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 3.8 | GO:0031110 | regulation of microtubule polymerization or depolymerization(GO:0031110) |
| 0.5 | 3.7 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.1 | 3.3 | GO:0032012 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 3.2 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
| 0.1 | 3.1 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.9 | GO:0099634 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 8.1 | GO:0043005 | neuron projection(GO:0043005) |
| 0.1 | 6.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 5.6 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.0 | 4.8 | GO:0045202 | synapse(GO:0045202) |
| 0.1 | 4.5 | GO:0001726 | ruffle(GO:0001726) |
| 0.2 | 3.7 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 3.6 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.1 | 3.3 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 3.3 | GO:0005768 | endosome(GO:0005768) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.6 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 8.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 8.0 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 3.8 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.3 | 3.7 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.0 | 3.5 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.3 | 3.3 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.0 | 3.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.4 | 3.0 | GO:0034485 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) |
| 0.1 | 2.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 2.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 2.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 2.2 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 2.0 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 1.7 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 1.7 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 1.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.1 | PID INSULIN PATHWAY | Insulin Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.0 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.3 | 4.4 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.3 | 3.7 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.2 | 3.2 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.1 | 2.4 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 2.3 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 2.0 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 1.9 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.0 | 1.6 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.3 | 1.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |