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PRJNA207719: Tissue specific transcriptome profiling
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Results for maza+mazb
Z-value: 6.23
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Transcription factors associated with maza+mazb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| si:ch211-166g5.4 | dr11_v1_chr12_-_3773869_3773869 | 0.89 | 4.5e-02 | Click! |
| maza | dr11_v1_chr3_-_21106093_21106093 | 0.76 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_30642819 Show fit | 9.44 |
ENSDART00000078154
|
neuronal PAS domain protein 4a |
|
| chr2_-_44183451 Show fit | 8.84 |
ENSDART00000111246
|
cell adhesion molecule 3 |
|
| chr2_-_44183613 Show fit | 8.69 |
ENSDART00000079596
|
cell adhesion molecule 3 |
|
| chr1_-_39943596 Show fit | 7.14 |
ENSDART00000149730
|
storkhead box 2a |
|
| chr21_+_5169154 Show fit | 6.36 |
ENSDART00000102559
|
zgc:122979 |
|
| chr23_-_31693309 Show fit | 6.22 |
ENSDART00000146327
|
serum/glucocorticoid regulated kinase 1 |
|
| chr16_-_17207754 Show fit | 5.66 |
ENSDART00000063804
|
wu:fj39g12 |
|
| chr25_+_37366698 Show fit | 5.59 |
ENSDART00000165400
ENSDART00000192589 |
solute carrier family 1 (glial high affinity glutamate transporter), member 2b |
|
| chr11_-_1291012 Show fit | 5.53 |
ENSDART00000158390
|
ATPase plasma membrane Ca2+ transporting 2 |
|
| chr24_-_4973765 Show fit | 5.29 |
ENSDART00000127597
|
zic family member 1 (odd-paired homolog, Drosophila) |
Network of associatons between targets according to the STRING database.
First level regulatory network of maza+mazb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 18.0 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.1 | 18.0 | GO:0070588 | calcium ion transmembrane transport(GO:0070588) |
| 0.2 | 16.1 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 10.0 | GO:0051260 | protein homooligomerization(GO:0051260) |
| 0.0 | 10.0 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 1.9 | 9.4 | GO:0060080 | inhibitory postsynaptic potential(GO:0060080) |
| 0.2 | 9.4 | GO:0006171 | cAMP biosynthetic process(GO:0006171) |
| 0.3 | 8.4 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.3 | 7.8 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 6.9 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 56.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 30.7 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 22.7 | GO:0005829 | cytosol(GO:0005829) |
| 0.4 | 18.4 | GO:0099634 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.5 | 15.7 | GO:0048788 | cytoskeleton of presynaptic active zone(GO:0048788) |
| 0.0 | 11.7 | GO:0030054 | cell junction(GO:0030054) |
| 0.0 | 9.8 | GO:0043005 | neuron projection(GO:0043005) |
| 0.1 | 8.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.2 | 7.5 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.0 | 7.5 | GO:0030424 | axon(GO:0030424) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.1 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 19.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 16.5 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.4 | 12.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.2 | 10.4 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.2 | 9.5 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.6 | 9.4 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.0 | 9.4 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 9.1 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.3 | 9.0 | GO:0004016 | adenylate cyclase activity(GO:0004016) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 5.0 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 4.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 3.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 2.6 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.2 | 2.6 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 2.6 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 2.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 2.1 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.3 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.4 | 8.5 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.6 | 8.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 5.8 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 4.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 4.7 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.3 | 4.3 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.6 | 4.1 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.2 | 4.0 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 3.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |