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PRJNA207719: Tissue specific transcriptome profiling
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Results for mbd2
Z-value: 1.90
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Transcription factors associated with mbd2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mbd2 | dr11_v1_chr5_-_1047222_1047222 | 0.29 | 6.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_-_46763170 Show fit | 2.45 |
ENSDART00000171880
|
delta/notch-like EGF repeat containing |
|
| chr18_-_46464501 Show fit | 2.06 |
ENSDART00000040669
|
SPHK1 interactor, AKAP domain containing |
|
| chr11_-_762721 Show fit | 1.99 |
ENSDART00000166465
|
synapsin IIb |
|
| chr25_+_34407529 Show fit | 1.97 |
ENSDART00000156751
|
si:dkey-37f18.2 |
|
| chr10_+_16225870 Show fit | 1.96 |
ENSDART00000164647
|
solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
|
| chr8_+_1148876 Show fit | 1.92 |
ENSDART00000148651
|
arginine vasopressin |
|
| chr7_+_30867008 Show fit | 1.86 |
ENSDART00000193106
|
amyloid beta (A4) precursor protein-binding, family A, member 2b |
|
| chr23_-_3681026 Show fit | 1.84 |
ENSDART00000192128
ENSDART00000040086 |
protein kinase C and casein kinase substrate in neurons 1a |
|
| chr21_-_12272543 Show fit | 1.77 |
ENSDART00000081510
ENSDART00000151297 |
CUGBP, Elav-like family member 4 |
|
| chr8_-_54223316 Show fit | 1.75 |
ENSDART00000018054
|
thyrotropin-releasing hormone |
Network of associatons between targets according to the STRING database.
First level regulatory network of mbd2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | GO:0048796 | swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798) |
| 0.0 | 2.7 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.8 | 2.5 | GO:0014014 | negative regulation of gliogenesis(GO:0014014) |
| 0.3 | 2.3 | GO:0035372 | protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825) |
| 0.2 | 2.0 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 2.0 | GO:0099643 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 0.6 | 1.8 | GO:0001692 | histamine metabolic process(GO:0001692) negative regulation of anion transport(GO:1903792) |
| 0.1 | 1.8 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
| 0.1 | 1.8 | GO:1900006 | positive regulation of dendrite development(GO:1900006) |
| 0.1 | 1.8 | GO:0045332 | phospholipid translocation(GO:0045332) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 2.7 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 2.3 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 2.1 | GO:0043197 | dendritic spine(GO:0043197) neuron spine(GO:0044309) |
| 0.0 | 2.0 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 1.7 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.1 | 1.5 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.1 | 1.0 | GO:0098982 | GABA-ergic synapse(GO:0098982) |
| 0.0 | 0.9 | GO:0098978 | glutamatergic synapse(GO:0098978) |
| 0.0 | 0.7 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.3 | 2.8 | GO:0008511 | sodium:potassium:chloride symporter activity(GO:0008511) |
| 0.1 | 2.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 2.1 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.2 | 2.0 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 1.9 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 1.9 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 1.7 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.0 | 1.7 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 1.6 | GO:0016307 | phosphatidylinositol phosphate kinase activity(GO:0016307) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.5 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 0.7 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 0.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 2.5 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 1.9 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 1.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.5 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 1.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 1.2 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 1.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 0.7 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.7 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |