ISMARA results: mef2ca+mef2cb

Project

PRJNA207719: Tissue specific transcriptome profiling

Navigation

Downloads

Results for mef2ca+mef2cb

Z-value: 3.14

Motif logo

Transcription factors associated with mef2ca+mef2cb

Gene Symbol	Gene ID	Gene Info
mef2cb NCBI UniProt	ENSDARG00000009418	myocyte enhancer factor 2cb
mef2ca NCBI UniProt	ENSDARG00000029764	myocyte enhancer factor 2ca

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mef2ca	dr11_v1_chr10_-_43568239_43568241	0.83	8.1e-02	Click!
mef2cb	dr11_v1_chr5_-_48307804_48307804	0.51	3.8e-01	Click!

Activity profile of mef2ca+mef2cb motif

Sorted Z-values of mef2ca+mef2cb motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_11201096 Show fit	4.69	ENSDART00000171916 ENSDART00000171521 ENSDART00000087105 ENSDART00000159603	myom2a NCBI UniProt Show fit	myomesin 2a
chr5_+_51597677 Show fit	3.28	ENSDART00000048210 ENSDART00000184797	ckmt2b NCBI UniProt Show fit	creatine kinase, mitochondrial 2b (sarcomeric)
chr11_+_11200550 Show fit	3.22	ENSDART00000181339 ENSDART00000187116	myom2a NCBI UniProt Show fit	myomesin 2a
chr8_-_26388090 Show fit	3.01	ENSDART00000147912	si:dkey-20d21.12 NCBI UniProt Show fit	si:dkey-20d21.12
chr25_+_29160102 Show fit	2.78	ENSDART00000162854	pkmb NCBI UniProt Show fit	pyruvate kinase M1/2b
chr9_-_42873700 Show fit	2.73	ENSDART00000125953	ttn.1 NCBI UniProt Show fit	titin, tandem duplicate 1
chr12_-_26064480 Show fit	2.68	ENSDART00000158215 ENSDART00000171206 ENSDART00000171212 ENSDART00000182956 ENSDART00000186779	ldb3b NCBI UniProt Show fit	LIM domain binding 3b
chr12_-_26064105 Show fit	2.66	ENSDART00000168825	ldb3b NCBI UniProt Show fit	LIM domain binding 3b
chr16_+_25245857 Show fit	2.62	ENSDART00000155220	klhl38b NCBI UniProt Show fit	kelch-like family member 38b
chr11_-_18253111 Show fit	2.53	ENSDART00000125984	mustn1b NCBI UniProt Show fit	musculoskeletal, embryonic nuclear protein 1b

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2ca+mef2cb

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.8	GO:0006936	muscle contraction(GO:0006936)
0.0	10.1	GO:0016567	protein ubiquitination(GO:0016567)
0.0	6.2	GO:0061061	muscle structure development(GO:0061061)
0.1	4.6	GO:0050821	protein stabilization(GO:0050821)
0.3	4.3	GO:0006599	phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.2	4.3	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.0	3.4	GO:0030239	myofibril assembly(GO:0030239)
0.3	2.9	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.2	2.9	GO:0048769	sarcomerogenesis(GO:0048769)
0.2	2.8	GO:0034629	cellular protein complex localization(GO:0034629)

Showing 1 to 10 of 101 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	17.8	GO:0031430	M band(GO:0031430)
0.2	17.2	GO:0030018	Z disc(GO:0030018)
0.1	6.2	GO:0016459	myosin complex(GO:0016459)
0.1	6.1	GO:0005865	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.1	4.6	GO:0042383	sarcolemma(GO:0042383)
0.1	3.0	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2	2.8	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.3	2.4	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.1	2.1	GO:0005869	dynactin complex(GO:0005869)
0.1	1.9	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)

Showing 1 to 10 of 36 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	21.4	GO:0051015	actin filament binding(GO:0051015)
0.4	7.2	GO:0051371	muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0	6.2	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.2	5.1	GO:0005523	tropomyosin binding(GO:0005523)
0.3	4.3	GO:0016775	creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1	3.9	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.0	3.7	GO:0003779	actin binding(GO:0003779)
0.0	3.5	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2	3.1	GO:0051879	Hsp90 protein binding(GO:0051879)
0.5	2.8	GO:0004743	pyruvate kinase activity(GO:0004743)

Showing 1 to 10 of 73 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Total log-likelihood	Term	Description
2.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.5	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
1.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
1.3	PID ILK PATHWAY	Integrin-linked kinase signaling
0.7	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.5	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.5	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.3	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells

Showing 1 to 10 of 10 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	2.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	1.7	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	1.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.1	1.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	1.0	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.6	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.6	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.6	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels

Showing 1 to 10 of 21 entries

Results for mef2ca+mef2cb

Z-value: 3.14

Motif logo

Transcription factors associated with mef2ca+mef2cb

Activity-expression correlation:

Activity profile of mef2ca+mef2cb motif

Sorted Z-values of mef2ca+mef2cb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2ca+mef2cb

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: