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PRJNA207719: Tissue specific transcriptome profiling

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Results for meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

Z-value: 0.98

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Transcription factors associated with meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

Gene Symbol Gene ID Gene Info
meis2b
ENSDARG00000077840 Meis homeobox 2a
meis2a
ENSDARG00000098240 Meis homeobox 2a
FO834857.1
ENSDARG00000112895 homeobox protein TGIF2-like
pknox1.1
ENSDARG00000018765 pbx/knotted 1 homeobox 1.1
pknox1.2
ENSDARG00000036542 pbx/knotted 1 homeobox 1.2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FO834857.1dr11_v1_chr6_-_1820606_1820606-0.662.2e-01Click!
meis2bdr11_v1_chr20_-_10118818_10118818-0.326.0e-01Click!
meis2adr11_v1_chr17_+_52822422_52822422-0.296.4e-01Click!
pknox1.2dr11_v1_chr1_-_46984142_46984142-0.217.3e-01Click!
pknox1.1dr11_v1_chr9_+_19529951_195299510.049.4e-01Click!

Activity profile of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2 motif

Sorted Z-values of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_45627775 0.85 ENSDART00000185466
irf1b
interferon regulatory factor 1b
chr19_-_5369486 0.76 ENSDART00000105004
krt17
keratin 17
chr16_+_23397785 0.75 ENSDART00000148961
s100a10b
S100 calcium binding protein A10b
chr16_+_23398369 0.70 ENSDART00000037694
s100a10b
S100 calcium binding protein A10b
chr22_+_7480465 0.63 ENSDART00000034545
CELA1 (1 of many)
zgc:92745
chr22_-_6194517 0.58 ENSDART00000134757
ENSDART00000181598
ENSDART00000129829
si:rp71-36a1.5
si:rp71-36a1.5
chr5_-_71722257 0.57 ENSDART00000013404
ak1
adenylate kinase 1
chr7_+_6879534 0.51 ENSDART00000157731
zgc:175248
zgc:175248
chr21_-_41025340 0.50 ENSDART00000148231
plac8l1
PLAC8-like 1
chr21_-_38153824 0.49 ENSDART00000151226
klf5l
Kruppel-like factor 5 like
chr12_-_48168135 0.46 ENSDART00000186624
pald1a
phosphatase domain containing, paladin 1a
chr6_-_10809546 0.45 ENSDART00000151661
wipf1b
WAS/WASL interacting protein family, member 1b
chr9_+_27876146 0.43 ENSDART00000133997
armc8
armadillo repeat containing 8
chr10_+_35417099 0.42 ENSDART00000063398
hhla2a.1
HERV-H LTR-associating 2a, tandem duplicate 1
chr22_+_19188809 0.40 ENSDART00000134791
ENSDART00000133682
si:dkey-21e2.8
si:dkey-21e2.8
chr16_-_563235 0.39 ENSDART00000016303
irx2a
iroquois homeobox 2a
chr13_-_7031033 0.37 ENSDART00000193211
CABZ01061524.1

chr6_+_49052741 0.37 ENSDART00000011876
sycp1
synaptonemal complex protein 1
chr2_-_45510699 0.36 ENSDART00000024034
ENSDART00000145634
gpsm2
G protein signaling modulator 2
chr18_+_44673990 0.36 ENSDART00000018625
napab
N-ethylmaleimide-sensitive factor attachment protein, alpha b
chr5_-_12587053 0.36 ENSDART00000162780
vsig10
V-set and immunoglobulin domain containing 10
chr1_-_8653385 0.35 ENSDART00000193041
actb1
actin, beta 1
chr25_+_5068442 0.35 ENSDART00000097522
parvg
parvin, gamma
chr24_+_42148140 0.34 ENSDART00000010658
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr13_-_42749916 0.34 ENSDART00000140019
capn2a
calpain 2, (m/II) large subunit a
chr5_+_27432958 0.33 ENSDART00000124705
histh1l
histone H1 like
chr23_-_45705525 0.33 ENSDART00000148959
ednrab
endothelin receptor type Ab
chr8_+_34731982 0.33 ENSDART00000066050
hpdb
4-hydroxyphenylpyruvate dioxygenase b
chr3_-_55099272 0.32 ENSDART00000130869
hbba1
hemoglobin, beta adult 1
chr4_-_15603511 0.32 ENSDART00000122520
ENSDART00000162356
chchd3a
coiled-coil-helix-coiled-coil-helix domain containing 3a
chr13_+_46803979 0.32 ENSDART00000159260
CU695232.1

chr20_+_32152355 0.32 ENSDART00000152904
ENSDART00000139507
sesn1
sestrin 1
chr16_-_563732 0.31 ENSDART00000183394
irx2a
iroquois homeobox 2a
chr3_-_55104310 0.31 ENSDART00000101713
hbba1
hemoglobin, beta adult 1
chr15_-_19724932 0.30 ENSDART00000152345
sytl2b
synaptotagmin-like 2b
chr3_+_24275766 0.30 ENSDART00000055607
pdgfbb
platelet-derived growth factor beta polypeptide b
chr18_+_29403017 0.30 ENSDART00000176966
mafa
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
chr12_-_36511939 0.30 ENSDART00000153759
unc13d
unc-13 homolog D (C. elegans)
chr24_-_36095526 0.30 ENSDART00000158145
CABZ01075509.1

chr7_+_55149001 0.30 ENSDART00000148642
cdh31
cadherin 31
chr9_-_31135901 0.30 ENSDART00000113027
ENSDART00000193210
ENSDART00000128896
si:ch211-184m13.4
si:ch211-184m13.4
chr14_+_22022441 0.30 ENSDART00000149121
clcf1
cardiotrophin-like cytokine factor 1
chr1_-_58000438 0.28 ENSDART00000163761
si:ch211-114l13.9
si:ch211-114l13.9
chr5_+_30741730 0.28 ENSDART00000098246
ENSDART00000186992
ENSDART00000182533
ftr83
finTRIM family, member 83
chr22_-_17677947 0.28 ENSDART00000139911
tjp3
tight junction protein 3
chr7_-_56766100 0.27 ENSDART00000189934
csnk2a2a
casein kinase 2, alpha prime polypeptide a
chr7_+_17816006 0.27 ENSDART00000080834
eml3
echinoderm microtubule associated protein like 3
chr13_+_12671513 0.27 ENSDART00000010517
eif4eb
eukaryotic translation initiation factor 4eb
chr20_+_29634653 0.26 ENSDART00000101556
asap2b
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2b
chr20_-_54564018 0.26 ENSDART00000099832
zgc:153012
zgc:153012
chr3_-_1400309 0.25 ENSDART00000159893
wbp11
WW domain binding protein 11
chr24_+_6353394 0.25 ENSDART00000165118
CR352329.1

chr1_+_57145072 0.25 ENSDART00000152776
si:ch73-94k4.4
si:ch73-94k4.4
chr10_+_7671260 0.25 ENSDART00000157608
fam136a
family with sequence similarity 136, member A
chr21_-_27338639 0.24 ENSDART00000130632
hif1al2
hypoxia-inducible factor 1, alpha subunit, like 2
chr24_+_38534550 0.24 ENSDART00000105677
zgc:154125
zgc:154125
chr17_-_7792376 0.24 ENSDART00000064655
zbtb2a
zinc finger and BTB domain containing 2a
chr5_-_54497319 0.23 ENSDART00000160492
alad
aminolevulinate dehydratase
chr25_-_3192405 0.23 ENSDART00000104835
hps5
Hermansky-Pudlak syndrome 5
chr12_-_46176115 0.23 ENSDART00000152848
si:ch211-226h7.8
si:ch211-226h7.8
chr1_+_14253118 0.23 ENSDART00000161996
cxcl8a
chemokine (C-X-C motif) ligand 8a
chr18_+_15758375 0.23 ENSDART00000137554
si:ch211-219a15.4
si:ch211-219a15.4
chr11_+_25459697 0.23 ENSDART00000161481
opn1sw2
opsin 1 (cone pigments), short-wave-sensitive 2
chr17_+_35362851 0.23 ENSDART00000137659
cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr18_+_24562188 0.23 ENSDART00000099463
lysmd4
LysM, putative peptidoglycan-binding, domain containing 4
chr1_+_57187794 0.22 ENSDART00000152485
si:dkey-27j5.9
si:dkey-27j5.9
chr5_+_22307605 0.22 ENSDART00000138154
arhgap20b
Rho GTPase activating protein 20b
chr4_+_76692834 0.22 ENSDART00000064315
ENSDART00000137653
ms4a17a.1
membrane-spanning 4-domains, subfamily A, member 17A.1
chr18_+_29402623 0.22 ENSDART00000014703
mafa
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
chr24_-_27430612 0.21 ENSDART00000158139
CR383669.2

chr11_+_6136220 0.21 ENSDART00000082223
tax1bp3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr17_-_24890843 0.21 ENSDART00000184984
ENSDART00000135569
ENSDART00000193661
gale
UDP-galactose-4-epimerase
chr1_-_19402802 0.21 ENSDART00000135552
rbm47
RNA binding motif protein 47
chr4_+_76775837 0.21 ENSDART00000174167
ms4a17a.10
membrane-spanning 4-domains, subfamily A, member 17A.10
chr13_-_15700060 0.21 ENSDART00000170689
ENSDART00000010986
ENSDART00000101741
ENSDART00000139124
ckba
creatine kinase, brain a
chr4_+_12931763 0.21 ENSDART00000016382
wif1
wnt inhibitory factor 1
chr23_-_9768700 0.21 ENSDART00000045126
lama5
laminin, alpha 5
chr1_-_30473422 0.21 ENSDART00000164202
igf2bp2b
insulin-like growth factor 2 mRNA binding protein 2b
chr7_+_17816470 0.20 ENSDART00000173807
eml3
echinoderm microtubule associated protein like 3
chr10_+_28160265 0.20 ENSDART00000022484
rnft1
ring finger protein, transmembrane 1
chr1_-_52437056 0.20 ENSDART00000138337
si:ch211-217k17.12
si:ch211-217k17.12
chr3_+_28576173 0.20 ENSDART00000151189
sept12
septin 12
chr22_-_17458070 0.20 ENSDART00000139658
si:ch211-197g15.10
si:ch211-197g15.10
chr19_+_26923274 0.20 ENSDART00000148439
ENSDART00000148877
nelfe
negative elongation factor complex member E
chr13_+_30696286 0.20 ENSDART00000192411
cxcl18a.1
chemokine (C-X-C motif) ligand 18a, duplicate 1
chr4_+_76752707 0.19 ENSDART00000082121
ms4a17a.4
membrane-spanning 4-domains, subfamily A, member 17A.4
chr1_-_56213723 0.19 ENSDART00000142505
ENSDART00000137237
si:dkey-76b14.2
si:dkey-76b14.2
chr14_-_689841 0.19 ENSDART00000125969
ube2ka
ubiquitin-conjugating enzyme E2Ka (UBC1 homolog, yeast)
chr23_-_13875252 0.19 ENSDART00000104834
ENSDART00000193807
g6pd
glucose-6-phosphate dehydrogenase
chr14_+_29769336 0.19 ENSDART00000105898
si:dkey-34l15.1
si:dkey-34l15.1
chr3_+_29941777 0.19 ENSDART00000113889
ifi35
interferon-induced protein 35
chr23_-_20258490 0.19 ENSDART00000147326
lamb2
laminin, beta 2 (laminin S)
chr9_-_48281941 0.19 ENSDART00000099787
klhl41a
kelch-like family member 41a
chr3_+_22273123 0.18 ENSDART00000044157
scn4ab
sodium channel, voltage-gated, type IV, alpha, b
chr24_-_37568359 0.18 ENSDART00000056286
h1f0
H1 histone family, member 0
chr11_+_44503774 0.18 ENSDART00000169295
ero1b
endoplasmic reticulum oxidoreductase beta
chr9_-_7539297 0.18 ENSDART00000081550
ENSDART00000081553
desma
desmin a
chr19_+_7575341 0.18 ENSDART00000134271
s100u
S100 calcium binding protein U
chr19_+_7575141 0.18 ENSDART00000051528
s100u
S100 calcium binding protein U
chr2_+_394166 0.18 ENSDART00000155733
mylk4a
myosin light chain kinase family, member 4a
chr23_+_13528053 0.18 ENSDART00000162217
uckl1b
uridine-cytidine kinase 1-like 1b
chr8_+_7033049 0.18 ENSDART00000064172
ENSDART00000134440
gpd1a
glycerol-3-phosphate dehydrogenase 1a
chr14_+_30340251 0.18 ENSDART00000148448
mtus1a
microtubule associated tumor suppressor 1a
chr16_-_7239457 0.18 ENSDART00000148992
ENSDART00000149260
nt5c3a
5'-nucleotidase, cytosolic IIIA
chr20_+_47434709 0.18 ENSDART00000067776
rab10
RAB10, member RAS oncogene family
chr20_+_329032 0.18 ENSDART00000036635
fynb
FYN proto-oncogene, Src family tyrosine kinase b
chr6_+_23931236 0.18 ENSDART00000166079
gadd45ab
growth arrest and DNA-damage-inducible, alpha, b
chr4_-_685412 0.18 ENSDART00000168167
rtcb
RNA 2',3'-cyclic phosphate and 5'-OH ligase
chr12_-_43819253 0.17 ENSDART00000160261
ENSDART00000170045
ENSDART00000159106
si:ch73-329n5.6
si:ch73-329n5.6
chr25_+_5288665 0.17 ENSDART00000169540
CABZ01039861.1

chr10_+_44955106 0.17 ENSDART00000185837
il1b
interleukin 1, beta
chr7_+_51103416 0.17 ENSDART00000174236
col4a5
collagen, type IV, alpha 5 (Alport syndrome)
chr21_+_43882274 0.17 ENSDART00000075672
sra1
steroid receptor RNA activator 1
chr25_+_19008497 0.17 ENSDART00000104420
samm50
SAMM50 sorting and assembly machinery component
chr16_+_33144306 0.17 ENSDART00000101953
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr21_-_32684570 0.17 ENSDART00000162873
adamts2
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr16_+_20167811 0.17 ENSDART00000004031
hacl1
2-hydroxyacyl-CoA lyase 1
chr22_-_21046843 0.16 ENSDART00000133982
ssbp4
single stranded DNA binding protein 4
chr20_+_1329509 0.16 ENSDART00000017791
ENSDART00000136669
tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr12_+_18916285 0.16 ENSDART00000127536
cbx7b
chromobox homolog 7b
chr19_+_7453996 0.16 ENSDART00000147491
ENSDART00000136502
mindy1
MINDY lysine 48 deubiquitinase 1
chr15_-_28587147 0.16 ENSDART00000156049
ssh2a
slingshot protein phosphatase 2a
chr5_+_20112032 0.16 ENSDART00000130554
isg15
ISG15 ubiquitin-like modifier
chr11_+_8152872 0.16 ENSDART00000091638
ENSDART00000138057
ENSDART00000166379
samd13
sterile alpha motif domain containing 13
chr5_-_19494048 0.16 ENSDART00000098795
mmab
methylmalonic aciduria (cobalamin deficiency) cblB type
chr11_+_26375979 0.16 ENSDART00000087652
ENSDART00000171748
ENSDART00000103513
ENSDART00000165931
ENSDART00000170043
cpne1
rbm12
copine I
RNA binding motif protein 12
chr23_+_6586467 0.15 ENSDART00000081763
ENSDART00000121480
rbm38
RNA binding motif protein 38
chr6_-_49510553 0.15 ENSDART00000166238
rplp2
ribosomal protein, large P2
chr7_+_20467549 0.15 ENSDART00000173724
si:dkey-33c9.8
si:dkey-33c9.8
chr5_-_24127310 0.15 ENSDART00000182700
ENSDART00000154313
capga
capping protein (actin filament), gelsolin-like a
chr16_+_5251768 0.15 ENSDART00000144558
plecb
plectin b
chr1_+_58332000 0.15 ENSDART00000145234
ggt1l2.1
gamma-glutamyltransferase 1 like 2.1
chr10_+_11355841 0.15 ENSDART00000193067
ENSDART00000064215
cops4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr24_-_40667800 0.15 ENSDART00000169315
smyhc1
slow myosin heavy chain 1
chr10_+_26667475 0.15 ENSDART00000133281
ENSDART00000147013
si:ch73-52f15.5
si:ch73-52f15.5
chr22_+_25590391 0.15 ENSDART00000178133
aars2
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr24_+_10413484 0.15 ENSDART00000111014
myca
MYC proto-oncogene, bHLH transcription factor a
chr20_+_27712714 0.15 ENSDART00000008306
zbtb1
zinc finger and BTB domain containing 1
chr16_+_17089114 0.15 ENSDART00000173223
cd27
CD27 molecule
chr18_+_907266 0.15 ENSDART00000171729
pkma
pyruvate kinase M1/2a
chr8_-_17184482 0.15 ENSDART00000025803
pola2
polymerase (DNA directed), alpha 2
chr1_-_2449395 0.15 ENSDART00000103785
ggact.3
gamma-glutamylamine cyclotransferase, tandem duplicate 3
chr1_+_58150000 0.14 ENSDART00000137836
si:ch211-15j1.3
si:ch211-15j1.3
chr19_+_48351624 0.14 ENSDART00000169729
sgo1
shugoshin 1
chr19_-_38611814 0.14 ENSDART00000151958
col16a1
collagen, type XVI, alpha 1
chr12_+_34127573 0.14 ENSDART00000153413
cyth1b
cytohesin 1b
chr23_-_23401305 0.14 ENSDART00000078936
her9
hairy-related 9
chr1_+_56972616 0.14 ENSDART00000152812
si:ch211-1f22.11
si:ch211-1f22.11
chr15_+_41027466 0.14 ENSDART00000075940
mtnr1ba
melatonin receptor type 1Ba
chr23_-_38054 0.14 ENSDART00000170393
CABZ01074076.1

chr3_-_16039619 0.14 ENSDART00000143324
spsb3a
splA/ryanodine receptor domain and SOCS box containing 3a
chr19_+_7567763 0.14 ENSDART00000140411
s100a11
S100 calcium binding protein A11
chr21_+_45267589 0.14 ENSDART00000182963
ENSDART00000155681
ENSDART00000192632
tcf7
transcription factor 7
chr8_+_25959940 0.13 ENSDART00000143011
ENSDART00000140626
si:dkey-72l14.4
si:dkey-72l14.4
chr19_-_12212692 0.13 ENSDART00000142077
ENSDART00000151599
ENSDART00000140834
ENSDART00000078781
znf706
zinc finger protein 706
chr8_-_4586696 0.13 ENSDART00000143511
ENSDART00000134324
gp1bb
glycoprotein Ib (platelet), beta polypeptide
chr6_+_38773376 0.13 ENSDART00000078128
ENSDART00000184053
ube3a
ubiquitin protein ligase E3A
chr1_-_44084071 0.13 ENSDART00000166912
vwa11
von Willebrand factor A domain containing 11
chr24_-_27452488 0.13 ENSDART00000136433
ccl34b.8
chemokine (C-C motif) ligand 34b, duplicate 8
chr13_+_24396666 0.13 ENSDART00000139197
ENSDART00000101200
zgc:153169
zgc:153169
chr14_+_35369979 0.13 ENSDART00000144702
ENSDART00000169712
clint1a
clathrin interactor 1a
chr24_+_23716918 0.13 ENSDART00000080332
cops5
COP9 signalosome subunit 5
chr14_-_25956804 0.13 ENSDART00000135627
ENSDART00000146022
ENSDART00000039660
sparc
secreted protein, acidic, cysteine-rich (osteonectin)
chr22_+_980290 0.12 ENSDART00000065377
def6b
differentially expressed in FDCP 6b homolog (mouse)
chr25_-_2723682 0.12 ENSDART00000113382
adpgk
ADP-dependent glucokinase
chr2_+_55365727 0.12 ENSDART00000162943
FP245456.1

chr3_-_60316118 0.12 ENSDART00000171458
si:ch211-214b16.2
si:ch211-214b16.2
chr4_+_73085993 0.12 ENSDART00000165749
si:ch73-170d6.2
si:ch73-170d6.2
chr21_-_38581903 0.12 ENSDART00000148939
pof1b
POF1B, actin binding protein
chr16_+_33144112 0.12 ENSDART00000183149
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr7_-_38340674 0.12 ENSDART00000075782
slc7a10a
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10a
chr13_+_45524475 0.12 ENSDART00000074567
ENSDART00000019113
maco1b
macoilin 1b
chr21_-_34658266 0.12 ENSDART00000023038
dacha
dachshund a
chr6_-_42003780 0.12 ENSDART00000032527
cav3
caveolin 3
chr1_-_12397258 0.12 ENSDART00000144596
sclt1
sodium channel and clathrin linker 1
chr13_-_37631092 0.12 ENSDART00000108855
si:dkey-188i13.7
si:dkey-188i13.7
chr5_-_37103487 0.11 ENSDART00000149211
il13ra2
interleukin 13 receptor, alpha 2
chr21_+_17768174 0.11 ENSDART00000141380
rxraa
retinoid X receptor, alpha a
chr1_+_53945934 0.11 ENSDART00000052838
acta1a
actin, alpha 1a, skeletal muscle
chr23_+_24705424 0.11 ENSDART00000104029
c1qtnf12
C1q and TNF related 12
chr2_+_36103309 0.11 ENSDART00000190038
CT867973.1

chr12_-_3721957 0.11 ENSDART00000152433
vps25
vacuolar protein sorting 25 homolog (S. cerevisiae)
chr22_-_21046654 0.11 ENSDART00000064902
ssbp4
single stranded DNA binding protein 4
chr15_-_28587490 0.11 ENSDART00000186196
ssh2a
slingshot protein phosphatase 2a
chr6_+_41452979 0.11 ENSDART00000007353
wdr82
WD repeat domain 82
chr22_-_14128716 0.11 ENSDART00000140323
si:ch211-246m6.4
si:ch211-246m6.4
chr7_+_65673885 0.11 ENSDART00000169182
parvab
parvin, alpha b
chr21_+_30937690 0.11 ENSDART00000022562
rhogb
ras homolog family member Gb
chr5_+_6796291 0.11 ENSDART00000166868
ENSDART00000165308
me2
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr14_-_41468892 0.11 ENSDART00000173099
ENSDART00000003170
mid1ip1l
MID1 interacting protein 1, like
chr15_-_17071328 0.11 ENSDART00000122617
si:ch211-24o10.6
si:ch211-24o10.6
chr17_-_28797395 0.11 ENSDART00000134735
scfd1
sec1 family domain containing 1
chr8_+_25616946 0.11 ENSDART00000133983
slc38a5a
solute carrier family 38, member 5a
chr11_+_2506516 0.11 ENSDART00000130886
ENSDART00000189767
NABP2
si:ch73-190f16.2
chr14_+_46410766 0.11 ENSDART00000032342
anxa5a
annexin A5a
chr13_-_42400647 0.11 ENSDART00000043069
march5
membrane-associated ring finger (C3HC4) 5
chr16_-_54978981 0.11 ENSDART00000154023
wdtc1
WD and tetratricopeptide repeats 1
chr4_+_25574827 0.10 ENSDART00000187726
zgc:195175
zgc:195175
chr20_-_20270191 0.10 ENSDART00000009356
ppp2r5ea
protein phosphatase 2, regulatory subunit B', epsilon isoform a
chr4_-_27897160 0.10 ENSDART00000066924
ENSDART00000066925
ENSDART00000193020
tbc1d22a
TBC1 domain family, member 22a

Network of associatons between targets according to the STRING database.

First level regulatory network of meis2a+meis2b_FO834857.1_pknox1.1+pknox1.2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903392 epicardial cell to mesenchymal cell transition(GO:0003347) negative regulation of adherens junction organization(GO:1903392)
0.1 0.4 GO:0051026 meiotic DNA repair synthesis(GO:0000711) chiasma assembly(GO:0051026)
0.1 0.4 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.1 0.6 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.1 0.2 GO:0002631 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.1 0.2 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.1 0.2 GO:2000009 regulation of protein localization to cell surface(GO:2000008) negative regulation of protein localization to cell surface(GO:2000009)
0.1 0.9 GO:0050688 regulation of defense response to virus(GO:0050688)
0.1 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.2 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.2 GO:0002568 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.1 0.2 GO:0001961 positive regulation of cytokine-mediated signaling pathway(GO:0001961) positive regulation of response to cytokine stimulus(GO:0060760)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.3 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.0 0.2 GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling(GO:0010882)
0.0 0.3 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.0 0.2 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.0 0.2 GO:2000660 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.2 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.3 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.2 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.0 0.1 GO:0042942 D-amino acid transport(GO:0042940) D-alanine transport(GO:0042941) D-serine transport(GO:0042942)
0.0 0.7 GO:0035778 pronephric nephron tubule epithelial cell differentiation(GO:0035778) cell differentiation involved in pronephros development(GO:0039014)
0.0 0.4 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.1 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.1 GO:0071962 mitotic sister chromatid cohesion, centromeric(GO:0071962)
0.0 0.7 GO:0015671 oxygen transport(GO:0015671)
0.0 0.3 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.0 0.2 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0051095 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.0 0.2 GO:0048069 eye pigmentation(GO:0048069)
0.0 0.1 GO:0002792 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.0 0.1 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.1 GO:0046324 regulation of glucose import(GO:0046324)
0.0 0.3 GO:0030104 water homeostasis(GO:0030104)
0.0 0.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0032329 serine transport(GO:0032329) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.1 GO:0045922 negative regulation of fatty acid metabolic process(GO:0045922)
0.0 0.1 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 0.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.2 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.2 GO:0031179 peptide modification(GO:0031179)
0.0 0.1 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.0 0.0 GO:0022009 central nervous system vasculogenesis(GO:0022009)
0.0 0.2 GO:0044211 CTP salvage(GO:0044211)
0.0 0.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0044321 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.0 0.1 GO:0001783 B cell apoptotic process(GO:0001783) regulation of B cell apoptotic process(GO:0002902) abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878) regulation of lymphocyte apoptotic process(GO:0070228)
0.0 0.1 GO:0060296 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.1 GO:0099625 regulation of membrane repolarization(GO:0060306) regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) regulation of cardiac muscle cell membrane repolarization(GO:0099623) ventricular cardiac muscle cell membrane repolarization(GO:0099625)
0.0 0.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.2 GO:0042396 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.0 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.0 GO:0003156 regulation of organ formation(GO:0003156)
0.0 0.1 GO:0044854 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.2 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.1 GO:0060468 negative regulation of fertilization(GO:0060467) prevention of polyspermy(GO:0060468) cortical granule exocytosis(GO:0060471)
0.0 0.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:0007624 ultradian rhythm(GO:0007624)
0.0 0.2 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.1 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.1 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 1.2 GO:0031101 fin regeneration(GO:0031101)
0.0 0.0 GO:0006297 leading strand elongation(GO:0006272) nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.2 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.1 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.1 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.0 0.1 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0043073 germ cell nucleus(GO:0043073)
0.1 0.4 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 0.4 GO:0034657 GID complex(GO:0034657)
0.1 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.6 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.3 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.3 GO:0032021 NELF complex(GO:0032021)
0.0 0.1 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0030428 cell septum(GO:0030428)
0.0 0.4 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.1 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.0 0.1 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.2 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.4 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.0 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.0 GO:1990909 Wnt signalosome(GO:1990909)
0.0 1.0 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.1 0.2 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 2.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.4 GO:0098973 structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 0.2 GO:0003978 UDP-glucose 4-epimerase activity(GO:0003978)
0.1 0.2 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1 0.4 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.1 0.2 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 0.2 GO:0000810 diacylglycerol diphosphate phosphatase activity(GO:0000810)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.3 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.3 GO:0070728 leucine binding(GO:0070728)
0.0 0.2 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.6 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.7 GO:0005344 oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
0.0 0.2 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.2 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.1 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.2 GO:0036374 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.0 0.1 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0043185 vascular endothelial growth factor receptor 3 binding(GO:0043185)
0.0 0.1 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.0 0.2 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 0.0 GO:0003875 ADP-ribosylarginine hydrolase activity(GO:0003875)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.0 0.1 GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.0 0.1 GO:0019778 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.2 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.1 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.0 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.1 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1