Project
PRJNA207719: Tissue specific transcriptome profiling
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Results for mycn
Z-value: 2.13
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Transcription factors associated with mycn
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mycn | dr11_v1_chr20_+_33294428_33294428 | -0.59 | 3.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of mycn
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0032922 | circadian regulation of gene expression(GO:0032922) |
| 0.1 | 1.6 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.1 | 1.6 | GO:0009746 | response to carbohydrate(GO:0009743) response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284) |
| 0.0 | 1.5 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.1 | 1.4 | GO:0045807 | positive regulation of endocytosis(GO:0045807) |
| 0.4 | 1.3 | GO:0034382 | chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831) |
| 0.2 | 1.2 | GO:0034380 | regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) high-density lipoprotein particle assembly(GO:0034380) |
| 0.2 | 1.1 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.0 | 1.1 | GO:0060117 | auditory receptor cell development(GO:0060117) |
| 0.0 | 1.0 | GO:0030488 | tRNA methylation(GO:0030488) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 1.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 1.5 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.3 | 1.3 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 1.2 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 1.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.3 | 0.8 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.2 | 0.8 | GO:0031515 | tRNA (m1A) methyltransferase complex(GO:0031515) |
| 0.0 | 0.8 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.0 | 0.8 | GO:0005902 | microvillus(GO:0005902) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.5 | GO:0004373 | glycogen (starch) synthase activity(GO:0004373) |
| 0.4 | 1.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.2 | 1.2 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.2 | 1.1 | GO:0016880 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.0 | 1.1 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 0.9 | GO:0000064 | L-ornithine transmembrane transporter activity(GO:0000064) |
| 0.0 | 0.9 | GO:0004540 | ribonuclease activity(GO:0004540) |
| 0.2 | 0.8 | GO:0016429 | tRNA (adenine-N1-)-methyltransferase activity(GO:0016429) |
| 0.1 | 0.7 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 0.7 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.6 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.6 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.5 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 0.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 0.4 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.4 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.2 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.2 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 1.7 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.0 | 1.5 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.0 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 0.9 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 0.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 0.8 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 0.8 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.7 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 0.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |