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PRJNA207719: Tissue specific transcriptome profiling

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Results for nkx2.1

Z-value: 0.79

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Transcription factors associated with nkx2.1

Gene Symbol Gene ID Gene Info
nkx2.1
ENSDARG00000019835 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.1dr11_v1_chr17_+_38262408_38262408-0.434.7e-01Click!

Activity profile of nkx2.1 motif

Sorted Z-values of nkx2.1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_-_28674739 0.96 ENSDART00000067073
lrrc10
leucine rich repeat containing 10
chr5_+_51597677 0.81 ENSDART00000048210
ENSDART00000184797
ckmt2b
creatine kinase, mitochondrial 2b (sarcomeric)
chr5_+_51594209 0.73 ENSDART00000164668
ENSDART00000058403
ENSDART00000055857
ckmt2b
creatine kinase, mitochondrial 2b (sarcomeric)
chr17_+_20605013 0.59 ENSDART00000156878
si:ch73-288o11.5
si:ch73-288o11.5
chr4_-_67799941 0.50 ENSDART00000185830
si:ch211-66c13.1
si:ch211-66c13.1
chr25_+_25124684 0.50 ENSDART00000167542
ldha
lactate dehydrogenase A4
chr3_+_24207243 0.49 ENSDART00000023454
ENSDART00000136400
adsl
adenylosuccinate lyase
chr2_+_26237322 0.46 ENSDART00000030520
palm1b
paralemmin 1b
chr7_+_48555400 0.46 ENSDART00000174474
kcnq1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr7_+_48555626 0.43 ENSDART00000125483
ENSDART00000083514
kcnq1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr6_-_39051319 0.35 ENSDART00000155093
tns2b
tensin 2b
chr22_+_39096911 0.35 ENSDART00000157127
ENSDART00000153841
lmcd1
LIM and cysteine-rich domains 1
chrM_+_10590 0.33 ENSDART00000093615
mt-nd3
NADH dehydrogenase 3, mitochondrial
chr23_-_33558161 0.33 ENSDART00000018301
itga5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr2_+_26240339 0.27 ENSDART00000191006
palm1b
paralemmin 1b
chr7_+_25053331 0.25 ENSDART00000173998
si:dkey-23i12.7
si:dkey-23i12.7
chr18_+_808911 0.25 ENSDART00000172518
cox5ab
cytochrome c oxidase subunit Vab
chr12_+_34953038 0.23 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
qki2
QKI, KH domain containing, RNA binding 2
chr1_+_55662491 0.21 ENSDART00000152386
adgre8
adhesion G protein-coupled receptor E8
chr22_-_24248420 0.21 ENSDART00000165433
rgs2
regulator of G protein signaling 2
chr7_+_34602991 0.20 ENSDART00000073447
fhod1
formin homology 2 domain containing 1
chr3_-_31019715 0.18 ENSDART00000156687
ENSDART00000156127
ENSDART00000153945
si:dkeyp-71f10.5
si:dkeyp-71f10.5
chr8_-_36469117 0.18 ENSDART00000111240
mhc2dab
major histocompatibility complex class II DAB gene
chr21_-_2348838 0.17 ENSDART00000160337
si:ch73-299h12.8
si:ch73-299h12.8
chr22_+_38762693 0.16 ENSDART00000015016
ENSDART00000150187
alpi.1
alkaline phosphatase, intestinal, tandem duplicate 1
chr13_-_36579086 0.15 ENSDART00000146671
lgals3a
lectin, galactoside binding soluble 3a
chr12_-_30583668 0.15 ENSDART00000153406
casp7
caspase 7, apoptosis-related cysteine peptidase
chr2_-_8609653 0.14 ENSDART00000193354
ENSDART00000189489
ENSDART00000186144
si:ch211-71m22.1
si:ch211-71m22.1
chr11_-_24063196 0.13 ENSDART00000036513
trib3
tribbles pseudokinase 3
chr4_-_20314749 0.13 ENSDART00000066894
ENSDART00000188123
dcp1b
decapping mRNA 1B
chr3_+_17933132 0.12 ENSDART00000104299
ENSDART00000162144
ENSDART00000162242
ENSDART00000166289
ENSDART00000171101
ENSDART00000164853
cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr4_-_14531687 0.12 ENSDART00000182093
ENSDART00000159447
plxnb2a
plexin b2a
chr11_-_36040549 0.11 ENSDART00000112684
setmar
SET domain and mariner transposase fusion gene
chr7_-_30639385 0.11 ENSDART00000173618
myo1ea
myosin IE, a
chr5_-_35456269 0.11 ENSDART00000051312
ttc33
tetratricopeptide repeat domain 33
chr6_+_38880166 0.11 ENSDART00000019939
ENSDART00000144286
bin2b
bridging integrator 2b
chr11_+_43403525 0.10 ENSDART00000180683
vipb
vasoactive intestinal peptide b
chr15_-_434503 0.10 ENSDART00000122286
CABZ01056629.1

chr3_-_8510201 0.09 ENSDART00000009151
CABZ01064671.1

chr10_-_16062565 0.08 ENSDART00000188728
si:dkey-184a18.5
si:dkey-184a18.5
chr2_-_59345920 0.08 ENSDART00000134662
ftr37
finTRIM family, member 37
chr1_+_46026457 0.08 ENSDART00000132705
si:ch211-138g9.2
si:ch211-138g9.2
chr22_-_5724085 0.08 ENSDART00000110526
ENSDART00000140905
pgbd4
piggyBac transposable element derived 4
chr13_+_27040887 0.08 ENSDART00000132714
soul2
heme-binding protein soul2
chr1_+_27977297 0.07 ENSDART00000180692
ENSDART00000166819
sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr25_+_19485198 0.06 ENSDART00000156730
glsl
glutaminase like
chr1_-_59571758 0.06 ENSDART00000193546
ENSDART00000167087
wfikkn1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr6_-_46875310 0.06 ENSDART00000154442
igfn1.3
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 3
chr9_+_7724152 0.06 ENSDART00000061716
mnx2a
motor neuron and pancreas homeobox 2a
chr6_+_38879961 0.06 ENSDART00000184798
bin2b
bridging integrator 2b
chr7_+_48675347 0.06 ENSDART00000157917
ENSDART00000185580
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr4_+_76748500 0.05 ENSDART00000075607
ms4a17a.10
membrane-spanning 4-domains, subfamily A, member 17A.10
chr18_-_39321484 0.05 ENSDART00000077694
leo1
LEO1 homolog, Paf1/RNA polymerase II complex component
chr11_-_8271374 0.05 ENSDART00000168253
pimr202
Pim proto-oncogene, serine/threonine kinase, related 202
chr21_+_34088377 0.05 ENSDART00000170070
mtmr1b
myotubularin related protein 1b
chr7_-_48733662 0.05 ENSDART00000191675
traf6
TNF receptor-associated factor 6
chr15_-_23482088 0.04 ENSDART00000185823
ENSDART00000185523
nlrx1
NLR family member X1
chr1_-_43862638 0.04 ENSDART00000145044
tacr3a
tachykinin receptor 3a
chr1_-_58000438 0.04 ENSDART00000163761
si:ch211-114l13.9
si:ch211-114l13.9
chr16_+_5539189 0.04 ENSDART00000178106
CR848788.2

chr17_+_23975762 0.03 ENSDART00000155941
xpo1b
exportin 1 (CRM1 homolog, yeast) b
chr11_+_12879635 0.03 ENSDART00000182515
ENSDART00000081296
si:dkey-11m19.5
si:dkey-11m19.5
chr4_-_50926767 0.03 ENSDART00000183430
si:ch211-208f21.3
si:ch211-208f21.3
chr11_+_583725 0.03 ENSDART00000189415
mkrn2os.2
MKRN2 opposite strand, tandem duplicate 2
chr1_-_23294753 0.03 ENSDART00000013263
ugdh
UDP-glucose 6-dehydrogenase
chr3_+_22335030 0.03 ENSDART00000055676
zgc:103564
zgc:103564
chr8_-_44298964 0.03 ENSDART00000098520
fzd10
frizzled class receptor 10
chr15_-_4053149 0.03 ENSDART00000189076
CR626884.4

chr12_+_20506197 0.02 ENSDART00000153010
si:zfos-754c12.2
si:zfos-754c12.2
chr4_-_2052687 0.02 ENSDART00000138291
ENSDART00000150844
cpsf6
cleavage and polyadenylation specific factor 6
chr1_+_55583116 0.02 ENSDART00000152163
adgre19
adhesion G protein-coupled receptor E19
chr9_-_7089303 0.02 ENSDART00000146609
coa5
cytochrome C oxidase assembly factor 5
chr14_-_33478963 0.02 ENSDART00000132813
lamp2
lysosomal-associated membrane protein 2
chr7_-_59123066 0.02 ENSDART00000175438
dennd4c
DENN/MADD domain containing 4C
chr7_+_42461850 0.02 ENSDART00000190350
adamts18
ADAM metallopeptidase with thrombospondin type 1 motif, 18
chr21_-_2162850 0.02 ENSDART00000159731
gb:ai877918
expressed sequence AI877918
chr20_+_46255057 0.02 ENSDART00000100536
taar14i
trace amine associated receptor 14i
chr12_+_30788912 0.02 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr6_+_18531932 0.01 ENSDART00000165271
suz12b
SUZ12 polycomb repressive complex 2b subunit
chr7_-_3895071 0.01 ENSDART00000175200
si:dkey-88n24.11
si:dkey-88n24.11
chr20_+_9128829 0.01 ENSDART00000064144
ENSDART00000137450
bpnt1
bisphosphate nucleotidase 1
chr7_+_25825667 0.01 ENSDART00000149835
mtm1
myotubularin 1
chr11_-_1956204 0.01 ENSDART00000185541
nr1d4b
nuclear receptor subfamily 1, group D, member 4b
chr18_-_22701800 0.00 ENSDART00000135098
si:ch73-113g13.3
si:ch73-113g13.3
chr2_-_52020049 0.00 ENSDART00000128198
ENSDART00000135331
scn12aa
sodium channel, voltage gated, type XII, alpha a
chr3_-_7464250 0.00 ENSDART00000159873
znf1001
zinc finger protein 1001
chr14_-_16476863 0.00 ENSDART00000089021
canx
calnexin
chr17_+_24597001 0.00 ENSDART00000191834
rlf
rearranged L-myc fusion

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 1.0 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.1 0.3 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 0.5 GO:0006167 AMP biosynthetic process(GO:0006167)
0.1 0.2 GO:0090299 regulation of neural crest formation(GO:0090299)
0.0 0.2 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677)
0.0 0.2 GO:0071800 podosome assembly(GO:0071800)
0.0 0.1 GO:0048241 copulation(GO:0007620) regulation of epinephrine secretion(GO:0014060) positive regulation of epinephrine secretion(GO:0032812) positive regulation of catecholamine secretion(GO:0033605) penile erection(GO:0043084) epinephrine transport(GO:0048241) epinephrine secretion(GO:0048242) regulation of penile erection(GO:0060405) positive regulation of penile erection(GO:0060406) prolactin secretion(GO:0070459)
0.0 0.3 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 1.5 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.5 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.2 GO:0019865 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 0.2 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0017128 phospholipid scramblase activity(GO:0017128)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.3 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1