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PRJNA207719: Tissue specific transcriptome profiling

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Results for nkx2.2a

Z-value: 0.78

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Transcription factors associated with nkx2.2a

Gene Symbol Gene ID Gene Info
nkx2.2a
ENSDARG00000053298 NK2 homeobox 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.2adr11_v1_chr17_-_42218652_422186520.168.0e-01Click!

Activity profile of nkx2.2a motif

Sorted Z-values of nkx2.2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_28349144 0.55 ENSDART00000179690
ENSDART00000188059
ino80
INO80 complex subunit
chr22_+_21317597 0.38 ENSDART00000132605
shc2
SHC (Src homology 2 domain containing) transforming protein 2
chr25_-_32311048 0.38 ENSDART00000181806
ENSDART00000086334
CU372926.1

chr5_+_1983495 0.38 ENSDART00000179860
CT573103.2

chr24_+_22039964 0.37 ENSDART00000081220
ankrd33ba
ankyrin repeat domain 33ba
chr11_-_3629201 0.35 ENSDART00000136577
ENSDART00000132121
itih3a
inter-alpha-trypsin inhibitor heavy chain 3a
chr1_-_45888608 0.34 ENSDART00000139219
pnpla6
patatin-like phospholipase domain containing 6
chr23_+_1078072 0.33 ENSDART00000159263
ENSDART00000053527
slc34a2b
solute carrier family 34 (type II sodium/phosphate cotransporter), member 2b
chr24_-_2829049 0.32 ENSDART00000164913
PPP1R3G
si:ch211-152c8.5
chr14_-_42997145 0.29 ENSDART00000172801
pcdh10b
protocadherin 10b
chr8_-_9118958 0.26 ENSDART00000037922
slc6a8
solute carrier family 6 (neurotransmitter transporter), member 8
chr19_-_32940040 0.26 ENSDART00000179947
azin1b
antizyme inhibitor 1b
chr22_+_20720808 0.26 ENSDART00000171321
si:dkey-211f22.5
si:dkey-211f22.5
chr13_-_18637244 0.24 ENSDART00000057869
mat1a
methionine adenosyltransferase I, alpha
chr22_+_25236657 0.24 ENSDART00000138012
zgc:172218
zgc:172218
chr19_-_41213718 0.24 ENSDART00000077121
pdk4
pyruvate dehydrogenase kinase, isozyme 4
chr22_+_25249193 0.24 ENSDART00000171851
si:ch211-226h8.11
si:ch211-226h8.11
chr5_-_23277939 0.23 ENSDART00000003514
plp1b
proteolipid protein 1b
chr1_+_15137901 0.23 ENSDART00000111475
pcdh7a
protocadherin 7a
chr5_+_72087619 0.22 ENSDART00000062885
oxt
oxytocin
chr1_+_45323142 0.21 ENSDART00000132210
emp1
epithelial membrane protein 1
chr7_+_41295974 0.21 ENSDART00000173568
ENSDART00000173544
si:dkey-86l18.10
si:dkey-86l18.10
chr8_-_39739627 0.21 ENSDART00000135422
ENSDART00000067844
si:ch211-170d8.5
si:ch211-170d8.5
chr3_-_48603471 0.21 ENSDART00000189027
ndel1b
nudE neurodevelopment protein 1-like 1b
chr8_-_1698155 0.20 ENSDART00000186159
CABZ01065417.1

chr1_+_17695426 0.20 ENSDART00000103236
ankrd37
ankyrin repeat domain 37
chr7_-_69636502 0.20 ENSDART00000126739
tspan5a
tetraspanin 5a
chr23_+_40460333 0.20 ENSDART00000184658
soga3b
SOGA family member 3b
chr22_-_8006342 0.19 ENSDART00000162028
sc:d217
sc:d217
chr25_-_7974494 0.19 ENSDART00000171446
hal
histidine ammonia-lyase
chr12_-_9438227 0.19 ENSDART00000003932
erbb2
erb-b2 receptor tyrosine kinase 2
chr23_+_27740788 0.19 ENSDART00000053871
dhh
desert hedgehog
chr20_+_33904258 0.19 ENSDART00000170930
rxrgb
retinoid X receptor, gamma b
chr17_-_14726824 0.19 ENSDART00000162947
si:ch73-305o9.3
si:ch73-305o9.3
chr8_-_39739056 0.19 ENSDART00000147992
si:ch211-170d8.5
si:ch211-170d8.5
chr22_-_24757785 0.18 ENSDART00000078225
vtg5
vitellogenin 5
chr4_-_18436899 0.18 ENSDART00000141671
socs2
suppressor of cytokine signaling 2
chr2_-_20052561 0.18 ENSDART00000100133
dpydb
dihydropyrimidine dehydrogenase b
chr21_+_9628854 0.18 ENSDART00000161753
ENSDART00000160711
mapk10
mitogen-activated protein kinase 10
chr9_-_23156908 0.18 ENSDART00000135461
lypd6b
LY6/PLAUR domain containing 6B
chr19_+_1184878 0.18 ENSDART00000163539
scrt1a
scratch family zinc finger 1a
chr8_+_28065803 0.17 ENSDART00000178481
kcnd3
potassium voltage-gated channel, Shal-related subfamily, member 3
chr13_-_40726865 0.17 ENSDART00000099847
st3gal7
ST3 beta-galactoside alpha-2,3-sialyltransferase 7
chr5_+_31965845 0.17 ENSDART00000112968
myo1hb
myosin IHb
chr19_+_47783137 0.17 ENSDART00000024777
ENSDART00000158979
c19h1orf109
c19h1orf109 homolog (H. sapiens)
chr2_+_243778 0.17 ENSDART00000182262
CABZ01085887.1

chr23_+_6795709 0.16 ENSDART00000149136
si:ch211-117c9.5
si:ch211-117c9.5
chr6_+_9793791 0.16 ENSDART00000149896
als2b
amyotrophic lateral sclerosis 2b (juvenile)
chr23_+_27740592 0.16 ENSDART00000137875
dhh
desert hedgehog
chr20_+_66857 0.16 ENSDART00000114999
lrfn2b
leucine rich repeat and fibronectin type III domain containing 2b
chr19_+_9344171 0.16 ENSDART00000133447
ENSDART00000104622
si:ch211-288g17.4
si:ch211-288g17.4
chr12_-_19865585 0.16 ENSDART00000066386
shisa9a
shisa family member 9a
chr11_+_43114108 0.16 ENSDART00000013642
ENSDART00000190266
foxg1b
forkhead box G1b
chr13_+_33368140 0.15 ENSDART00000033848
brf1a
BRF1, RNA polymerase III transcription initiation factor a
chr6_+_49255706 0.15 ENSDART00000156866
si:dkey-183k8.2
si:dkey-183k8.2
chr4_+_19535946 0.15 ENSDART00000192342
ENSDART00000183740
ENSDART00000180812
ENSDART00000180017
lrrc4.1
leucine rich repeat containing 4.1
chr16_-_25400257 0.15 ENSDART00000040756
zgc:136493
zgc:136493
chr9_-_18911608 0.15 ENSDART00000138785
si:dkey-239h2.3
si:dkey-239h2.3
chr2_+_1487118 0.15 ENSDART00000147283
c8a
complement component 8, alpha polypeptide
chr23_+_6795531 0.15 ENSDART00000092131
si:ch211-117c9.5
si:ch211-117c9.5
chr19_+_37848830 0.15 ENSDART00000042276
ENSDART00000180872
nxph1
neurexophilin 1
chr2_+_1486822 0.15 ENSDART00000132500
c8a
complement component 8, alpha polypeptide
chr11_-_7410537 0.15 ENSDART00000009859
adgrl4
adhesion G protein-coupled receptor L4
chr17_+_30205258 0.15 ENSDART00000076596
ENSDART00000153795
spata17
spermatogenesis associated 17
chr18_-_14937211 0.14 ENSDART00000141893
mlc1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr7_-_26518086 0.14 ENSDART00000058913
eif4a1a
eukaryotic translation initiation factor 4A1A
chr8_+_31248917 0.14 ENSDART00000112170
unm_hu7912
un-named hu7912
chr24_-_7699356 0.14 ENSDART00000013117
syt5b
synaptotagmin Vb
chr9_-_51323545 0.14 ENSDART00000139316
slc4a10b
solute carrier family 4, sodium bicarbonate transporter, member 10b
chr13_-_32995324 0.14 ENSDART00000140542
ENSDART00000037740
kcnf1b
potassium voltage-gated channel, subfamily F, member 1b
chr10_+_9372702 0.14 ENSDART00000021100
lhx6
LIM homeobox 6
chr13_+_47710434 0.14 ENSDART00000188724
TMEM87B
transmembrane protein 87B
chr15_+_19472129 0.14 ENSDART00000154779
zgc:77784
zgc:77784
chr17_-_30205302 0.14 ENSDART00000156827
si:dkey-27l15.1
si:dkey-27l15.1
chr8_+_51050554 0.14 ENSDART00000166249
DISP3
si:dkey-32e23.6
chr5_+_20035284 0.14 ENSDART00000191808
sgsm1a
small G protein signaling modulator 1a
chr6_+_20650003 0.13 ENSDART00000049465
slc19a1
solute carrier family 19 (folate transporter), member 1
chr14_-_26536504 0.13 ENSDART00000105933
tgfbi
transforming growth factor, beta-induced
chr2_+_51818039 0.13 ENSDART00000170353
acvr2bb
activin A receptor type 2Bb
chr2_+_38924975 0.13 ENSDART00000109219
rem2
RAS (RAD and GEM)-like GTP binding 2
chr23_+_36730713 0.13 ENSDART00000113179
tspan31
tetraspanin 31
chr23_-_39784368 0.13 ENSDART00000110282
si:ch211-286f9.2
si:ch211-286f9.2
chr1_+_8534698 0.13 ENSDART00000021504
smcr8b
Smith-Magenis syndrome chromosome region, candidate 8b
chr24_-_31332087 0.13 ENSDART00000161179
abcd3a
ATP-binding cassette, sub-family D (ALD), member 3a
chr15_-_44601331 0.13 ENSDART00000161514
zgc:165508
zgc:165508
chr16_-_41465542 0.13 ENSDART00000169116
ENSDART00000187446
cpne4a
copine IVa
chr9_-_9998087 0.13 ENSDART00000124423
ugt1ab
UDP glucuronosyltransferase 1 family a, b
chr25_+_35375848 0.13 ENSDART00000155721
ano3
anoctamin 3
chr13_+_33368503 0.13 ENSDART00000139650
brf1a
BRF1, RNA polymerase III transcription initiation factor a
chr12_+_16281312 0.13 ENSDART00000152500
ppp1r3cb
protein phosphatase 1, regulatory subunit 3Cb
chr13_+_29352842 0.12 ENSDART00000113009
ogdhl
oxoglutarate dehydrogenase like
chr3_-_32927516 0.12 ENSDART00000140117
aoc2
amine oxidase, copper containing 2
chr5_+_54685175 0.12 ENSDART00000115016
pmchl
pro-melanin-concentrating hormone, like
chr8_+_3431671 0.12 ENSDART00000017850
ctu1
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr1_-_21297748 0.12 ENSDART00000142109
npy1r
neuropeptide Y receptor Y1
chr2_+_37424261 0.12 ENSDART00000132427
phc3
polyhomeotic homolog 3 (Drosophila)
chr5_+_16117871 0.12 ENSDART00000090657
znrf3
zinc and ring finger 3
chr7_-_35083585 0.12 ENSDART00000192732
agrp
agouti related neuropeptide
chr11_+_42422638 0.12 ENSDART00000042599
ENSDART00000181175
dennd6aa
DENN/MADD domain containing 6Aa
chr22_-_17586064 0.12 ENSDART00000060786
ENSDART00000188303
ENSDART00000181212
ENSDART00000181951
pip5k1ca
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a
chr21_-_25573064 0.12 ENSDART00000134310
CR388166.1

chr9_+_21722733 0.12 ENSDART00000102021
sox1a
SRY (sex determining region Y)-box 1a
chr6_+_10094061 0.12 ENSDART00000150998
ENSDART00000162236
atp7b
ATPase copper transporting beta
chr20_-_6812688 0.12 ENSDART00000170934
igfbp1a
insulin-like growth factor binding protein 1a
chr9_-_22158784 0.11 ENSDART00000167850
crygm2d14
crystallin, gamma M2d14
chr9_+_42095220 0.11 ENSDART00000148317
ENSDART00000134431
pcbp3
poly(rC) binding protein 3
chr19_-_677713 0.11 ENSDART00000025146
slc6a19a.1
solute carrier family 6 (neutral amino acid transporter), member 19a, tandem duplicate 1
chr11_-_29623380 0.11 ENSDART00000162587
ENSDART00000193935
ENSDART00000191646
chd5
chromodomain helicase DNA binding protein 5
chr2_+_22531185 0.11 ENSDART00000171959
hfm1
HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
chr1_+_37196106 0.11 ENSDART00000008756
ENSDART00000157503
ENSDART00000162971
ENSDART00000191004
ENSDART00000078206
ENSDART00000045111
dclk2a
doublecortin-like kinase 2a
chr5_-_58939460 0.11 ENSDART00000122413
mcama
melanoma cell adhesion molecule a
chr15_-_20731638 0.11 ENSDART00000170616
tpst1
tyrosylprotein sulfotransferase 1
chr4_-_41269844 0.11 ENSDART00000186177
CR388165.2

chr2_-_17044959 0.11 ENSDART00000090260
clcn2a
chloride channel, voltage-sensitive 2a
chr6_+_1724889 0.11 ENSDART00000157415
acvr2ab
activin A receptor type 2Ab
chr23_-_27701361 0.11 ENSDART00000186688
ENSDART00000183985
dnajc22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr24_+_5935377 0.11 ENSDART00000191989
ENSDART00000185932
ENSDART00000131768
abi1a
abl-interactor 1a
chr13_+_36770738 0.11 ENSDART00000146696
atl1
atlastin GTPase 1
chr3_+_40856095 0.11 ENSDART00000143207
mmd2a
monocyte to macrophage differentiation-associated 2a
chr13_-_29424454 0.11 ENSDART00000026765
slc18a3a
solute carrier family 18 (vesicular acetylcholine transporter), member 3a
chr10_-_24868581 0.11 ENSDART00000193055
CABZ01058107.1

chr16_+_17763848 0.11 ENSDART00000149408
ENSDART00000148878
them4
thioesterase superfamily member 4
chr7_-_38698583 0.11 ENSDART00000173900
ENSDART00000126737
cd59
CD59 molecule (CD59 blood group)
chr14_+_29200772 0.11 ENSDART00000166608
TENM2
si:dkey-34l15.2
chr23_-_24856025 0.10 ENSDART00000142171
syt6a
synaptotagmin VIa
chr7_-_41489997 0.10 ENSDART00000174300
smarcd3b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3b
chr21_-_42055872 0.10 ENSDART00000144767
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr7_-_35083184 0.10 ENSDART00000100253
ENSDART00000135250
ENSDART00000173511
agrp
agouti related neuropeptide
chr13_-_24379271 0.10 ENSDART00000046360
rhoua
ras homolog family member Ua
chr2_-_32386942 0.10 ENSDART00000131408
ubtfl
upstream binding transcription factor, like
chr1_-_354115 0.10 ENSDART00000141590
ENSDART00000098627
pros1
protein S
chr9_-_31596016 0.10 ENSDART00000142289
nalcn
sodium leak channel, non-selective
chr25_+_3358701 0.10 ENSDART00000104877
chchd3b
coiled-coil-helix-coiled-coil-helix domain containing 3b
chr19_-_11157659 0.10 ENSDART00000146557
si:dkey-240h12.3
si:dkey-240h12.3
chr8_+_8845932 0.10 ENSDART00000112028
si:ch211-180f4.1
si:ch211-180f4.1
chr19_+_1835940 0.10 ENSDART00000167372
ptk2aa
protein tyrosine kinase 2aa
chr6_-_10168822 0.10 ENSDART00000151016
b3galt1a
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1a
chr6_-_40098641 0.09 ENSDART00000017402
ip6k2b
inositol hexakisphosphate kinase 2b
chr22_-_20924564 0.09 ENSDART00000100642
ENSDART00000032770
ell
elongation factor RNA polymerase II
chr15_-_13254480 0.09 ENSDART00000190499
zgc:172282
zgc:172282
chr23_+_4362463 0.09 ENSDART00000039829
zgc:112175
zgc:112175
chr9_+_23900703 0.09 ENSDART00000127859
trim63b
tripartite motif containing 63b
chr2_+_20472150 0.09 ENSDART00000168537
agla
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase a
chr2_-_32352946 0.09 ENSDART00000144870
ENSDART00000077151
asap1a
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a
chr15_-_16070731 0.09 ENSDART00000122099
dynll2a
dynein, light chain, LC8-type 2a
chr1_+_36651059 0.09 ENSDART00000187475
ednraa
endothelin receptor type Aa
chr5_+_32009080 0.09 ENSDART00000186885
scai
suppressor of cancer cell invasion
chr12_-_35883814 0.09 ENSDART00000177986
ENSDART00000129888
cep131
centrosomal protein 131
chr2_+_7557912 0.09 ENSDART00000160053
ripk2
receptor-interacting serine-threonine kinase 2
chr5_+_9408901 0.09 ENSDART00000193364
FP236810.1

chr16_-_31284922 0.09 ENSDART00000142638
mroh1
maestro heat-like repeat family member 1
chr1_+_41690402 0.09 ENSDART00000177298
fbxo41
F-box protein 41
chr6_+_21395051 0.09 ENSDART00000017774
cacng5a
calcium channel, voltage-dependent, gamma subunit 5a
chr16_-_12097394 0.09 ENSDART00000103944
pex5
peroxisomal biogenesis factor 5
chr17_+_10501647 0.09 ENSDART00000140391
tyro3
TYRO3 protein tyrosine kinase
chr21_+_11684830 0.09 ENSDART00000147473
pcsk1
proprotein convertase subtilisin/kexin type 1
chr15_-_34322915 0.09 ENSDART00000190543
ENSDART00000019651
ENSDART00000193601
dgkb
diacylglycerol kinase, beta
chr19_-_22328154 0.09 ENSDART00000090464
si:ch73-196l6.5
si:ch73-196l6.5
chr1_+_8304904 0.09 ENSDART00000168631
cacna1hb
calcium channel, voltage-dependent, T type, alpha 1H subunit b
chr11_+_25064519 0.09 ENSDART00000016181
ndrg3a
ndrg family member 3a
chr2_-_38992304 0.09 ENSDART00000114085
ENSDART00000146812
si:ch211-119o8.6
si:ch211-119o8.6
chr16_-_28594181 0.09 ENSDART00000059053
rpp38
ribonuclease P/MRP 38 subunit
chr19_+_7552699 0.09 ENSDART00000180788
ENSDART00000115058
pbxip1a
pre-B-cell leukemia homeobox interacting protein 1a
chr16_+_30301539 0.09 ENSDART00000186018
LO017848.1

chr11_+_7580079 0.09 ENSDART00000091550
ENSDART00000193223
ENSDART00000193386
adgrl2a
adhesion G protein-coupled receptor L2a
chr8_+_23485079 0.09 ENSDART00000026316
sema3gb
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr11_+_18873113 0.08 ENSDART00000103969
ENSDART00000103968
magi1b
membrane associated guanylate kinase, WW and PDZ domain containing 1b
chr13_-_18863680 0.08 ENSDART00000109277
lzts2a
leucine zipper, putative tumor suppressor 2a
chr21_+_39948300 0.08 ENSDART00000137740
slc47a1
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr11_-_3954691 0.08 ENSDART00000182041
pbrm1
polybromo 1
chr21_-_37951819 0.08 ENSDART00000139549
si:dkey-38k9.5
si:dkey-38k9.5
chr12_-_3237561 0.08 ENSDART00000164665
si:ch1073-13h15.3
si:ch1073-13h15.3
chr14_+_3449780 0.08 ENSDART00000163849
trpc3
transient receptor potential cation channel, subfamily C, member 3
chr12_-_24812403 0.08 ENSDART00000185517
foxn2b
forkhead box N2b
chr24_+_15655069 0.08 ENSDART00000042943
ENSDART00000181296
fbxo15
F-box protein 15
chr2_-_11662851 0.08 ENSDART00000145108
zgc:110130
zgc:110130
chr23_-_31512496 0.08 ENSDART00000158755
ENSDART00000143425
eya4
EYA transcriptional coactivator and phosphatase 4
chr17_+_8324345 0.08 ENSDART00000172443
cdc42bpaa
CDC42 binding protein kinase alpha (DMPK-like) a
chr16_-_28593951 0.08 ENSDART00000183322
rpp38
ribonuclease P/MRP 38 subunit
chr1_-_54622227 0.08 ENSDART00000049010
tekt4
tektin 4
chr10_-_28395620 0.08 ENSDART00000168907
CR392341.4

chr10_+_34394454 0.08 ENSDART00000110121
stard13a
StAR-related lipid transfer (START) domain containing 13a
chr12_+_36413886 0.08 ENSDART00000126325
si:ch211-250n8.1
si:ch211-250n8.1
chr12_+_16440708 0.08 ENSDART00000113810
ankrd1b
ankyrin repeat domain 1b (cardiac muscle)
chr1_-_51261420 0.08 ENSDART00000168685
kif16ba
kinesin family member 16Ba
chr4_+_37992753 0.08 ENSDART00000193890
CR759843.2

chr16_+_14707960 0.08 ENSDART00000137912
col14a1a
collagen, type XIV, alpha 1a
chr17_+_27545183 0.08 ENSDART00000129392
pacrg
PARK2 co-regulated
chr7_-_32875552 0.08 ENSDART00000132504
ano5b
anoctamin 5b
chr10_+_21807497 0.08 ENSDART00000164634
pcdh1g32
protocadherin 1 gamma 32
chr24_-_33308045 0.08 ENSDART00000149711
slc4a2b
solute carrier family 4 (anion exchanger), member 2b
chr11_-_34522249 0.08 ENSDART00000158616
pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr6_+_4872883 0.08 ENSDART00000186730
ENSDART00000092290
ENSDART00000151674
pcdh9
protocadherin 9
chr11_+_34522554 0.08 ENSDART00000109833
zmat3
zinc finger, matrin-type 3
chr25_-_5119162 0.08 ENSDART00000153961
shisal1b
shisa like 1b
chr25_+_31323978 0.08 ENSDART00000067030
lsp1
lymphocyte-specific protein 1
chr9_+_49727611 0.08 ENSDART00000110069
CSRNP3
cysteine and serine rich nuclear protein 3
chr3_+_49521106 0.08 ENSDART00000162799
crb3a
crumbs homolog 3a
chr15_-_20731297 0.08 ENSDART00000114464
tpst1
tyrosylprotein sulfotransferase 1
chr23_-_15090782 0.08 ENSDART00000133624
si:ch211-218g4.2
si:ch211-218g4.2

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0042766 nucleosome mobilization(GO:0042766)
0.1 0.2 GO:0015942 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.1 0.4 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 0.2 GO:0046104 deoxyribonucleoside metabolic process(GO:0009120) thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 0.2 GO:0097623 potassium ion export(GO:0071435) potassium ion export across plasma membrane(GO:0097623)
0.1 0.4 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.2 GO:0048939 anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
0.0 0.1 GO:0015884 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.0 0.3 GO:1902047 polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
0.0 0.1 GO:0042908 xenobiotic transport(GO:0042908)
0.0 0.2 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.2 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.1 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.3 GO:0021794 thalamus development(GO:0021794)
0.0 0.1 GO:0032801 receptor catabolic process(GO:0032801)
0.0 0.2 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.1 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.3 GO:0046470 phosphatidylcholine metabolic process(GO:0046470)
0.0 0.1 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.1 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.0 0.1 GO:0032447 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.0 0.1 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.1 GO:0033335 anal fin development(GO:0033335)
0.0 0.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.1 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.0 0.0 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.1 GO:0002931 response to ischemia(GO:0002931)
0.0 0.2 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.1 GO:0033345 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.0 0.0 GO:0048389 paraxial mesoderm morphogenesis(GO:0048340) paraxial mesoderm formation(GO:0048341) intermediate mesoderm development(GO:0048389) convergent extension involved in nephron morphogenesis(GO:0072045)
0.0 0.1 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.0 GO:0055015 ventricular cardiac muscle cell development(GO:0055015)
0.0 0.1 GO:1903405 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576) protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) protein localization to nucleoplasm(GO:1990173)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 0.1 GO:0010754 negative regulation of cGMP-mediated signaling(GO:0010754)
0.0 0.2 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.1 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.1 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735) negative regulation of intracellular protein transport(GO:0090317)
0.0 0.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.1 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.0 0.1 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.3 GO:0070897 DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0 0.0 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.1 GO:0032986 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:1901099 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.2 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.0 0.1 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.0 GO:0015990 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.0 0.0 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) distal tubule morphogenesis(GO:0072156) proximal/distal pattern formation involved in pronephric nephron development(GO:0072196)
0.0 0.1 GO:0090134 establishment or maintenance of cytoskeleton polarity(GO:0030952) mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.0 0.1 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:0010447 response to acidic pH(GO:0010447)
0.0 0.2 GO:0015701 bicarbonate transport(GO:0015701)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.2 GO:0001650 fibrillar center(GO:0001650) multimeric ribonuclease P complex(GO:0030681)
0.0 0.4 GO:0005903 brush border(GO:0005903)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0005883 neurofilament(GO:0005883)
0.0 0.0 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.1 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.1 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0016586 RSC complex(GO:0016586)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.1 0.2 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.1 0.2 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.1 0.2 GO:0031782 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1 0.2 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.2 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.1 GO:0015350 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.0 0.3 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.2 GO:0033204 ribonuclease P RNA binding(GO:0033204)
0.0 0.3 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.0 0.4 GO:0005113 patched binding(GO:0005113)
0.0 0.2 GO:0002061 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.0 0.2 GO:0045735 nutrient reservoir activity(GO:0045735)
0.0 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.2 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.6 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0004133 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.2 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.0 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.2 GO:0042910 xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.0 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.0 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.1 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0004096 catalase activity(GO:0004096)
0.0 0.1 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.2 REACTOME PEPTIDE HORMONE BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.2 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.2 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism