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PRJNA207719: Tissue specific transcriptome profiling

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Results for nkx2.3+nkx2.7

Z-value: 1.40

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Transcription factors associated with nkx2.3+nkx2.7

Gene Symbol Gene ID Gene Info
nkx2.7
ENSDARG00000021232 NK2 transcription factor related 7
nkx2.3
ENSDARG00000039095 NK2 homeobox 3
nkx2.3
ENSDARG00000113490 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.7dr11_v1_chr8_-_50287949_50287949-0.533.6e-01Click!
nkx2.3dr11_v1_chr13_-_40411908_40411917-0.207.4e-01Click!

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_3828560 1.63 ENSDART00000185273
ENSDART00000179091
gad1b
glutamate decarboxylase 1b
chr13_+_38430466 1.53 ENSDART00000132691
adgrb3
adhesion G protein-coupled receptor B3
chr9_-_51323545 1.14 ENSDART00000139316
slc4a10b
solute carrier family 4, sodium bicarbonate transporter, member 10b
chr17_-_29119362 1.10 ENSDART00000104204
foxg1a
forkhead box G1a
chr12_+_24342303 1.08 ENSDART00000111239
nrxn1a
neurexin 1a
chr15_-_15357178 1.02 ENSDART00000106120
ywhag2
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr24_-_6158933 1.02 ENSDART00000021609
gad2
glutamate decarboxylase 2
chr4_+_21129752 1.00 ENSDART00000169764
syt1a
synaptotagmin Ia
chr15_-_34213898 0.98 ENSDART00000191945
ENSDART00000186089
etv1
ets variant 1
chr5_-_10946232 0.98 ENSDART00000163139
ENSDART00000031265
rtn4r
reticulon 4 receptor
chr14_+_29609245 0.97 ENSDART00000043058
TENM2
si:dkey-34l15.2
chr20_+_18551657 0.95 ENSDART00000147001
si:dkeyp-72h1.1
si:dkeyp-72h1.1
chr12_-_25916530 0.95 ENSDART00000186386
sncgb
synuclein, gamma b (breast cancer-specific protein 1)
chr21_+_18353703 0.95 ENSDART00000181396
ENSDART00000166359
si:ch73-287m6.1
si:ch73-287m6.1
chr17_+_23298928 0.93 ENSDART00000153652
zgc:165461
zgc:165461
chr11_+_7324704 0.91 ENSDART00000031937
diras1a
DIRAS family, GTP-binding RAS-like 1a
chr24_+_2519761 0.91 ENSDART00000106619
nrn1a
neuritin 1a
chr17_-_12389259 0.91 ENSDART00000185724
snap25b
synaptosomal-associated protein, 25b
chr7_+_73397283 0.89 ENSDART00000174390
CABZ01081780.1

chr8_+_24861264 0.87 ENSDART00000099607
slc6a17
solute carrier family 6 (neutral amino acid transporter), member 17
chr7_-_28148310 0.87 ENSDART00000044208
lmo1
LIM domain only 1
chr5_+_23622177 0.85 ENSDART00000121504
cx27.5
connexin 27.5
chr22_-_13851297 0.85 ENSDART00000080306
s100b
S100 calcium binding protein, beta (neural)
chr12_+_5081759 0.81 ENSDART00000164178
prrt2
proline-rich transmembrane protein 2
chr2_+_22702488 0.80 ENSDART00000076647
kif1ab
kinesin family member 1Ab
chr19_-_868187 0.79 ENSDART00000186626
eomesa
eomesodermin homolog a
chr15_-_6247775 0.78 ENSDART00000148350
dscamb
Down syndrome cell adhesion molecule b
chr1_-_23110740 0.78 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adgrl3.1
adhesion G protein-coupled receptor L3.1
chr16_+_9779680 0.77 ENSDART00000154253
zgc:92912
zgc:92912
chr21_+_7582036 0.77 ENSDART00000135485
ENSDART00000027268
otpa
orthopedia homeobox a
chr1_+_45085194 0.75 ENSDART00000193863
si:ch211-151p13.8
si:ch211-151p13.8
chr20_+_34717403 0.74 ENSDART00000034252
pnocb
prepronociceptin b
chr23_-_14990865 0.73 ENSDART00000147799
ndrg3b
ndrg family member 3b
chr8_+_3820134 0.72 ENSDART00000122454
citb
citron rho-interacting serine/threonine kinase b
chr19_+_24872159 0.72 ENSDART00000158490
si:ch211-195b13.1
si:ch211-195b13.1
chr10_+_22381802 0.72 ENSDART00000112484
nlgn2b
neuroligin 2b
chr5_-_58939460 0.71 ENSDART00000122413
mcama
melanoma cell adhesion molecule a
chr22_-_33679277 0.71 ENSDART00000169948
FO904977.1

chr12_+_18578597 0.70 ENSDART00000134944
grid2ipb
glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein, b
chr3_+_29714775 0.69 ENSDART00000041388
cacng2a
calcium channel, voltage-dependent, gamma subunit 2a
chr19_+_1184878 0.68 ENSDART00000163539
scrt1a
scratch family zinc finger 1a
chr5_+_20147830 0.68 ENSDART00000098727
svopa
SV2 related protein a
chr17_-_44247707 0.67 ENSDART00000126097
otx2b
orthodenticle homeobox 2b
chr24_+_34606966 0.67 ENSDART00000105477
lrrtm2
leucine rich repeat transmembrane neuronal 2
chr20_-_39271844 0.67 ENSDART00000192708
clu
clusterin
chr20_-_28800999 0.67 ENSDART00000049462
rab15
RAB15, member RAS oncogene family
chr12_+_39685485 0.67 ENSDART00000163403
LO017650.1

chr25_-_9805269 0.67 ENSDART00000192048
lrrc4c
leucine rich repeat containing 4C
chr3_-_35800221 0.66 ENSDART00000031390
caskin1
CASK interacting protein 1
chr9_+_21722733 0.66 ENSDART00000102021
sox1a
SRY (sex determining region Y)-box 1a
chr9_-_3671911 0.65 ENSDART00000102900
sp5a
Sp5 transcription factor a
chr5_-_14373662 0.65 ENSDART00000183694
tet3
tet methylcytosine dioxygenase 3
chr8_+_31821396 0.65 ENSDART00000077053
plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr15_+_36115955 0.63 ENSDART00000032702
sst1.2
somatostatin 1, tandem duplicate 2
chr21_+_9628854 0.63 ENSDART00000161753
ENSDART00000160711
mapk10
mitogen-activated protein kinase 10
chr16_+_32059785 0.63 ENSDART00000134459
si:dkey-40m6.8
si:dkey-40m6.8
chr5_+_36611128 0.62 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr22_+_696931 0.62 ENSDART00000149712
ENSDART00000009756
gpr37l1a
G protein-coupled receptor 37 like 1a
chr10_-_8033468 0.61 ENSDART00000140476
atp6v0a2a
ATPase H+ transporting V0 subunit a2a
chr21_+_28958471 0.61 ENSDART00000144331
ENSDART00000005929
ppp3ca
protein phosphatase 3, catalytic subunit, alpha isozyme
chr2_+_20332044 0.60 ENSDART00000112131
plppr4a
phospholipid phosphatase related 4a
chr8_-_33114202 0.58 ENSDART00000098840
ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr5_+_32009080 0.58 ENSDART00000186885
scai
suppressor of cancer cell invasion
chr3_-_30061985 0.57 ENSDART00000189583
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr12_+_3022882 0.57 ENSDART00000122905
rac3b
Rac family small GTPase 3b
chr19_+_13099541 0.57 ENSDART00000171607
ENSDART00000165448
ENSDART00000170365
rims2b
regulating synaptic membrane exocytosis 2b
chr4_+_12615836 0.57 ENSDART00000003583
lmo3
LIM domain only 3
chr3_+_56366395 0.57 ENSDART00000154367
cacng5b
calcium channel, voltage-dependent, gamma subunit 5b
chr5_-_28679135 0.57 ENSDART00000193585
tnc
tenascin C
chr23_-_36823932 0.56 ENSDART00000142305
hipk1a
homeodomain interacting protein kinase 1a
chr21_+_40417152 0.56 ENSDART00000171244
ssh2b
slingshot protein phosphatase 2b
chr24_+_41915878 0.56 ENSDART00000171523
TMEM200C
transmembrane protein 200C
chr25_+_14165447 0.55 ENSDART00000145387
shank2
SH3 and multiple ankyrin repeat domains 2
chr12_+_7497882 0.55 ENSDART00000134608
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr13_+_24834199 0.55 ENSDART00000101274
zgc:153981
zgc:153981
chr16_+_26766423 0.54 ENSDART00000048036
gem
GTP binding protein overexpressed in skeletal muscle
chr7_-_28147838 0.54 ENSDART00000158921
lmo1
LIM domain only 1
chr22_-_7129631 0.54 ENSDART00000171359
asic1b
acid-sensing (proton-gated) ion channel 1b
chr10_-_8032885 0.53 ENSDART00000188619
atp6v0a2a
ATPase H+ transporting V0 subunit a2a
chr13_-_14487524 0.53 ENSDART00000141103
gfra4a
GDNF family receptor alpha 4a
chr12_+_34953038 0.53 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
qki2
QKI, KH domain containing, RNA binding 2
chr19_-_44089509 0.53 ENSDART00000189136
rad21b
RAD21 cohesin complex component b
chr8_+_22582146 0.53 ENSDART00000157655
ENSDART00000189892
CT583651.2

chr19_-_5865766 0.52 ENSDART00000191007
LO018585.1

chr15_-_12319065 0.52 ENSDART00000162973
ENSDART00000170543
fxyd6
FXYD domain containing ion transport regulator 6
chr18_+_24921587 0.52 ENSDART00000191345
rgma
repulsive guidance molecule family member a
chr9_+_17983463 0.52 ENSDART00000182150
akap11
A kinase (PRKA) anchor protein 11
chr8_-_19051906 0.52 ENSDART00000089024
sema6bb
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr6_+_21001264 0.52 ENSDART00000044519
ENSDART00000151278
cx44.2
connexin 44.2
chr11_+_30057762 0.51 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr17_+_13664442 0.51 ENSDART00000171689
lrfn5a
leucine rich repeat and fibronectin type III domain containing 5a
chr6_-_11780070 0.51 ENSDART00000151195
march7
membrane-associated ring finger (C3HC4) 7
chr21_-_43015383 0.51 ENSDART00000065097
dpysl3
dihydropyrimidinase-like 3
chr12_+_33038757 0.51 ENSDART00000153146
rbfox3a
RNA binding fox-1 homolog 3a
chr21_-_42100471 0.51 ENSDART00000166148
gabra1
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr23_+_44741500 0.50 ENSDART00000166421
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr1_+_33969015 0.50 ENSDART00000042984
ENSDART00000146530
epha6
eph receptor A6
chr16_+_20161805 0.49 ENSDART00000192146
c16h2orf66
chromosome 16 C2orf66 homolog
chr8_-_50888806 0.49 ENSDART00000053750
acsl2
acyl-CoA synthetase long chain family member 2
chr15_+_26399538 0.49 ENSDART00000159589
rtn4rl1b
reticulon 4 receptor-like 1b
chr17_-_6399920 0.49 ENSDART00000022010
hivep2b
human immunodeficiency virus type I enhancer binding protein 2b
chr8_-_9570511 0.49 ENSDART00000044000
plxna3
plexin A3
chr14_-_4682114 0.48 ENSDART00000014454
gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr25_-_7683316 0.48 ENSDART00000128820
si:ch211-286c4.6
si:ch211-286c4.6
chr1_+_52929185 0.48 ENSDART00000147683
inpp4b
inositol polyphosphate-4-phosphatase type II B
chr25_-_4482449 0.47 ENSDART00000056278
ENSDART00000149425
slc25a22a
solute carrier family 25 member 22a
chr5_-_12407194 0.46 ENSDART00000125291
ksr2
kinase suppressor of ras 2
chr3_-_28250722 0.46 ENSDART00000165936
rbfox1
RNA binding fox-1 homolog 1
chr22_+_27090136 0.46 ENSDART00000136770
si:dkey-246e1.3
si:dkey-246e1.3
chr9_+_40939336 0.46 ENSDART00000100386
mstnb
myostatin b
chr13_-_43599898 0.46 ENSDART00000084416
ENSDART00000145705
ablim1a
actin binding LIM protein 1a
chr6_-_30210378 0.46 ENSDART00000157359
ENSDART00000113924
lrrc7
leucine rich repeat containing 7
chr6_-_41229787 0.45 ENSDART00000065013
synpr
synaptoporin
chr10_+_37137464 0.45 ENSDART00000114909
cuedc1a
CUE domain containing 1a
chr1_+_40023640 0.45 ENSDART00000101623
lgi2b
leucine-rich repeat LGI family, member 2b
chr19_+_37848830 0.45 ENSDART00000042276
ENSDART00000180872
nxph1
neurexophilin 1
chr18_+_9637744 0.45 ENSDART00000190171
pclob
piccolo presynaptic cytomatrix protein b
chr11_+_44804685 0.44 ENSDART00000163660
strn
striatin, calmodulin binding protein
chr8_+_26874924 0.44 ENSDART00000141794
rimkla
ribosomal modification protein rimK-like family member A
chr22_+_18389271 0.44 ENSDART00000088270
yjefn3
YjeF N-terminal domain containing 3
chr16_-_55028740 0.43 ENSDART00000156368
ENSDART00000161704
zgc:114181
zgc:114181
chr19_+_20178978 0.43 ENSDART00000145115
ENSDART00000151175
tra2a
transformer 2 alpha homolog
chr20_-_27711970 0.43 ENSDART00000139637
zbtb25
zinc finger and BTB domain containing 25
chr10_+_37181780 0.43 ENSDART00000187625
ksr1a
kinase suppressor of ras 1a
chr24_+_26039464 0.42 ENSDART00000131017
tnk2a
tyrosine kinase, non-receptor, 2a
chr20_-_47732703 0.42 ENSDART00000193975
tfap2d
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr4_+_12612145 0.42 ENSDART00000181201
lmo3
LIM domain only 3
chr8_-_51507144 0.41 ENSDART00000024882
ENSDART00000135166
fgfr1a
fibroblast growth factor receptor 1a
chr7_+_32722227 0.41 ENSDART00000126565
si:ch211-150g13.3
si:ch211-150g13.3
chr17_-_3986236 0.41 ENSDART00000188794
ENSDART00000160830
PLCB1
si:ch1073-140o9.2
chr5_+_26156079 0.41 ENSDART00000088141
ankrd34bb
ankyrin repeat domain 34Bb
chr14_+_25465346 0.40 ENSDART00000173436
si:dkey-280e21.3
si:dkey-280e21.3
chr2_+_26656283 0.40 ENSDART00000133202
ENSDART00000099208
asph
aspartate beta-hydroxylase
chr20_-_27857676 0.40 ENSDART00000192934
syndig1l
synapse differentiation inducing 1-like
chr16_+_39159752 0.40 ENSDART00000122081
sybu
syntabulin (syntaxin-interacting)
chr19_-_25301711 0.40 ENSDART00000175739
rims3
regulating synaptic membrane exocytosis 3
chr17_-_21249651 0.40 ENSDART00000156580
ENSDART00000155221
hspa12a
heat shock protein 12A
chr6_+_40661703 0.40 ENSDART00000142492
eno1b
enolase 1b, (alpha)
chr1_-_22512063 0.39 ENSDART00000031546
ENSDART00000190987
chrna6
cholinergic receptor, nicotinic, alpha 6
chr14_-_2206476 0.39 ENSDART00000081870
pcdh2ab6
protocadherin 2 alpha b 6
chr14_+_49135264 0.39 ENSDART00000084119
si:ch1073-44g3.1
si:ch1073-44g3.1
chr11_+_25583950 0.39 ENSDART00000111961
ccdc120
coiled-coil domain containing 120
chr21_+_39705483 0.39 ENSDART00000147718
ENSDART00000168996
plrdgb
PITP-less RdgB-like protein
chr7_-_26497947 0.39 ENSDART00000058910
sox19b
SRY (sex determining region Y)-box 19b
chr17_-_14700889 0.38 ENSDART00000179975
ptp4a2a
protein tyrosine phosphatase type IVA, member 2a
chr23_-_7799184 0.38 ENSDART00000190946
ENSDART00000165427
myt1b
myelin transcription factor 1b
chr9_-_1702648 0.38 ENSDART00000102934
hnrnpa3
heterogeneous nuclear ribonucleoprotein A3
chr18_+_36769758 0.38 ENSDART00000180375
ENSDART00000136463
ENSDART00000133487
ENSDART00000130206
fosb
FBJ murine osteosarcoma viral oncogene homolog B
chr10_+_29698467 0.37 ENSDART00000163402
dlg2
discs, large homolog 2 (Drosophila)
chr14_-_2203124 0.37 ENSDART00000124171
si:dkeyp-115d7.2
si:dkeyp-115d7.2
chr23_-_29505645 0.37 ENSDART00000146458
kif1b
kinesin family member 1B
chr15_-_20024205 0.37 ENSDART00000161379
auts2b
autism susceptibility candidate 2b
chr3_-_61336841 0.37 ENSDART00000155414
tecpr1b
tectonin beta-propeller repeat containing 1b
chr9_+_51265283 0.37 ENSDART00000137426
gcgb
glucagon b
chr9_+_49659114 0.37 ENSDART00000189643
CSRNP3
cysteine and serine rich nuclear protein 3
chr9_-_32753535 0.36 ENSDART00000060006
olig2
oligodendrocyte lineage transcription factor 2
chr2_+_51183320 0.36 ENSDART00000167430
lrrc24
leucine rich repeat containing 24
chr5_+_32009542 0.36 ENSDART00000182025
ENSDART00000179879
scai
suppressor of cancer cell invasion
chr10_+_42690374 0.36 ENSDART00000123496
rhobtb2b
Rho-related BTB domain containing 2b
chr10_+_9372702 0.36 ENSDART00000021100
lhx6
LIM homeobox 6
chr13_+_2442841 0.36 ENSDART00000114456
ENSDART00000137124
ENSDART00000193737
ENSDART00000189722
ENSDART00000187485
arfgef3
ARFGEF family member 3
chr15_+_41555593 0.36 ENSDART00000152376
si:ch211-276c2.2
si:ch211-276c2.2
chr1_-_36152131 0.36 ENSDART00000182113
ENSDART00000182904
znf827
zinc finger protein 827
chr18_-_9046805 0.36 ENSDART00000134224
grm3
glutamate receptor, metabotropic 3
chr7_-_24699985 0.35 ENSDART00000052802
calb2b
calbindin 2b
chr14_-_24410673 0.35 ENSDART00000125923
cxcl14
chemokine (C-X-C motif) ligand 14
chr11_-_6188413 0.35 ENSDART00000109972
ccl44
chemokine (C-C motif) ligand 44
chr16_+_2820340 0.35 ENSDART00000092299
ENSDART00000192931
ENSDART00000148512
si:dkey-288i20.2
si:dkey-288i20.2
chr1_-_44701313 0.35 ENSDART00000193926
si:dkey-28b4.8
si:dkey-28b4.8
chr6_+_13726844 0.35 ENSDART00000055833
wnt6a
wingless-type MMTV integration site family, member 6a
chr1_-_50859053 0.34 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr16_-_29480335 0.34 ENSDART00000148930
lingo4b
leucine rich repeat and Ig domain containing 4b
chr5_-_31901468 0.34 ENSDART00000147814
ENSDART00000141446
coro1cb
coronin, actin binding protein, 1Cb
chr5_-_58112032 0.34 ENSDART00000016418
drd2b
dopamine receptor D2b
chr11_-_37589293 0.33 ENSDART00000172989
bsnb
bassoon (presynaptic cytomatrix protein) b
chr2_+_30786773 0.33 ENSDART00000019029
ENSDART00000145681
atp6v1h
ATPase H+ transporting V1 subunit H
chr20_-_5052786 0.33 ENSDART00000138818
ENSDART00000181655
ENSDART00000164274
arid1b
AT rich interactive domain 1B (SWI1-like)
chr19_-_7358184 0.33 ENSDART00000092379
oxr1b
oxidation resistance 1b
chr14_+_36628131 0.33 ENSDART00000188625
ENSDART00000125345
TENM3
si:dkey-237h12.3
chr9_-_18735256 0.33 ENSDART00000143165
tsc22d1
TSC22 domain family, member 1
chr12_+_26706745 0.33 ENSDART00000141401
arhgap12b
Rho GTPase activating protein 12b
chr5_-_16734060 0.33 ENSDART00000035859
ENSDART00000190457
ENSDART00000179244
atad1a
ATPase family, AAA domain containing 1a
chr18_+_10884996 0.32 ENSDART00000147613
mical3a
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr8_+_2757821 0.32 ENSDART00000051403
ENSDART00000160551
sh3glb2a
SH3-domain GRB2-like endophilin B2a
chr12_-_9087566 0.32 ENSDART00000152793
exoc6
exocyst complex component 6
chr14_+_5936996 0.32 ENSDART00000097144
ENSDART00000126777
kctd8
potassium channel tetramerization domain containing 8
chr4_-_4259079 0.32 ENSDART00000135352
ENSDART00000026559
cd9b
CD9 molecule b
chr3_+_9379877 0.31 ENSDART00000182080
LO018550.1

chr6_+_37623693 0.31 ENSDART00000144812
ENSDART00000182709
tubgcp5
tubulin, gamma complex associated protein 5
chr1_-_36151377 0.31 ENSDART00000037516
znf827
zinc finger protein 827
chr17_-_8656155 0.31 ENSDART00000148990
ctbp2a
C-terminal binding protein 2a
chr22_-_3564563 0.31 ENSDART00000145114
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr1_+_7517454 0.31 ENSDART00000016139
lancl1
LanC antibiotic synthetase component C-like 1 (bacterial)
chr1_-_13271569 0.31 ENSDART00000127838
pcdh18a
protocadherin 18a
chr9_-_51436377 0.31 ENSDART00000006612
tbr1b
T-box, brain, 1b
chr17_-_42213285 0.31 ENSDART00000140549
nkx2.2a
NK2 homeobox 2a
chr5_+_32206378 0.31 ENSDART00000126873
ENSDART00000051361
myhz2
myosin, heavy polypeptide 2, fast muscle specific
chr2_+_30787128 0.30 ENSDART00000189233
atp6v1h
ATPase H+ transporting V1 subunit H
chr21_+_22404662 0.30 ENSDART00000183455
lmbrd2b
LMBR1 domain containing 2b
chr2_-_32352946 0.30 ENSDART00000144870
ENSDART00000077151
asap1a
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.3 1.5 GO:0016322 neuron remodeling(GO:0016322)
0.3 0.9 GO:0015824 proline transport(GO:0015824)
0.3 0.8 GO:0060571 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.2 0.6 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.2 0.9 GO:0061551 trigeminal ganglion development(GO:0061551)
0.1 0.4 GO:1900274 positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274)
0.1 1.1 GO:0043584 nose development(GO:0043584)
0.1 0.7 GO:0032616 interleukin-13 production(GO:0032616) regulation of interleukin-13 production(GO:0032656)
0.1 0.8 GO:0021767 mammillary body development(GO:0021767) social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.1 0.4 GO:0048917 posterior lateral line ganglion development(GO:0048917)
0.1 0.5 GO:1901862 negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
0.1 0.4 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.1 0.5 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.3 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.3 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.1 0.5 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.4 GO:0060074 synapse maturation(GO:0060074)
0.1 0.6 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.1 0.4 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 0.6 GO:0048069 eye pigmentation(GO:0048069)
0.1 0.4 GO:0021742 abducens nucleus development(GO:0021742)
0.1 2.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.4 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.1 1.1 GO:0007035 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.4 GO:0042264 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 0.8 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.1 0.5 GO:0070207 protein homotrimerization(GO:0070207)
0.1 1.3 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 0.4 GO:0016115 diterpenoid catabolic process(GO:0016103) terpenoid catabolic process(GO:0016115) forebrain anterior/posterior pattern specification(GO:0021797) retinoic acid catabolic process(GO:0034653)
0.1 0.3 GO:1901017 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 0.3 GO:0044068 modification by symbiont of host morphology or physiology(GO:0044003) modulation by symbiont of host cellular process(GO:0044068)
0.1 1.5 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 0.2 GO:0019852 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.1 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.1 0.9 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.5 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.2 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.1 0.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 1.1 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.8 GO:0051967 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.4 GO:0060114 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.0 0.1 GO:0046087 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.1 GO:1902410 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
0.0 0.6 GO:0021654 rhombomere boundary formation(GO:0021654)
0.0 0.5 GO:0015813 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0006499 N-terminal protein myristoylation(GO:0006499) N-terminal peptidyl-glycine N-myristoylation(GO:0018008) protein myristoylation(GO:0018377)
0.0 0.9 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.3 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.0 0.5 GO:0014036 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0 0.9 GO:0030537 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537) dopaminergic neuron differentiation(GO:0071542)
0.0 0.1 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.0 0.6 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.6 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.3 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.2 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.2 GO:0050746 regulation of lipoprotein metabolic process(GO:0050746) regulation of protein lipidation(GO:1903059)
0.0 0.1 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.0 0.3 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.3 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.0 0.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.2 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.0 0.2 GO:0060295 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.3 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.0 0.2 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.0 0.3 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.2 GO:0055071 manganese ion homeostasis(GO:0055071)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.4 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 0.2 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.9 GO:0048935 peripheral nervous system neuron development(GO:0048935)
0.0 0.5 GO:0051932 synaptic transmission, GABAergic(GO:0051932)
0.0 0.1 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.6 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.5 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.2 GO:0031113 regulation of microtubule polymerization(GO:0031113)
0.0 0.2 GO:0019627 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.0 0.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.2 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.2 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.1 GO:0021634 optic nerve formation(GO:0021634)
0.0 0.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.1 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.2 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0072575 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.0 0.3 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.1 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 0.5 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.0 2.0 GO:0048024 regulation of mRNA splicing, via spliceosome(GO:0048024)
0.0 0.1 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 1.1 GO:0050919 negative chemotaxis(GO:0050919)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.1 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 0.9 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.2 GO:0045176 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.0 0.0 GO:0044108 calcitriol biosynthetic process from calciol(GO:0036378) vitamin D biosynthetic process(GO:0042368) cellular alcohol metabolic process(GO:0044107) cellular alcohol biosynthetic process(GO:0044108)
0.0 0.5 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.2 GO:0007398 ectoderm development(GO:0007398)
0.0 0.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.3 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.0 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.0 0.2 GO:0031060 regulation of histone methylation(GO:0031060)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.3 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 0.2 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.0 0.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.5 GO:0071696 ectodermal placode development(GO:0071696)
0.0 0.1 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.6 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.5 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.9 GO:0007254 JNK cascade(GO:0007254)
0.0 0.1 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.2 GO:0010765 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.3 GO:0071875 adrenergic receptor signaling pathway(GO:0071875)
0.0 0.5 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.4 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0 0.2 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.9 GO:0046839 phospholipid dephosphorylation(GO:0046839)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0043083 synaptic cleft(GO:0043083)
0.2 0.7 GO:0060077 inhibitory synapse(GO:0060077)
0.2 1.0 GO:0042584 chromaffin granule membrane(GO:0042584)
0.2 0.9 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.7 GO:0042583 chromaffin granule(GO:0042583)
0.1 1.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.6 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.6 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 0.5 GO:0034990 nuclear cohesin complex(GO:0000798) mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) nuclear meiotic cohesin complex(GO:0034991)
0.1 0.3 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1 0.8 GO:0098982 GABA-ergic synapse(GO:0098982)
0.1 0.2 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 0.3 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.1 2.0 GO:0043679 axon terminus(GO:0043679)
0.1 1.0 GO:0048788 cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831)
0.0 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.3 GO:0035060 brahma complex(GO:0035060)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 1.6 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 1.0 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.1 GO:0097189 apoptotic body(GO:0097189)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.2 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.6 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.1 GO:0097268 cytoophidium(GO:0097268)
0.0 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.0 1.3 GO:0005871 kinesin complex(GO:0005871)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.8 GO:0031201 SNARE complex(GO:0031201)
0.0 1.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.0 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.2 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.0 0.1 GO:0000815 ESCRT III complex(GO:0000815)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.3 0.9 GO:1903136 cuprous ion binding(GO:1903136)
0.2 0.8 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.4 GO:0072591 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.1 0.4 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.1 0.5 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.1 0.6 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.4 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.1 0.6 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.7 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 1.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 1.3 GO:0048495 Roundabout binding(GO:0048495)
0.1 1.1 GO:0051117 ATPase binding(GO:0051117)
0.1 0.4 GO:0031769 glucagon receptor binding(GO:0031769)
0.1 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.0 GO:0022851 benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.1 0.5 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.1 2.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.6 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 0.3 GO:0043295 glutathione binding(GO:0043295)
0.1 0.7 GO:0031628 opioid receptor binding(GO:0031628)
0.1 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.8 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.7 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.4 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.1 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.5 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.8 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.4 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.5 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0035197 siRNA binding(GO:0035197)
0.0 0.5 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.2 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 1.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.0 0.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 0.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 1.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.5 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 1.3 GO:0044325 ion channel binding(GO:0044325)
0.0 0.2 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 1.6 GO:0016247 channel regulator activity(GO:0016247)
0.0 0.5 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.8 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.6 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0031782 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.4 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 1.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.3 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700) pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.0 0.3 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.3 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.5 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.0 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) cholesterol 26-hydroxylase activity(GO:0031073)
0.0 0.1 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.7 GO:0008009 chemokine activity(GO:0008009)
0.0 1.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.3 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.0 0.6 GO:0017124 SH3 domain binding(GO:0017124)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.2 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.6 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.6 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.9 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.5 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.1 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 1.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway
0.0 0.3 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.4 PID AP1 PATHWAY AP-1 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 1.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.8 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 0.3 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.0 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport