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PRJNA207719: Tissue specific transcriptome profiling

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Results for nkx3-1

Z-value: 1.51

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Transcription factors associated with nkx3-1

Gene Symbol Gene ID Gene Info
nkx3-1
ENSDARG00000078280 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx3-1dr11_v1_chr8_-_50259448_502594480.168.0e-01Click!

Activity profile of nkx3-1 motif

Sorted Z-values of nkx3-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_25249193 1.15 ENSDART00000171851
si:ch211-226h8.11
si:ch211-226h8.11
chr22_+_25236657 1.12 ENSDART00000138012
zgc:172218
zgc:172218
chr9_+_8396755 0.98 ENSDART00000043067
zgc:171776
zgc:171776
chr11_-_30636163 0.94 ENSDART00000140516
zgc:153665
zgc:153665
chr2_+_11031360 0.80 ENSDART00000180020
ENSDART00000145093
acot11a
acyl-CoA thioesterase 11a
chr1_-_5542565 0.78 ENSDART00000160791
ENSDART00000103754
fn1b
fibronectin 1b
chr22_-_11623063 0.76 ENSDART00000145653
gcga
glucagon a
chr2_+_4208323 0.75 ENSDART00000167906
gata6
GATA binding protein 6
chr19_-_5699703 0.74 ENSDART00000082050
zgc:174904
zgc:174904
chr2_+_1486822 0.74 ENSDART00000132500
c8a
complement component 8, alpha polypeptide
chr17_+_24615091 0.73 ENSDART00000064739
rpl13a
ribosomal protein L13a
chr6_-_54826061 0.73 ENSDART00000149982
tnni1b
troponin I type 1b (skeletal, slow)
chr8_-_40464935 0.73 ENSDART00000040013
myl7
myosin, light chain 7, regulatory
chr9_+_44994214 0.72 ENSDART00000141434
retsatl
retinol saturase (all-trans-retinol 13,14-reductase) like
chr2_+_1487118 0.71 ENSDART00000147283
c8a
complement component 8, alpha polypeptide
chr25_+_31323978 0.70 ENSDART00000067030
lsp1
lymphocyte-specific protein 1
chr11_-_5865744 0.68 ENSDART00000104360
gamt
guanidinoacetate N-methyltransferase
chr16_+_54641230 0.68 ENSDART00000157641
ENSDART00000159540
fbxo43
F-box protein 43
chr8_-_39739627 0.64 ENSDART00000135422
ENSDART00000067844
si:ch211-170d8.5
si:ch211-170d8.5
chr22_+_21324398 0.62 ENSDART00000168509
shc2
SHC (Src homology 2 domain containing) transforming protein 2
chr3_+_29942338 0.61 ENSDART00000158220
ifi35
interferon-induced protein 35
chr4_-_9891874 0.58 ENSDART00000067193
adm2a
adrenomedullin 2a
chr23_+_31431956 0.56 ENSDART00000138350
ENSDART00000053542
rps12
ribosomal protein S12
chr14_+_52440161 0.55 ENSDART00000168437
b4galt1l
DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like
chr8_+_6576940 0.55 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr25_-_13403726 0.54 ENSDART00000056723
gins3
GINS complex subunit 3
chr22_+_12770877 0.53 ENSDART00000044683
ftcd
formimidoyltransferase cyclodeaminase
chr1_-_59169815 0.52 ENSDART00000100163
wu:fk65c09
wu:fk65c09
chr23_-_10254288 0.52 ENSDART00000081215
krt8
keratin 8
chr20_-_33566640 0.52 ENSDART00000159729
si:dkey-65b13.9
si:dkey-65b13.9
chr8_-_39739056 0.52 ENSDART00000147992
si:ch211-170d8.5
si:ch211-170d8.5
chr16_-_31686602 0.51 ENSDART00000170357
c1s
complement component 1, s subcomponent
chr2_-_879800 0.51 ENSDART00000019733
irf4a
interferon regulatory factor 4a
chr7_+_8358547 0.50 ENSDART00000173016
jac7
jacalin 7
chr15_+_29025090 0.49 ENSDART00000131755
si:ch211-137a8.2
si:ch211-137a8.2
chr20_-_33507458 0.47 ENSDART00000140287
paplnb
papilin b, proteoglycan-like sulfated glycoprotein
chr24_-_30263301 0.47 ENSDART00000162328
snx7
sorting nexin 7
chr3_+_22377312 0.47 ENSDART00000155597
arhgap27l
Rho GTPase activating protein 27, like
chr5_-_64883082 0.46 ENSDART00000064983
ENSDART00000139066
krt1-c5
keratin, type 1, gene c5
chr15_-_28805493 0.46 ENSDART00000179617
cd3eap
CD3e molecule, epsilon associated protein
chr4_+_76671012 0.45 ENSDART00000005585
ms4a17a.2
membrane-spanning 4-domains, subfamily A, member 17a.2
chr14_+_48903640 0.45 ENSDART00000165323
zgc:154054
zgc:154054
chr16_+_31922065 0.45 ENSDART00000131661
ENSDART00000144194
ENSDART00000145510
rps9
ribosomal protein S9
chr23_+_25832689 0.44 ENSDART00000138907
hnf4a
hepatocyte nuclear factor 4, alpha
chr9_-_12888082 0.43 ENSDART00000133135
ENSDART00000134415
si:ch211-167j6.3
si:ch211-167j6.3
chr5_-_25037454 0.43 ENSDART00000027237
abo
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
chr16_-_51299061 0.43 ENSDART00000148677
serpinb1l4
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 4
chr24_-_27473771 0.43 ENSDART00000139874
cxl34b.11
CX chemokine ligand 34b, duplicate 11
chr19_-_42556086 0.42 ENSDART00000051731
si:dkey-267n13.1
si:dkey-267n13.1
chr19_-_31372896 0.42 ENSDART00000046609
scin
scinderin
chr6_-_11091449 0.42 ENSDART00000127209
pttg1ipa
PTTG1 interacting protein a
chr7_+_17947217 0.42 ENSDART00000101601
cth1
cysteine three histidine 1
chr13_+_159504 0.42 ENSDART00000057248
ewsr1b
EWS RNA-binding protein 1b
chr2_-_10877228 0.42 ENSDART00000138718
ENSDART00000034246
cdc7
cell division cycle 7 homolog (S. cerevisiae)
chr7_+_2455344 0.41 ENSDART00000172942
si:dkey-125e8.4
si:dkey-125e8.4
chr18_+_40471826 0.41 ENSDART00000098806
ugt5c3
UDP glucuronosyltransferase 5 family, polypeptide C3
chr13_-_37647209 0.41 ENSDART00000189102
si:dkey-188i13.10
si:dkey-188i13.10
chr11_-_40128722 0.41 ENSDART00000165781
fam83e
family with sequence similarity 83, member E
chr5_-_67499279 0.40 ENSDART00000128050
si:dkey-251i10.3
si:dkey-251i10.3
chr18_+_6558338 0.40 ENSDART00000110892
b4galnt3b
beta-1,4-N-acetyl-galactosaminyl transferase 3b
chr9_-_51563575 0.40 ENSDART00000167034
ENSDART00000148918
tank
TRAF family member-associated NFKB activator
chr21_-_30658509 0.40 ENSDART00000139764
si:dkey-22f5.9
si:dkey-22f5.9
chr4_-_4119396 0.40 ENSDART00000067409
ENSDART00000138221
lmod2b
leiomodin 2 (cardiac) b
chr16_+_33142734 0.39 ENSDART00000138244
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr12_-_13155653 0.39 ENSDART00000152467
cxl34c
CX chemokine ligand 34c
chr15_-_39969988 0.39 ENSDART00000146054
rps5
ribosomal protein S5
chr5_-_10082244 0.39 ENSDART00000036421
chek2
checkpoint kinase 2
chr19_+_4051695 0.38 ENSDART00000166368
btr24
bloodthirsty-related gene family, member 24
chr3_+_29941777 0.38 ENSDART00000113889
ifi35
interferon-induced protein 35
chr16_-_4203022 0.37 ENSDART00000018686
rrp15
ribosomal RNA processing 15 homolog
chr10_-_34915886 0.37 ENSDART00000141201
ENSDART00000002166
ccna1
cyclin A1
chr3_-_13921173 0.37 ENSDART00000159177
ENSDART00000165174
si:dkey-61n16.5
si:dkey-61n16.5
chr10_-_34916208 0.37 ENSDART00000187371
ccna1
cyclin A1
chr24_-_26328721 0.37 ENSDART00000125468
apodb
apolipoprotein Db
chr16_+_24842662 0.37 ENSDART00000157333
si:dkey-79d12.6
si:dkey-79d12.6
chr12_-_5418340 0.36 ENSDART00000028043
noc3l
NOC3-like DNA replication regulator
chr5_+_26795773 0.36 ENSDART00000145631
tcn2
transcobalamin II
chr11_+_20899029 0.36 ENSDART00000163029
zgc:162182
zgc:162182
chr11_+_24729346 0.35 ENSDART00000087740
zgc:153953
zgc:153953
chr4_+_76735113 0.35 ENSDART00000075602
ms4a17a.6
membrane-spanning 4-domains, subfamily A, member 17A.6
chr8_-_38105053 0.35 ENSDART00000131546
adgra2
adhesion G protein-coupled receptor A2
chr7_+_12950507 0.34 ENSDART00000067629
ENSDART00000158004
saa
serum amyloid A
chr24_+_26328787 0.34 ENSDART00000003884
mynn
myoneurin
chr9_-_50001606 0.33 ENSDART00000161648
ENSDART00000168514
scn1a
sodium channel, voltage-gated, type I, alpha
chr4_+_76705830 0.33 ENSDART00000064312
ms4a17a.7
membrane-spanning 4-domains, subfamily A, member 17A.7
chr3_+_25849560 0.33 ENSDART00000007119
mfsd6l
major facilitator superfamily domain containing 6-like
chr17_-_1705013 0.32 ENSDART00000182864
CABZ01086293.1

chr10_-_3427589 0.32 ENSDART00000133452
ENSDART00000037183
tmed2
transmembrane p24 trafficking protein 2
chr5_+_36666715 0.32 ENSDART00000097686
zgc:153990
zgc:153990
chr25_-_13050959 0.32 ENSDART00000169041
ccl35.1
chemokine (C-C motif) ligand 35, duplicate 1
chr14_+_14806851 0.32 ENSDART00000169235
fhdc2
FH2 domain containing 2
chr12_+_23850661 0.31 ENSDART00000152921
svila
supervillin a
chr17_+_30894431 0.31 ENSDART00000127996
degs2
delta(4)-desaturase, sphingolipid 2
chr17_-_6765877 0.30 ENSDART00000193102
CR352340.1

chr2_-_7757273 0.30 ENSDART00000136074
b3gnt5b
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5b
chr20_+_25552057 0.29 ENSDART00000102913
cyp2v1
cytochrome P450, family 2, subfamily V, polypeptide 1
chr21_+_25198637 0.29 ENSDART00000164972
si:dkey-183i3.6
si:dkey-183i3.6
chr19_+_7424347 0.29 ENSDART00000004622
sf3b4
splicing factor 3b, subunit 4
chr12_-_28548789 0.29 ENSDART00000153062
si:ch73-180n10.1
si:ch73-180n10.1
chr18_-_22753637 0.28 ENSDART00000181589
ENSDART00000009912
hsf4
heat shock transcription factor 4
chr20_-_25902141 0.28 ENSDART00000142611
ENSDART00000024821
elmsan1a
ELM2 and Myb/SANT-like domain containing 1a
chr17_+_6538733 0.28 ENSDART00000193712
slc5a6b
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr13_+_27328098 0.28 ENSDART00000037585
mb21d1
Mab-21 domain containing 1
chr7_-_20464468 0.28 ENSDART00000134700
cnpy4
canopy4
chr23_+_4362463 0.28 ENSDART00000039829
zgc:112175
zgc:112175
chr6_+_7466223 0.28 ENSDART00000148908
erbb3a
erb-b2 receptor tyrosine kinase 3a
chr22_+_13886821 0.27 ENSDART00000130585
ENSDART00000105711
sh3bp4a
SH3-domain binding protein 4a
chr7_+_41322407 0.27 ENSDART00000114076
ENSDART00000139093
dph2
DPH2 homolog (S. cerevisiae)
chr9_-_8296723 0.27 ENSDART00000139867
si:ch211-145c1.1
si:ch211-145c1.1
chr8_-_38317914 0.27 ENSDART00000125920
pdlim2
PDZ and LIM domain 2 (mystique)
chr9_+_35015747 0.27 ENSDART00000140110
gabpa
GA binding protein transcription factor, alpha subunit
chr1_+_24365582 0.27 ENSDART00000169389
pimr178
Pim proto-oncogene, serine/threonine kinase, related 178
chr3_+_3139240 0.26 ENSDART00000105014
si:dkey-30g5.1
si:dkey-30g5.1
chr3_+_16922226 0.26 ENSDART00000017646
atp6v0a1a
ATPase H+ transporting V0 subunit a1a
chr14_+_8715527 0.25 ENSDART00000170754
kcnk4a
potassium channel, subfamily K, member 4a
chr13_-_48058779 0.25 ENSDART00000186623
ENSDART00000045475
itga9
integrin, alpha 9
chr25_+_10953351 0.25 ENSDART00000154050
mhc1lda
major histocompatibility complex class I LDA
chr5_+_1933131 0.25 ENSDART00000061693
si:ch73-55i23.1
si:ch73-55i23.1
chr12_-_30548244 0.25 ENSDART00000193616
zgc:158404
zgc:158404
chr8_+_30784020 0.25 ENSDART00000112981
tas2r200.1
taste receptor, type 2, member 200, tandem duplicate 1
chr1_-_55248496 0.25 ENSDART00000098615
nanos3
nanos homolog 3
chr18_+_35861930 0.25 ENSDART00000185223
ppp1r13l
protein phosphatase 1, regulatory subunit 13 like
chr16_-_9425451 0.24 ENSDART00000149163
ccr8.1
chemokine (C-C motif) receptor 8.1
chr2_+_10771787 0.24 ENSDART00000187782
gfi1aa
growth factor independent 1A transcription repressor a
chr21_+_19547806 0.24 ENSDART00000159707
ENSDART00000184869
ENSDART00000181321
ENSDART00000058487
ENSDART00000058485
rai14
retinoic acid induced 14
chr15_+_25452092 0.24 ENSDART00000009545
pak4
p21 protein (Cdc42/Rac)-activated kinase 4
chr12_-_31461219 0.24 ENSDART00000148954
acsl5
acyl-CoA synthetase long chain family member 5
chr5_+_27429872 0.24 ENSDART00000087894
zgc:165555
zgc:165555
chr7_+_2259413 0.23 ENSDART00000173420
si:dkey-187j14.7
si:dkey-187j14.7
chr3_-_20957011 0.23 ENSDART00000159787
ENSDART00000180531
ndufa4l
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4, like
chr20_+_33904258 0.23 ENSDART00000170930
rxrgb
retinoid X receptor, gamma b
chr19_-_10330778 0.23 ENSDART00000081465
ENSDART00000136653
ENSDART00000171232
ccdc106b
coiled-coil domain containing 106b
chr21_+_10828828 0.23 ENSDART00000136449
oacyl
O-acyltransferase like
chr18_-_6766354 0.23 ENSDART00000132611
adm2b
adrenomedullin 2b
chr7_+_13702248 0.22 ENSDART00000172811
pdcd7
programmed cell death 7
chr21_+_25236297 0.22 ENSDART00000112783
tmem45b
transmembrane protein 45B
chr7_+_22981441 0.22 ENSDART00000182887
ccnb3
cyclin B3
chr2_-_11101329 0.22 ENSDART00000164416
lrrc53
leucine rich repeat containing 53
chr5_-_16475682 0.22 ENSDART00000090695
piwil2
piwi-like RNA-mediated gene silencing 2
chr5_-_57204352 0.22 ENSDART00000171252
ENSDART00000180727
man2a1
mannosidase, alpha, class 2A, member 1
chr4_-_67800414 0.22 ENSDART00000160213
si:ch211-66c13.1
si:ch211-66c13.1
chr7_+_22680560 0.21 ENSDART00000133761
ponzr4
plac8 onzin related protein 4
chr9_+_15893093 0.21 ENSDART00000099483
ENSDART00000134657
si:dkey-14o1.20
si:dkey-14o1.20
chr24_-_31904924 0.21 ENSDART00000156060
ENSDART00000129741
ENSDART00000154276
si:ch73-78o10.1
si:ch73-78o10.1
chr4_-_18434924 0.20 ENSDART00000190271
socs2
suppressor of cytokine signaling 2
chr5_-_23795688 0.20 ENSDART00000099084
gbgt1l4
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr16_-_42175617 0.20 ENSDART00000084715
alkbh8
alkB homolog 8, tRNA methyltransferase
chr9_-_52386733 0.20 ENSDART00000171721
dap1b
death associated protein 1b
chr16_-_41535690 0.20 ENSDART00000102662
rpp25l
ribonuclease P/MRP 25 subunit-like
chr1_+_57040472 0.20 ENSDART00000181365
si:ch211-1f22.16
si:ch211-1f22.16
chr19_+_45962016 0.19 ENSDART00000169710
utp23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr15_+_38025319 0.19 ENSDART00000155000
si:ch73-380l3.3
si:ch73-380l3.3
chr15_+_12030367 0.19 ENSDART00000176178
FO904901.1

chr20_-_18535502 0.18 ENSDART00000049437
cdc42bpb
CDC42 binding protein kinase beta (DMPK-like)
chr1_-_354115 0.18 ENSDART00000141590
ENSDART00000098627
pros1
protein S
chr17_-_43623356 0.17 ENSDART00000075596
ENSDART00000136431
rtkn2a
rhotekin 2a
chr7_+_48667081 0.17 ENSDART00000083473
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr14_+_14806692 0.17 ENSDART00000193050
fhdc2
FH2 domain containing 2
chr4_-_65323874 0.17 ENSDART00000175271
ENSDART00000187913
BX571813.1

chr18_+_2228737 0.17 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr15_+_17848590 0.17 ENSDART00000168940
zgc:113279
zgc:113279
chr1_-_5455498 0.17 ENSDART00000040368
ENSDART00000114035
mnx2b
motor neuron and pancreas homeobox 2b
chr13_-_31370184 0.17 ENSDART00000034829
rrp12
ribosomal RNA processing 12 homolog
chr22_-_11626014 0.16 ENSDART00000063133
ENSDART00000160085
gcga
glucagon a
chr1_-_58002973 0.16 ENSDART00000140390
si:ch211-114l13.9
si:ch211-114l13.9
chr12_+_33361948 0.16 ENSDART00000124982
fasn
fatty acid synthase
chr6_+_11438972 0.16 ENSDART00000029314
col5a2b
collagen, type V, alpha 2b
chr13_+_7242916 0.16 ENSDART00000184238
aifm2
apoptosis-inducing factor, mitochondrion-associated, 2
chr12_-_4424424 0.16 ENSDART00000152314
si:ch211-173d10.1
si:ch211-173d10.1
chr9_+_35016201 0.16 ENSDART00000182404
gabpa
GA binding protein transcription factor, alpha subunit
chr14_+_3495542 0.15 ENSDART00000168934
gstp2
glutathione S-transferase pi 2
chr19_-_18152942 0.15 ENSDART00000190182
nfe2l3
nuclear factor, erythroid 2-like 3
chr12_+_17100021 0.15 ENSDART00000177923
acta2
actin, alpha 2, smooth muscle, aorta
chr8_+_25616946 0.15 ENSDART00000133983
slc38a5a
solute carrier family 38, member 5a
chr24_+_24086491 0.15 ENSDART00000145092
lipib
lipase, member Ib
chr22_-_23000815 0.14 ENSDART00000137111
ptprc
protein tyrosine phosphatase, receptor type, C
chr8_+_45004997 0.14 ENSDART00000159779
si:ch211-163b2.4
si:ch211-163b2.4
chr23_+_36340520 0.14 ENSDART00000011201
copz1
coatomer protein complex, subunit zeta 1
chr5_-_16475374 0.14 ENSDART00000134274
ENSDART00000136004
piwil2
piwi-like RNA-mediated gene silencing 2
chr21_-_11286483 0.14 ENSDART00000074845
rtkn2b
rhotekin 2b
chr13_-_41947996 0.14 ENSDART00000132808
nanp
N-acetylneuraminic acid phosphatase
chr4_+_3312852 0.14 ENSDART00000084691
fgd4b
FYVE, RhoGEF and PH domain containing 4b
chr1_-_2457546 0.14 ENSDART00000103795
ggact.1
gamma-glutamylamine cyclotransferase, tandem duplicate 1
chr21_+_944715 0.14 ENSDART00000144766
nars
asparaginyl-tRNA synthetase
chr6_+_72040 0.13 ENSDART00000122957
crygm4
crystallin, gamma M4
chr17_-_24703778 0.13 ENSDART00000156061
si:ch211-15d5.12
si:ch211-15d5.12
chr10_-_8957480 0.13 ENSDART00000150049
mocs2
molybdenum cofactor synthesis 2
chr2_+_33747509 0.13 ENSDART00000134187
si:dkey-31m5.5
si:dkey-31m5.5
chr17_+_14886828 0.13 ENSDART00000010507
ENSDART00000131052
ptger2a
prostaglandin E receptor 2a (subtype EP2)
chr15_+_37331585 0.13 ENSDART00000170715
zgc:171592
zgc:171592
chr23_+_35672542 0.13 ENSDART00000046268
pmelb
premelanosome protein b
chr14_-_48786708 0.13 ENSDART00000169730
si:ch211-199b20.3
si:ch211-199b20.3
chr3_-_13599482 0.13 ENSDART00000166639
tufm
Tu translation elongation factor, mitochondrial
chr17_-_43031763 0.13 ENSDART00000132754
ENSDART00000050399
npc2
Niemann-Pick disease, type C2
chr4_+_76745015 0.13 ENSDART00000155883
ms4a17a.10
membrane-spanning 4-domains, subfamily A, member 17A.10
chr3_-_22366562 0.13 ENSDART00000129447
ifnphi1
interferon phi 1
chr4_+_54948890 0.12 ENSDART00000166873
si:dkey-56m15.7
si:dkey-56m15.7
chr10_+_15310811 0.12 ENSDART00000136239
kcnv2a
potassium channel, subfamily V, member 2a
chr2_-_10641998 0.12 ENSDART00000188323
mtf2
metal response element binding transcription factor 2
chr16_+_11603096 0.12 ENSDART00000146286
si:dkey-11o1.3
si:dkey-11o1.3

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.5 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.2 0.7 GO:0006600 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.2 0.5 GO:0015942 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.2 1.1 GO:0006953 acute-phase response(GO:0006953)
0.2 0.6 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 0.7 GO:0055014 ventricular cardiac myofibril assembly(GO:0055005) atrial cardiac muscle cell development(GO:0055014)
0.1 0.4 GO:0006824 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.1 0.3 GO:0022009 central nervous system vasculogenesis(GO:0022009)
0.1 0.4 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.1 0.6 GO:0043011 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.1 0.3 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.1 0.7 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.1 0.2 GO:0015911 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.1 0.5 GO:1902975 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.1 0.3 GO:0051182 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.1 0.2 GO:0042730 fibrinolysis(GO:0042730)
0.1 0.2 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 1.4 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.3 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.4 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.6 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.1 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 1.1 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.4 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.2 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.1 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.0 0.5 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.0 0.7 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.0 0.1 GO:0072512 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0 0.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.3 GO:0034311 diol metabolic process(GO:0034311)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778) monocyte activation(GO:0042117)
0.0 0.1 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.0 0.1 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 0.1 GO:0032185 septin ring organization(GO:0031106) septin cytoskeleton organization(GO:0032185)
0.0 0.1 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.0 0.3 GO:0001845 phagolysosome assembly(GO:0001845)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.8 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.4 GO:0044773 mitotic DNA damage checkpoint(GO:0044773)
0.0 0.1 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.1 GO:0021886 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.0 0.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 0.1 GO:0051189 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.3 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.6 GO:0000187 activation of MAPK activity(GO:0000187)
0.0 0.2 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.4 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.4 GO:0007568 aging(GO:0007568)
0.0 0.0 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 0.1 GO:0090133 establishment or maintenance of cytoskeleton polarity(GO:0030952) mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.1 0.5 GO:0000811 GINS complex(GO:0000811)
0.1 1.4 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 0.4 GO:1990923 PET complex(GO:1990923)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.4 GO:0002102 podosome(GO:0002102)
0.0 1.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.2 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.5 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.1 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.1 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.6 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.8 GO:0005865 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.4 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.7 GO:0022626 cytosolic large ribosomal subunit(GO:0022625) cytosolic ribosome(GO:0022626)
0.0 0.4 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.0 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0031769 glucagon receptor binding(GO:0031769)
0.2 0.5 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.5 GO:0016841 ammonia-lyase activity(GO:0016841)
0.1 0.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.3 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.8 GO:0001948 glycoprotein binding(GO:0001948) proteoglycan binding(GO:0043394)
0.1 0.4 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.1 0.2 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462)
0.1 0.3 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.1 0.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.5 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.1 0.3 GO:0038131 neuregulin receptor activity(GO:0038131) neuregulin binding(GO:0038132)
0.1 0.2 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.4 GO:0034584 piRNA binding(GO:0034584)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0051139 calcium:proton antiporter activity(GO:0015369) metal ion:proton antiporter activity(GO:0051139)
0.0 0.1 GO:0034246 core DNA-dependent RNA polymerase binding promoter specificity activity(GO:0000996) mitochondrial RNA polymerase binding promoter specificity activity(GO:0034246)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.3 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0004998 transferrin receptor activity(GO:0004998)
0.0 0.2 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.5 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153)
0.0 0.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.0 0.8 GO:0019843 rRNA binding(GO:0019843)
0.0 0.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.8 GO:0008009 chemokine activity(GO:0008009)
0.0 0.3 GO:0051117 ATPase binding(GO:0051117)
0.0 0.1 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.1 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 0.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.8 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 3.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.0 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 1.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 0.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.1 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.1 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 0.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.6 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.7 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.2 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.2 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation