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PRJNA207719: Tissue specific transcriptome profiling

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Results for nkx3-2+nkx3.3-2

Z-value: 0.52

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Transcription factors associated with nkx3-2+nkx3.3-2

Gene Symbol Gene ID Gene Info
nkx3-2
ENSDARG00000037639 NK3 homeobox 2
nkx3.3-2
ENSDARG00000069327 NK3 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx3.3dr11_v1_chr13_-_40401870_404018700.504.0e-01Click!
nkx3.2dr11_v1_chr14_-_215051_215051-0.375.4e-01Click!

Activity profile of nkx3-2+nkx3.3-2 motif

Sorted Z-values of nkx3-2+nkx3.3-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_19188809 0.45 ENSDART00000134791
ENSDART00000133682
si:dkey-21e2.8
si:dkey-21e2.8
chr12_+_22580579 0.42 ENSDART00000171725
ENSDART00000192290
capgb
capping protein (actin filament), gelsolin-like b
chr1_-_48933 0.36 ENSDART00000171162
ildr1a
immunoglobulin-like domain containing receptor 1a
chr15_-_31027112 0.36 ENSDART00000100185
lgals9l4
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 4
chr19_+_19989380 0.31 ENSDART00000142841
osbpl3a
oxysterol binding protein-like 3a
chr1_+_1789357 0.30 ENSDART00000006449
atp1a1a.2
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 2
chr17_+_6563307 0.29 ENSDART00000156454
adgrf3a
adhesion G protein-coupled receptor F3a
chr6_+_42918933 0.26 ENSDART00000064896
gnat1
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1
chr2_+_39618951 0.25 ENSDART00000077108
zgc:136870
zgc:136870
chr16_-_24815091 0.24 ENSDART00000154269
ENSDART00000131025
kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr18_-_20458412 0.23 ENSDART00000012241
kif23
kinesin family member 23
chr6_+_13201358 0.21 ENSDART00000190290
CT009620.1

chr11_+_14333441 0.21 ENSDART00000171969
ptbp1b
polypyrimidine tract binding protein 1b
chr3_-_34060153 0.20 ENSDART00000151610
ighv1-1
immunoglobulin heavy variable 1-1
chr16_-_16522013 0.20 ENSDART00000160602
nbeal2
neurobeachin-like 2
chr16_+_49005321 0.19 ENSDART00000160919
CABZ01068499.1

chr3_-_32603191 0.19 ENSDART00000150997
si:ch73-248e21.7
si:ch73-248e21.7
chr4_+_72668095 0.18 ENSDART00000182282
ENSDART00000162637
CABZ01054391.1

chr16_+_26612401 0.18 ENSDART00000145571
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr5_-_26764880 0.18 ENSDART00000140392
ENSDART00000134728
rnf181
ring finger protein 181
chr20_-_30377221 0.17 ENSDART00000126229
rps7
ribosomal protein S7
chr10_+_13209580 0.17 ENSDART00000000887
ENSDART00000136932
rassf6
Ras association (RalGDS/AF-6) domain family 6
chr6_-_40038543 0.17 ENSDART00000154792
si:dkey-197j19.6
si:dkey-197j19.6
chr7_-_4843401 0.16 ENSDART00000137489
si:dkey-83f18.8
si:dkey-83f18.8
chr24_+_17005647 0.15 ENSDART00000149149
zfx
zinc finger protein, X-linked
chr19_+_32855139 0.15 ENSDART00000052082
rpl30
ribosomal protein L30
chr19_+_43604643 0.14 ENSDART00000151168
si:ch211-199g17.9
si:ch211-199g17.9
chr21_-_11791909 0.14 ENSDART00000180893
RHOBTB3
si:dkey-6b12.5
chr17_+_51746830 0.14 ENSDART00000184230
odc1
ornithine decarboxylase 1
chr5_-_42083363 0.13 ENSDART00000162596
cxcl11.5
chemokine (C-X-C motif) ligand 11, duplicate 5
chr7_-_23777445 0.13 ENSDART00000173527
si:ch211-200p22.4
si:ch211-200p22.4
chr18_+_16943911 0.13 ENSDART00000157609
si:dkey-8l13.5
si:dkey-8l13.5
chr1_-_51710225 0.13 ENSDART00000057601
ENSDART00000152745
snrpb2
small nuclear ribonucleoprotein polypeptide B2
chr13_+_23093743 0.12 ENSDART00000148034
pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr4_-_71436560 0.12 ENSDART00000166884
si:dkey-82i20.1
si:dkey-82i20.1
chr5_+_61843752 0.12 ENSDART00000130940
CR759879.1
Danio rerio interferon-induced protein with tetratricopeptide repeats 5 (LOC572297), mRNA.
chr3_-_34054081 0.12 ENSDART00000151590
ighv1-2
immunoglobulin heavy variable 1-2
chr21_-_11996769 0.12 ENSDART00000143537
zgc:64106
zgc:64106
chr8_-_48847772 0.12 ENSDART00000122458
wrap73
WD repeat containing, antisense to TP73
chr8_+_25299069 0.11 ENSDART00000114676
gstm.2
glutathione S-transferase mu tandem duplicate 2
chr15_-_41245962 0.11 ENSDART00000155359
smco4
single-pass membrane protein with coiled-coil domains 4
chr7_+_54222156 0.11 ENSDART00000165201
ENSDART00000158518
pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr2_-_51644044 0.11 ENSDART00000157899
dad1
defender against cell death 1
chr15_+_15173611 0.11 ENSDART00000155267
si:ch211-149e23.4
si:ch211-149e23.4
chr23_+_25292147 0.11 ENSDART00000131486
pa2g4b
proliferation-associated 2G4, b
chr2_+_49631850 0.11 ENSDART00000114274
ENSDART00000114516
si:dkey-53k12.18
si:dkey-53k12.18
chr25_+_19670273 0.10 ENSDART00000073472
zgc:113426
zgc:113426
chr8_+_24281512 0.10 ENSDART00000062845
mmp9
matrix metallopeptidase 9
chr16_+_27444098 0.09 ENSDART00000157690
invs
inversin
chr8_-_4971205 0.09 ENSDART00000184250
tmem230b
transmembrane protein 230b
chr18_-_22094102 0.09 ENSDART00000100904
pard6a
par-6 family cell polarity regulator alpha
chr4_+_17327704 0.09 ENSDART00000016075
ENSDART00000133160
nup37
nucleoporin 37
chr5_-_26765188 0.09 ENSDART00000029450
rnf181
ring finger protein 181
chr7_+_20917966 0.09 ENSDART00000129161
wrap53
WD repeat containing, antisense to TP53
chr4_-_75812937 0.09 ENSDART00000125096
si:ch211-203c5.3
si:ch211-203c5.3
chr6_-_39198912 0.09 ENSDART00000077938
c1galt1b
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b
chr20_-_25643667 0.09 ENSDART00000137457
si:dkeyp-117h8.4
si:dkeyp-117h8.4
chr3_-_16413606 0.08 ENSDART00000127309
ENSDART00000017172
ENSDART00000136465
eftud2
elongation factor Tu GTP binding domain containing 2
chr18_-_26781616 0.08 ENSDART00000136776
ENSDART00000076484
kti12
KTI12 chromatin associated homolog
chr6_+_374875 0.08 ENSDART00000171698
si:zfos-169g10.3
si:zfos-169g10.3
chr12_+_19030391 0.08 ENSDART00000153927
si:ch73-139e5.2
si:ch73-139e5.2
chr3_-_16039619 0.07 ENSDART00000143324
spsb3a
splA/ryanodine receptor domain and SOCS box containing 3a
chr21_+_4388489 0.07 ENSDART00000144555
HTRA2 (1 of many)
si:dkey-84o3.3
chr15_+_5360407 0.07 ENSDART00000110420
or112-1
odorant receptor, family A, subfamily 112, member 1
chr12_+_17754859 0.07 ENSDART00000112119
bhlha15
basic helix-loop-helix family, member a15
chr2_+_42135719 0.07 ENSDART00000008268
cyp7b1
cytochrome P450, family 7, subfamily B, polypeptide 1
chr4_-_13931508 0.07 ENSDART00000067174
zcrb1
zinc finger CCHC-type and RNA binding motif 1
chr19_-_3777217 0.06 ENSDART00000160510
si:dkey-206d17.15
si:dkey-206d17.15
chr4_+_71382288 0.06 ENSDART00000181926
si:ch211-76m11.8
si:ch211-76m11.8
chr8_-_4031121 0.06 ENSDART00000169474
ENSDART00000163754
mtmr3
myotubularin related protein 3
chr22_+_9431853 0.06 ENSDART00000181028
si:ch211-11p18.6
si:ch211-11p18.6
chr3_-_41791178 0.06 ENSDART00000049687
grifin
galectin-related inter-fiber protein
chr25_+_16356083 0.06 ENSDART00000125925
ENSDART00000125444
tead1a
TEA domain family member 1a
chr7_-_6441865 0.06 ENSDART00000172831
hist1h2a10
histone cluster 1 H2A family member 10
chr16_-_22585289 0.06 ENSDART00000134239
ENSDART00000193959
ENSDART00000077998
si:dkey-238m4.3
cgna
si:dkey-238m4.3
cingulin a
chr25_+_11456696 0.06 ENSDART00000171408
AGBL1
si:ch73-141f14.1
chr5_-_8907819 0.05 ENSDART00000188523
adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr16_+_28994709 0.05 ENSDART00000088023
gon4l
gon-4-like (C. elegans)
chr11_-_36474306 0.05 ENSDART00000170678
ENSDART00000123591
usp48
ubiquitin specific peptidase 48
chr22_-_26514386 0.05 ENSDART00000125628
CR759791.1

chr10_+_24048883 0.05 ENSDART00000149265
gbe1a
glucan (1,4-alpha-), branching enzyme 1a
chr5_-_23117078 0.05 ENSDART00000051529
uprt
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr15_-_36347858 0.05 ENSDART00000155274
ENSDART00000157936
si:dkey-23k10.2
si:dkey-23k10.2
chr23_+_12840080 0.04 ENSDART00000081016
ENSDART00000121697
smc1al
structural maintenance of chromosomes 1A, like
chr5_+_60928576 0.04 ENSDART00000131041
doc2b
double C2-like domains, beta
chr22_-_27113332 0.04 ENSDART00000146951
ENSDART00000178855
xpnpep1
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
chr15_+_24676905 0.04 ENSDART00000078014
ENSDART00000143137
poldip2
polymerase (DNA-directed), delta interacting protein 2
chr3_-_41795917 0.04 ENSDART00000182662
grifin
galectin-related inter-fiber protein
chr15_-_36727462 0.04 ENSDART00000085971
nphs1
nephrosis 1, congenital, Finnish type (nephrin)
chr21_+_34814444 0.04 ENSDART00000161816
wdr55
WD repeat domain 55
chr21_+_4403155 0.04 ENSDART00000161623
HTRA2 (1 of many)
si:dkey-84o3.3
chr12_-_13729263 0.04 ENSDART00000078021
foxh1
forkhead box H1
chr4_+_45357558 0.03 ENSDART00000150769
si:ch211-162i8.5
si:ch211-162i8.5
chr10_-_29831944 0.03 ENSDART00000063923
ENSDART00000136264
zpr1
ZPR1 zinc finger
chr6_+_58622831 0.03 ENSDART00000128793
sp7
Sp7 transcription factor
chr22_-_20386982 0.03 ENSDART00000089015
zbtb7a
zinc finger and BTB domain containing 7a
chr12_-_16636627 0.03 ENSDART00000128811
si:dkey-239j18.3
si:dkey-239j18.3
chr8_-_17987547 0.02 ENSDART00000112699
ENSDART00000061747
fpgt
fucose-1-phosphate guanylyltransferase
chr18_-_38216584 0.02 ENSDART00000144622
si:dkey-10o6.2
si:dkey-10o6.2
chr20_+_25568694 0.02 ENSDART00000063107
ENSDART00000063128
cyp2p7
cytochrome P450, family 2, subfamily P, polypeptide 7
chr9_-_9225980 0.02 ENSDART00000180301
cbsb
cystathionine-beta-synthase b
chr11_-_5953636 0.02 ENSDART00000140960
ENSDART00000123601
dda1
DET1 and DDB1 associated 1
chr4_+_71018579 0.02 ENSDART00000186727
si:dkeyp-80d11.10
si:dkeyp-80d11.10
chr7_+_44715224 0.02 ENSDART00000184630
si:dkey-56m19.5
si:dkey-56m19.5
chr14_-_1200854 0.02 ENSDART00000106672
arl9
ADP-ribosylation factor-like 9
chr22_+_9922301 0.02 ENSDART00000105924
blf
bloody fingers
chr11_-_12634017 0.02 ENSDART00000158286
ENSDART00000193090
CR450764.1

chr2_-_55797318 0.01 ENSDART00000158147
calr3b
calreticulin 3b
chr1_-_14258409 0.01 ENSDART00000079359
pde5aa
phosphodiesterase 5A, cGMP-specific, a
chr15_-_35246742 0.01 ENSDART00000131479
mff
mitochondrial fission factor
chr18_-_27858123 0.01 ENSDART00000142068
iqcg
IQ motif containing G
chr8_+_28547687 0.01 ENSDART00000110291
srxn1
sulfiredoxin 1 homolog (S. cerevisiae)
chr1_-_28861226 0.01 ENSDART00000075502
timmdc1
translocase of inner mitochondrial membrane domain containing 1
chr20_+_6773790 0.00 ENSDART00000169966
igfbp3
insulin-like growth factor binding protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx3-2+nkx3.3-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032689 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 0.2 GO:0036344 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.0 0.1 GO:0002432 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.0 0.2 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.3 GO:0001973 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 0.1 GO:0072003 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.0 0.1 GO:0030575 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576)
0.0 0.1 GO:0014028 notochord formation(GO:0014028)
0.0 0.3 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.4 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0008206 bile acid biosynthetic process(GO:0006699) bile acid metabolic process(GO:0008206)
0.0 0.2 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.0 GO:0070987 error-free translesion synthesis(GO:0070987)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0048030 disaccharide binding(GO:0048030)
0.0 0.3 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.1 GO:0030623 U5 snRNA binding(GO:0030623)
0.0 0.2 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0030619 U1 snRNA binding(GO:0030619)
0.0 0.1 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.0 0.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.0 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation