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PRJNA207719: Tissue specific transcriptome profiling

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Results for nkx6.3

Z-value: 0.24

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Transcription factors associated with nkx6.3

Gene Symbol Gene ID Gene Info
nkx6.3
ENSDARG00000060529 NK6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx6.3dr11_v1_chr8_+_38415374_384153740.128.5e-01Click!

Activity profile of nkx6.3 motif

Sorted Z-values of nkx6.3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_12173554 0.15 ENSDART00000110567
ENSDART00000155935
clstn3
calsyntenin 3
chr16_+_46111849 0.15 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr17_+_15433518 0.14 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr17_+_15433671 0.13 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr21_-_13123176 0.12 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr2_-_1486023 0.12 ENSDART00000113774
si:ch211-188c16.1
si:ch211-188c16.1
chr16_-_12173399 0.12 ENSDART00000142574
clstn3
calsyntenin 3
chr16_-_22294265 0.11 ENSDART00000124718
aqp10a
aquaporin 10a
chr9_-_31278048 0.10 ENSDART00000022204
zic5
zic family member 5 (odd-paired homolog, Drosophila)
chr12_-_10409961 0.10 ENSDART00000149521
ENSDART00000052001
eef2k
eukaryotic elongation factor 2 kinase
chr20_-_40755614 0.10 ENSDART00000061247
cx32.3
connexin 32.3
chr6_+_54187643 0.09 ENSDART00000056830
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b
chr21_+_28445052 0.08 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr4_-_1801519 0.08 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr21_-_26918901 0.07 ENSDART00000100685
lrfn4a
leucine rich repeat and fibronectin type III domain containing 4a
chr20_+_40457599 0.07 ENSDART00000017553
serinc1
serine incorporator 1
chr13_+_31286076 0.06 ENSDART00000142725
gdf10a
growth differentiation factor 10a
chr9_-_43538328 0.05 ENSDART00000140526
znf385b
zinc finger protein 385B
chr14_+_14662116 0.05 ENSDART00000161693
cetn2
centrin, EF-hand protein, 2
chr5_+_34623107 0.05 ENSDART00000184126
enc1
ectodermal-neural cortex 1
chr2_+_2223837 0.05 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr4_+_43522680 0.05 ENSDART00000182252
si:dkeyp-53e4.4
si:dkeyp-53e4.4
chr3_+_45687266 0.05 ENSDART00000131652
gpr146
G protein-coupled receptor 146
chr3_-_60175470 0.04 ENSDART00000156597
si:ch73-364h19.1
si:ch73-364h19.1
chr11_-_34219211 0.04 ENSDART00000098472
tmem44
transmembrane protein 44
chr3_+_18795570 0.04 ENSDART00000042368
fahd1
fumarylacetoacetate hydrolase domain containing 1
chr6_-_12588044 0.04 ENSDART00000047896
slc15a1b
solute carrier family 15 (oligopeptide transporter), member 1b
chr13_+_22476742 0.04 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
ldb3a
LIM domain binding 3a
chr18_-_17485419 0.03 ENSDART00000018764
foxl1
forkhead box L1
chr21_+_34088110 0.03 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
mtmr1b
myotubularin related protein 1b
chr17_+_30369396 0.03 ENSDART00000076611
greb1
growth regulation by estrogen in breast cancer 1
chr20_-_9095105 0.02 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr25_+_24291156 0.02 ENSDART00000083407
b4galnt4a
beta-1,4-N-acetyl-galactosaminyl transferase 4a
chr6_-_16717878 0.02 ENSDART00000153552
nomo
nodal modulator
chr10_+_39248911 0.02 ENSDART00000170079
ENSDART00000167974
foxred1
FAD-dependent oxidoreductase domain containing 1
chr4_+_2637947 0.02 ENSDART00000130623
dus4l
dihydrouridine synthase 4-like (S. cerevisiae)
chr13_-_40141630 0.02 ENSDART00000181618
ENSDART00000171583
ENSDART00000192780
crtac1b
cartilage acidic protein 1b
chr11_-_2478374 0.02 ENSDART00000173205
si:ch73-267c23.10
si:ch73-267c23.10
chr13_+_36958086 0.01 ENSDART00000024386
frmd6
FERM domain containing 6
chr3_-_58798377 0.01 ENSDART00000161248
si:ch73-281f12.4
si:ch73-281f12.4
chr17_-_31483469 0.01 ENSDART00000062907
ENSDART00000061547
ltk
leukocyte receptor tyrosine kinase
chr12_+_48803098 0.01 ENSDART00000074768
ppifb
peptidylprolyl isomerase Fb
chr20_-_43663494 0.01 ENSDART00000144564
BX470188.1

chr6_-_37469775 0.01 ENSDART00000156546
plcxd1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr15_+_31344472 0.00 ENSDART00000146695
ENSDART00000159182
ENSDART00000060125
or107-1
odorant receptor, family D, subfamily 107, member 1
chr4_+_4509996 0.00 ENSDART00000028694
gnsa
glucosamine (N-acetyl)-6-sulfatase a
chr20_-_45060241 0.00 ENSDART00000185227
klhl29
kelch-like family member 29
chr12_-_6880694 0.00 ENSDART00000171846
pcdh15b
protocadherin-related 15b
chr20_-_43750771 0.00 ENSDART00000100605
ttc32
tetratricopeptide repeat domain 32
chr3_-_26787430 0.00 ENSDART00000087047
rab40c
RAB40c, member RAS oncogene family
chr3_-_58798815 0.00 ENSDART00000082920
si:ch73-281f12.4
si:ch73-281f12.4
chr6_+_4033832 0.00 ENSDART00000159952
sema5bb
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Bb

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx6.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0052576 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.0 0.1 GO:0071543 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.1 GO:0033278 cell proliferation in midbrain(GO:0033278)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0015105 arsenite transmembrane transporter activity(GO:0015105)
0.0 0.3 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.1 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling