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PRJNA207719: Tissue specific transcriptome profiling
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Results for nr2f2
Z-value: 2.20
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Transcription factors associated with nr2f2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr2f2 | dr11_v1_chr18_-_23875370_23875370 | -0.83 | 8.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_+_37022601 Show fit | 2.74 |
ENSDART00000131800
ENSDART00000041300 |
estrogen receptor 2b |
|
| chr15_-_108414 Show fit | 2.51 |
ENSDART00000170044
|
apolipoprotein A-Ib |
|
| chr10_-_322769 Show fit | 2.21 |
ENSDART00000165244
|
v-akt murine thymoma viral oncogene homolog 2, like |
|
| chr7_+_25036188 Show fit | 2.16 |
ENSDART00000163957
ENSDART00000169749 |
sb:cb1058 |
|
| chr10_+_19569052 Show fit | 2.13 |
ENSDART00000058425
|
|
|
| chr18_-_43866526 Show fit | 2.07 |
ENSDART00000111309
|
trehalase (brush-border membrane glycoprotein) |
|
| chr19_-_27564458 Show fit | 1.98 |
ENSDART00000123155
|
si:dkeyp-46h3.6 |
|
| chr9_-_9982696 Show fit | 1.86 |
ENSDART00000192548
ENSDART00000125852 |
UDP glucuronosyltransferase 1 family a, b |
|
| chr9_+_38292947 Show fit | 1.84 |
ENSDART00000146663
|
transcription factor CP2-like 1 |
|
| chr18_+_13162728 Show fit | 1.83 |
ENSDART00000101472
|
tyrosine aminotransferase |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr2f2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.1 | GO:0042737 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 0.4 | 6.1 | GO:2000344 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 1.2 | 3.5 | GO:0005991 | trehalose metabolic process(GO:0005991) |
| 0.6 | 3.4 | GO:0034372 | triglyceride-rich lipoprotein particle remodeling(GO:0034370) very-low-density lipoprotein particle remodeling(GO:0034372) reverse cholesterol transport(GO:0043691) |
| 0.3 | 2.7 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
| 0.5 | 2.3 | GO:0019483 | beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483) |
| 0.3 | 1.8 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.1 | 1.7 | GO:0007143 | female meiotic division(GO:0007143) |
| 0.1 | 1.7 | GO:0032355 | response to estradiol(GO:0032355) |
| 0.1 | 1.5 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.3 | 4.0 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 1.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 1.1 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.3 | 1.0 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.0 | 0.9 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.9 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 0.8 | GO:0031332 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 0.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 0.7 | GO:0061689 | tricellular tight junction(GO:0061689) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.6 | 6.1 | GO:0035804 | structural constituent of egg coat(GO:0035804) |
| 1.2 | 3.5 | GO:0004555 | alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927) |
| 0.0 | 3.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 3.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 2.8 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.4 | 2.7 | GO:1903924 | estradiol binding(GO:1903924) |
| 0.5 | 2.5 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.1 | 1.8 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.2 | 1.7 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.9 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.5 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.1 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.0 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 2.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 1.5 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 1.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 1.2 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 1.2 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.4 | 1.1 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 1.1 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |