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PRJNA207719: Tissue specific transcriptome profiling
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Results for nr6a1a
Z-value: 2.37
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Transcription factors associated with nr6a1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr6a1a | dr11_v1_chr8_-_52938439_52938439 | -0.73 | 1.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_12660318 Show fit | 3.98 |
ENSDART00000008498
|
alcohol dehydrogenase 8a |
|
| chr20_+_10539293 Show fit | 3.03 |
ENSDART00000182265
|
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1, like |
|
| chr4_-_17409533 Show fit | 2.13 |
ENSDART00000011943
|
phenylalanine hydroxylase |
|
| chr22_-_24858042 Show fit | 2.08 |
ENSDART00000137998
ENSDART00000078216 ENSDART00000138378 |
vitellogenin 7 |
|
| chr3_+_19299309 Show fit | 2.01 |
ENSDART00000046297
ENSDART00000146955 |
low density lipoprotein receptor a |
|
| chr20_+_10545514 Show fit | 2.01 |
ENSDART00000153667
|
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
|
| chr8_+_1769475 Show fit | 1.82 |
ENSDART00000079073
|
serpin peptidase inhibitor, clade D (heparin cofactor), member 1 |
|
| chr15_-_26549693 Show fit | 1.67 |
ENSDART00000186432
|
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b |
|
| chr6_-_8498908 Show fit | 1.52 |
ENSDART00000149222
|
peptidoglycan recognition protein 2 |
|
| chr6_-_8498676 Show fit | 1.46 |
ENSDART00000148627
|
peptidoglycan recognition protein 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr6a1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.6 | 4.0 | GO:0046294 | formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294) |
| 0.2 | 3.8 | GO:0042574 | retinal metabolic process(GO:0042574) |
| 1.0 | 3.0 | GO:0009595 | detection of biotic stimulus(GO:0009595) detection of bacterium(GO:0016045) detection of other organism(GO:0098543) detection of external biotic stimulus(GO:0098581) |
| 0.4 | 2.5 | GO:0032367 | intracellular cholesterol transport(GO:0032367) |
| 0.0 | 2.2 | GO:0042742 | defense response to bacterium(GO:0042742) |
| 0.2 | 2.1 | GO:0006558 | L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222) |
| 0.1 | 2.1 | GO:0032355 | response to estradiol(GO:0032355) |
| 0.0 | 1.7 | GO:0042738 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 0.5 | 1.4 | GO:0000256 | allantoin catabolic process(GO:0000256) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 1.8 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 1.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.4 | 1.3 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.1 | 1.3 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 1.3 | GO:0044853 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.0 | 1.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.3 | 1.2 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 1.2 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.2 | 1.1 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.8 | 4.0 | GO:0051903 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903) |
| 0.4 | 3.4 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 1.0 | 3.0 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.0 | 2.7 | GO:0017171 | serine-type peptidase activity(GO:0008236) serine hydrolase activity(GO:0017171) |
| 0.3 | 2.1 | GO:0045735 | nutrient reservoir activity(GO:0045735) |
| 0.2 | 2.1 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.5 | 2.0 | GO:0030228 | lipoprotein particle receptor activity(GO:0030228) |
| 0.0 | 2.0 | GO:0019955 | cytokine binding(GO:0019955) |
| 0.3 | 1.9 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 1.3 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 1.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.0 | 0.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.3 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.3 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 1.0 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 0.8 | REACTOME EARLY PHASE OF HIV LIFE CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.0 | 0.6 | REACTOME SEMA4D IN SEMAPHORIN SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.0 | 0.6 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.6 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.1 | 0.5 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.5 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |