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PRJNA207719: Tissue specific transcriptome profiling

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Results for pax8

Z-value: 1.01

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Transcription factors associated with pax8

Gene Symbol Gene ID Gene Info
pax8
ENSDARG00000015879 paired box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pax8dr11_v1_chr5_-_72415578_72415578-0.662.2e-01Click!

Activity profile of pax8 motif

Sorted Z-values of pax8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_23487051 1.67 ENSDART00000145496
icn2
ictacalcin 2
chr21_-_22928214 0.92 ENSDART00000182760
dub
duboraya
chr23_+_32039386 0.82 ENSDART00000133801
mylk2
myosin light chain kinase 2
chr10_+_2715548 0.75 ENSDART00000130793
grk5
G protein-coupled receptor kinase 5
chr1_+_9966384 0.75 ENSDART00000132607
si:dkeyp-75b4.8
si:dkeyp-75b4.8
chr6_+_168962 0.74 ENSDART00000182631
CABZ01066694.1

chr7_-_8981507 0.54 ENSDART00000161422
si:ch211-183d5.2
si:ch211-183d5.2
chr7_+_10610791 0.52 ENSDART00000166064
fah
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr6_-_436658 0.47 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr23_+_44049509 0.47 ENSDART00000102003
txk
TXK tyrosine kinase
chr24_-_36727922 0.46 ENSDART00000135142
si:ch73-334d15.1
si:ch73-334d15.1
chr6_-_10927766 0.46 ENSDART00000134327
ccr7
chemokine (C-C motif) receptor 7
chr25_+_18475032 0.43 ENSDART00000073564
tes
testis derived transcript (3 LIM domains)
chr23_+_42813415 0.41 ENSDART00000055577
myl9a
myosin, light chain 9a, regulatory
chr12_+_4900981 0.40 ENSDART00000171507
cd79b
CD79b molecule, immunoglobulin-associated beta
chr2_-_55337585 0.39 ENSDART00000177924
tpm4b
tropomyosin 4b
chr9_+_35014728 0.39 ENSDART00000100700
gabpa
GA binding protein transcription factor, alpha subunit
chr16_+_49601838 0.39 ENSDART00000168570
ENSDART00000159236
si:dkey-82o10.4
si:dkey-82o10.4
chr23_+_26733232 0.38 ENSDART00000035080
zgc:158263
zgc:158263
chr22_+_1751640 0.38 ENSDART00000162093
znf1169
zinc finger protein 1169
chr7_+_19374683 0.36 ENSDART00000162700
snrpf
small nuclear ribonucleoprotein polypeptide F
chr23_+_7505943 0.33 ENSDART00000135787
hck
HCK proto-oncogene, Src family tyrosine kinase
chr9_+_23765587 0.31 ENSDART00000145120
si:ch211-219a4.3
si:ch211-219a4.3
chr2_+_45552901 0.31 ENSDART00000131701
fndc7a
fibronectin type III domain containing 7a
chr25_+_13620555 0.30 ENSDART00000163642
si:ch211-172l8.4
si:ch211-172l8.4
chr23_+_6141541 0.29 ENSDART00000105257
zmp:0000001139
zmp:0000001139
chr20_-_9436521 0.29 ENSDART00000133000
zgc:101840
zgc:101840
chr3_-_3019979 0.26 ENSDART00000111174
zgc:172090
zgc:172090
chr3_+_46444999 0.24 ENSDART00000186530
si:ch211-66e2.3
si:ch211-66e2.3
chr3_-_16110351 0.23 ENSDART00000064838
lasp1
LIM and SH3 protein 1
chr1_-_30457062 0.23 ENSDART00000185318
ENSDART00000157924
ENSDART00000161380
igf2bp2b
insulin-like growth factor 2 mRNA binding protein 2b
chr9_-_21825913 0.23 ENSDART00000101986
mrpl30
mitochondrial ribosomal protein L30
chr3_+_46444625 0.23 ENSDART00000108686
si:ch211-66e2.3
si:ch211-66e2.3
chr23_+_43255328 0.23 ENSDART00000102712
tgm2a
transglutaminase 2, C polypeptide A
chr2_-_985417 0.23 ENSDART00000140540
si:ch211-241e1.3
si:ch211-241e1.3
chr3_-_16110100 0.22 ENSDART00000051807
lasp1
LIM and SH3 protein 1
chr16_+_41135018 0.21 ENSDART00000139435
si:ch211-53m15.2
si:ch211-53m15.2
chr15_-_34892664 0.20 ENSDART00000153787
ENSDART00000099721
rnf183
ring finger protein 183
chr5_+_23630384 0.20 ENSDART00000013745
cx39.9
connexin 39.9
chr9_+_23665777 0.20 ENSDART00000060905
gypc
glycophorin C (Gerbich blood group)
chr9_+_39027123 0.19 ENSDART00000004742
cps1
carbamoyl-phosphate synthase 1, mitochondrial
chr7_+_2797795 0.19 ENSDART00000161208
si:ch211-217i17.1
si:ch211-217i17.1
chr20_+_35445462 0.19 ENSDART00000124497
tdrd6
tudor domain containing 6
chr7_+_3444473 0.18 ENSDART00000122334
si:ch211-285c6.2
si:ch211-285c6.2
chr22_-_4813345 0.18 ENSDART00000190650
CU570881.2

chr1_+_51721851 0.18 ENSDART00000040397
prdx2
peroxiredoxin 2
chr25_-_17579701 0.17 ENSDART00000073684
mmp15a
matrix metallopeptidase 15a
chr4_-_30528239 0.16 ENSDART00000169290
znf1052
zinc finger protein 1052
chr21_-_45891262 0.15 ENSDART00000169816
galnt10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr3_-_10749691 0.15 ENSDART00000183088
CU210890.1

chr2_+_45479841 0.15 ENSDART00000151856
si:ch211-66k16.28
si:ch211-66k16.28
chr20_+_15164482 0.13 ENSDART00000181842
ENSDART00000063877
prdx6
peroxiredoxin 6
chr5_+_20437124 0.13 ENSDART00000159001
tmem119a
transmembrane protein 119a
chr7_-_73843720 0.13 ENSDART00000111622
caap1
caspase activity and apoptosis inhibitor 1
chr14_+_48062180 0.13 ENSDART00000056713
ppid
peptidylprolyl isomerase D
chr11_+_355305 0.13 ENSDART00000147426
pdrg1
p53 and DNA-damage regulated 1
chr14_-_29906209 0.12 ENSDART00000192952
sorbs2b
sorbin and SH3 domain containing 2b
chr7_-_28549361 0.11 ENSDART00000173918
ENSDART00000054368
ENSDART00000113313
st5
suppression of tumorigenicity 5
chr22_+_4447387 0.11 ENSDART00000189742
ENSDART00000166768
timm44
translocase of inner mitochondrial membrane 44 homolog (yeast)
chr25_+_37285737 0.10 ENSDART00000126879
tmed6
transmembrane p24 trafficking protein 6
chr7_-_29356084 0.10 ENSDART00000075757
gtf2a2
general transcription factor IIA, 2
chr10_+_24660225 0.09 ENSDART00000190695
vps36
vacuolar protein sorting 36 homolog (S. cerevisiae)
chr9_+_39027312 0.09 ENSDART00000192258
ENSDART00000164407
cps1
carbamoyl-phosphate synthase 1, mitochondrial
chr13_-_36049008 0.08 ENSDART00000189978
lgmn
legumain
chr17_+_20576848 0.08 ENSDART00000183203
SAMD8
zgc:162183
chr9_+_43797902 0.07 ENSDART00000020550
ube2e3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr22_-_16154771 0.07 ENSDART00000009464
slc30a7
solute carrier family 30 (zinc transporter), member 7
chr4_-_39265279 0.07 ENSDART00000164912
si:ch73-236c18.2
si:ch73-236c18.2
chr10_+_24660017 0.07 ENSDART00000079597
vps36
vacuolar protein sorting 36 homolog (S. cerevisiae)
chr20_+_32224405 0.07 ENSDART00000062993
ENSDART00000147448
sesn1
sestrin 1
chr4_+_36489448 0.06 ENSDART00000143181
znf1149
zinc finger protein 1149
chr20_+_36234335 0.06 ENSDART00000193484
ENSDART00000181664
cnih3
cornichon family AMPA receptor auxiliary protein 3
chr20_+_10498704 0.06 ENSDART00000192985
zgc:100997
zgc:100997
chr6_-_130849 0.05 ENSDART00000108710
LRRC8E
si:zfos-323e3.4
chr10_+_25726694 0.05 ENSDART00000140308
ugt5d1
UDP glucuronosyltransferase 5 family, polypeptide D1
chr16_-_43011470 0.05 ENSDART00000131898
ENSDART00000142003
ENSDART00000017966
nudt17
nudix (nucleoside diphosphate linked moiety X)-type motif 17
chr7_-_52388090 0.04 ENSDART00000174104
wdr93
WD repeat domain 93
chr11_-_37693019 0.04 ENSDART00000102898
zgc:158258
zgc:158258
chr5_+_4298636 0.04 ENSDART00000100061
prdx4
peroxiredoxin 4
chr25_-_3139805 0.04 ENSDART00000166625
epx
eosinophil peroxidase
chr2_+_23130389 0.03 ENSDART00000142834
si:dkey-218h11.6
si:dkey-218h11.6
chr6_+_25215944 0.03 ENSDART00000165456
si:ch73-97h19.2
si:ch73-97h19.2
chr11_-_165288 0.02 ENSDART00000108703
ENSDART00000173151
tegt
testis enhanced gene transcript (BAX inhibitor 1)
chr21_-_20120543 0.02 ENSDART00000065664
dusp4
dual specificity phosphatase 4
chr5_+_68826514 0.01 ENSDART00000061406
usp39
ubiquitin specific peptidase 39
chr5_-_27438812 0.01 ENSDART00000078755
drd7
dopamine receptor D7
chr1_+_55239710 0.00 ENSDART00000174846
si:ch211-286b5.2
si:ch211-286b5.2

Network of associatons between targets according to the STRING database.

First level regulatory network of pax8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.1 0.5 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 0.4 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.1 0.3 GO:0097272 ammonia homeostasis(GO:0097272)
0.0 0.1 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.1 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.4 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.2 GO:0071451 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.2 GO:0030719 P granule organization(GO:0030719)
0.0 0.0 GO:0072526 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 1.7 GO:0021782 glial cell development(GO:0021782)
0.0 0.2 GO:0018149 peptide cross-linking(GO:0018149)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019815 B cell receptor complex(GO:0019815)
0.1 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.1 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.4 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.1 GO:0016272 prefoldin complex(GO:0016272)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001729 ceramide kinase activity(GO:0001729)
0.1 0.5 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 0.3 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087)
0.1 0.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 1.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.7 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.3 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.5 GO:0019957 C-C chemokine binding(GO:0019957)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.3 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers