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PRJNA207719: Tissue specific transcriptome profiling

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Results for pdx1_pbx4

Z-value: 1.84

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Transcription factors associated with pdx1_pbx4

Gene Symbol Gene ID Gene Info
pdx1
ENSDARG00000002779 pancreatic and duodenal homeobox 1
pdx1
ENSDARG00000109275 pancreatic and duodenal homeobox 1
pbx4
ENSDARG00000052150 pre-B-cell leukemia transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pbx4dr11_v1_chr3_+_53052769_53052769-0.079.1e-01Click!
pdx1dr11_v1_chr24_+_21684189_21684189-0.079.1e-01Click!

Activity profile of pdx1_pbx4 motif

Sorted Z-values of pdx1_pbx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr24_+_38301080 17.54 ENSDART00000105672
mybpc2b
myosin binding protein C, fast type b
chr21_-_23308286 1.68 ENSDART00000184419
zbtb16a
zinc finger and BTB domain containing 16a
chr2_+_47623202 1.64 ENSDART00000154465
si:ch211-165b10.3
si:ch211-165b10.3
chr24_-_6898302 1.35 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr21_-_23307653 1.25 ENSDART00000140284
ENSDART00000134103
zbtb16a
zinc finger and BTB domain containing 16a
chr15_+_4632782 1.17 ENSDART00000156012
si:dkey-35i13.1
si:dkey-35i13.1
chr24_-_6897884 1.16 ENSDART00000080766
dpp6a
dipeptidyl-peptidase 6a
chr20_-_8443425 1.06 ENSDART00000083908
dab1a
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr5_-_23280098 1.03 ENSDART00000126540
ENSDART00000051533
plp1b
proteolipid protein 1b
chr4_+_21129752 1.00 ENSDART00000169764
syt1a
synaptotagmin Ia
chr13_-_24447332 0.95 ENSDART00000043004
slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr10_-_39011514 0.78 ENSDART00000075123
pcp4a
Purkinje cell protein 4a
chr12_+_39685485 0.77 ENSDART00000163403
LO017650.1

chr3_-_32818607 0.76 ENSDART00000075465
mylpfa
myosin light chain, phosphorylatable, fast skeletal muscle a
chr24_-_4973765 0.72 ENSDART00000127597
zic1
zic family member 1 (odd-paired homolog, Drosophila)
chr10_-_17745345 0.70 ENSDART00000132690
ENSDART00000135376
si:dkey-200l5.4
si:dkey-200l5.4
chr19_-_26869103 0.69 ENSDART00000089699
prrt1
proline-rich transmembrane protein 1
chr11_-_1509773 0.68 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr7_+_29952719 0.68 ENSDART00000173737
tpma
alpha-tropomyosin
chr15_-_10341048 0.66 ENSDART00000171013
tenm4
teneurin transmembrane protein 4
chr19_+_37925616 0.64 ENSDART00000148348
nxph1
neurexophilin 1
chr9_-_22834860 0.63 ENSDART00000146486
neb
nebulin
chr2_-_54039293 0.59 ENSDART00000166013
abhd8a
abhydrolase domain containing 8a
chr3_+_33300522 0.58 ENSDART00000114023
hspb9
heat shock protein, alpha-crystallin-related, 9
chr4_-_25485404 0.58 ENSDART00000041402
pfkfb3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr1_-_9277986 0.57 ENSDART00000146065
ENSDART00000114876
ENSDART00000132812
ubn1
ubinuclein 1
chr21_-_43079161 0.56 ENSDART00000144151
jakmip2
janus kinase and microtubule interacting protein 2
chr9_-_23217196 0.55 ENSDART00000083567
kif5c
kinesin family member 5C
chr1_+_17676745 0.55 ENSDART00000030665
slc25a4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr9_+_42066030 0.52 ENSDART00000185311
ENSDART00000015267
pcbp3
poly(rC) binding protein 3
chr18_-_36135799 0.52 ENSDART00000059344
b3gat1a
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) a
chr3_-_16068236 0.48 ENSDART00000157315
si:dkey-81l17.6
si:dkey-81l17.6
chr24_-_40009446 0.47 ENSDART00000087422
aoc1
amine oxidase, copper containing 1
chr18_+_783936 0.46 ENSDART00000193357
rpp25b
ribonuclease P and MRP subunit p25, b
chr3_-_62380146 0.45 ENSDART00000155853
gprc5ba
G protein-coupled receptor, class C, group 5, member Ba
chr4_-_5291256 0.45 ENSDART00000150864
SNAP91 (1 of many)
si:ch211-214j24.9
chr22_+_3223489 0.45 ENSDART00000082011
lim2.2
lens intrinsic membrane protein 2.2
chr24_+_34113424 0.42 ENSDART00000105572
gbx1
gastrulation brain homeobox 1
chr20_-_29420713 0.42 ENSDART00000147464
ryr3
ryanodine receptor 3
chr17_+_27434626 0.41 ENSDART00000052446
vgll2b
vestigial-like family member 2b
chr23_-_11870962 0.41 ENSDART00000143481
si:dkey-178k16.1
si:dkey-178k16.1
chr4_-_4780667 0.41 ENSDART00000133973
si:ch211-258f14.2
si:ch211-258f14.2
chr23_+_6077503 0.41 ENSDART00000081714
ENSDART00000139834
mybpha
myosin binding protein Ha
chr8_+_22931427 0.41 ENSDART00000063096
sypa
synaptophysin a
chr11_-_13341483 0.41 ENSDART00000164978
mast3b
microtubule associated serine/threonine kinase 3b
chr14_+_35237613 0.40 ENSDART00000163465
ebf3a
early B cell factor 3a
chr19_-_10395683 0.40 ENSDART00000109488
zgc:194578
zgc:194578
chr13_+_38990939 0.39 ENSDART00000145979
col19a1
collagen, type XIX, alpha 1
chr18_+_41495841 0.39 ENSDART00000098671
si:ch211-203b8.6
si:ch211-203b8.6
chr11_-_13341051 0.39 ENSDART00000121872
mast3b
microtubule associated serine/threonine kinase 3b
chr14_+_36231126 0.39 ENSDART00000141766
elovl6
ELOVL fatty acid elongase 6
chr15_-_33925851 0.38 ENSDART00000187807
ENSDART00000187780
mag
myelin associated glycoprotein
chr4_-_4261673 0.38 ENSDART00000150694
cd9b
CD9 molecule b
chr25_-_4482449 0.38 ENSDART00000056278
ENSDART00000149425
slc25a22a
solute carrier family 25 member 22a
chr18_-_38088099 0.37 ENSDART00000146120
luzp2
leucine zipper protein 2
chr15_-_27710513 0.37 ENSDART00000005641
ENSDART00000134373
lhx1a
LIM homeobox 1a
chr22_-_38508112 0.37 ENSDART00000192004
klc4
kinesin light chain 4
chr20_+_15015557 0.36 ENSDART00000039345
myoc
myocilin
chr16_-_13004166 0.36 ENSDART00000133735
cacng7b
calcium channel, voltage-dependent, gamma subunit 7b
chr24_-_24881996 0.36 ENSDART00000145712
crhb
corticotropin releasing hormone b
chr17_-_200316 0.36 ENSDART00000190561
CABZ01083778.1

chr14_-_31893996 0.35 ENSDART00000173222
gpr101
G protein-coupled receptor 101
chr19_-_10243148 0.35 ENSDART00000148073
shisa7b
shisa family member 7
chr8_+_49778756 0.35 ENSDART00000083790
ntrk2a
neurotrophic tyrosine kinase, receptor, type 2a
chr7_-_52842007 0.35 ENSDART00000182710
map1aa
microtubule-associated protein 1Aa
chr22_+_24715282 0.35 ENSDART00000088027
ENSDART00000189054
ENSDART00000140430
ssx2ipb
synovial sarcoma, X breakpoint 2 interacting protein b
chr17_-_12385308 0.35 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr1_-_8428736 0.34 ENSDART00000138435
ENSDART00000121823
syngr3b
synaptogyrin 3b
chr16_-_44649053 0.34 ENSDART00000184807
CR925804.2

chr4_-_27301356 0.34 ENSDART00000100444
fam19a5a
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr16_+_26777473 0.34 ENSDART00000188870
cdh17
cadherin 17, LI cadherin (liver-intestine)
chr25_+_15354095 0.34 ENSDART00000090397
kiaa1549la
KIAA1549-like a
chr21_+_31151197 0.33 ENSDART00000137728
st6gal1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr13_+_14006118 0.33 ENSDART00000131875
ENSDART00000089528
atrn
attractin
chr25_-_29363934 0.33 ENSDART00000166889
nptna
neuroplastin a
chr5_-_29643930 0.33 ENSDART00000161250
grin1b
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr8_+_49778486 0.33 ENSDART00000131732
ntrk2a
neurotrophic tyrosine kinase, receptor, type 2a
chr1_-_19215336 0.33 ENSDART00000162949
ENSDART00000170680
ptprdb
protein tyrosine phosphatase, receptor type, D, b
chr4_+_842010 0.32 ENSDART00000067461
si:ch211-152c2.3
si:ch211-152c2.3
chr25_-_13842618 0.32 ENSDART00000160258
mapk8ip1a
mitogen-activated protein kinase 8 interacting protein 1a
chr12_+_38770654 0.32 ENSDART00000155367
kif19
kinesin family member 19
chr22_+_15438513 0.31 ENSDART00000010846
gpc5b
glypican 5b
chr13_+_38302665 0.31 ENSDART00000145777
adgrb3
adhesion G protein-coupled receptor B3
chr21_-_26918901 0.31 ENSDART00000100685
lrfn4a
leucine rich repeat and fibronectin type III domain containing 4a
chr1_-_7917062 0.31 ENSDART00000177068
mmd2b
monocyte to macrophage differentiation-associated 2b
chr4_+_13810811 0.30 ENSDART00000067168
pdzrn4
PDZ domain containing ring finger 4
chr18_-_42172101 0.30 ENSDART00000124211
cntn5
contactin 5
chr8_-_34052019 0.29 ENSDART00000040126
ENSDART00000159208
ENSDART00000048994
ENSDART00000098822
pbx3b
pre-B-cell leukemia homeobox 3b
chr5_-_7834582 0.29 ENSDART00000162626
ENSDART00000157661
pdlim5a
PDZ and LIM domain 5a
chr16_-_18960333 0.29 ENSDART00000143185
fhod3b
formin homology 2 domain containing 3b
chr17_+_23937262 0.29 ENSDART00000113276
si:ch211-189k9.2
si:ch211-189k9.2
chr20_-_42702832 0.29 ENSDART00000134689
ENSDART00000045816
plg
plasminogen
chr2_+_24199276 0.29 ENSDART00000140575
map4l
microtubule associated protein 4 like
chr14_-_32403554 0.29 ENSDART00000172873
ENSDART00000173408
ENSDART00000173114
ENSDART00000185594
ENSDART00000186762
ENSDART00000010982
fgf13a
fibroblast growth factor 13a
chr24_+_39186940 0.28 ENSDART00000155817
spsb3b
splA/ryanodine receptor domain and SOCS box containing 3b
chr2_+_27010439 0.28 ENSDART00000030547
cdh7a
cadherin 7a
chr21_+_25181003 0.28 ENSDART00000169700
si:dkey-183i3.9
si:dkey-183i3.9
chr12_-_26406323 0.28 ENSDART00000131896
myoz1b
myozenin 1b
chr7_+_50109239 0.28 ENSDART00000021605
LRRC4C (1 of many)
si:dkey-6l15.1
chr24_+_41915878 0.28 ENSDART00000171523
TMEM200C
transmembrane protein 200C
chr25_+_21833287 0.28 ENSDART00000187606
ckmt1
creatine kinase, mitochondrial 1
chr14_-_2199573 0.28 ENSDART00000124485
pcdh2ab8
protocadherin 2 alpha b 8
chr24_+_37370064 0.28 ENSDART00000185870
si:ch211-183d21.3
si:ch211-183d21.3
chr17_+_19626479 0.28 ENSDART00000044993
ENSDART00000131863
rgs7a
regulator of G protein signaling 7a
chr13_+_24842857 0.28 ENSDART00000123866
dusp13a
dual specificity phosphatase 13a
chr20_-_29418620 0.28 ENSDART00000172634
ryr3
ryanodine receptor 3
chr7_+_4384863 0.27 ENSDART00000042955
ENSDART00000134653
slc12a10.3
slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 3
chr23_+_40460333 0.27 ENSDART00000184658
soga3b
SOGA family member 3b
chr1_-_40227166 0.27 ENSDART00000146680
si:ch211-113e8.3
si:ch211-113e8.3
chr13_+_30421472 0.27 ENSDART00000143569
zmiz1a
zinc finger, MIZ-type containing 1a
chr13_+_23282549 0.26 ENSDART00000101134
khdrbs2
KH domain containing, RNA binding, signal transduction associated 2
chr1_-_681116 0.26 ENSDART00000165894
adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_+_25129013 0.26 ENSDART00000132879
ndrg3a
ndrg family member 3a
chr5_-_50992690 0.26 ENSDART00000149553
ENSDART00000097460
ENSDART00000192021
hmgcra
3-hydroxy-3-methylglutaryl-CoA reductase a
chr17_+_50127648 0.26 ENSDART00000156460
galnt16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr18_+_13792490 0.25 ENSDART00000136754
cdh13
cadherin 13, H-cadherin (heart)
chr15_-_25527580 0.25 ENSDART00000167005
ENSDART00000157498
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr6_-_53143667 0.25 ENSDART00000079694
gnai2b
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr2_+_42724404 0.25 ENSDART00000075392
basp1
brain abundant, membrane attached signal protein 1
chr7_+_4386753 0.25 ENSDART00000172915
slc12a10.3
slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 3
chr11_-_4220167 0.24 ENSDART00000185406
si:ch211-236d3.4
si:ch211-236d3.4
chr8_+_23165749 0.24 ENSDART00000063057
dnajc5aa
DnaJ (Hsp40) homolog, subfamily C, member 5aa
chr20_+_522457 0.24 ENSDART00000138585
nt5dc1
5'-nucleotidase domain containing 1
chr19_-_25149034 0.24 ENSDART00000148432
ENSDART00000175266
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr2_+_24199073 0.24 ENSDART00000144110
map4l
microtubule associated protein 4 like
chr20_+_34717403 0.24 ENSDART00000034252
pnocb
prepronociceptin b
chr3_-_12890670 0.23 ENSDART00000159934
ENSDART00000188607
btbd17b
BTB (POZ) domain containing 17b
chr3_-_59981476 0.23 ENSDART00000035878
ENSDART00000124038
cdr2l
cerebellar degeneration-related protein 2-like
chr1_-_26023678 0.23 ENSDART00000054202
si:ch211-145b13.5
si:ch211-145b13.5
chr16_+_30301539 0.23 ENSDART00000186018
LO017848.1

chr7_+_30875273 0.23 ENSDART00000173693
apba2b
amyloid beta (A4) precursor protein-binding, family A, member 2b
chr15_+_30917282 0.22 ENSDART00000129474
omgb
oligodendrocyte myelin glycoprotein b
chr5_+_23622177 0.22 ENSDART00000121504
cx27.5
connexin 27.5
chr24_+_32472155 0.22 ENSDART00000098859
neurod6a
neuronal differentiation 6a
chr7_+_26629084 0.22 ENSDART00000101044
ENSDART00000173765
hsbp1a
heat shock factor binding protein 1a
chr2_-_10188598 0.22 ENSDART00000189122
dmbx1a
diencephalon/mesencephalon homeobox 1a
chr5_-_34185115 0.22 ENSDART00000192771
fibcd1
fibrinogen C domain containing 1
chr10_-_26744131 0.22 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fgf13b
fibroblast growth factor 13b
chr13_+_22249636 0.22 ENSDART00000108472
ENSDART00000173123
synpo2la
synaptopodin 2-like a
chr15_+_43093044 0.22 ENSDART00000141125
kcne4
potassium voltage-gated channel, Isk-related family, member 4
chr18_+_28102620 0.22 ENSDART00000132342
kiaa1549lb
KIAA1549-like b
chr6_-_53144336 0.22 ENSDART00000154429
gnai2b
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b
chr7_+_46252993 0.21 ENSDART00000167149
znf536
zinc finger protein 536
chr21_-_20328375 0.21 ENSDART00000079593
slc26a1
solute carrier family 26 (anion exchanger), member 1
chr4_+_26496489 0.21 ENSDART00000160652
iqsec3a
IQ motif and Sec7 domain 3a
chr3_+_56366395 0.21 ENSDART00000154367
cacng5b
calcium channel, voltage-dependent, gamma subunit 5b
chr10_-_27741793 0.21 ENSDART00000129369
ENSDART00000192440
ENSDART00000189808
ENSDART00000138149
auts2a
si:dkey-33o22.1
autism susceptibility candidate 2a
si:dkey-33o22.1
chr10_-_20445549 0.21 ENSDART00000064613
loxl2a
lysyl oxidase-like 2a
chr5_+_44654535 0.21 ENSDART00000182190
ENSDART00000181872
dapk1
death-associated protein kinase 1
chr17_-_6399920 0.21 ENSDART00000022010
hivep2b
human immunodeficiency virus type I enhancer binding protein 2b
chr7_-_19940473 0.20 ENSDART00000127669
prox1b
prospero homeobox 1b
chr25_-_16818978 0.20 ENSDART00000104140
dyrk4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr23_+_23182037 0.20 ENSDART00000137353
klhl17
kelch-like family member 17
chr18_-_25051846 0.20 ENSDART00000013082
st8sia2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr24_+_27548474 0.20 ENSDART00000105774
ENSDART00000123368
ek1
eph-like kinase 1
chr6_+_39232245 0.20 ENSDART00000187351
b4galnt1b
beta-1,4-N-acetyl-galactosaminyl transferase 1b
chr22_-_33679277 0.20 ENSDART00000169948
FO904977.1

chr5_+_64842730 0.20 ENSDART00000144732
lrrc8ab
leucine rich repeat containing 8 VRAC subunit Ab
chr18_-_14836600 0.19 ENSDART00000045232
mtss1la
metastasis suppressor 1-like a
chr20_-_54381034 0.19 ENSDART00000136779
entpd5b
ectonucleoside triphosphate diphosphohydrolase 5b
chr25_-_7925269 0.19 ENSDART00000014274
glcea
glucuronic acid epimerase a
chr12_-_31009315 0.19 ENSDART00000133854
tcf7l2
transcription factor 7 like 2
chr19_-_10425140 0.19 ENSDART00000145319
si:ch211-171h4.3
si:ch211-171h4.3
chr23_+_216012 0.19 ENSDART00000181115
ENSDART00000004678
ENSDART00000190439
ENSDART00000189322
PDZD4
si:ch73-162j3.4
chr7_-_41964877 0.19 ENSDART00000092351
ENSDART00000193395
ENSDART00000187947
neto2b
neuropilin (NRP) and tolloid (TLL)-like 2b
chr5_-_11573490 0.19 ENSDART00000109577
FO704871.1

chr25_+_20215964 0.19 ENSDART00000139235
tnnt2d
troponin T2d, cardiac
chr3_-_16227490 0.19 ENSDART00000057159
ENSDART00000130611
ENSDART00000012835
cacnb1
calcium channel, voltage-dependent, beta 1 subunit
chr19_+_9790806 0.18 ENSDART00000155948
cacng6a
calcium channel, voltage-dependent, gamma subunit 6a
chr6_-_47246948 0.18 ENSDART00000162435
grm4
glutamate receptor, metabotropic 4
chr9_-_23156908 0.18 ENSDART00000135461
lypd6b
LY6/PLAUR domain containing 6B
chr23_+_27703749 0.18 ENSDART00000027224
lmbr1l
limb development membrane protein 1-like
chr1_-_23557877 0.18 ENSDART00000145942
fam184b
family with sequence similarity 184, member B
chr25_-_7925019 0.18 ENSDART00000183309
glcea
glucuronic acid epimerase a
chr1_+_39387876 0.18 ENSDART00000084891
ENSDART00000148701
tenm3
teneurin transmembrane protein 3
chr13_-_36545258 0.18 ENSDART00000186171
FP103009.1

chr24_+_18948665 0.18 ENSDART00000106186
prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr12_+_34827808 0.18 ENSDART00000105533
tepsin
TEPSIN, adaptor related protein complex 4 accessory protein
chr16_-_29458806 0.18 ENSDART00000047931
lingo4b
leucine rich repeat and Ig domain containing 4b
chr17_+_31914877 0.18 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr21_+_20715020 0.18 ENSDART00000015224
gadd45gb.1
growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1
chr19_-_867071 0.18 ENSDART00000122257
eomesa
eomesodermin homolog a
chr6_+_18367388 0.18 ENSDART00000163394
dgke
diacylglycerol kinase, epsilon
chr8_-_19051906 0.18 ENSDART00000089024
sema6bb
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr2_-_10192459 0.18 ENSDART00000128535
ENSDART00000017173
dmbx1a
diencephalon/mesencephalon homeobox 1a
chr3_-_28857195 0.17 ENSDART00000114319
si:ch211-76l23.7
si:ch211-76l23.7
chr15_-_34213898 0.17 ENSDART00000191945
ENSDART00000186089
etv1
ets variant 1
chr2_+_35240764 0.17 ENSDART00000015827
tnr
tenascin R (restrictin, janusin)
chr16_+_14707960 0.17 ENSDART00000137912
col14a1a
collagen, type XIV, alpha 1a
chr16_+_23282655 0.17 ENSDART00000015956
efna1b
ephrin-A1b
chr22_-_3595439 0.17 ENSDART00000083308
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr6_+_4872883 0.17 ENSDART00000186730
ENSDART00000092290
ENSDART00000151674
pcdh9
protocadherin 9
chr8_-_31393429 0.17 ENSDART00000192369
nim1k
NIM1 serine/threonine protein kinase
chr15_-_5467477 0.17 ENSDART00000123839
arrb1
arrestin, beta 1
chr20_+_46897504 0.17 ENSDART00000158124
si:ch73-21k16.1
si:ch73-21k16.1
chr12_+_9703172 0.17 ENSDART00000091489
ppp1r9bb
protein phosphatase 1, regulatory subunit 9Bb
chr2_+_2223837 0.16 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr21_+_43669943 0.16 ENSDART00000136025
tmlhe
trimethyllysine hydroxylase, epsilon
chr10_+_26571174 0.16 ENSDART00000148617
ENSDART00000112956
slc9a6b
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6b
chr13_-_16191674 0.16 ENSDART00000147868
vwc2
von Willebrand factor C domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of pdx1_pbx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 2.9 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.2 1.4 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.6 GO:0051503 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.1 0.7 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 0.4 GO:0035902 response to immobilization stress(GO:0035902)
0.1 0.7 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.1 0.6 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.1 0.3 GO:0042730 fibrinolysis(GO:0042730)
0.1 0.5 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.6 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.1 0.6 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) anterograde dendritic transport of neurotransmitter receptor complex(GO:0098971)
0.1 1.1 GO:0032291 central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291)
0.1 2.2 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.1 0.3 GO:0016322 neuron remodeling(GO:0016322)
0.1 0.2 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.1 0.2 GO:0019532 oxalate transport(GO:0019532)
0.1 0.2 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 0.5 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 17.1 GO:0060537 muscle tissue development(GO:0060537)
0.0 0.2 GO:0010226 response to lithium ion(GO:0010226)
0.0 0.5 GO:0035588 adenosine receptor signaling pathway(GO:0001973) purinergic receptor signaling pathway(GO:0035587) G-protein coupled purinergic receptor signaling pathway(GO:0035588)
0.0 1.0 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:1903385 dendrite guidance(GO:0070983) regulation of homophilic cell adhesion(GO:1903385)
0.0 0.1 GO:0048795 swim bladder morphogenesis(GO:0048795)
0.0 0.1 GO:0005986 sucrose metabolic process(GO:0005985) sucrose biosynthetic process(GO:0005986) disaccharide biosynthetic process(GO:0046351)
0.0 0.2 GO:0060300 regulation of cytokine activity(GO:0060300) regulation of receptor binding(GO:1900120) regulation of chemokine activity(GO:1900136)
0.0 0.2 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.0 0.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.4 GO:0015813 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.6 GO:0001952 regulation of cell-matrix adhesion(GO:0001952)
0.0 0.2 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.6 GO:0006003 fructose metabolic process(GO:0006000) fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.5 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) peptidyl-glutamine modification(GO:0018199)
0.0 0.6 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.2 GO:0003311 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.0 0.1 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.3 GO:1902262 apoptotic process involved in patterning of blood vessels(GO:1902262)
0.0 0.4 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.0 0.9 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.1 GO:1903146 regulation of mitophagy(GO:1903146)
0.0 0.1 GO:1901910 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.1 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)
0.0 0.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.0 0.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.1 GO:0015882 L-ascorbic acid transport(GO:0015882)
0.0 0.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0035988 chondrocyte proliferation(GO:0035988)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0050938 regulation of xanthophore differentiation(GO:0050938)
0.0 0.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.4 GO:0061074 regulation of neural retina development(GO:0061074)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.9 GO:0031102 neuron projection regeneration(GO:0031102)
0.0 0.3 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.3 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.0 GO:0033292 T-tubule organization(GO:0033292)
0.0 0.1 GO:0048644 muscle organ morphogenesis(GO:0048644)
0.0 0.4 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.4 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.2 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.1 GO:1903292 protein localization to Golgi membrane(GO:1903292)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.3 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.1 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.1 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.2 GO:0014823 response to activity(GO:0014823)
0.0 0.1 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.0 0.2 GO:0034394 protein localization to cell surface(GO:0034394) energy homeostasis(GO:0097009)
0.0 0.3 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.3 GO:0060034 notochord cell differentiation(GO:0060034)
0.0 0.2 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 0.1 GO:0016199 axon choice point recognition(GO:0016198) axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.2 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.3 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.1 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.0 0.0 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.0 0.3 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.0 GO:0099563 modification of synaptic structure(GO:0099563)
0.0 0.0 GO:0010159 specification of organ position(GO:0010159)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.7 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.4 GO:0070062 extracellular exosome(GO:0070062)
0.1 0.5 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 0.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 1.0 GO:0043209 myelin sheath(GO:0043209)
0.1 0.3 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 2.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.1 GO:0001534 radial spoke(GO:0001534)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.0 0.9 GO:0016342 catenin complex(GO:0016342)
0.0 0.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.4 GO:0043679 axon terminus(GO:0043679)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.6 GO:0030426 growth cone(GO:0030426)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0060175 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.1 2.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.7 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.1 0.6 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.1 0.5 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.1 0.4 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 1.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 0.1 GO:0015562 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.0 0.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.2 GO:0031781 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.1 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0 0.1 GO:0008459 chondroitin 6-sulfotransferase activity(GO:0008459)
0.0 0.4 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 2.9 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.2 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.0 0.4 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.3 GO:0031433 telethonin binding(GO:0031433) FATZ binding(GO:0051373)
0.0 0.1 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.3 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0 0.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.4 GO:0033691 sialic acid binding(GO:0033691)
0.0 1.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.1 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.0 0.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.4 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0035255 GKAP/Homer scaffold activity(GO:0030160) ionotropic glutamate receptor binding(GO:0035255)
0.0 0.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.2 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.1 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0051393 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.0 1.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.4 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.0 GO:0070699 adrenergic receptor binding(GO:0031690) beta-1 adrenergic receptor binding(GO:0031697) type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0098988 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.0 0.2 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.9 GO:0016247 channel regulator activity(GO:0016247)
0.0 0.1 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.1 GO:0019808 polyamine binding(GO:0019808) spermidine binding(GO:0019809)
0.0 0.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.2 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.5 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.0 0.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus