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PRJNA207719: Tissue specific transcriptome profiling

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Results for phox2bb

Z-value: 0.41

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Transcription factors associated with phox2bb

Gene Symbol Gene ID Gene Info
phox2bb
ENSDARG00000091029 paired like homeobox 2Bb

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
phox2bbdr11_v1_chr14_-_17068712_170687121.003.2e-05Click!

Activity profile of phox2bb motif

Sorted Z-values of phox2bb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_50608099 0.62 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr16_-_12173399 0.52 ENSDART00000142574
clstn3
calsyntenin 3
chr16_-_12173554 0.47 ENSDART00000110567
ENSDART00000155935
clstn3
calsyntenin 3
chr10_-_27049170 0.46 ENSDART00000143451
cnih2
cornichon family AMPA receptor auxiliary protein 2
chr17_+_15433518 0.43 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr17_+_15433671 0.43 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr14_-_4556896 0.41 ENSDART00000044678
ENSDART00000192863
GABRA2
gamma-aminobutyric acid type A receptor alpha2 subunit
chr6_-_11768198 0.40 ENSDART00000183463
march7
membrane-associated ring finger (C3HC4) 7
chr23_+_16638639 0.33 ENSDART00000143545
snphb
syntaphilin b
chr9_-_43538328 0.32 ENSDART00000140526
znf385b
zinc finger protein 385B
chr16_+_46111849 0.30 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr21_-_13123176 0.30 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr9_+_54039006 0.26 ENSDART00000112441
tlr7
toll-like receptor 7
chr4_-_1801519 0.25 ENSDART00000188604
ENSDART00000135749
nudt4b
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr17_-_21418340 0.24 ENSDART00000007021
atp6v1ba
ATPase, H+ transporting, lysosomal, V1 subunit B, member a
chr2_+_2223837 0.23 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr3_-_48716422 0.22 ENSDART00000164979
si:ch211-114m9.1
si:ch211-114m9.1
chr9_-_37749973 0.22 ENSDART00000087663
sema5ba
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr5_+_29851433 0.22 ENSDART00000143434
ubash3ba
ubiquitin associated and SH3 domain containing Ba
chr15_-_14552101 0.19 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr21_+_27513859 0.18 ENSDART00000065420
pacs1a
phosphofurin acidic cluster sorting protein 1a
chr14_-_470505 0.18 ENSDART00000067147
ANKRD50
ankyrin repeat domain 50
chr25_-_13490744 0.17 ENSDART00000056721
ldhd
lactate dehydrogenase D
chr6_+_11249706 0.17 ENSDART00000186547
ENSDART00000193287
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr6_+_11250033 0.14 ENSDART00000065411
ENSDART00000132677
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr2_-_16216568 0.14 ENSDART00000173758
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr1_-_15797663 0.14 ENSDART00000177122
SGCZ
sarcoglycan zeta
chr21_-_22635245 0.13 ENSDART00000115224
ENSDART00000101782
nectin1a
nectin cell adhesion molecule 1a
chr4_-_2219705 0.12 ENSDART00000131046
si:ch73-278m9.1
si:ch73-278m9.1
chr15_-_22074315 0.12 ENSDART00000149830
drd2a
dopamine receptor D2a
chr9_-_32177117 0.12 ENSDART00000078568
sf3b1
splicing factor 3b, subunit 1
chr1_+_10318089 0.10 ENSDART00000029774
pip4p1b
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b
chr6_+_11250316 0.10 ENSDART00000137122
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr24_+_28953089 0.09 ENSDART00000153761
rnpc3
RNA-binding region (RNP1, RRM) containing 3
chr17_+_31914877 0.08 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr17_+_22577472 0.07 ENSDART00000045099
yipf4
Yip1 domain family, member 4
chr17_-_4245902 0.07 ENSDART00000151851
gdf3
growth differentiation factor 3
chr3_-_26787430 0.07 ENSDART00000087047
rab40c
RAB40c, member RAS oncogene family
chr5_+_60590796 0.06 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr22_+_2751887 0.06 ENSDART00000133652
si:dkey-20i20.11
si:dkey-20i20.11
chr7_+_38811800 0.06 ENSDART00000052322
zgc:110699
zgc:110699
chr8_-_44926077 0.05 ENSDART00000084417
timm17b
translocase of inner mitochondrial membrane 17 homolog B (yeast)
chr5_+_63302660 0.05 ENSDART00000142131
si:ch73-376l24.2
si:ch73-376l24.2
chr17_-_16422654 0.04 ENSDART00000150149
tdp1
tyrosyl-DNA phosphodiesterase 1
chr11_-_2838699 0.03 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr23_-_2901167 0.02 ENSDART00000165955
ENSDART00000190616
zhx3
zinc fingers and homeoboxes 3
chr2_+_38373272 0.02 ENSDART00000113111
psmb5
proteasome subunit beta 5
chr9_-_27398369 0.01 ENSDART00000186499
tex30
testis expressed 30
chr1_-_31534089 0.01 ENSDART00000007770
lbx1b
ladybird homeobox 1b
chr22_+_23359369 0.01 ENSDART00000170886
dennd1b
DENN/MADD domain containing 1B
chr2_-_17393216 0.01 ENSDART00000123137
st3gal3b
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr1_+_21731382 0.01 ENSDART00000054395
pax5
paired box 5

Network of associatons between targets according to the STRING database.

First level regulatory network of phox2bb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.3 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 0.3 GO:0051659 maintenance of mitochondrion location(GO:0051659)
0.1 0.2 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.2 GO:0099563 modification of synaptic structure(GO:0099563)
0.0 0.2 GO:1901910 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.1 GO:0044406 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.0 0.4 GO:0044805 late nucleophagy(GO:0044805)
0.0 0.2 GO:0050975 sensory perception of touch(GO:0050975)
0.0 0.1 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.1 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 0.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0034431 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.2 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.0 0.0 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.0 0.1 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR