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PRJNA207719: Tissue specific transcriptome profiling

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Results for pitx1+pitx3

Z-value: 0.40

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Transcription factors associated with pitx1+pitx3

Gene Symbol Gene ID Gene Info
pitx3
ENSDARG00000070069 paired-like homeodomain 3
pitx1
ENSDARG00000116608 paired-like homeodomain 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pitx1dr11_v1_chr21_+_45819662_458197290.856.9e-02Click!
pitx3dr11_v1_chr13_-_7573670_75736700.533.6e-01Click!

Activity profile of pitx1+pitx3 motif

Sorted Z-values of pitx1+pitx3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_45510977 0.26 ENSDART00000090596
fgf12b
fibroblast growth factor 12b
chr24_-_38079261 0.26 ENSDART00000105662
crp1
C-reactive protein 1
chr12_+_33151246 0.26 ENSDART00000162681
rbfox3a
RNA binding fox-1 homolog 3a
chr13_+_15838151 0.22 ENSDART00000008987
klc1a
kinesin light chain 1a
chr25_+_21832938 0.22 ENSDART00000148299
ckmt1
creatine kinase, mitochondrial 1
chr7_+_57866292 0.22 ENSDART00000138757
camk2d1
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1
chr2_-_32738535 0.21 ENSDART00000135293
nrbp2a
nuclear receptor binding protein 2a
chr5_-_16983336 0.19 ENSDART00000038740
galnt9
polypeptide N-acetylgalactosaminyltransferase 9
chr5_-_28606916 0.16 ENSDART00000026107
ENSDART00000137717
tnc
tenascin C
chr25_-_8030113 0.16 ENSDART00000104674
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr23_-_28141419 0.16 ENSDART00000133039
tac3a
tachykinin 3a
chr4_+_10365857 0.15 ENSDART00000138890
kcnd2
potassium voltage-gated channel, Shal-related subfamily, member 2
chr20_+_38525567 0.15 ENSDART00000147787
znf512
zinc finger protein 512
chr25_-_8030425 0.13 ENSDART00000014964
camk1db
calcium/calmodulin-dependent protein kinase 1Db
chr23_-_32334208 0.13 ENSDART00000053472
rnf41
ring finger protein 41
chr10_-_10016348 0.11 ENSDART00000129151
strbp
spermatid perinuclear RNA binding protein
chr18_+_13203831 0.10 ENSDART00000032151
cotl1
coactosin-like F-actin binding protein 1
chr6_+_41554794 0.10 ENSDART00000165424
srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr21_+_27382893 0.10 ENSDART00000005682
actn3a
actinin alpha 3a
chr17_+_16046314 0.10 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr18_+_7639401 0.10 ENSDART00000092416
rabl2
RAB, member of RAS oncogene family-like 2
chr8_+_694218 0.09 ENSDART00000147753
rnf165b
ring finger protein 165b
chr17_+_16046132 0.09 ENSDART00000155005
si:ch73-204p21.2
si:ch73-204p21.2
chr8_+_16990120 0.09 ENSDART00000018934
pde4d
phosphodiesterase 4D, cAMP-specific
chr15_-_14467394 0.08 ENSDART00000191944
numbl
numb homolog (Drosophila)-like
chr4_-_77432218 0.08 ENSDART00000158683
slco1d1
solute carrier organic anion transporter family, member 1D1
chr10_-_25628555 0.08 ENSDART00000143978
tiam1a
T cell lymphoma invasion and metastasis 1a
chr10_+_6013076 0.08 ENSDART00000167613
ENSDART00000159216
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr6_-_14040136 0.08 ENSDART00000065361
ENSDART00000179765
etv5b
ets variant 5b
chr3_-_33574576 0.07 ENSDART00000184881
CR847537.1

chr17_+_25289431 0.07 ENSDART00000161002
kbtbd11
kelch repeat and BTB (POZ) domain containing 11
chr2_-_32505091 0.07 ENSDART00000141884
ENSDART00000056639
faim2a
Fas apoptotic inhibitory molecule 2a
chr11_-_29563437 0.06 ENSDART00000163958
arhgef10la
Rho guanine nucleotide exchange factor (GEF) 10-like a
chr8_+_23105117 0.06 ENSDART00000025171
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr23_+_22335407 0.06 ENSDART00000147696
rap1gap
RAP1 GTPase activating protein
chr4_-_20483954 0.05 ENSDART00000187240
napepld
N-acyl phosphatidylethanolamine phospholipase D
chr22_+_26703026 0.05 ENSDART00000158756
crebbpa
CREB binding protein a
chr4_-_5077158 0.04 ENSDART00000155915
ahcyl2
adenosylhomocysteinase-like 2
chr15_+_45640906 0.04 ENSDART00000149361
ENSDART00000149079
sagb
S-antigen; retina and pineal gland (arrestin) b
chr12_+_47917971 0.04 ENSDART00000185933
tbata
thymus, brain and testes associated
chr1_+_33383644 0.04 ENSDART00000187194
dhrsx
dehydrogenase/reductase (SDR family) X-linked
chr15_+_11693624 0.04 ENSDART00000193630
ENSDART00000161930
strn4
striatin, calmodulin binding protein 4
chr3_-_33175583 0.04 ENSDART00000126022
rarab
retinoic acid receptor, alpha b
chr5_+_60919378 0.04 ENSDART00000184915
doc2b
double C2-like domains, beta
chr3_+_15296824 0.04 ENSDART00000043801
cabp5b
calcium binding protein 5b
chr9_-_40935934 0.03 ENSDART00000155604
C2orf88
Small membrane A-kinase anchor protein
chr18_+_29898955 0.03 ENSDART00000064080
cenpn
centromere protein N
chr14_+_1124409 0.03 ENSDART00000190043
ENSDART00000106708
ENSDART00000160246
sec24b
SEC24 homolog B, COPII coat complex component
chr22_-_20695237 0.03 ENSDART00000112722
org
oogenesis-related gene
chr20_+_29587995 0.03 ENSDART00000153339
adam17b
ADAM metallopeptidase domain 17b
chr16_-_51299061 0.02 ENSDART00000148677
serpinb1l4
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 4
chr11_-_27778831 0.02 ENSDART00000023823
cass4
Cas scaffolding protein family member 4
chr7_+_38962459 0.02 ENSDART00000173851
dgkza
diacylglycerol kinase, zeta a
chr21_+_10756154 0.02 ENSDART00000074833
rx3
retinal homeobox gene 3
chr20_-_1141722 0.01 ENSDART00000152675
gabrr1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr1_+_56180416 0.01 ENSDART00000089358
crb3b
crumbs homolog 3b
chr19_+_2631565 0.01 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr19_-_10207103 0.01 ENSDART00000151629
znf865
zinc finger protein 865
chr8_+_21010850 0.00 ENSDART00000100295
si:dkeyp-82a1.4
si:dkeyp-82a1.4
chr12_+_27213733 0.00 ENSDART00000133048
nbr1a
neighbor of brca1 gene 1a
chr6_-_54126463 0.00 ENSDART00000161059
tusc2a
tumor suppressor candidate 2a
chr16_-_25663846 0.00 ENSDART00000031304
derl1
derlin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of pitx1+pitx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0014814 regulation of synaptic growth at neuromuscular junction(GO:0008582) axon regeneration at neuromuscular junction(GO:0014814) positive regulation of synaptic growth at neuromuscular junction(GO:0045887)
0.0 0.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.1 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.0 0.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.2 GO:0006599 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.1 GO:0070291 N-acylethanolamine metabolic process(GO:0070291)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.2 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 0.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling