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PRJNA207719: Tissue specific transcriptome profiling

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Results for plag1+plagx

Z-value: 0.73

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Transcription factors associated with plag1+plagx

Gene Symbol Gene ID Gene Info
plagx
ENSDARG00000036855 pleiomorphic adenoma gene X
plag1
ENSDARG00000051926 pleiomorphic adenoma gene 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
plag1dr11_v1_chr7_+_58730201_587302010.612.7e-01Click!
plagxdr11_v1_chr23_+_32011768_320117680.513.8e-01Click!

Activity profile of plag1+plagx motif

Sorted Z-values of plag1+plagx motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_4010263 0.56 ENSDART00000159605
ENSDART00000165541
map7d1b
MAP7 domain containing 1b
chr23_+_43954809 0.49 ENSDART00000164080
corin
corin, serine peptidase
chr23_+_44732863 0.47 ENSDART00000160044
ENSDART00000172268
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr7_+_568819 0.42 ENSDART00000173716
nrxn2b
neurexin 2b
chr12_-_25916530 0.41 ENSDART00000186386
sncgb
synuclein, gamma b (breast cancer-specific protein 1)
chr21_+_7823146 0.40 ENSDART00000030579
crhbp
corticotropin releasing hormone binding protein
chr24_-_26383978 0.37 ENSDART00000031426
skilb
SKI-like proto-oncogene b
chr6_-_35401282 0.36 ENSDART00000127612
rgs5a
regulator of G protein signaling 5a
chr4_+_9400012 0.35 ENSDART00000191960
tmtc1
transmembrane and tetratricopeptide repeat containing 1
chr4_+_19534833 0.32 ENSDART00000140028
lrrc4.1
leucine rich repeat containing 4.1
chr4_+_6572364 0.25 ENSDART00000122574
ppp1r3aa
protein phosphatase 1, regulatory subunit 3Aa
chr14_-_1958994 0.25 ENSDART00000161783
pcdh2g5
protocadherin 2 gamma 5
chr7_-_38477235 0.24 ENSDART00000084355
zgc:165481
zgc:165481
chr24_-_21490628 0.24 ENSDART00000181546
atp8a2
ATPase phospholipid transporting 8A2
chr8_+_25247245 0.24 ENSDART00000045798
ampd2b
adenosine monophosphate deaminase 2b
chr10_-_167782 0.23 ENSDART00000108780
erg
v-ets avian erythroblastosis virus E26 oncogene homolog
chr21_+_5801105 0.23 ENSDART00000151225
ENSDART00000184487
ccng2
cyclin G2
chr22_-_15957041 0.21 ENSDART00000149236
ENSDART00000187500
ENSDART00000176304
ENSDART00000080047
ENSDART00000190068
eps15l1a
epidermal growth factor receptor pathway substrate 15-like 1a
chr14_-_33177935 0.20 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr19_+_42336523 0.19 ENSDART00000151304
anp32e
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr16_-_36798783 0.17 ENSDART00000145697
calb1
calbindin 1
chr14_-_21661015 0.17 ENSDART00000189403
ENSDART00000172442
ENSDART00000181913
kdm3b
lysine (K)-specific demethylase 3B
chr20_-_14665002 0.16 ENSDART00000152816
scrn2
secernin 2
chr20_+_28245164 0.13 ENSDART00000103320
dll4
delta-like 4 (Drosophila)
chr5_+_63785339 0.13 ENSDART00000050871
rgs3b
regulator of G protein signaling 3b
chr6_-_29105727 0.12 ENSDART00000184355
fam69ab
family with sequence similarity 69, member Ab
chr3_-_25420931 0.11 ENSDART00000109601
ENSDART00000182184
bptf
bromodomain PHD finger transcription factor
chr2_+_2470687 0.10 ENSDART00000184024
ENSDART00000061955
myl13
myosin, light chain 13
chr7_-_38570878 0.09 ENSDART00000139187
ENSDART00000134570
ENSDART00000041055
celf1
cugbp, Elav-like family member 1
chr23_+_30859086 0.08 ENSDART00000053661
zgc:198371
zgc:198371
chr23_+_30736895 0.08 ENSDART00000042944
asxl1
additional sex combs like transcriptional regulator 1
chr20_-_24183333 0.07 ENSDART00000025862
ENSDART00000153075
map3k7
mitogen-activated protein kinase kinase kinase 7
chr24_-_35534273 0.06 ENSDART00000026578
ube2v2
ubiquitin-conjugating enzyme E2 variant 2
chr11_+_13630107 0.06 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr5_+_38886499 0.05 ENSDART00000076845
fras1
Fraser extracellular matrix complex subunit 1
chr14_-_2209742 0.05 ENSDART00000054889
pcdh2ab5
protocadherin 2 alpha b 5
chr19_-_20093341 0.05 ENSDART00000129917
mpp6b
membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
chr7_-_41403022 0.04 ENSDART00000174285
BX322787.1

chr24_+_42131564 0.04 ENSDART00000153854
wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr19_+_37620342 0.04 ENSDART00000158960
thsd7aa
thrombospondin, type I, domain containing 7Aa
chr9_-_3496548 0.03 ENSDART00000102876
cybrd1
cytochrome b reductase 1
chr4_-_73411863 0.03 ENSDART00000171434
zgc:162958
zgc:162958
chr20_-_21910043 0.02 ENSDART00000152290
ENSDART00000109084
daam1b
dishevelled associated activator of morphogenesis 1b
chr7_+_44608224 0.02 ENSDART00000005033
cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr5_-_14326959 0.00 ENSDART00000137355
tet3
tet methylcytosine dioxygenase 3

Network of associatons between targets according to the STRING database.

First level regulatory network of plag1+plagx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0002792 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.0 0.1 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.2 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.0 0.2 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.5 GO:0071436 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.1 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031) pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.2 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.4 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.4 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.3 GO:0005979 regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.2 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.6 GO:0043679 axon terminus(GO:0043679)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.1 GO:0035517 PR-DUB complex(GO:0035517)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903136 cuprous ion binding(GO:1903136)
0.1 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.2 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.5 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.3 GO:2001069 glycogen binding(GO:2001069)
0.0 0.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.0 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors