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PRJNA207719: Tissue specific transcriptome profiling

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Results for pou6f1

Z-value: 0.95

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Transcription factors associated with pou6f1

Gene Symbol Gene ID Gene Info
pou6f1
ENSDARG00000011570 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pou6f1dr11_v1_chr23_-_33709964_337100290.942.0e-02Click!

Activity profile of pou6f1 motif

Sorted Z-values of pou6f1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_16098531 1.22 ENSDART00000080377
aldoca
aldolase C, fructose-bisphosphate, a
chr14_+_50770537 1.14 ENSDART00000158723
sncb
synuclein, beta
chr5_+_64732270 0.94 ENSDART00000134241
olfm1a
olfactomedin 1a
chr4_+_12615836 0.86 ENSDART00000003583
lmo3
LIM domain only 3
chr19_+_30662529 0.83 ENSDART00000175662
fam49al
family with sequence similarity 49, member A-like
chr4_+_22365061 0.82 ENSDART00000039277
lhfpl3
LHFPL tetraspan subfamily member 3
chr7_+_38717624 0.78 ENSDART00000132522
syt13
synaptotagmin XIII
chr18_-_1185772 0.69 ENSDART00000143245
nptnb
neuroplastin b
chr21_-_26918901 0.67 ENSDART00000100685
lrfn4a
leucine rich repeat and fibronectin type III domain containing 4a
chr15_-_33172246 0.60 ENSDART00000158666
nbeab
neurobeachin b
chr3_-_28250722 0.59 ENSDART00000165936
rbfox1
RNA binding fox-1 homolog 1
chr11_-_7320211 0.57 ENSDART00000091664
apc2
adenomatosis polyposis coli 2
chr11_+_39672874 0.55 ENSDART00000046663
ENSDART00000157659
camta1b
calmodulin binding transcription activator 1b
chr12_+_32729470 0.53 ENSDART00000175712
rbfox3a
RNA binding fox-1 homolog 3a
chr22_-_15385442 0.52 ENSDART00000090975
tmem264
transmembrane protein 264
chr6_-_29105727 0.48 ENSDART00000184355
fam69ab
family with sequence similarity 69, member Ab
chr6_+_3004972 0.48 ENSDART00000186750
ENSDART00000183862
ENSDART00000191485
ENSDART00000171014
ptprfa
protein tyrosine phosphatase, receptor type, f, a
chr14_-_31465905 0.48 ENSDART00000173108
gpc3
glypican 3
chr1_-_57280585 0.47 ENSDART00000152220
si:dkey-27j5.5
si:dkey-27j5.5
chr17_+_12698532 0.45 ENSDART00000064509
ENSDART00000136830
stmn4l
stathmin-like 4, like
chr16_-_5154024 0.44 ENSDART00000132069
ENSDART00000060635
dctn3
dynactin 3 (p22)
chr2_+_29249204 0.43 ENSDART00000168957
cdh18a
cadherin 18, type 2a
chr22_-_11829436 0.42 ENSDART00000126784
ptpn4b
protein tyrosine phosphatase, non-receptor type 4b
chr3_-_21288202 0.41 ENSDART00000191766
ENSDART00000187319
fam171a2a
family with sequence similarity 171, member A2a
chr2_-_12243213 0.40 ENSDART00000113081
gpr158b
G protein-coupled receptor 158b
chr4_-_19028861 0.39 ENSDART00000166374
si:dkey-31f5.11
si:dkey-31f5.11
chr2_-_50372467 0.39 ENSDART00000108900
cntnap2b
contactin associated protein like 2b
chr19_-_8600383 0.39 ENSDART00000081546
trim46b
tripartite motif containing 46b
chr7_-_19364813 0.38 ENSDART00000173977
ntn4
netrin 4
chr9_-_6624663 0.38 ENSDART00000092537
GPR45
si:dkeyp-118h3.5
chr9_+_41612642 0.38 ENSDART00000138473
spegb
SPEG complex locus b
chr12_+_18681477 0.37 ENSDART00000127981
ENSDART00000143979
rgs9b
regulator of G protein signaling 9b
chr13_-_21701323 0.36 ENSDART00000164112
si:dkey-191g9.7
si:dkey-191g9.7
chr1_+_25801648 0.36 ENSDART00000129471
gucy1b1
guanylate cyclase 1 soluble subunit beta 1
chr19_-_5103313 0.36 ENSDART00000037007
tpi1a
triosephosphate isomerase 1a
chr19_-_9503473 0.35 ENSDART00000091615
iffo1a
intermediate filament family orphan 1a
chr13_+_22119798 0.34 ENSDART00000173206
ENSDART00000078652
ENSDART00000165842
camk2g2
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 2
chr19_-_31402429 0.33 ENSDART00000137292
tmem106bb
transmembrane protein 106Bb
chr9_-_14504834 0.33 ENSDART00000056103
nrp2b
neuropilin 2b
chr16_-_24044664 0.32 ENSDART00000136982
bcam
basal cell adhesion molecule (Lutheran blood group)
chr22_+_16535575 0.31 ENSDART00000083063
tal1
T-cell acute lymphocytic leukemia 1
chr11_-_26180714 0.31 ENSDART00000173597
kaznb
kazrin, periplakin interacting protein b
chr2_-_48966431 0.30 ENSDART00000147948
kcnj9
potassium inwardly-rectifying channel, subfamily J, member 9
chr3_+_33341640 0.30 ENSDART00000186352
pyya
peptide YYa
chr25_-_20666328 0.30 ENSDART00000098076
csk
C-terminal Src kinase
chr5_-_39736383 0.30 ENSDART00000127123
rasgef1ba
RasGEF domain family, member 1Ba
chr2_+_9552456 0.29 ENSDART00000056896
dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr18_+_3243292 0.28 ENSDART00000166580
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr24_-_21404367 0.28 ENSDART00000152093
atp8a2
ATPase phospholipid transporting 8A2
chr4_-_18202291 0.27 ENSDART00000169704
anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr24_-_32408404 0.27 ENSDART00000144157
si:ch211-56a11.2
si:ch211-56a11.2
chr10_-_27199135 0.25 ENSDART00000189511
ENSDART00000180314
auts2a
autism susceptibility candidate 2a
chr25_+_37480285 0.25 ENSDART00000166187
CABZ01095001.1

chr19_+_46222918 0.24 ENSDART00000158703
vps28
vacuolar protein sorting 28 (yeast)
chr11_+_33628104 0.23 ENSDART00000165318
thsd7bb
thrombospondin, type I, domain containing 7Bb
chr25_-_20666754 0.23 ENSDART00000158418
csk
C-terminal Src kinase
chr15_-_33640890 0.22 ENSDART00000167705
stard13b
StAR-related lipid transfer (START) domain containing 13b
chr4_+_12612723 0.22 ENSDART00000133767
lmo3
LIM domain only 3
chr13_-_5965423 0.22 ENSDART00000144931
actr2b
ARP2 actin related protein 2b homolog
chr1_+_33634186 0.21 ENSDART00000075626
htr1fb
5-hydroxytryptamine (serotonin) receptor 1Fb
chr13_+_3938526 0.21 ENSDART00000012759
yipf3
Yip1 domain family, member 3
chr8_-_10961991 0.21 ENSDART00000139603
trim33
tripartite motif containing 33
chr19_+_46222428 0.21 ENSDART00000183984
vps28
vacuolar protein sorting 28 (yeast)
chr24_+_41931585 0.20 ENSDART00000130310
epb41l3a
erythrocyte membrane protein band 4.1-like 3a
chr22_+_2793382 0.20 ENSDART00000144980
si:dkey-20i20.8
si:dkey-20i20.8
chr17_+_22072337 0.19 ENSDART00000063716
ENSDART00000141684
nphp1
nephronophthisis 1
chr7_-_9803154 0.18 ENSDART00000055593
aldh1a3
aldehyde dehydrogenase 1 family, member A3
chr17_-_45150763 0.17 ENSDART00000155043
ENSDART00000156786
ENSDART00000191147
tmed8
transmembrane p24 trafficking protein 8
chr4_+_25431990 0.17 ENSDART00000176982
prkcq
protein kinase C, theta
chr4_+_14826299 0.17 ENSDART00000067035
shisal1a
shisa like 1a
chr1_+_11822 0.17 ENSDART00000166393
cep97
centrosomal protein 97
chr6_-_17849786 0.17 ENSDART00000172709
rptor
regulatory associated protein of MTOR, complex 1
chr7_-_22941472 0.16 ENSDART00000190334
tnfsf10l
TNF superfamily member 10, like
chr11_+_29770966 0.15 ENSDART00000088624
ENSDART00000124471
rpgrb
retinitis pigmentosa GTPase regulator b
chr5_-_35953472 0.15 ENSDART00000143448
rxfp2l
relaxin/insulin-like family peptide receptor 2, like
chr2_-_20981907 0.15 ENSDART00000113384
lyrm4
LYR motif containing 4
chr9_+_11034314 0.15 ENSDART00000032695
asic4a
acid-sensing (proton-gated) ion channel family member 4a
chr20_+_22067337 0.15 ENSDART00000152636
clocka
clock circadian regulator a
chr2_+_29249561 0.14 ENSDART00000099157
cdh18a
cadherin 18, type 2a
chr13_-_24825691 0.13 ENSDART00000142745
slka
STE20-like kinase a
chr4_-_72609735 0.12 ENSDART00000174299
ENSDART00000159227
si:cabz01054394.6
si:cabz01054394.6
chr21_-_22547496 0.12 ENSDART00000166835
ENSDART00000089030
myo5b
myosin VB
chr12_-_22509069 0.11 ENSDART00000179755
ENSDART00000109707
neurl4
neuralized E3 ubiquitin protein ligase 4
chr24_+_14595680 0.11 ENSDART00000137337
ENSDART00000091784
ENSDART00000136026
thtpa
thiamine triphosphatase
chr15_+_24704798 0.11 ENSDART00000192470
LRRC75A
si:dkey-151p21.7
chr1_+_11992 0.11 ENSDART00000161842
cep97
centrosomal protein 97
chr16_-_25368048 0.11 ENSDART00000132445
rbfa
ribosome binding factor A
chr14_+_44804326 0.11 ENSDART00000079866
ENSDART00000172974
slc30a9
solute carrier family 30 (zinc transporter), member 9
chr22_+_1462997 0.10 ENSDART00000157476
si:dkeyp-53d3.5
si:dkeyp-53d3.5
chr22_+_2830703 0.10 ENSDART00000145463
ENSDART00000144785
si:dkey-20i20.8
si:dkey-20i20.8
chr19_+_42469058 0.10 ENSDART00000076915
si:dkey-166k12.1
si:dkey-166k12.1
chr2_-_37312927 0.10 ENSDART00000141214
skila
SKI-like proto-oncogene a
chr15_-_931815 0.09 ENSDART00000106627
ENSDART00000102239
ENSDART00000184754
ENSDART00000186733
zgc:162936
zgc:162936
chr3_+_57038033 0.09 ENSDART00000162930
bahcc1a
BAH domain and coiled-coil containing 1a
chr22_+_2504524 0.09 ENSDART00000136686
znf1170
zinc finger protein 1170
chr13_+_25434932 0.08 ENSDART00000128562
si:dkey-51a16.9
si:dkey-51a16.9
chr25_+_6186823 0.08 ENSDART00000153526
oaz2a
ornithine decarboxylase antizyme 2a
chr21_-_40938382 0.08 ENSDART00000008593
yipf5
Yip1 domain family, member 5
chr2_-_57941037 0.07 ENSDART00000131420
si:dkeyp-68b7.5
si:dkeyp-68b7.5
chr10_-_45058886 0.07 ENSDART00000159347
mrps24
mitochondrial ribosomal protein S24
chr15_-_15968883 0.07 ENSDART00000166583
ENSDART00000154042
synrg
synergin, gamma
chr22_-_10019768 0.07 ENSDART00000162077
BX324216.2

chr24_-_16979728 0.07 ENSDART00000005331
klhl15
kelch-like family member 15
chr4_+_5848229 0.06 ENSDART00000161101
ENSDART00000067357
lyrm5a
LYR motif containing 5a
chr7_+_41147732 0.05 ENSDART00000185388
puf60b
poly-U binding splicing factor b
chr3_+_40796110 0.05 ENSDART00000014729
arpc1a
actin related protein 2/3 complex, subunit 1A
chr4_+_359970 0.04 ENSDART00000139832
tmem181
transmembrane protein 181
chr7_+_44715224 0.04 ENSDART00000184630
si:dkey-56m19.5
si:dkey-56m19.5
chr11_-_45138857 0.04 ENSDART00000166501
cant1b
calcium activated nucleotidase 1b
chr7_+_48297842 0.04 ENSDART00000052123
slc25a44b
solute carrier family 25, member 44 b
chr2_+_6243144 0.04 ENSDART00000058258
gng5
guanine nucleotide binding protein (G protein), gamma 5
chr16_-_48071632 0.04 ENSDART00000148564
CSMD3 (1 of many)
si:ch211-236p22.1
chr18_+_34181655 0.03 ENSDART00000130831
ENSDART00000109535
gmps
guanine monophosphate synthase
chr7_+_53498152 0.03 ENSDART00000184497
znf609b
zinc finger protein 609b
chr4_-_76370630 0.03 ENSDART00000168831
ENSDART00000174313
si:ch73-158p21.3
si:ch73-158p21.3
chr11_-_14813029 0.03 ENSDART00000004920
ENSDART00000122645
sgta
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr1_+_19649545 0.03 ENSDART00000054575
tmem192
transmembrane protein 192
chr17_-_49438873 0.03 ENSDART00000004424
znf292a
zinc finger protein 292a
chr17_-_24587686 0.02 ENSDART00000143084
aftphb
aftiphilin b
chr9_+_34151367 0.02 ENSDART00000143991
gpr161
G protein-coupled receptor 161
chr1_+_52633367 0.01 ENSDART00000134658
slc44a1a
solute carrier family 44 (choline transporter), member 1a
chr1_-_51710225 0.01 ENSDART00000057601
ENSDART00000152745
snrpb2
small nuclear ribonucleoprotein polypeptide B2
chr2_-_21625493 0.01 ENSDART00000137169
zgc:55781
zgc:55781
chr2_+_38892631 0.01 ENSDART00000134040
si:ch211-119o8.4
si:ch211-119o8.4
chr25_-_8625601 0.01 ENSDART00000155280
GDPGP1
zgc:153343
chr18_-_50523399 0.01 ENSDART00000033591
cd276
CD276 molecule
chr23_+_45860676 0.00 ENSDART00000012234
syap1
synapse associated protein 1
chr22_-_14696667 0.00 ENSDART00000180379
lrp1ba
low density lipoprotein receptor-related protein 1Ba
chr2_-_27619954 0.00 ENSDART00000144826
tgs1
trimethylguanosine synthase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of pou6f1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.1 0.3 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.1 0.9 GO:1902868 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.1 0.4 GO:0099543 trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 0.4 GO:0046166 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.4 GO:0071205 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.1 0.2 GO:0048569 post-embryonic organ development(GO:0048569)
0.1 0.5 GO:0060976 coronary vasculature development(GO:0060976)
0.1 0.5 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 1.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 0.3 GO:0003232 bulbus arteriosus development(GO:0003232)
0.0 1.1 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.3 GO:0071678 olfactory bulb axon guidance(GO:0071678)
0.0 0.1 GO:0003241 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0 0.2 GO:2001032 positive regulation of double-strand break repair via homologous recombination(GO:1905168) regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0 0.7 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.2 GO:1904861 excitatory synapse assembly(GO:1904861)
0.0 0.3 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.3 GO:0032418 lysosome localization(GO:0032418)
0.0 0.1 GO:0006772 thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0 0.8 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.2 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.4 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.6 GO:0021854 limbic system development(GO:0021761) hypothalamus development(GO:0021854)
0.0 0.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.2 GO:0007210 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) serotonin receptor signaling pathway(GO:0007210)
0.0 0.4 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.3 GO:0007631 feeding behavior(GO:0007631)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.4 GO:0033010 paranodal junction(GO:0033010)
0.0 1.1 GO:0043679 axon terminus(GO:0043679)
0.0 0.1 GO:1990513 CLOCK-BMAL transcription complex(GO:1990513)
0.0 0.4 GO:0005869 dynactin complex(GO:0005869)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.2 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0031430 M band(GO:0031430)
0.0 0.4 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.6 GO:0016342 catenin complex(GO:0016342)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:1903136 cuprous ion binding(GO:1903136)
0.2 1.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.4 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.1 0.3 GO:0031841 neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843)
0.0 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.7 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.2 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.6 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.5 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity