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PRJNA207719: Tissue specific transcriptome profiling

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Results for pparaa+pparda+ppardb

Z-value: 1.19

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Transcription factors associated with pparaa+pparda+ppardb

Gene Symbol Gene ID Gene Info
ppardb
ENSDARG00000009473 peroxisome proliferator-activated receptor delta b
pparaa
ENSDARG00000031777 peroxisome proliferator-activated receptor alpha a
pparda
ENSDARG00000044525 peroxisome proliferator-activated receptor delta a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ppardbdr11_v1_chr8_+_23709280_23709280-0.523.7e-01Click!
ppardadr11_v1_chr22_+_1006573_1006573-0.405.0e-01Click!
pparaadr11_v1_chr4_-_18635005_186350050.177.8e-01Click!

Activity profile of pparaa+pparda+ppardb motif

Sorted Z-values of pparaa+pparda+ppardb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_11201096 1.47 ENSDART00000171916
ENSDART00000171521
ENSDART00000087105
ENSDART00000159603
myom2a
myomesin 2a
chr9_-_43082945 0.94 ENSDART00000142257
ccdc141
coiled-coil domain containing 141
chr6_-_39765546 0.93 ENSDART00000185767
pfkmb
phosphofructokinase, muscle b
chr6_-_39764995 0.85 ENSDART00000085277
pfkmb
phosphofructokinase, muscle b
chr21_-_19006631 0.85 ENSDART00000080269
ENSDART00000191682
pgam2
phosphoglycerate mutase 2 (muscle)
chr1_-_17797802 0.83 ENSDART00000041215
sorbs2a
sorbin and SH3 domain containing 2a
chr11_-_6974022 0.80 ENSDART00000172851
COMP
si:ch211-43f4.1
chr7_+_34297271 0.78 ENSDART00000180342
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr15_-_12500938 0.78 ENSDART00000159627
scn4ba
sodium channel, voltage-gated, type IV, beta a
chr20_+_47953047 0.78 ENSDART00000079734
hadhaa
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a
chr3_+_27770110 0.74 ENSDART00000017962
eci1
enoyl-CoA delta isomerase 1
chr7_+_34296789 0.72 ENSDART00000052471
ENSDART00000173798
ENSDART00000173778
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr17_+_30545895 0.70 ENSDART00000076739
nhsl1a
NHS-like 1a
chr14_-_29826659 0.68 ENSDART00000138413
sorbs2b
sorbin and SH3 domain containing 2b
chr13_-_37127970 0.59 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b
chr16_+_28602423 0.59 ENSDART00000182350
crot
carnitine O-octanoyltransferase
chr23_+_17417539 0.56 ENSDART00000182605
BX649300.2

chr21_+_15704556 0.53 ENSDART00000024858
ENSDART00000146909
chchd10
coiled-coil-helix-coiled-coil-helix domain containing 10
chr20_-_47953524 0.52 ENSDART00000167986
HADHB
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
chr19_+_40861853 0.49 ENSDART00000126470
zgc:85777
zgc:85777
chr10_+_35417099 0.46 ENSDART00000063398
hhla2a.1
HERV-H LTR-associating 2a, tandem duplicate 1
chr23_-_24488696 0.46 ENSDART00000155593
tmem82
transmembrane protein 82
chr17_-_32370047 0.46 ENSDART00000145487
klf11b
Kruppel-like factor 11b
chr6_+_60036767 0.45 ENSDART00000155009
tgm8
transglutaminase 8
chr14_-_48103207 0.45 ENSDART00000056712
etfdh
electron-transferring-flavoprotein dehydrogenase
chr15_+_404891 0.44 ENSDART00000155682
nipsnap2
nipsnap homolog 2
chr16_+_28601974 0.44 ENSDART00000018235
crot
carnitine O-octanoyltransferase
chr1_+_40802454 0.42 ENSDART00000193568
cpz
carboxypeptidase Z
chr17_-_20711735 0.42 ENSDART00000150056
ank3b
ankyrin 3b
chr20_-_34164278 0.40 ENSDART00000153128
hmcn1
hemicentin 1
chr3_-_53486169 0.37 ENSDART00000115243
soul5
heme-binding protein soul5
chr17_+_30546579 0.37 ENSDART00000154385
nhsl1a
NHS-like 1a
chr24_+_9590188 0.34 ENSDART00000137092
si:dkey-96n2.1
si:dkey-96n2.1
chr3_-_34561624 0.34 ENSDART00000129313
sept9a
septin 9a
chr2_-_26476030 0.33 ENSDART00000145262
ENSDART00000132125
acadm
acyl-CoA dehydrogenase medium chain
chr20_+_15015557 0.32 ENSDART00000039345
myoc
myocilin
chr24_+_2961098 0.32 ENSDART00000163760
ENSDART00000170835
eci2
enoyl-CoA delta isomerase 2
chr16_-_50229193 0.30 ENSDART00000161782
ENSDART00000010081
etfb
electron-transfer-flavoprotein, beta polypeptide
chr24_+_81527 0.29 ENSDART00000192139
reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr8_-_2529878 0.28 ENSDART00000056767
acaa2
acetyl-CoA acyltransferase 2
chr13_+_9842276 0.25 ENSDART00000041700
ENSDART00000141406
prdx3
peroxiredoxin 3
chr5_+_58421536 0.25 ENSDART00000173410
ccdc15
coiled-coil domain containing 15
chr10_+_11265387 0.24 ENSDART00000038888
hsdl2
hydroxysteroid dehydrogenase like 2
chr7_-_24046999 0.24 ENSDART00000144616
ENSDART00000124653
ENSDART00000127813
dhrs4
dehydrogenase/reductase (SDR family) member 4
chr1_-_46859398 0.23 ENSDART00000135795
agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr8_-_979735 0.22 ENSDART00000149612
znf366
zinc finger protein 366
chr20_-_38836161 0.22 ENSDART00000061358
si:dkey-221h15.4
si:dkey-221h15.4
chr9_+_30626416 0.21 ENSDART00000147813
tbc1d4
TBC1 domain family, member 4
chr20_-_48604199 0.21 ENSDART00000161762
ENSDART00000170894
mgst3a
microsomal glutathione S-transferase 3a
chr15_-_6946286 0.20 ENSDART00000019330
ech1
enoyl CoA hydratase 1, peroxisomal
chr14_+_989733 0.19 ENSDART00000161487
ENSDART00000127317
si:ch73-308l14.2
si:ch73-308l14.2
chr17_+_30450163 0.19 ENSDART00000104257
lpin1
lipin 1
chr20_-_52967878 0.18 ENSDART00000164460
gata4
GATA binding protein 4
chr18_+_16744307 0.18 ENSDART00000179872
ENSDART00000133490
lyve1b
lymphatic vessel endothelial hyaluronic receptor 1b
chr18_+_27926839 0.17 ENSDART00000191835
hipk3b
homeodomain interacting protein kinase 3b
chr20_-_48604621 0.17 ENSDART00000161769
ENSDART00000157871
mgst3a
microsomal glutathione S-transferase 3a
chr19_+_2631565 0.16 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr19_+_19652439 0.15 ENSDART00000165934
hibadha
3-hydroxyisobutyrate dehydrogenase a
chr5_-_41875834 0.15 ENSDART00000133592
si:dkey-65b12.10
si:dkey-65b12.10
chr5_+_43870389 0.14 ENSDART00000141002
zgc:112966
zgc:112966
chr8_+_2530065 0.14 ENSDART00000063943
mrpl40
mitochondrial ribosomal protein L40
chr11_+_24957858 0.14 ENSDART00000145647
sulf2a
sulfatase 2a
chr15_+_31820536 0.13 ENSDART00000045921
frya
furry homolog a (Drosophila)
chr1_-_35113974 0.13 ENSDART00000192811
ENSDART00000167461
BX897691.1

chr13_+_28819768 0.13 ENSDART00000191401
ENSDART00000188895
ENSDART00000101653
CU639469.1

chr8_-_20291922 0.13 ENSDART00000148304
myo1f
myosin IF
chr8_-_8698607 0.12 ENSDART00000046712
zgc:86609
zgc:86609
chr3_+_30257582 0.11 ENSDART00000159497
ENSDART00000103457
ENSDART00000121883
mybpc2a
myosin binding protein C, fast type a
chr12_-_684200 0.11 ENSDART00000152122
si:ch211-176g6.2
si:ch211-176g6.2
chr13_+_28821841 0.11 ENSDART00000179900
CU639469.1

chr23_-_16737161 0.11 ENSDART00000132573
si:ch211-224l10.4
si:ch211-224l10.4
chr15_+_28268135 0.10 ENSDART00000152536
ENSDART00000188550
myo1cb
myosin Ic, paralog b
chr5_+_38276582 0.10 ENSDART00000158532
gnb2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr22_+_22888 0.10 ENSDART00000082471
mfap2
microfibril associated protein 2
chr7_+_23940933 0.10 ENSDART00000173628
si:dkey-183c6.7
si:dkey-183c6.7
chr19_-_7043355 0.10 ENSDART00000104845
tapbp.1
TAP binding protein (tapasin), tandem duplicate 1
chr3_+_58167288 0.08 ENSDART00000155874
ENSDART00000010395
uqcrc2a
ubiquinol-cytochrome c reductase core protein 2a
chr17_+_6538733 0.08 ENSDART00000193712
slc5a6b
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr7_+_17356482 0.08 ENSDART00000063629
nitr3r.1l
novel immune-type receptor 3, related 1-like
chr23_-_16734009 0.08 ENSDART00000125449
si:ch211-224l10.4
si:ch211-224l10.4
chr22_-_10774735 0.07 ENSDART00000081156
timm13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr5_-_35137365 0.07 ENSDART00000141218
fcho2
FCH domain only 2
chr19_+_32158010 0.06 ENSDART00000005255
mrpl53
mitochondrial ribosomal protein L53
chr22_+_18469004 0.06 ENSDART00000061430
cilp2
cartilage intermediate layer protein 2
chr5_-_41860556 0.05 ENSDART00000140154
si:dkey-65b12.12
si:dkey-65b12.12
chr6_-_30863046 0.05 ENSDART00000155330
pde4ba
phosphodiesterase 4B, cAMP-specific a
chr12_-_5120175 0.04 ENSDART00000160729
rbp4
retinol binding protein 4, plasma
chr20_-_25877793 0.04 ENSDART00000177333
ENSDART00000184619
exoc1
exocyst complex component 1
chr20_+_46286082 0.04 ENSDART00000073519
taar14f
trace amine associated receptor 14f
chr10_-_41400049 0.04 ENSDART00000009838
gpat4
glycerol-3-phosphate acyltransferase 4
chr22_+_9069081 0.04 ENSDART00000187842
BX248395.1

chr1_-_52292235 0.04 ENSDART00000132638
si:dkey-121b10.7
si:dkey-121b10.7
chr22_-_38274188 0.04 ENSDART00000139420
ENSDART00000015117
elavl2
ELAV like neuron-specific RNA binding protein 2
chr12_+_26670778 0.03 ENSDART00000144355
arhgap12b
Rho GTPase activating protein 12b
chr7_+_48675347 0.03 ENSDART00000157917
ENSDART00000185580
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr25_+_36347126 0.03 ENSDART00000152449
si:ch211-113a14.22
si:ch211-113a14.22
chr10_+_36441124 0.02 ENSDART00000185626
uspl1
ubiquitin specific peptidase like 1
chr20_+_1088658 0.02 ENSDART00000162991
BX537249.1

chr21_+_26720803 0.02 ENSDART00000053797
slc3a2b
solute carrier family 3 (amino acid transporter heavy chain), member 2b
chr12_-_44199316 0.02 ENSDART00000170378
si:ch73-329n5.1
si:ch73-329n5.1
chr5_-_30984010 0.02 ENSDART00000182367
spns3
spinster homolog 3 (Drosophila)
chr18_-_3456117 0.02 ENSDART00000158508
myo7aa
myosin VIIAa
chr12_+_46708920 0.02 ENSDART00000153089
exoc7
exocyst complex component 7
chr15_+_47618221 0.02 ENSDART00000168722
paf1
PAF1 homolog, Paf1/RNA polymerase II complex component
chr22_-_3595439 0.02 ENSDART00000083308
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr8_+_8699085 0.01 ENSDART00000021209
uxt
ubiquitously-expressed, prefoldin-like chaperone
chr12_-_5120339 0.01 ENSDART00000168759
rbp4
retinol binding protein 4, plasma
chr1_-_58868306 0.01 ENSDART00000166615
dnm2b
dynamin 2b
chr18_-_12957451 0.01 ENSDART00000140403
srgap1a
SLIT-ROBO Rho GTPase activating protein 1a
chr9_+_500052 0.01 ENSDART00000166707
CU984600.1

chr23_+_44633858 0.00 ENSDART00000180728
si:ch73-265d7.2
si:ch73-265d7.2
chr17_-_12196865 0.00 ENSDART00000154694
kif28
kinesin family member 28

Network of associatons between targets according to the STRING database.

First level regulatory network of pparaa+pparda+ppardb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 1.8 GO:0061718 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.3 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.1 0.3 GO:0051793 medium-chain fatty acid metabolic process(GO:0051791) medium-chain fatty acid catabolic process(GO:0051793)
0.0 1.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.5 GO:0031295 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.8 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.2 GO:0048795 swim bladder morphogenesis(GO:0048795)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.1 GO:0051182 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.0 0.5 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.9 GO:0019226 transmission of nerve impulse(GO:0019226)
0.0 0.3 GO:0001952 regulation of cell-matrix adhesion(GO:0001952)
0.0 0.5 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.4 GO:0071711 basement membrane organization(GO:0071711)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 1.5 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 1.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 1.4 GO:0005924 cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.3 0.8 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.2 1.0 GO:0016415 octanoyltransferase activity(GO:0016415)
0.2 0.8 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.2 1.8 GO:0003872 6-phosphofructokinase activity(GO:0003872) fructose-6-phosphate binding(GO:0070095)
0.1 0.4 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.7 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.1 0.3 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.1 0.8 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.1 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.0 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.5 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA