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PRJNA207719: Tissue specific transcriptome profiling

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Results for prox1a+prox2+prox3

Z-value: 1.11

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Transcription factors associated with prox1a+prox2+prox3

Gene Symbol Gene ID Gene Info
prox2
ENSDARG00000041952 prospero homeobox 2
prox1a
ENSDARG00000055158 prospero homeobox 1a
prox3
ENSDARG00000088810 prospero homeobox 3
prox3
ENSDARG00000113014 prospero homeobox 3
prox2
ENSDARG00000117137 prospero homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
prox1adr11_v1_chr17_-_32865788_32865788-0.781.2e-01Click!
prox2dr11_v1_chr17_-_52521002_52521002-0.414.9e-01Click!
prox1bdr11_v1_chr7_-_19940473_19940473-0.375.4e-01Click!

Activity profile of prox1a+prox2+prox3 motif

Sorted Z-values of prox1a+prox2+prox3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_29952169 1.67 ENSDART00000173540
ENSDART00000173940
ENSDART00000173906
ENSDART00000173772
ENSDART00000173506
ENSDART00000039657
tpma
alpha-tropomyosin
chr7_+_29951997 1.63 ENSDART00000173453
tpma
alpha-tropomyosin
chr17_-_5583345 1.07 ENSDART00000035944
clic5a
chloride intracellular channel 5a
chr2_+_2470687 0.98 ENSDART00000184024
ENSDART00000061955
myl13
myosin, light chain 13
chr25_+_19947096 0.66 ENSDART00000154221
kcna6a
potassium voltage-gated channel, shaker-related, subfamily, member 6 a
chr15_+_32711663 0.60 ENSDART00000157854
ENSDART00000167515
postnb
periostin, osteoblast specific factor b
chr25_+_19947298 0.60 ENSDART00000067648
kcna6a
potassium voltage-gated channel, shaker-related, subfamily, member 6 a
chr19_-_31042570 0.52 ENSDART00000144337
ENSDART00000136213
ENSDART00000133101
ENSDART00000190949
bzw2
basic leucine zipper and W2 domains 2
chr5_+_37785152 0.48 ENSDART00000053511
ENSDART00000189812
myo1ca
myosin Ic, paralog a
chr12_-_23365737 0.38 ENSDART00000170376
mpp7a
membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
chr9_+_8968702 0.38 ENSDART00000008490
ube2al
ubiquitin conjugating enzyme E2 A, like
chr5_+_27440325 0.37 ENSDART00000185815
ENSDART00000144013
loxl2b
lysyl oxidase-like 2b
chr5_+_37517800 0.36 ENSDART00000048107
FP102018.1
Danio rerio latent transforming growth factor beta binding protein 3 (ltbp3), mRNA.
chr1_-_59065217 0.35 ENSDART00000188972
CABZ01080042.1

chr7_-_38087865 0.34 ENSDART00000052366
cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
chr5_+_13870340 0.34 ENSDART00000160690
hk2
hexokinase 2
chr9_-_42696408 0.34 ENSDART00000144744
col5a2a
collagen, type V, alpha 2a
chr15_-_29162193 0.33 ENSDART00000138449
ENSDART00000099885
xaf1
XIAP associated factor 1
chr23_-_5759242 0.33 ENSDART00000055087
phlda3
pleckstrin homology-like domain, family A, member 3
chr19_+_19989380 0.31 ENSDART00000142841
osbpl3a
oxysterol binding protein-like 3a
chr13_+_7442023 0.29 ENSDART00000080975
tnfaip2b
tumor necrosis factor, alpha-induced protein 2b
chr12_+_27117609 0.27 ENSDART00000076154
hoxb8b
homeobox B8b
chr11_-_24681292 0.26 ENSDART00000089601
olfml3b
olfactomedin-like 3b
chr23_+_16889352 0.23 ENSDART00000145275
si:dkey-147f3.8
si:dkey-147f3.8
chr7_+_19562045 0.23 ENSDART00000077545
slc7a7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr15_-_31177324 0.22 ENSDART00000008854
wsb1
WD repeat and SOCS box containing 1
chr8_-_47800754 0.21 ENSDART00000115050
ENSDART00000133669
kank3
KN motif and ankyrin repeat domains 3
chr8_+_25616946 0.20 ENSDART00000133983
slc38a5a
solute carrier family 38, member 5a
chr10_-_8295294 0.18 ENSDART00000075412
ENSDART00000163803
plpp1a
phospholipid phosphatase 1a
chrM_+_9052 0.18 ENSDART00000093612
mt-atp6
ATP synthase 6, mitochondrial
chr3_+_22335030 0.18 ENSDART00000055676
zgc:103564
zgc:103564
chr19_+_42886413 0.18 ENSDART00000151298
arpp21
cAMP-regulated phosphoprotein, 21
chr5_+_22510639 0.17 ENSDART00000080919
rpl36a
ribosomal protein L36A
chr12_+_6065661 0.17 ENSDART00000142418
sgms1
sphingomyelin synthase 1
chr5_-_61638125 0.17 ENSDART00000134314
si:dkey-261j4.3
si:dkey-261j4.3
chr14_+_31751260 0.16 ENSDART00000169796
si:dkeyp-11e3.1
si:dkeyp-11e3.1
chr1_+_6161930 0.16 ENSDART00000037036
cnppd1
cyclin Pas1/PHO80 domain containing 1
chr3_+_21200763 0.16 ENSDART00000067841
zgc:112038
zgc:112038
chrM_+_8894 0.16 ENSDART00000093611
mt-atp8
ATP synthase 8, mitochondrial
chr10_-_8294965 0.15 ENSDART00000167380
plpp1a
phospholipid phosphatase 1a
chr14_+_28473173 0.15 ENSDART00000017075
xiap
X-linked inhibitor of apoptosis
chr5_+_42136359 0.15 ENSDART00000083731
trpv1
transient receptor potential cation channel, subfamily V, member 1
chr15_-_23475051 0.14 ENSDART00000152460
nlrx1
NLR family member X1
chr3_+_11072958 0.14 ENSDART00000158899
mrps7
mitochondrial ribosomal protein S7
chr20_+_192170 0.14 ENSDART00000189675
cx28.8
connexin 28.8
chr19_+_7929704 0.14 ENSDART00000147015
si:dkey-266f7.4
si:dkey-266f7.4
chr17_-_21832119 0.13 ENSDART00000153539
ENSDART00000079008
si:ch211-208g24.8
si:ch211-208g24.8
chr16_+_11779761 0.12 ENSDART00000140297
si:dkey-250k15.4
si:dkey-250k15.4
chr8_-_4475908 0.12 ENSDART00000191027
si:ch211-166a6.5
si:ch211-166a6.5
chr12_-_18898413 0.12 ENSDART00000181281
ENSDART00000121866
desi1b
desumoylating isopeptidase 1b
chr15_+_2190229 0.12 ENSDART00000147710
rsrc1
arginine/serine-rich coiled-coil 1
chr22_+_10678141 0.12 ENSDART00000193341
hyal2b
hyaluronoglucosaminidase 2b
chr18_+_7204378 0.10 ENSDART00000142905
vwf
von Willebrand factor
chr15_+_37954666 0.10 ENSDART00000126534
ENSDART00000155548
si:dkey-238d18.7
si:dkey-238d18.7
chr23_+_36118738 0.10 ENSDART00000139319
hoxc5a
homeobox C5a
chr3_-_26191960 0.09 ENSDART00000113843
ypel3
yippee-like 3
chr6_-_34006917 0.09 ENSDART00000190702
ENSDART00000184003
tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr19_-_22621811 0.08 ENSDART00000090669
pleca
plectin a
chr4_-_50933168 0.08 ENSDART00000150296
si:ch211-208f21.3
si:ch211-208f21.3
chr16_-_54919260 0.08 ENSDART00000156533
kdf1a
keratinocyte differentiation factor 1a
chr12_-_4408828 0.07 ENSDART00000152447
si:ch211-173d10.1
si:ch211-173d10.1
chr9_-_23033818 0.07 ENSDART00000022392
rnd3b
Rho family GTPase 3b
chr14_-_28566238 0.07 ENSDART00000172547
insb
preproinsulin b
chr11_-_23219367 0.07 ENSDART00000003646
optc
opticin
chr22_+_36692681 0.07 ENSDART00000186398
trim35-33
tripartite motif containing 35-33
chr14_+_9287683 0.06 ENSDART00000122485
msnb
moesin b
chr16_+_42772678 0.06 ENSDART00000155575
si:ch211-135n15.2
si:ch211-135n15.2
chr4_+_47789703 0.06 ENSDART00000161323
si:ch211-196h24.2
si:ch211-196h24.2
chr9_+_1138323 0.06 ENSDART00000190352
ENSDART00000190387
slc15a1a
solute carrier family 15 (oligopeptide transporter), member 1a
chr9_+_38684871 0.06 ENSDART00000147938
ENSDART00000004462
heg1
heart development protein with EGF-like domains 1
chr10_-_36254445 0.06 ENSDART00000123571
or110-2
odorant receptor, family D, subfamily 110, member 2
chr9_+_1138802 0.06 ENSDART00000191130
ENSDART00000187308
slc15a1a
solute carrier family 15 (oligopeptide transporter), member 1a
chr4_-_71551644 0.06 ENSDART00000168064
si:dkey-27n6.1
si:dkey-27n6.1
chr13_-_16066997 0.06 ENSDART00000184790
SPATA48
spermatogenesis associated 48
chr4_+_30788743 0.05 ENSDART00000184557
si:dkey-178j11.5
si:dkey-178j11.5
chr19_-_22621991 0.05 ENSDART00000175106
pleca
plectin a
chr22_+_9239831 0.05 ENSDART00000133720
si:ch211-250k18.5
si:ch211-250k18.5
chr13_-_12667220 0.04 ENSDART00000079594
fam241a
family with sequence similarity 241 member A
chr15_-_5245726 0.04 ENSDART00000174079
ENSDART00000174041
or128-1
odorant receptor, family E, subfamily 128, member 1
chr7_-_16205471 0.03 ENSDART00000173584
btr05
bloodthirsty-related gene family, member 5
chr21_-_303766 0.03 ENSDART00000150913
lhfpl2a
LHFPL tetraspan subfamily member 2a
chr22_+_9287929 0.03 ENSDART00000193522
si:ch211-250k18.7
si:ch211-250k18.7
chr8_-_49345388 0.03 ENSDART00000053203
plp2
proteolipid protein 2
chr4_-_75899294 0.03 ENSDART00000157887
si:dkey-261j11.3
si:dkey-261j11.3
chr25_+_8407892 0.03 ENSDART00000153536
muc5.2
mucin 5.2
chr4_+_3455665 0.02 ENSDART00000058277
znf800b
zinc finger protein 800b
chr6_+_11250033 0.02 ENSDART00000065411
ENSDART00000132677
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr16_+_51154918 0.02 ENSDART00000058290
dhdds
dehydrodolichyl diphosphate synthase
chr17_-_106291 0.02 ENSDART00000160738
arhgap11a
Rho GTPase activating protein 11A
chr25_+_16312258 0.02 ENSDART00000064187
parvaa
parvin, alpha a
chr21_-_22831388 0.01 ENSDART00000151040
angptl5
angiopoietin-like 5
chr23_+_35672542 0.01 ENSDART00000046268
pmelb
premelanosome protein b
chr4_+_3455146 0.01 ENSDART00000180124
znf800b
zinc finger protein 800b
chr1_+_44442140 0.01 ENSDART00000190592
crybb1l2
crystallin, beta B1, like 2
chr10_+_43037064 0.01 ENSDART00000160159
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr19_-_21766461 0.00 ENSDART00000104279
znf516
zinc finger protein 516
chr13_+_11829072 0.00 ENSDART00000079356
ENSDART00000170160
sufu
suppressor of fused homolog (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of prox1a+prox2+prox3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.2 GO:1902024 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.2 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521) microglia development(GO:0014005) regulation of cellular amine metabolic process(GO:0033238)
0.0 0.6 GO:0016203 muscle attachment(GO:0016203)
0.0 3.3 GO:0061515 myeloid cell development(GO:0061515)
0.0 0.3 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.3 GO:0051601 exocyst localization(GO:0051601)
0.0 0.3 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.0 0.3 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.4 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.1 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.2 GO:0006516 glycoprotein catabolic process(GO:0006516)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0060171 stereocilium membrane(GO:0060171)
0.1 0.3 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.4 GO:0033503 HULC complex(GO:0033503)
0.0 3.2 GO:0005884 actin filament(GO:0005884)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.2 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.3 GO:0000145 exocyst(GO:0000145)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0000810 diacylglycerol diphosphate phosphatase activity(GO:0000810)
0.1 0.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.3 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.1 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.0 0.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 3.0 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.0 0.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.0 1.1 GO:0005254 chloride channel activity(GO:0005254)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions