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PRJNA207719: Tissue specific transcriptome profiling
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Results for rargb_pparab
Z-value: 2.31
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Transcription factors associated with rargb_pparab
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rargb | dr11_v1_chr11_+_2089461_2089461 | -0.45 | 4.4e-01 | Click! |
| pparab | dr11_v1_chr25_+_2229301_2229301 | -0.24 | 7.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of rargb_pparab
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.7 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.2 | 4.3 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.0 | 3.2 | GO:0007626 | locomotory behavior(GO:0007626) |
| 0.0 | 2.9 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.1 | 2.7 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 2.1 | GO:0060840 | artery development(GO:0060840) |
| 0.3 | 1.9 | GO:0003319 | cardioblast migration to the midline involved in heart rudiment formation(GO:0003319) |
| 0.3 | 1.7 | GO:1901841 | regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.1 | 1.6 | GO:0032233 | positive regulation of actin filament bundle assembly(GO:0032233) |
| 0.0 | 1.5 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 4.7 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 4.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 4.0 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 3.6 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 2.8 | GO:0005865 | striated muscle thin filament(GO:0005865) myofilament(GO:0036379) |
| 0.1 | 2.7 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 2.3 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 2.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 1.9 | GO:0031430 | M band(GO:0031430) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 6.6 | GO:0003779 | actin binding(GO:0003779) |
| 0.6 | 4.5 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.1 | 2.8 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393) |
| 0.1 | 2.4 | GO:0016675 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 2.3 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 1.9 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.1 | 1.8 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 1.6 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.1 | 1.4 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.8 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.4 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 0.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.3 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 0.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.8 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 1.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 1.6 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 1.5 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 1.2 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.1 | 1.1 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 0.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 0.8 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 0.7 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |