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PRJNA207719: Tissue specific transcriptome profiling
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Results for rest
Z-value: 8.36
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Transcription factors associated with rest
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| rest | dr11_v1_chr14_-_52433292_52433292 | -0.18 | 7.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_34913069 Show fit | 16.88 |
ENSDART00000007584
|
synaptosomal-associated protein, 25a |
|
| chr23_+_45579497 Show fit | 14.57 |
ENSDART00000110381
|
early growth response 4 |
|
| chr17_-_12385308 Show fit | 13.85 |
ENSDART00000080927
|
synaptosomal-associated protein, 25b |
|
| chr15_+_36156986 Show fit | 13.58 |
ENSDART00000059791
|
somatostatin 1, tandem duplicate 1 |
|
| chr25_-_19443421 Show fit | 13.44 |
ENSDART00000067362
|
cocaine- and amphetamine-regulated transcript 2 |
|
| chr21_+_11468934 Show fit | 13.14 |
ENSDART00000126045
ENSDART00000129744 ENSDART00000102368 |
glutamate receptor, ionotropic, N-methyl D-aspartate 1a |
|
| chr25_+_35250976 Show fit | 12.98 |
ENSDART00000003494
|
solute carrier family 17 (vesicular glutamate transporter), member 6a |
|
| chr16_+_46148990 Show fit | 12.88 |
ENSDART00000083919
|
synaptic vesicle glycoprotein 2A |
|
| chr21_+_11468642 Show fit | 12.79 |
ENSDART00000041869
|
glutamate receptor, ionotropic, N-methyl D-aspartate 1a |
|
| chr18_+_26337869 Show fit | 12.41 |
ENSDART00000109257
|
si:ch211-234p18.3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of rest
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 52.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.6 | 46.5 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 34.3 | GO:0006357 | regulation of transcription from RNA polymerase II promoter(GO:0006357) |
| 1.2 | 30.7 | GO:0016082 | synaptic vesicle priming(GO:0016082) |
| 2.7 | 21.4 | GO:0098700 | neurotransmitter loading into synaptic vesicle(GO:0098700) |
| 0.4 | 20.1 | GO:0014059 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.9 | 19.5 | GO:0007631 | feeding behavior(GO:0007631) |
| 1.4 | 18.0 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 0.1 | 16.5 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
| 0.1 | 15.8 | GO:0002040 | sprouting angiogenesis(GO:0002040) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 105.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 91.8 | GO:0005576 | extracellular region(GO:0005576) |
| 3.1 | 46.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 5.1 | 30.7 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.0 | 27.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.4 | 21.4 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.3 | 19.2 | GO:0030141 | secretory granule(GO:0030141) |
| 0.4 | 18.0 | GO:0098978 | glutamatergic synapse(GO:0098978) |
| 0.1 | 17.4 | GO:0099503 | secretory vesicle(GO:0099503) |
| 0.2 | 13.7 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 58.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 49.1 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012) |
| 2.3 | 46.5 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 1.0 | 35.4 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.8 | 30.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 23.0 | GO:0005179 | hormone activity(GO:0005179) |
| 1.6 | 21.4 | GO:0005326 | neurotransmitter transporter activity(GO:0005326) |
| 0.4 | 20.1 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 3.9 | 19.5 | GO:0031841 | neuropeptide Y receptor binding(GO:0031841) type 2 neuropeptide Y receptor binding(GO:0031843) |
| 0.0 | 17.8 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.5 | 12.4 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 5.6 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 5.1 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.2 | 3.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.8 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 12.4 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.7 | 11.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 10.5 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.9 | 6.6 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.2 | 5.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 5.3 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.3 | 5.0 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.2 | 5.0 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 3.2 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.2 | 2.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |