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PRJNA207719: Tissue specific transcriptome profiling

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Results for rfx3_rfx2+rfx4

Z-value: 3.75

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Transcription factors associated with rfx3_rfx2+rfx4

Gene Symbol Gene ID Gene Info
rfx3
ENSDARG00000014550 regulatory factor X, 3 (influences HLA class II expression)
rfx2
ENSDARG00000013575 regulatory factor X, 2 (influences HLA class II expression)
rfx4
ENSDARG00000026395 regulatory factor X, 4
rfx4
ENSDARG00000116861 regulatory factor X, 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
rfx4dr11_v1_chr18_-_15373620_153736200.976.8e-03Click!
rfx3dr11_v1_chr10_-_625441_6254410.976.8e-03Click!
rfx2dr11_v1_chr8_-_20138054_201382510.474.3e-01Click!

Activity profile of rfx3_rfx2+rfx4 motif

Sorted Z-values of rfx3_rfx2+rfx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr24_-_205275 9.12 ENSDART00000108762
vopp1
VOPP1, WBP1/VOPP1 family member
chr17_-_6759006 3.56 ENSDART00000184692
ENSDART00000180530
vsnl1b
visinin-like 1b
chr21_+_26697536 3.07 ENSDART00000004109
gng3
guanine nucleotide binding protein (G protein), gamma 3
chr19_-_103289 2.96 ENSDART00000143118
adgrb1b
adhesion G protein-coupled receptor B1b
chr6_+_13933464 2.91 ENSDART00000109144
ptprnb
protein tyrosine phosphatase, receptor type, Nb
chr16_-_13662514 2.86 ENSDART00000146348
shisa7a
shisa family member 7a
chr19_-_9472893 2.79 ENSDART00000045565
ENSDART00000137505
vamp1
vesicle-associated membrane protein 1
chr5_-_23317477 2.71 ENSDART00000090171
nlgn3b
neuroligin 3b
chr18_-_46763170 2.69 ENSDART00000171880
dner
delta/notch-like EGF repeat containing
chr9_-_31747106 2.66 ENSDART00000048469
ENSDART00000145204
ENSDART00000186889
nalcn
sodium leak channel, non-selective
chr2_+_18988407 2.64 ENSDART00000170216
glula
glutamate-ammonia ligase (glutamine synthase) a
chr18_+_50890749 2.62 ENSDART00000174109
si:ch1073-450f2.1
si:ch1073-450f2.1
chr23_-_19953089 2.59 ENSDART00000153828
atp2b3b
ATPase plasma membrane Ca2+ transporting 3b
chr21_-_43952958 2.58 ENSDART00000039571
camk2a
calcium/calmodulin-dependent protein kinase II alpha
chr11_-_97817 2.47 ENSDART00000092903
elmo2
engulfment and cell motility 2
chr13_-_36911118 2.41 ENSDART00000048739
trim9
tripartite motif containing 9
chr5_+_20148671 2.41 ENSDART00000143205
svopa
SV2 related protein a
chr3_-_12890670 2.39 ENSDART00000159934
ENSDART00000188607
btbd17b
BTB (POZ) domain containing 17b
chr18_+_50880096 2.33 ENSDART00000169782
si:ch1073-450f2.1
si:ch1073-450f2.1
chr5_+_32162684 2.31 ENSDART00000134472
taok3b
TAO kinase 3b
chr24_-_24163201 2.31 ENSDART00000140170
map7d2b
MAP7 domain containing 2b
chr6_-_33023745 2.31 ENSDART00000156211
adcyap1r1b
adenylate cyclase activating polypeptide 1b (pituitary) receptor type I
chr22_+_31930650 2.29 ENSDART00000092090
dock3
dedicator of cytokinesis 3
chr16_+_221739 2.28 ENSDART00000180243
nrsn1
neurensin 1
chr21_-_15929041 2.16 ENSDART00000080693
lhx5
LIM homeobox 5
chr5_-_21044693 2.15 ENSDART00000140298
si:dkey-13n15.2
si:dkey-13n15.2
chr21_+_41743493 2.15 ENSDART00000192669
ppp2r2bb
protein phosphatase 2, regulatory subunit B, beta b
chr17_-_14726824 2.15 ENSDART00000162947
si:ch73-305o9.3
si:ch73-305o9.3
chr10_+_25222367 2.08 ENSDART00000042767
grm5a
glutamate receptor, metabotropic 5a
chr24_-_24162930 2.04 ENSDART00000080602
map7d2b
MAP7 domain containing 2b
chr22_+_16418688 2.01 ENSDART00000009360
ankrd29
ankyrin repeat domain 29
chr18_+_7283283 1.95 ENSDART00000141493
ANO2 (1 of many)
si:ch73-86n2.1
chr22_-_25033105 1.92 ENSDART00000124220
nptxrb
neuronal pentraxin receptor b
chr11_-_279328 1.91 ENSDART00000066179
npffl
neuropeptide FF-amide peptide precursor like
chr5_+_20147830 1.88 ENSDART00000098727
svopa
SV2 related protein a
chr6_-_46053300 1.85 ENSDART00000169722
ca16b
carbonic anhydrase XVI b
chr10_+_2234283 1.85 ENSDART00000136363
cntnap3
contactin associated protein like 3
chr19_-_8604429 1.85 ENSDART00000151165
trim46b
tripartite motif containing 46b
chr10_-_35542071 1.79 ENSDART00000162139
si:ch211-244c8.4
si:ch211-244c8.4
chr4_-_8903240 1.78 ENSDART00000129983
mpped1
metallophosphoesterase domain containing 1
chr11_-_29650930 1.77 ENSDART00000166969
chd5
chromodomain helicase DNA binding protein 5
chr9_-_3671911 1.77 ENSDART00000102900
sp5a
Sp5 transcription factor a
chr23_+_35708730 1.75 ENSDART00000009277
tuba1a
tubulin, alpha 1a
chr15_-_33172246 1.73 ENSDART00000158666
nbeab
neurobeachin b
chr13_+_33117528 1.70 ENSDART00000085719
si:ch211-10a23.2
si:ch211-10a23.2
chr5_-_42661012 1.69 ENSDART00000158339
pimr58
Pim proto-oncogene, serine/threonine kinase, related 58
chr13_-_31470439 1.67 ENSDART00000076574
rtn1a
reticulon 1a
chr18_+_50275933 1.67 ENSDART00000143911
si:dkey-105e17.1
si:dkey-105e17.1
chr5_-_29643930 1.66 ENSDART00000161250
grin1b
glutamate receptor, ionotropic, N-methyl D-aspartate 1b
chr17_+_28883353 1.65 ENSDART00000110322
prkd1
protein kinase D1
chr13_+_28821841 1.62 ENSDART00000179900
CU639469.1

chr3_-_22829710 1.62 ENSDART00000055659
cyb561
cytochrome b561
chr17_+_15534815 1.61 ENSDART00000159426
marcksb
myristoylated alanine-rich protein kinase C substrate b
chr7_-_58098814 1.61 ENSDART00000147287
ENSDART00000043984
ank2b
ankyrin 2b, neuronal
chr15_-_19669770 1.57 ENSDART00000152707
si:dkey-4p15.3
si:dkey-4p15.3
chr20_+_591505 1.55 ENSDART00000046438
kcnk2b
potassium channel, subfamily K, member 2b
chr17_-_39779906 1.55 ENSDART00000155181
pimr61
Pim proto-oncogene, serine/threonine kinase, related 61
chr1_-_56223913 1.55 ENSDART00000019573
zgc:65894
zgc:65894
chr16_-_12984631 1.54 ENSDART00000184863
cacng7b
calcium channel, voltage-dependent, gamma subunit 7b
chr1_+_54908895 1.53 ENSDART00000145652
golga7ba
golgin A7 family, member Ba
chr7_-_52842605 1.53 ENSDART00000083002
map1aa
microtubule-associated protein 1Aa
chr9_+_54891962 1.51 ENSDART00000148620
ENSDART00000105620
si:ch211-12n8.3
si:ch211-12n8.3
chr20_+_20638034 1.49 ENSDART00000189759
rtn1b
reticulon 1b
chr25_-_13381854 1.49 ENSDART00000164621
ENSDART00000169129
ndrg4
NDRG family member 4
chr25_-_25736958 1.48 ENSDART00000166308
cib2
calcium and integrin binding family member 2
chr16_-_44399335 1.48 ENSDART00000165058
rims2a
regulating synaptic membrane exocytosis 2a
chr17_+_28882977 1.47 ENSDART00000153937
prkd1
protein kinase D1
chr20_+_20637866 1.46 ENSDART00000060203
ENSDART00000079079
rtn1b
reticulon 1b
chr13_-_14269626 1.45 ENSDART00000079176
gfra4a
GDNF family receptor alpha 4a
chr3_-_50277959 1.44 ENSDART00000082773
ENSDART00000139524
arl16
ADP-ribosylation factor-like 16
chr4_-_27398385 1.43 ENSDART00000142117
ENSDART00000150553
ENSDART00000182746
fam19a5a
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
chr16_-_9869056 1.42 ENSDART00000149312
ncalda
neurocalcin delta a
chr18_+_50276337 1.41 ENSDART00000140352
si:dkey-105e17.1
si:dkey-105e17.1
chr2_-_44038698 1.40 ENSDART00000079582
ENSDART00000146804
kirrel1b
kirre like nephrin family adhesion molecule 1b
chr14_-_52542928 1.40 ENSDART00000075749
ppp2r2ba
protein phosphatase 2, regulatory subunit B, beta a
chr3_-_6767440 1.40 ENSDART00000156174
mast1b
microtubule associated serine/threonine kinase 1b
chr5_+_42400777 1.38 ENSDART00000183114
BX548073.8

chr4_-_9586713 1.38 ENSDART00000145613
shank3b
SH3 and multiple ankyrin repeat domains 3b
chr6_+_10534752 1.37 ENSDART00000090874
kcnh7
potassium channel, voltage gated eag related subfamily H, member 7
chr9_-_44289636 1.35 ENSDART00000110411
cerkl
ceramide kinase-like
chr20_+_18225329 1.34 ENSDART00000144172
kctd1
potassium channel tetramerization domain containing 1
chr5_+_64732036 1.34 ENSDART00000073950
olfm1a
olfactomedin 1a
chr3_-_37351225 1.34 ENSDART00000174685
si:ch211-278a6.1
si:ch211-278a6.1
chr9_+_2393764 1.32 ENSDART00000172624
chn1
chimerin 1
chr23_-_33654889 1.32 ENSDART00000146180
csrnp2
cysteine-serine-rich nuclear protein 2
chr2_+_47581997 1.32 ENSDART00000112579
scg2b
secretogranin II (chromogranin C), b
chr19_+_7001170 1.32 ENSDART00000110366
zbtb22b
zinc finger and BTB domain containing 22b
chr5_-_69271450 1.31 ENSDART00000133802
inpp5jb
inositol polyphosphate-5-phosphatase Jb
chr7_-_19364813 1.29 ENSDART00000173977
ntn4
netrin 4
chr2_+_47582681 1.29 ENSDART00000187579
scg2b
secretogranin II (chromogranin C), b
chr24_+_5912898 1.28 ENSDART00000132686
pimr63
Pim proto-oncogene, serine/threonine kinase, related 63
chr5_+_42379517 1.27 ENSDART00000103325
pimr59
Pim proto-oncogene, serine/threonine kinase, related 59
chr2_-_1569250 1.27 ENSDART00000167202
dab1b
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr5_+_42386705 1.27 ENSDART00000143034
pimr58
Pim proto-oncogene, serine/threonine kinase, related 58
chr5_+_42407962 1.27 ENSDART00000188489
BX548073.11

chr20_-_34868814 1.25 ENSDART00000153049
stmn4
stathmin-like 4
chr20_+_40766645 1.24 ENSDART00000144401
tbc1d32
TBC1 domain family, member 32
chr9_-_35155089 1.24 ENSDART00000077901
appb
amyloid beta (A4) precursor protein b
chr3_-_52644737 1.23 ENSDART00000126180
si:dkey-210j14.3
si:dkey-210j14.3
chr5_+_42393896 1.23 ENSDART00000189550
BX548073.13

chr16_+_21738194 1.22 ENSDART00000163688
FP085428.1
Danio rerio si:ch211-154o6.4 (si:ch211-154o6.4), mRNA.
chr17_-_40397752 1.21 ENSDART00000178483
BX548062.1

chr23_-_33640959 1.20 ENSDART00000187599
ENSDART00000189475
csrnp2
cysteine-serine-rich nuclear protein 2
chr24_+_5912635 1.20 ENSDART00000153736
pimr63
Pim proto-oncogene, serine/threonine kinase, related 63
chr9_+_23748342 1.19 ENSDART00000019053
faima
Fas apoptotic inhibitory molecule a
chr2_+_47582488 1.19 ENSDART00000149967
scg2b
secretogranin II (chromogranin C), b
chr17_-_39772999 1.18 ENSDART00000155727
pimr60
Pim proto-oncogene, serine/threonine kinase, related 60
chr5_-_46273938 1.16 ENSDART00000080033
si:ch211-130m23.3
si:ch211-130m23.3
chr10_+_36037977 1.15 ENSDART00000164678
katnal1
katanin p60 subunit A-like 1
chr14_-_9355177 1.15 ENSDART00000138535
fam46d
family with sequence similarity 46, member D
chr17_+_8988374 1.15 ENSDART00000109573
akap6
A kinase (PRKA) anchor protein 6
chr1_+_45085194 1.13 ENSDART00000193863
si:ch211-151p13.8
si:ch211-151p13.8
chr2_+_40294313 1.13 ENSDART00000037292
epha4b
eph receptor A4b
chr4_-_9579299 1.12 ENSDART00000183079
ENSDART00000192968
ENSDART00000091809
shank3b
SH3 and multiple ankyrin repeat domains 3b
chr24_-_1021318 1.12 ENSDART00000181403
ralaa
v-ral simian leukemia viral oncogene homolog Aa (ras related)
chr5_+_66353750 1.11 ENSDART00000143410
si:ch211-261c8.5
si:ch211-261c8.5
chr3_-_34337969 1.10 ENSDART00000151634
tnrc6c1
trinucleotide repeat containing 6C1
chr17_+_3390772 1.09 ENSDART00000160073
sntg2
syntrophin, gamma 2
chr18_+_7504691 1.09 ENSDART00000169075
neto2b
neuropilin (NRP) and tolloid (TLL)-like 2b
chr7_-_52876683 1.08 ENSDART00000172910
map1aa
microtubule-associated protein 1Aa
chr1_+_594584 1.07 ENSDART00000135944
jam2a
junctional adhesion molecule 2a
chr16_+_24632096 1.06 ENSDART00000157237
si:dkey-56f14.7
si:dkey-56f14.7
chr11_+_45299447 1.06 ENSDART00000172999
mafgb
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb
chr10_+_37145007 1.05 ENSDART00000131777
cuedc1a
CUE domain containing 1a
chr17_-_45009782 1.04 ENSDART00000123971
fam161b
family with sequence similarity 161, member B
chr14_-_25577094 1.04 ENSDART00000163669
cplx2
complexin 2
chr17_+_33296436 1.04 ENSDART00000123114
dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr20_-_9436521 1.03 ENSDART00000133000
zgc:101840
zgc:101840
chr20_-_28404362 1.03 ENSDART00000055932
ENSDART00000188161
pigh
phosphatidylinositol glycan anchor biosynthesis, class H
chr17_+_33296852 1.03 ENSDART00000154580
dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr3_-_30123113 1.02 ENSDART00000153562
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr4_-_12388535 1.02 ENSDART00000017180
rergla
RERG/RAS-like a
chr7_+_7279903 1.02 ENSDART00000102603
si:ch211-168d1.3
si:ch211-168d1.3
chr23_+_19558574 1.00 ENSDART00000137811
atp6ap1lb
ATPase H+ transporting accessory protein 1 like b
chr24_+_26345427 1.00 ENSDART00000089756
lrrc34
leucine rich repeat containing 34
chr23_+_25172682 0.99 ENSDART00000191197
ENSDART00000183497
si:dkey-151g10.3
si:dkey-151g10.3
chr8_-_54304381 0.99 ENSDART00000184177
RHO (1 of many)
rhodopsin
chr3_-_12026741 0.98 ENSDART00000132238
cfap70
cilia and flagella associated protein 70
chr7_-_24236364 0.98 ENSDART00000010124
slc7a8a
solute carrier family 7 (amino acid transporter light chain, L system), member 8a
chr6_+_49722970 0.97 ENSDART00000155934
ENSDART00000154738
stx16
syntaxin 16
chr8_-_43716897 0.96 ENSDART00000163237
ep400
E1A binding protein p400
chr21_+_13387965 0.95 ENSDART00000134347
zgc:113162
zgc:113162
chr12_-_17147473 0.95 ENSDART00000106035
stambpl1
STAM binding protein-like 1
chr8_-_49345388 0.94 ENSDART00000053203
plp2
proteolipid protein 2
chr4_+_31259 0.94 ENSDART00000166826
phtf2
putative homeodomain transcription factor 2
chr6_+_49723289 0.93 ENSDART00000190452
stx16
syntaxin 16
chr24_-_5911973 0.93 ENSDART00000077933
ENSDART00000077922
pimr64
Pim proto-oncogene, serine/threonine kinase, related 64
chr7_-_72423666 0.93 ENSDART00000191214
rph3ab
rabphilin 3A homolog (mouse), b
chr18_+_30028135 0.92 ENSDART00000140825
ENSDART00000145306
ENSDART00000136810
si:ch211-220f16.1
si:ch211-220f16.1
chr10_+_34685135 0.92 ENSDART00000184999
nbeaa
neurobeachin a
chr3_-_19899914 0.92 ENSDART00000134969
rnd2
Rho family GTPase 2
chr24_-_26386627 0.92 ENSDART00000125344
skilb
SKI-like proto-oncogene b
chr1_+_2301961 0.91 ENSDART00000108919
ENSDART00000143361
ENSDART00000142944
farp1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr18_-_21271373 0.91 ENSDART00000060001
pnp6
purine nucleoside phosphorylase 6
chr22_+_2937485 0.90 ENSDART00000082222
ENSDART00000135507
ENSDART00000143258
cep19
centrosomal protein 19
chr16_+_42667560 0.90 ENSDART00000023452
dpy19l1l
dpy-19-like 1, like (H. sapiens)
chr17_-_43558494 0.90 ENSDART00000103830
nt5c1ab
5'-nucleotidase, cytosolic IAb
chr22_+_438714 0.90 ENSDART00000136491
celsr2
cadherin, EGF LAG seven-pass G-type receptor 2
chr3_+_33367954 0.89 ENSDART00000103161
mpp2a
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr8_-_39859688 0.89 ENSDART00000019907
unc119.1
unc-119 homolog 1
chr7_-_41013575 0.88 ENSDART00000150139
insig1
insulin induced gene 1
chr9_-_25255490 0.88 ENSDART00000141502
htr2aa
5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a
chr3_-_51142942 0.88 ENSDART00000160789
si:ch211-148f13.1
si:ch211-148f13.1
chr16_-_45069882 0.87 ENSDART00000058384
gapdhs
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr5_-_8406192 0.86 ENSDART00000159718
spef2
sperm flagellar 2
chr8_+_47571211 0.86 ENSDART00000131460
plch2a
phospholipase C, eta 2a
chr3_-_23596809 0.86 ENSDART00000156897
ube2z
ubiquitin-conjugating enzyme E2Z
chr17_+_39790388 0.86 ENSDART00000149488
ubr1
ubiquitin protein ligase E3 component n-recognin 1
chr16_+_34531486 0.85 ENSDART00000043291
paqr7b
progestin and adipoQ receptor family member VII, b
chr25_+_2668892 0.85 ENSDART00000122929
bbs4
Bardet-Biedl syndrome 4
chr8_+_25247245 0.85 ENSDART00000045798
ampd2b
adenosine monophosphate deaminase 2b
chr9_-_327901 0.85 ENSDART00000159956
ndufa4l2a
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2a
chr21_+_25071805 0.84 ENSDART00000078651
dixdc1b
DIX domain containing 1b
chr5_+_66353589 0.84 ENSDART00000138246
si:ch211-261c8.5
si:ch211-261c8.5
chr12_-_41684729 0.83 ENSDART00000184461
jakmip3
Janus kinase and microtubule interacting protein 3
chr2_-_36819624 0.83 ENSDART00000140844
slitrk3b
SLIT and NTRK-like family, member 3b
chr24_+_26345609 0.83 ENSDART00000186844
lrrc34
leucine rich repeat containing 34
chr21_-_43550120 0.83 ENSDART00000151627
si:ch73-362m14.2
si:ch73-362m14.2
chr4_+_3980247 0.82 ENSDART00000049194
gpr37b
G protein-coupled receptor 37b
chr25_+_35375848 0.82 ENSDART00000155721
ano3
anoctamin 3
chr2_+_366429 0.82 ENSDART00000111746
si:dkey-33c14.6
si:dkey-33c14.6
chr14_+_4796168 0.82 ENSDART00000041468
ap1ar
adaptor-related protein complex 1 associated regulatory protein
chr6_+_58543336 0.81 ENSDART00000157018
stmn3
stathmin-like 3
chr5_-_5326010 0.81 ENSDART00000161946
pbx3a
pre-B-cell leukemia homeobox 3a
chr8_-_19216657 0.80 ENSDART00000135096
ENSDART00000135869
ENSDART00000145951
si:ch73-222f22.2
si:ch73-222f22.2
si:ch73-222f22.2
si:ch73-222f22.2
chr17_-_21784152 0.80 ENSDART00000127254
hmx2
H6 family homeobox 2
chr13_-_10261383 0.79 ENSDART00000080808
six3a
SIX homeobox 3a
chr3_-_3327573 0.78 ENSDART00000136319
ENSDART00000166667
tmem184bb
transmembrane protein 184bb
chr23_+_22335407 0.77 ENSDART00000147696
rap1gap
RAP1 GTPase activating protein
chr11_-_43002262 0.77 ENSDART00000172477
ENSDART00000181513
CABZ01069998.1

chr15_-_43768776 0.77 ENSDART00000170398
grm5b
glutamate receptor, metabotropic 5b
chr13_-_13294847 0.76 ENSDART00000125883
ENSDART00000013534
fgfr3
fibroblast growth factor receptor 3
chr2_-_56131312 0.76 ENSDART00000097755
jund
JunD proto-oncogene, AP-1 transcription factor subunit
chr8_-_20380750 0.76 ENSDART00000113910
adamts10
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr17_+_33767890 0.76 ENSDART00000193177
fut8a
fucosyltransferase 8a (alpha (1,6) fucosyltransferase)
chr25_+_25737386 0.75 ENSDART00000108476
lrrc61
leucine rich repeat containing 61
chr15_+_17100412 0.75 ENSDART00000154418
relb
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr13_+_13805385 0.75 ENSDART00000166859
slc4a11
solute carrier family 4, sodium borate transporter, member 11
chr20_+_20672163 0.75 ENSDART00000027758
rtn1b
reticulon 1b
chr25_-_3503164 0.73 ENSDART00000191477
ENSDART00000186345
ENSDART00000180199
PRKAR2B
si:ch211-272n13.7

Network of associatons between targets according to the STRING database.

First level regulatory network of rfx3_rfx2+rfx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.9 2.7 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.7 3.0 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.5 3.1 GO:0089700 protein kinase D signaling(GO:0089700) regulation of lymphangiogenesis(GO:1901490)
0.5 1.4 GO:2000425 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176) regulation of apoptotic cell clearance(GO:2000425)
0.4 2.6 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.4 2.5 GO:0097107 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.4 1.4 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.3 1.3 GO:0021557 oculomotor nerve development(GO:0021557)
0.3 1.6 GO:0036371 protein localization to T-tubule(GO:0036371)
0.3 1.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 2.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 3.2 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.3 0.9 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.3 0.9 GO:2000638 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.2 2.7 GO:0097104 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.2 2.2 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.2 0.8 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.2 2.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.2 0.9 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 0.9 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.2 1.9 GO:0039023 pronephric duct morphogenesis(GO:0039023)
0.2 1.8 GO:1902042 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.2 1.3 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.2 1.6 GO:0050714 positive regulation of protein secretion(GO:0050714)
0.2 1.3 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.2 1.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.2 1.1 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 1.3 GO:0061075 positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868)
0.1 1.1 GO:0051013 microtubule severing(GO:0051013)
0.1 2.2 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.1 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.1 0.6 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.1 0.7 GO:1902019 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.1 0.5 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.1 0.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.4 GO:0072176 pronephric duct development(GO:0039022) nephric duct development(GO:0072176)
0.1 1.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 4.7 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 1.1 GO:0051877 pigment granule aggregation in cell center(GO:0051877)
0.1 0.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 1.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.5 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.1 1.5 GO:1903288 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1 3.8 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.1 1.3 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.1 0.6 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 0.3 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.1 0.8 GO:0061588 calcium activated phospholipid scrambling(GO:0061588)
0.1 1.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.1 GO:0003356 regulation of cilium beat frequency(GO:0003356)
0.1 1.4 GO:0030007 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 0.7 GO:0072595 maintenance of protein localization in organelle(GO:0072595)
0.1 0.7 GO:0046548 retinal rod cell development(GO:0046548)
0.1 0.9 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.9 GO:0021754 facial nucleus development(GO:0021754)
0.1 1.1 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 0.2 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.1 2.0 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 0.3 GO:0070169 positive regulation of bone mineralization(GO:0030501) positive regulation of osteoblast differentiation(GO:0045669) positive regulation of ossification(GO:0045778) positive regulation of biomineral tissue development(GO:0070169)
0.1 0.3 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.1 0.4 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.6 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.1 0.5 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 0.5 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.1 0.3 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.1 0.4 GO:1990798 pancreas regeneration(GO:1990798)
0.1 1.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.5 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 2.5 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.3 GO:0051454 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.1 2.6 GO:0003146 heart jogging(GO:0003146)
0.0 2.3 GO:0021854 hypothalamus development(GO:0021854)
0.0 1.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.2 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.8 GO:0036065 fucosylation(GO:0036065)
0.0 0.9 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 1.3 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.6 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.6 GO:0032264 IMP salvage(GO:0032264)
0.0 1.2 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.6 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.7 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 1.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.1 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 1.1 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.2 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.0 0.9 GO:0001556 oocyte maturation(GO:0001556)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.3 GO:0071376 neutrophil homeostasis(GO:0001780) response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.3 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.2 GO:0007398 ectoderm development(GO:0007398)
0.0 0.3 GO:0036372 opsin transport(GO:0036372)
0.0 0.5 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.6 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.9 GO:0003094 glomerular filtration(GO:0003094)
0.0 0.9 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 1.8 GO:0048332 mesoderm morphogenesis(GO:0048332)
0.0 5.7 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.1 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.0 0.3 GO:0035094 response to nicotine(GO:0035094)
0.0 0.4 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.3 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 1.8 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 1.8 GO:0007416 synapse assembly(GO:0007416)
0.0 1.0 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 0.1 GO:2000058 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.0 1.0 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.1 GO:0032475 otolith formation(GO:0032475)
0.0 1.0 GO:0030641 regulation of cellular pH(GO:0030641)
0.0 6.6 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.4 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.2 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.0 0.1 GO:0015729 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 0.5 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.8 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 0.4 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 1.3 GO:0008593 regulation of Notch signaling pathway(GO:0008593)
0.0 0.6 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.0 0.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.8 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.1 GO:0007624 ultradian rhythm(GO:0007624)
0.0 1.3 GO:0051260 protein homooligomerization(GO:0051260)
0.0 0.4 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.5 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.5 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.1 GO:1903963 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 2.4 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.9 GO:0048841 regulation of axon extension involved in axon guidance(GO:0048841)
0.0 0.3 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 0.4 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.8 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 0.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 5.4 GO:0000226 microtubule cytoskeleton organization(GO:0000226)
0.0 1.4 GO:0006909 phagocytosis(GO:0006909)
0.0 5.5 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 0.8 GO:0048916 posterior lateral line development(GO:0048916)
0.0 0.4 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.2 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.5 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.3 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.0 GO:0009182 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202) dGDP metabolic process(GO:0046066)
0.0 0.5 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 1.3 GO:0030900 forebrain development(GO:0030900)
0.0 0.1 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.0 0.9 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.3 1.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 1.5 GO:0034464 BBSome(GO:0034464)
0.2 3.1 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.2 2.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 0.7 GO:0097255 R2TP complex(GO:0097255)
0.2 1.0 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 0.4 GO:0001534 radial spoke(GO:0001534)
0.1 0.9 GO:0097225 sperm midpiece(GO:0097225)
0.1 1.2 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1 3.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 1.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 4.4 GO:0099634 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 0.4 GO:0042641 actomyosin(GO:0042641)
0.1 2.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 1.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.6 GO:0030315 T-tubule(GO:0030315)
0.1 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 6.8 GO:0030141 secretory granule(GO:0030141)
0.1 0.3 GO:0070724 BMP receptor complex(GO:0070724)
0.1 1.2 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 2.5 GO:0008328 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.1 2.0 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.1 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.3 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.1 7.8 GO:0043025 neuronal cell body(GO:0043025)
0.1 0.7 GO:1990246 uniplex complex(GO:1990246)
0.0 1.1 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.0 GO:0043195 terminal bouton(GO:0043195)
0.0 9.6 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.3 GO:0030990 intraciliary transport particle(GO:0030990)
0.0 0.6 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.5 GO:0097546 ciliary base(GO:0097546)
0.0 2.1 GO:0031201 SNARE complex(GO:0031201)
0.0 0.5 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.5 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.1 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)
0.0 1.4 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 2.5 GO:0099572 postsynaptic specialization(GO:0099572)
0.0 1.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.8 GO:0000922 spindle pole(GO:0000922)
0.0 1.3 GO:0001726 ruffle(GO:0001726)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.6 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 5.8 GO:0045202 synapse(GO:0045202)
0.0 0.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0 4.3 GO:0043235 receptor complex(GO:0043235)
0.0 0.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.4 GO:0005795 Golgi stack(GO:0005795)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 4.2 GO:0043005 neuron projection(GO:0043005)
0.0 0.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.5 GO:0031901 early endosome membrane(GO:0031901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.4 2.8 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.4 2.6 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.4 2.5 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.2 2.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 1.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 0.9 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 1.4 GO:0001727 lipid kinase activity(GO:0001727)
0.2 1.3 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 0.9 GO:0008142 oxysterol binding(GO:0008142)
0.1 3.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 0.6 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.1 0.5 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 0.4 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.1 3.1 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.1 0.6 GO:0005119 smoothened binding(GO:0005119)
0.1 1.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.1 2.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.6 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 0.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 3.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.5 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.1 2.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.6 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.7 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.9 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.4 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.8 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.2 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.1 1.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 0.5 GO:0035613 RNA stem-loop binding(GO:0035613)
0.1 3.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.6 GO:0008494 translation activator activity(GO:0008494)
0.1 3.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.3 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 2.2 GO:0019003 GDP binding(GO:0019003)
0.1 0.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 0.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 0.7 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.3 GO:0008126 acetylesterase activity(GO:0008126)
0.1 3.2 GO:0017124 SH3 domain binding(GO:0017124)
0.1 0.5 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 1.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 1.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.9 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.8 GO:0019894 kinesin binding(GO:0019894)
0.0 3.7 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.8 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.7 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 1.5 GO:0044325 ion channel binding(GO:0044325)
0.0 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.7 GO:0016229 steroid dehydrogenase activity(GO:0016229)
0.0 5.1 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0098809 nitrite reductase activity(GO:0098809)
0.0 0.9 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 1.0 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.4 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 1.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 2.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 1.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.1 GO:0046332 SMAD binding(GO:0046332)
0.0 0.5 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.1 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.9 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.0 1.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.6 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.6 GO:0051087 chaperone binding(GO:0051087)
0.0 0.4 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 1.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.2 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 5.4 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 4.8 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 4.4 GO:0015631 tubulin binding(GO:0015631)
0.0 0.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.5 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 1.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.1 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 PID IGF1 PATHWAY IGF1 pathway
0.1 2.6 PID IFNG PATHWAY IFN-gamma pathway
0.1 2.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 1.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.2 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.8 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.3 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.6 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.3 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.5 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 4.5 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 3.1 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 0.8 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 3.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.8 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 0.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 1.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.3 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.1 0.7 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 2.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.6 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 2.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.1 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK